The DOI matches its Crossref record; 42 of the 44 references it cites were found in a registry or an index.
Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice
Open accessAbstract
The main purpose of this study was to determine whether intake of coenzyme Q10, which can potentially act as both an antioxidant and a prooxidant, has an impact on indicators of oxidative stress and the aging process. Mice were fed diets providing daily supplements of 0, 93, or 371 mg CoQ10 /kg body weight, starting at 3.5 months of age. Effects on mitochondrial superoxide generation, activities of oxidoreductases, protein oxidative damage, glutathione redox state, and life span of male mice were determined. Amounts of CoQ9 and CoQ10, measured after 3.5 or 17.5 months of intake, in homogenates and mitochondria of liver, heart, kidney, skeletal muscle, and brain increased with the dosage and duration of CoQ10 intake in all the tissues except brain. Activities of mitochondrial electron transport chain oxidoreductases, rates of mitochondrial O2-* generation, state 3 respiration, carbonyl content, glutathione redox state of tissues, and activities of superoxide dismutase, catalase, and glutathione peroxidase, determined at 19 or 25 months of age, were unaffected by CoQ10 administration. Life span studies, conducted on 50 mice in each group, showed that CoQ10 administration had no effect on mortality. Altogether, the results indicated that contrary to the historical view, supplemental intake of CoQ10 elevates the endogenous content of both CoQ9 and CoQ10, but has no discernable effect on the main antioxidant defenses or prooxidant generation in most tissues, and has no impact on the life span of mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although beneficial, lifelong supplementation with CoQ10 may also be deleterious [92,93,94].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [92]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895
Merritt, A. J. (1964) · Microchemical Journal · doi:10.1016/0026-265x(64)90139-0 · Cited by 5,180
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,032
Red Cell Metabolism: A Manual of Biochemical Methods.
(1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-6-985_1 · Cited by 2,327
Biochemical, physiological and medical aspects of ubiquinone function
Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,246
Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
Turrens, J. F., Alexandre, A., & Lehninger, A. L. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90293-0 · Cited by 1,214
Rates of Behavior and Aging Specified by Mitochondrial Function During Development
Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121
An assay for superoxide dismutase activity in mammalian tissue homogenates
Spitz, D. R., & Oberley, L. W. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90192-9 · Cited by 751
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
Boveris, A., Cadenas, E., & Stoppani, A. O. M. (1976) · Biochemical Journal · doi:10.1042/bj1560435 · Cited by 655
Sohal, R. S., Mockett, R. J., & Orr, W. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00886-9 · Cited by 604
Self-citationMatthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557
Ku, H., Brunk, U. T., & Sohal, R. S. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90165-q · Cited by 488
Self-citationKagan, V. E., Serbinova, E. A., & Packer, L. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91971-t · Cited by 363
Antioxidant and prooxidant properties of mitochondrial Coenzyme Q
James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.025 · Cited by 292
Kwong, L. K., & Sohal, R. S. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1495 · Cited by 273
Self-citationHodgson, J., Watts, G. F., Playford, D. A., Burke, V., & Croft, K. D. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601464 · Cited by 253
Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q
Larsen, P. L., & Clarke, C. F. (2002) · Science · doi:10.1126/science.1064653 · Cited by 249
A cell-intrinsic timer that operates during oligodendrocyte development
Durand, B., & RAFF, M. C. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200001)22:1 · Cited by 245
Effects of age and caloric restriction on glutathione redox state in mice
Rebrin, I., Kamzalov, S., & Sohal, R. S. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00388-5 · Cited by 243
Self-citationKwong, L. K., Kamzalov, S., Rebrin, I., Bayne, A.-C. V., Jana, C. K., Morris, P., Forster, M. J., & Sohal, R. S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00916-4 · Cited by 199
Self-citationCoenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress
Ishii, N., Senoo‐Matsuda, N., Miyake, K., Yasuda, K., Ishii, T., Hartman, P. S., & Furukawa, S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.10.002 · Cited by 197
Uptake of Dietary Coenzyme Q Supplement is Limited in Rats
Zhang, Y., Åberg, F. O., Appelkvist, E., Dallner, G., & Ernster, L. (1995) · Journal of Nutrition · doi:10.1093/jn/125.3.446 · Cited by 192
Lass, A., & Sohal, R. S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0606 · Cited by 162
Self-citationDistribution and breakdown of labeled coenzyme Q10 in rat
Bentinger, M., Dallner, G., Chojnacki, T., & Świeżewska, E. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01357-6 · Cited by 146
Lee, C., Pugh, T. D., Klopp, R. G., Edwards, J. W., Allison, D. B., Weindruch, R. H., & Prolla, T. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.015 · Cited by 134
Lass, A., Agarwal, S., & Sohal, R. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19199 · Cited by 117
Self-citationZhang, Y., Turunen, M., & Appelkvist, E. (1996) · Journal of Nutrition · doi:10.1093/jn/126.9.2089 · Cited by 116
Yarian, C. S., Rebrin, I., & Sohal, R. S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.135 · Cited by 111
Self-citationForsmark-Andrée, P., Dallner, G., & Ernster, L. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00076-a · Cited by 107
Natural Distribution and Occurrence of Coenzyme Q Homologues
Battino, M. A., Ferri, E. N., Gorini, A., Villa, R. F., Huertas, J. R., Fiorella, P. L., Genova, M. L., Lenaz, G., & Marchetti, M. (1990) · Membrane Biochemistry · doi:10.3109/09687689009025839 · Cited by 103
Rebrin, I., & Sohal, R. S. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.014 · Cited by 100
Self-citationPlayford, D. A., Watts, G. F., Croft, K. D., & Burke, V. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00417-3 · Cited by 97
[17] Simultaneous determination of reduced and oxidized ubiquinones
Takada, M., Ikenoya, S., YUZURIHA, T., & Katayama, K. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05020-5 · Cited by 94
Kamzalov, S., Sohal, R. S., Sumien, N., & Forster, M. J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3175 · Cited by 89
Self-citationSilencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans
Asencio, C., Rodríguez‐Aguilera, J. C., Ruiz‐Ferrer, M., Vela, J., & Navas, P. (2003) · The FASEB Journal · doi:10.1096/fj.02-1022fje · Cited by 74
Lönnrot, K., Alho, H., Holm, P., Lagerstedt, A., & Huhtala, H. (1998) · IUBMB Life · doi:10.1080/15216549800201772 · Cited by 64
Comparisons of coenzyme Q bound to mitochondrial membrane proteins among different mammalian species
Lass, A., & Sohal, R. S. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00085-4 · Cited by 60
Self-citationKatayama, K., Takada, M., YUZURIHA, T., Abe, K., & Ikenoya, S. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)91568-5 · Cited by 57
Rowland, M. A., Nagley, P., Linnane, A. W., & Rosenfeldt, F. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00132-1 · Cited by 29
Rosenfeldt, F., Rowland, M. A., NAGLEY, P., & Linnane, A. W. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09937.x · Cited by 23
The effects of dietary coenzyme Q on Drosophila life span
Palmer, M. R., & Sackton, T. B. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00065.x · Cited by 16
Research works printed but not linked: 1
- Branicky, 2000, clk-1, mitochondria and physiological rates, Bio essays, 22, 48
Cited by
Sorted by citations
Oxidative Stress, Mitochondrial Dysfunction, and Aging
Cui, H., Kong, Y., & Zhang, H. (2011) · Journal of Signal Transduction · doi:10.1155/2012/646354 · Cited by 1,076
Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments
Littarru, G. P., & Tiano, L. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0052-y · Cited by 465
Mitochondrial Metabolism in Aging Heart
Lesnefsky, E. J., Chen, Q., & Hoppel, C. L. (2016) · Circulation Research · doi:10.1161/circresaha.116.307505 · Cited by 358
When a theory of aging ages badly
Lapointe, J., & Hekimi, S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0138-8 · Cited by 274
Discovering the link between nutrition and skin aging
Schagen, S., Zampeli, V., Makrantonaki, E., & Zouboulis, C. C. (2012) · Dermato-Endocrinology · doi:10.4161/derm.22876 · Cited by 254
Metadata
- Authors
- Sohal, R. S., Kamzalov, S., Sumien, N., Ferguson, M., Rebrin, I., Heinrich, K. R., & Forster, M. J.
- Affiliations
- University of Southern California (US)
- University of North Texas Health Science Center (US)
- Corresponding author
- Sohal, Rajindar S.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 40
- Issue
- 3
- Pages
- 480-487
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC2834650
- OpenAlex
- W2071820285
- Cited by
- 131
- References
- 44
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 1 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01 AG17526, R01AG007657, R01AG017526)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- coenzyme Q10, dietary supplementation, mitochondrial electron transport chain, oxidative stress, antioxidant defense, protein carbonylation, glutathione redox state, superoxide dismutase, catalase, glutathione peroxidase, aging, lifespan, pro-oxidant activity
- MeSH terms
- Aging, Animals, Antioxidants, Catalase, Coenzymes, Electron Transport, Glutathione, Glutathione Peroxidase, Male, Mice, Inbred C57BL, Mitochondria, Oxidation-Reduction, Oxidoreductases, Superoxides, Superoxide Dismutase, Ubiquinone, Oxidative Stress, Dietary Supplements, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
