Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

James, Andrew M.; Smith, Robin A.J.; Murphy, Michael P.

doi:10.1016/j.abb.2003.12.025

Cited by 292Coenzyme Q10 studies and effectsAntioxidant Activity and Oxidative StressBioactive Compounds and Antitumor Agents

Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

James, Andrew M., Smith, Robin A.J., Murphy, Michael P.·2004·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2003.12.025

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Abstract

Coenzyme Q is both an essential electron carrier and an important antioxidant in the mitochondrial inner membrane. The reduced form, ubiquinol, decreases lipid peroxidation directly by acting as a chain breaking antioxidant and indirectly by recycling Vitamin E. The ubiquinone formed in preventing oxidative damage is reduced back to ubiquinol by the respiratory chain. As well as preventing lipid peroxidation, Coenzyme Q reacts with other reactive oxygen species, contributing to its effectiveness as an antioxidant. There is growing interest in using Coenzyme Q and related compounds therapeutically because mitochondrial oxidative damage contributes to degenerative diseases. Paradoxically, Coenzyme Q is also involved in superoxide production by the respiratory chain. To help understand how Coenzyme Q contributes to both mitochondrial oxidative damage and antioxidant defences, we have reviewed its antioxidant and prooxidant properties.

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CoQ in the semiquinone form acts as a chain-breaking agent, thereby protecting against lipid peroxidation.
“Moreover, CoQ in the semiquinone form also acts as a chain-breaking agent, thereby protecting against lipid peroxidation (147).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [147]
A major action of mitoQ may be to decrease lipid peroxidation by virtue of the quinol moiety acting as a chain-breaking antioxidant.
“A major action may be to decrease lipid peroxidation by virtue of the quinol moiety acting as a chain-breaking antioxidant (147).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [147]

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Authors: James, A. M., Smith, R. A. J., & Murphy, M. P.
Affiliations: MRC Mitochondrial Biology Unit (GB)
University of Otago (NZ)
Corresponding author: Murphy, Michael P.
ORCID: James, Andrew M.
Murphy, Michael P.
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2004-03
Volume: 423
Issue: 1
Pages: 47-56
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2003.12.025
OpenAlex: W1969628253
Cited by: 292
References: 56
Citations by year: 2026: 7 · 2025: 14 · 2024: 5 · 2023: 16 · 2022: 17 · 2021: 17 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 14 · 2016: 18 · 2015: 12 · 2014: 10 · 2013: 13 · 2012: 15
FWCI: 0.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: coenzyme Q10, ubiquinol, mitochondrial antioxidant defense, lipid peroxidation, chain-breaking antioxidants, reactive oxygen species, superoxide production, electron transport chain, mitochondrial oxidative damage, degenerative diseases
MeSH terms: Animals, Antioxidants, Humans, Mitochondria, Oxidation-Reduction, Ubiquinone, Oxidants, Hydrophobic and Hydrophilic Interactions

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Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

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