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Cited by 81Coenzyme Q10 studies and effectsGenetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

The Paradox of Coenzyme Q10 in Aging

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Díaz-Casado, M. Elena, Quiles, José L., Barriocanal-Casado, Eliana, González-García, Pilar, Battino, Maurizio, López, Luis C., Varela-López, Alfonso·2019·Nutrients
DOI 10.3390/nu11092221PMC PMC6770889
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Abstract

Coenzyme Q (CoQ) is an essential endogenously synthesized molecule that links different metabolic pathways to mitochondrial energy production thanks to its location in the mitochondrial inner membrane and its redox capacity, which also provide it with the capability to work as an antioxidant. Although defects in CoQ biosynthesis in human and mouse models cause CoQ deficiency syndrome, some animals models with particular defects in the CoQ biosynthetic pathway have shown an increase in life span, a fact that has been attributed to the concept of mitohormesis. Paradoxically, CoQ levels decline in some tissues in human and rodents during aging and coenzyme Q10 (CoQ10) supplementation has shown benefits as an anti-aging agent, especially under certain conditions associated with increased oxidative stress. Also, CoQ10 has shown therapeutic benefits in aging-related disorders, particularly in cardiovascular and metabolic diseases. Thus, we discuss the paradox of health benefits due to a defect in the CoQ biosynthetic pathway or exogenous supplementation of CoQ10.

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  • Coenzyme Q10 has demonstrated therapeutic benefits in aging-related disorders and in mitigation of heavy metal toxicities due to anti-inflammatory, antioxidant, and antiapoptotic properties.

    “Therapeutic benefits of CoQ10 were demonstrated in aging-related disorders, mainly those accompanied by increased oxidative stress (Diaz-Casado et al. 2019) and in the mitigation of heavy metal toxicities from lead and arsenic due to its antiinflammatory, antioxidant, and antiapoptotic properties (Al-Megrin et al. 2020; Silva et al. 2022).”

    From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Diaz-Casado et al. 2019

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Authors
Díaz-Casado, M. E., Quiles, J. L., Barriocanal-Casado, E., González-García, P., Battino, M., López, L. C., & Varela-López, A.
Affiliations
  • Universidad de Granada (ES)
  • Institute of Biotechnology, Department of Physiology, Biomedical Research Center, University of Granada, Avda del Conocimiento sn, 18016 Granada, Spain
  • Jiangsu University (CN)
  • Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Physiology, Biomedical Research Center, University of Granada, Avda del Conocimiento sn, 18016 Granada, Spain
Corresponding author
Díaz-Casado, M. Elena
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2019-09-14
Volume
11
Issue
9
Pages
2221
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu11092221
PMC
PMC6770889
OpenAlex
W2973207286
Cited by
81
References
12
Citations by year
2026: 5 · 2025: 14 · 2024: 8 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 8
FWCI
0.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
  • Institutional Repository of the University of Granada (University of Granada) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ministerio de Ciencia, Innovación y Universidades, Spain, and the ERDF (RTI2018-093503-B-I00)
  • Muscular Dystrophy Association (602322)
  • University of Granada (“UNETE”, UCE-PP2017-06)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
coenzyme Q10, aging, mitohormesis, longevity, oxidative stress, antioxidants, mitochondrial energy production, coenzyme Q10 supplementation, cardiovascular disease, metabolic disorders, anti-aging
MeSH terms
Adult, Aging, Animals, Antioxidants, Ataxia, Diet, Female, Humans, Male, Middle Aged, Mitochondria, Ubiquinone, Caenorhabditis elegans, Muscle Weakness, Mitochondrial Diseases, Mice, Rats, Young Adult, Hormesis

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