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Cited by 105Magnesium in Health and DiseaseAntioxidant Activity and Oxidative StressMagnesium Alloys: Properties and Applications

Long-Term Moderate Magnesium-Deficient Diet Shows Relationships between Blood Pressure, Inflammation and Oxidant Stress Defense in Aging Rats

Blache, Denis, Devaux, Sylvie, Joubert, Olivier, Loreau, Nadine, Schneider, Martina, Durand, Philippe, Prost, Michel, Gaume, Vincent +3 more·2006·Free Radical Biology and Medicine
DOI 10.1016/j.freeradbiomed.2006.04.008
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Abstract

Epidemiological and experimental studies have indicated a relationship among aging, dietary Mg, inflammatory stress, and cardiovascular disease. Our aim in the present study was to investigate possible links between dietary Mg, oxidant stress parameters, and inflammatory status with aging in rats. We designed a long-term study in which rats were fed for 22 months with moderately deficient (150 mg/kg), standard (800 mg/kg), or supplemented (3200 mg/kg) Mg diets. Comparisons were made with young rats fed with the same diets for 1 month. Compared to the standard and supplemented diets, the Mg-deficient diet significantly increased blood pressure, plasma interleukin-6, fibrinogen, and erythrocyte lysophosphatidylcholine, particularly in aging rats, it decreased plasma albumin. The impairment of redox status was indicated by increases in plasma thiobarbituric acid reactive substances and oxysterols and an increased blood susceptibility to in vitro free-radical-induced hemolysis. We concluded that Mg deficiency induced a chronic impairment of redox status associated with inflammation which could significantly contribute to increased oxidized lipids and promote hypertension and vascular disorders with aging. Extrapolating to the human situation and given that Mg deficiency has been reported to be surprisingly common, particularly in the elderly, Mg supplementation might be useful as an adjuvant therapy in preventing cardiovascular disease.

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  • In animals, a long-term magnesium-deficient diet disrupts redox balance and homeostasis, increases inflammation, and exacerbates development and progression of aging-related diseases such as cardiovascular diseases, hypertension, and diabetes.

    “Accordingly, animal studies have confirmed that a long-term Mg-deficient diet disrupts the redox balance and homeostasis and increases inflammation, consequently exacerbating the development and progression of aging-related diseases such as cardiovascular diseases, hypertension, or diabetes [420,446].”

    From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [420]

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Authors
Blache, D., Devaux, S., Joubert, O., Loreau, N., Schneider, M., Durand, P., Prost, M., Gaume, V., Adrian, M., Laurant, P., & Berthelot, A.
Affiliations
  • Inserm (FR)
  • Université de Franche-Comté (FR)
Corresponding author
Blache, Denis
ORCID
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2006-07
Volume
41
Issue
2
Pages
277-284
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/j.freeradbiomed.2006.04.008
OpenAlex
W2029061627
Cited by
105
References
49
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 5 · 2012: 5
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
Institut National de la Santé et de la Recherche Médicale
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Keywords
hypomagnesemia, dietary magnesium, aging, hypertension, blood pressure, inflammation, oxidative stress, redox state, lipid peroxidation, oxysterols, interleukin-6, fibrinogen, lysophosphatidylcholine, serum albumin, magnesium supplementation, cardiovascular disease, rats
MeSH terms
Animals, Blood Pressure, Inflammation, Magnesium Deficiency, Male, Rats, Sprague-Dawley, Oxidative Stress, Rats

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