Prevention of mutation, Cancer, and other Age-Associated diseases by optimizing micronutrient intake
Open accessAbstract
I review three of our research efforts which suggest that optimizing micronutrient intake will in turn optimize metabolism, resulting in decreased DNA damage and less cancer as well as other degenerative diseases of aging. (1) Research on delay of the mitochondrial decay of aging, including release of mutagenic oxidants, by supplementing rats with lipoic acid and acetyl carnitine. (2) The triage theory, which posits that modest micronutrient deficiencies (common in much of the population) accelerate molecular aging, including DNA damage, mitochondrial decay, and supportive evidence for the theory, including an in‐depth analysis of vitamin K that suggests the importance of achieving optimal micronutrient intake for longevity. (3) The finding that decreased enzyme binding constants (increased Km) for coenzymes (or substrates) can result from protein deformation and loss of function due to an age‐related decline in membrane fluidity, or to polymorphisms or mutation. The loss of enzyme function can be compensated by a high dietary intake of any of the B vitamins, which increases the level of the vitamin‐derived coenzyme. This dietary remediation illustrates the importance of understanding the effects of age and polymorphisms on optimal micronutrient requirements. Optimizing micronutrient intake could have a major effect on the prevention of cancer and other degenerative diseases of aging.
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More DNA repair at least correlates with improved healthspan and lifespan.
“Collectively, there is abundant evidence that more DNA repair at least correlates with improved healthspan and lifespan.”
From DNA damage-how and why we age? (2021) · cites this paper as Ames, 2010
Caloric restriction, dietary micronutrients, chronic exercise, and improved socialization of the elderly can enhance genome stability.
“there is evidence that CR (Matt et al., 2016), dietary micronutrients (Ames, 2010), chronic exercise, and improved socialization of the elderly (Franzke et al., 2015b) can enhance genome stability”
From DNA damage-how and why we age? (2021) · cites this paper as Ames, 2010
The enhancement of genome stability by caloric restriction, dietary micronutrients, chronic exercise, and improved socialization of the elderly is ascribed to improved DNA repair capacity.
“which is ascribed to improved DNA repair capacity.”
From DNA damage-how and why we age? (2021) · cites this paper as Ames, 2010
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Self-citationMicronutrients and Brain Health
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Delaying the mitochondrial decay of aging in the brain
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Self-citationAmes, B. N., & McCann, J. C. (2009) · Oxidative stress and disease · doi:10.1201/9781420073522.ch24 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [70]Institute of Medicine Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board 1997 Washington, DC, USA National Academy of Sciences, National Academy Press
- [141]Institute of Medicine Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board 1998 Washington, DC, USA National Academy of Sciences, National Academy Press
Cited by
Sorted by citations
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Self-citationDNA damage-how and why we age?
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Colapinto, G., Volpi, R., Forino, G., Tricarico, V., Benedittis, M. D., Cortelazzi, R., Testori, T., & FABBRO, M. D. (2017) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2017.10.015 · Cited by 8 · see citing works
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Additional file 1 of Low serum vitamin B12 levels are associated with degenerative rotator cuff tear
Kim, J. H., Kim, G.-T., Yoon, S., Lee, H. I., Ko, K. R., Lee, S.-C., Kim, D. K., Shin, J., Lee, S.-Y., & Lee, S. (2021) · Figshare · doi:10.6084/m9.figshare.14445088
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HaiBo, P. A. N., YangRuiJie, Y. I. N., Xin, H. U., & Chen, W. J. (2026) · Scientia Sinica Vitae · doi:10.1360/ssv-2025-0266
- Authors
- Ames, B. N.
- Corresponding author
- Ames, Bruce N.
- Venue
- Journal of Nucleic Acids
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 2010
- Issue
- 1
- ISSN
- 2090-0201 (ISSN-L)
- 2090-021X
- PMC
- PMC2945683
- OpenAlex
- W2122596918
- Cited by
- 51
- References
- 141
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 4
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Nucleic Acids (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- micronutrient intake, cancer prevention, aging, DNA damage, alpha-lipoic acid, acetyl-L-carnitine, vitamin K, B vitamins, membrane fluidity, enzyme polymorphism, dietary supplementation, longevity
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