Cited by 51Genetics, Aging, and Longevity in Model OrganismsNutrition and Health StudiesAntioxidant Activity and Oxidative Stress

Prevention of mutation, Cancer, and other Age-Associated diseases by optimizing micronutrient intake

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Ames, Bruce N.·2010·Journal of Nucleic Acids

Abstract

I review three of our research efforts which suggest that optimizing micronutrient intake will in turn optimize metabolism, resulting in decreased DNA damage and less cancer as well as other degenerative diseases of aging. (1) Research on delay of the mitochondrial decay of aging, including release of mutagenic oxidants, by supplementing rats with lipoic acid and acetyl carnitine. (2) The triage theory, which posits that modest micronutrient deficiencies (common in much of the population) accelerate molecular aging, including DNA damage, mitochondrial decay, and supportive evidence for the theory, including an in‐depth analysis of vitamin K that suggests the importance of achieving optimal micronutrient intake for longevity. (3) The finding that decreased enzyme binding constants (increased Km) for coenzymes (or substrates) can result from protein deformation and loss of function due to an age‐related decline in membrane fluidity, or to polymorphisms or mutation. The loss of enzyme function can be compensated by a high dietary intake of any of the B vitamins, which increases the level of the vitamin‐derived coenzyme. This dietary remediation illustrates the importance of understanding the effects of age and polymorphisms on optimal micronutrient requirements. Optimizing micronutrient intake could have a major effect on the prevention of cancer and other degenerative diseases of aging.

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Crossref · 10.4061/2010/725071

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141 of 141 references verified0 citation errors · 0 not checkable

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  • More DNA repair at least correlates with improved healthspan and lifespan.

    “Collectively, there is abundant evidence that more DNA repair at least correlates with improved healthspan and lifespan.”

    From DNA damage-how and why we age? (2021) · cites this paper as Ames, 2010

  • Caloric restriction, dietary micronutrients, chronic exercise, and improved socialization of the elderly can enhance genome stability.

    “there is evidence that CR (Matt et al., 2016), dietary micronutrients (Ames, 2010), chronic exercise, and improved socialization of the elderly (Franzke et al., 2015b) can enhance genome stability”

    From DNA damage-how and why we age? (2021) · cites this paper as Ames, 2010

  • The enhancement of genome stability by caloric restriction, dietary micronutrients, chronic exercise, and improved socialization of the elderly is ascribed to improved DNA repair capacity.

    “which is ascribed to improved DNA repair capacity.”

    From DNA damage-how and why we age? (2021) · cites this paper as Ames, 2010

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Research works printed but not linked: 2

  1. [70]Institute of Medicine Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board 1997 Washington, DC, USA National Academy of Sciences, National Academy Press
  2. [141]Institute of Medicine Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board 1998 Washington, DC, USA National Academy of Sciences, National Academy Press

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Authors
Ames, B. N.
Corresponding author
Ames, Bruce N.
Venue
Journal of Nucleic Acids
Publisher
Wiley
Published
2010-01
Volume
2010
Issue
1
ISSN
  • 2090-0201 (ISSN-L)
  • 2090-021X
OpenAlex
W2122596918
Cited by
51
References
141
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 4
FWCI
1.76
Type
journal article
Language
en
Open access
Locations
  • Journal of Nucleic Acids (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
micronutrient intake, cancer prevention, aging, DNA damage, alpha-lipoic acid, acetyl-L-carnitine, vitamin K, B vitamins, membrane fluidity, enzyme polymorphism, dietary supplementation, longevity

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