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Cited by 146Meat and Animal Product QualityNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Diet-induced endogenous formation of nitroso compounds in the GI tract

Kuhnle, Gunter G.C., Story, Giles W., Reda, Torsten, Mani, Ali R., Moore, Kevin P., Lunn, Joanne C., Bingham, Sheila A.·2007·Free Radical Biology and Medicine
DOI 10.1016/j.freeradbiomed.2007.03.011
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Abstract

Red or processed meat, but not white meat or fish, is associated with colorectal cancer. The endogenous formation of nitroso compounds is a possible explanation, as red or processed meat--but not white meat or fish--causes a dose-dependent increase in fecal apparent total N-nitroso compounds (ATNC) and the formation of nitroso-compound-specific DNA adducts. Red meat is particularly rich in heme and heme has also been found to promote the formation of ATNC. To investigate the underlying mechanism of ATNC formation, fecal and ileal samples of volunteers fed a high red meat or a vegetarian diet were analyzed for nitrosyl iron, nitrosothiols, and heme. To simulate the processes in the stomach, food homogenates and hemoglobin were incubated under simulated gastric conditions. Nitrosyl iron and nitrosothiols were significantly (p < 0.0001) increased in ileal and fecal samples after a high red meat diet compared with a vegetarian diet; significantly more nitrosyl iron than nitrosothiols was detectable in ileal (p < 0.0001) and fecal (p < 0.001) samples. The strong correlation between fecal nitrosyl iron and heme (0.776; p < 0.0001) suggested that nitrosyl heme is the main source of nitrosyl iron, and ESR confirmed the presence of nitrosyl heme in fecal samples after a high red meat diet. Under simulated gastric conditions, mainly nitrosothiols were formed, suggesting that acid-catalyzed thionitrosation is the initial step in the endogenous formation of nitroso compounds. Nitrosyl heme and other nitroso compounds can then form under the alkaline and reductive conditions of the small and large bowel.

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Research works printed but not linked: 3

  1. Williams, 1983, Nitrosation mechanisms, Adv. Phys. Org. Chem., 19, 381
  2. Fischer, 1886, Chem. Ber., 1886, 2291
  3. Eisenbrand, 1970, Eine neue Methode zur kolorimetrischen Bestimmung von Nitrosaminen nach Spaltung der N-Nitrosogruppe mit Bromwasserstoff in Eisessig, Arzneimittelforschung, 20, 1512

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Metadata

Authors
Kuhnle, G. G. C., Story, G. W., Reda, T., Mani, A. R., Moore, K. P., Lunn, J. C., & Bingham, S. A.
Affiliations
  • MRC Mitochondrial Biology Unit (GB)
  • The Royal Free Hospital (GB)
Corresponding author
Bingham, Sheila A.
ORCID
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2007-10
Volume
43
Issue
7
Pages
1040-1047
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/j.freeradbiomed.2007.03.011
OpenAlex
W2079577516
Cited by
146
References
59
Citations by year
2026: 5 · 2025: 4 · 2024: 27 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 7 · 2012: 4
FWCI
10.10
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Food Standards Agency
  • Medical Research Council
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
nitroso compounds, endogenous nitrosation, red meat, processed meat, heme, S-nitrosothiols, colorectal cancer, DNA adducts, simulated gastric conditions, hemoglobin, vegetarian diet, gastrointestinal tract
MeSH terms
Apoproteins, Diet, Electron Spin Resonance Spectroscopy, Feces, Gastric Mucosa, Heme, Hemoglobins, Humans, Ileum, Iron, Kinetics, Meat, Nitroso Compounds, Serum Albumin, Bovine, Diet, Vegetarian, S-Nitrosothiols, Gastrointestinal Tract

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