Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC
Abstract
The questions of whether and how N-nitroso compounds (NOC) may be inducing cancer in humans are discussed. The principal subjects covered include nitrite-derived alkylating agents that are not NOC, reasons for the wide tissue specificity of carcinogenesis by NOC, the acute toxicity of nitrosamines in humans, mechanisms of in vivo formation of NOC by chemical and bacterial nitrosation in the stomach and via nitric oxide (NO) formation during inflammation, studies on nitrite esters, use of the nitrosoproline test to follow human gastric nitrosation, correlations of nitrate in food and water with in vivo nitrosation and the inhibition of gastric nitrosation by vitamin C and polyphenols. Evidence that specific cancers are caused by NOC is reviewed for cancer of the stomach, esophagus, nasopharynx, urinary bladder in bilharzia and colon. I review the occurrence of nitrosamines in tobacco products, nitrite-cured meat (which might be linked with childhood leukemia and brain cancer) and other foods, and in drugs and industrial situations. Finally, I discuss clues from mutations in ras and p53 genes in human tumors about whether NOC are etiologic agents and draw some general conclusions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
After that report, a number of studies followed in relation to the carcinogenic effects of N-nitroso compounds in animal models.
“After this report, a number of studies followed in relation to the carcinogenic effects of N-nitroso compounds in animal models [134,135].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [135]
Cites
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811 · see citing works
Goodman and Gilman's the Pharmacological Basis of Therapeutics
Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,793 · see citing works
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463 · see citing works
Blot, W. J., Li, J., Taylor, P. R., Guo, W., Dawsey, S. M., Wang, G.-Q., Yang, C. S., Zheng, S., Gail, M. H., Li, G.-Y., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.18.1483 · Cited by 1,758 · see citing works
[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].
Druckrey, H., Preußmann, R., Ivankovic, S., & Schmähl, D. (1967) · PubMed · Cited by 1,407 · see citing works
Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten
Druckrey, H., Preußmann, R., Ivankovic, S., Schm�hl, D., Afkham, J., Blum, G., Mennel, H. D., M�ller, M., Petropoulos, P., & Schneider, H. (1967) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00524152 · Cited by 1,349 · see citing works
Hausen, H. Z., Schulte‐Holthausen, H., KLEIN, G., Henle, W., Henle, G., Clifford, P., & Santesson, L. (1970) · Nature · doi:10.1038/2281056a0 · Cited by 1,256 · see citing works
DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors
Wink, D. A., Kasprzak, K. S., Maragos, C. M., Elespuru, R. K., Misra, M., Dunams, T. M., Cebula, T. A., Koch, W. H., Andrews, A. W., Allen, J. S., et al. (1991) · Science · doi:10.1126/science.1948068 · Cited by 1,235 · see citing works
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
Guengerich, F. P., Kim, D., & Iwasaki, M. (1991) · Chemical Research in Toxicology · doi:10.1021/tx00020a008 · Cited by 1,174 · see citing works
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126 · see citing works
Carcinogenic Nitroso Compounds
MAGEE, P. N., & Barnes, J. M. (1967) · Advances in cancer research · doi:10.1016/s0065-230x(08)60079-2 · Cited by 1,096 · see citing works
Ohshima, H., & Bartsch, H. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90245-3 · Cited by 1,050 · see citing works
Yang, C. S., & Wang, Z.-Y. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.13.1038 · Cited by 995 · see citing works
DNA damage and mutation in human cells exposed to nitric oxide in vitro.
Nguyen, T., Brunson, D. C., Crespi, C. L., Penman, B. W., Wishnok, J. S., & Tannenbaum, S. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3030 · Cited by 972 · see citing works
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
Fraga, C., Motchnik, P., Shigenaga, M., Helbock, H., Jacob, R., & Ames, B. (1991) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.88.24.11003 · Cited by 809 · see citing works
Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence
Mirvish, S. S. (1975) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(75)90255-0 · Cited by 779 · see citing works
Self-citationStuehr, D. J., & Marletta, M. A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.2.518 · Cited by 713 · see citing works
Iyengar, R., Stuehr, D. J., & Marletta, M. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6369 · Cited by 664 · see citing works
Toxicity and carcinogenicity of the Fusanum monilzforine metabolite, fumonisin B1, in rats
Gelderblom, W. C. A., Kriek, N. P. J., Marasas, W. F. O., et al. (1991) · Carcinogenesis · doi:10.1093/carcin/12.7.1247 · Cited by 663 · see citing works
Hruban, R. H., van Mansfeld, A. D. M., Offerhaus, G. J. A., van Weering, D. H. J., Allison, D. C., Goodman, S. N., Kensler, T. W., Bose, K., Cameron, J. L., & Bos, J. L. (1993) · PubMed Central · Cited by 650 · see citing works
Chu, F. S., & Li, G. Y. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.3.847-852.1994 · Cited by 531 · see citing works
Mirvish, S. S., Wallcave, L., Eagen, M., & Shubik, P. (1972) · Science · doi:10.1126/science.177.4043.65 · Cited by 496 · see citing works
Self-citationRelevance of nitrosamines to human cancer
Bartsch, H., & Montesano, R. (1984) · Carcinogenesis · doi:10.1093/carcin/5.11.1381 · Cited by 495 · see citing works
Vitamin C and cancer prevention: the epidemiologic evidence
Block, G. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.270s · Cited by 472 · see citing works
Cytochrome P450IIe1: Roles in Nitrosamine Metabolism and Mechanisms of Regulation
Yang, C. S., Yoo, J.-S. H., Ishizaki, H., & Hong, J. (1990) · Drug Metabolism Reviews · doi:10.3109/03602539009041082 · Cited by 360 · see citing works
Ohshima, H., & Bartsch, H. (1981) · PubMed · Cited by 344 · see citing works
Some Toxic Properties of Dimethylnitrosamine
Barnes, J., & MAGEE, P. N. (1954) · Occupational and Environmental Medicine · doi:10.1136/oem.11.3.167 · Cited by 327 · see citing works
The Etiology of Gastric Cancer Intragastric Nitrosamide Formation and Other Theories
Mirvish, S. S. (1983) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/71.3.629 · Cited by 274 · see citing works
Self-citationTransplacentare Erzeugung maligner Tumoren des Nervensystems
Ivankovic, S., & Druckrey, H. (1968) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00524414 · Cited by 263 · see citing works
Fusarium moniliforme contamination of maize in oesophageal cancer areas in Transkei.
Marasas, W. F. O., Jaskiewicz, K., Venter, F. S., et al. (1988) · PubMed · Cited by 241 · see citing works
The relevance of tobacco-specific nitrosamines to human cancer.
Hecht, S. S., & Hoffmann, D. (1989) · PubMed · Cited by 233 · see citing works
Epidemiologic and Dietary Evidence for a Specific Nutritional Predisposition to Esophageal Cancer
Rensburg, S. J. V. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.2.243 · Cited by 231 · see citing works
Peto, R., Gray, R. G., Brantom, P., & GRASSO, P. (1991) · PubMed · Cited by 208 · see citing works
Nitromation of amines by stimulated macrophages
Miwa, M., Stuehr, D. J., Marletta, M. A., Wishnok, J. S., & Tannenbaum, S. R. (1987) · Carcinogenesis · doi:10.1093/carcin/8.7.955 · Cited by 208 · see citing works
Stoner, G. D., Morrissey, D. T., Heur, Y., et al. (1991) · PubMed · Cited by 205 · see citing works
Nair, J., Ohshima, H., Friesen, M. D., Croisy, A., Bhide, S. V., & Bartsch, H. (1985) · Carcinogenesis · doi:10.1093/carcin/6.2.295 · Cited by 201 · see citing works
Primary liver cancer and oesophageal basal cell hyperplasia in rats caused by fusarium moniliforme
Marasas, W. F. O., Kriek, N. P. J., Fincham, J. E., & Rensburg, S. J. V. (1984) · International Journal of Cancer · doi:10.1002/ijc.2910340315 · Cited by 193 · see citing works
Soman, N. R., Corréa, P., Ruiz, B. A., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4892 · Cited by 190 · see citing works
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten, R. R., Bunin, G. R., Nass, C. C., et al. (1990) · PubMed · Cited by 190 · see citing works
The Health Effects of Nitrate, Nitrite, and N-Nitroso Compounds
National Research Council (1981) · National Academies Press eBooks · doi:10.17226/19738 · Cited by 189 · see citing works
Björkhem-bergman, L., Torndal, U.-B., Eken, S., et al. (1963) · Annals of Internal Medicine · doi:10.7326/0003-4819-59-2-259_1 · Cited by 183 · see citing works
Sobala, G. M., Pignatelli, B., Schorah, C. J., Bartsch, H., Sanderson, M. J., Dixon, M. F., Shires, S., King, R. F. G. J., & Axon, A. T. R. (1991) · Carcinogenesis · doi:10.1093/carcin/12.2.193 · Cited by 176 · see citing works
Maize and Risk of Cancers of the Oral Cavity, Pharynx, and Esophagus in Northeastern Italy
Franceschi, S., Bidoli, E., Barón, A. E., et al. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.17.1407 · Cited by 173 · see citing works
Esophageal Cancer Among Black Men in Washington, D.C. II. Role of nutrition
Ziegler, R. G., Brown, L. M., Blot, W. J., Pottern, L. M., Hoover, R. N., & Fraumeni, J. F. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.6.1199 · Cited by 166 · see citing works
06‐Methyldeoxyguanosine in oesophageal dna among individuals at high risk of oesophageal cancer
Umbenhauer, D. R., Wild, C. P., Montesano, R., Saffhill, R., Boyle, J. M., Huh, N., Kirstein, U., Thomale, J., Rajewsky, M. F., & Lu, S. H. (1985) · International Journal of Cancer · doi:10.1002/ijc.2910360607 · Cited by 161 · see citing works
Mycotoxins and phycotoxins 1988:
Harborne, J. B. (1990) · Phytochemistry · doi:10.1016/0031-9422(90)87148-n · Cited by 156 · see citing works
Preserved foods and nasopharyngeal carcinoma: a case-control study in Guangxi, China.
Yu, M. C., Mo, C.-C., Chong, W. X., Yeh, F. S., & Henderson, B. E. (1988) · PubMed · Cited by 153 · see citing works
Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations.
Sobala, G. M., Schorah, C. J., Shires, S., Lynch, D. A., Gallacher, B., Dixon, M. F., & Axon, A. T. R. (1993) · Gut · doi:10.1136/gut.34.8.1038 · Cited by 153 · see citing works
Ronai, Z. A., Gradia, S., Peterson, L. A., et al. (1993) · Carcinogenesis · doi:10.1093/carcin/14.11.2419 · Cited by 151 · see citing works
Metabolism of N-nitrosodialkylamines by human liver microsomes.
Yoo, J. S. H., Guengerich, F. P., & Yang, C. S. (1988) · PubMed · Cited by 149 · see citing works
Structure-activity relations in carcinogenesis by N-nitroso compounds
Lijinsky, W. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00144269 · Cited by 142 · see citing works
Lu, S.-H., Ohshima, H., Fu, H.-M., Tian, Y., Li, F.-M., Blettner, M., Wahrendorf, J., & Bartsch, H. (1986) · PubMed · Cited by 134 · see citing works
Epidemiological research in stomach cancer: progress over the last ten years
Boeing, H. (1991) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01613137 · Cited by 129 · see citing works
Contamination of beer with trace quantities of N-nitrosodimethylamine
Spiegelhalder, B., Eisenbrand, G., & Preußmann, R. (1979) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(79)90155-x · Cited by 126 · see citing works
Ning, J.-P., Yu, M. C., Wang, Q.-S., & Henderson, B. E. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.4.291 · Cited by 126 · see citing works
N -Nitrosodiethanolamine in Synthetic Cutting Fluids: A Part-Per-Hundred Impurity
Fan, T. Y., Morrison, J., Rounbehler, D. P., Ross, R. D., Fine, D. H., Miles, W. F., & Sen, N. P. (1977) · Science · doi:10.1126/science.841341 · Cited by 124 · see citing works
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Cerny, W. L., Mangold, K. A., & Scarpelli, D. G. (1992) · PubMed · Cited by 123 · see citing works
Cured and broiled meat consumption in relation to childhood cancer: Denver, Colorado (United States)
Sarasua, S. M., & Savitz, D. A. (1994) · Cancer Causes & Control · doi:10.1007/bf01830260 · Cited by 123 · see citing works
Bunin, G. R., Kuijten, R. R., Boesel, C. P., et al. (1994) · Cancer Causes & Control · doi:10.1007/bf01830264 · Cited by 122 · see citing works
Occupational nitrosamine exposure. 1. Rubber and tyre industry
Spiegelhalder, B., & Preußmann, R. (1983) · Carcinogenesis · doi:10.1093/carcin/4.9.1147 · Cited by 117 · see citing works
Cytochrome P450IIE1 Is Elevated in Lymphocytes from Poorly Controlled Insulin-Dependent Diabetics*
Song, B. J., Veech, R. L., & Saenger, P. H. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-4-1036 · Cited by 116 · see citing works
The experimental basis for the role of nitroso compounds in human cancer.
Pn, M. (1989) · PubMed · Cited by 116 · see citing works
Poirier, S., De‐Thé, G., Hubert, A., et al. (1987) · International Journal of Cancer · doi:10.1002/ijc.2910390305 · Cited by 112 · see citing works
Zou, X. N., Lu, S., & Liu, B. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910590202 · Cited by 108 · see citing works
Processed meats and risk of childhood leukemia (California, USA)
Peters, J. M., Preston‐Martin, S., London, S. J., Bowthan, J. D., Buckley, J. D., & Thomas, D. C. (1994) · Cancer Causes & Control · doi:10.1007/bf01830266 · Cited by 107 · see citing works
Preformed N-nitroso compounds in foods and beverages.
Hotchkiss, J. H. (1989) · PubMed · Cited by 107 · see citing works
Ascorbic acid: a factor concentrated in human gastric juice
Rathbone, B. J., Johnson, A. W., Wyatt, J. I., et al. (1989) · Clinical Science · doi:10.1042/cs0760237 · Cited by 101 · see citing works
MacGregor, I. L., Martin, P., & Meyer, J. (1977) · Gastroenterology · doi:10.1016/s0016-5085(77)80073-5 · Cited by 101 · see citing works
Tricker, A. R., Mostafa, M. H., Spiegelhalder, B., et al. (1989) · Carcinogenesis · doi:10.1093/carcin/10.3.547 · Cited by 100 · see citing works
Srivatanakul, P., Sukaryodhin, S., Ohshima, H., et al. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910480606 · Cited by 100 · see citing works
Bartsch, H., Ohshima, H., Pignatelli, B., & Calmels, S. (1989) · PubMed · Cited by 99 · see citing works
Leach, S. A., Thompson, M., & Hill, M. (1987) · Carcinogenesis · doi:10.1093/carcin/8.12.1907 · Cited by 97 · see citing works
Seroepidemiological Studies on Nasopharyngeal Carcinoma in China
Zeng, Y. (1985) · Advances in cancer research · doi:10.1016/s0065-230x(08)60027-5 · Cited by 95 · see citing works
Fujii, H., Egami, H., Chaney, W. G., et al. (1990) · Molecular Carcinogenesis · doi:10.1002/mc.2940030510 · Cited by 95 · see citing works
Rogers, M. A. M., Vaughan, T. L., Davis, S., & Thomas, D. B. (1995) · PubMed · Cited by 95 · see citing works
Recent Progress in Research on Esophageal Cancer in China
Li, M., Li, P., & Baorong, L. (1980) · Advances in cancer research · doi:10.1016/s0065-230x(08)60671-5 · Cited by 90 · see citing works
Neutrophil-mediated nitrosamine formation: Role of nitric oxide in rats
Grisham, M. B., Ware, K., Gilleland, H. E., et al. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91513-4 · Cited by 89 · see citing works
Ohshima, H., Bandaletova, T. Y., Brouet, I., et al. (1994) · Carcinogenesis · doi:10.1093/carcin/15.2.271 · Cited by 89 · see citing works
Mirvish, S. S. (1994) · PubMed · Cited by 87 · see citing works
Self-citationWu, Y., Chen, J., Ohshima, H., Pignatelli, B., Boreham, J., Li, J., Campbell, T. C., Peto, R., & Bartsch, H. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910540502 · Cited by 87 · see citing works
O'Connor, H. J., Schorah, C. J., Habibzedah, N., Axon, A. T. R., & Cockel, R. (1989) · Gut · doi:10.1136/gut.30.4.436 · Cited by 87 · see citing works
Are nitrates a significant risk factor in human cancer?
Forman, D. E. (1989) · PubMed · Cited by 86 · see citing works
Carcinogenicity of Fusarium moniliforme Culture Material in Rats
Jaskiewicz, K., Rensburg, S. J. V., Marasas, W. F. O., et al. (1987) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/78.2.321 · Cited by 86 · see citing works
Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates
Kosaka, H., Wishnok, J. S., Miwa, M., Leaf, C. D., & Tannenbaum, S. R. (1989) · Carcinogenesis · doi:10.1093/carcin/10.3.563 · Cited by 79 · see citing works
Yang, C. S., Sun, Y., Yang, Q., et al. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/73.6.1449 · Cited by 79 · see citing works
Hicks, R. M., Ismail, M. M., Walters, C. L., Pt, B., Rabie, M. F., & el Alamy, M. A. (1982) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(82)90153-5 · Cited by 78 · see citing works
Metabolism of Dimethylnitrosamine by Human Liver Slices in Vitro
Montesano, R., & MAGEE, P. N. (1970) · Nature · doi:10.1038/228173a0 · Cited by 76 · see citing works
Hecht, S. S. (1994) · Drug Metabolism Reviews · doi:10.3109/03602539409029803 · Cited by 75 · see citing works
Mochizuki, M., Anjo, T., & Okada, M. (1980) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)78747-8 · Cited by 75 · see citing works
Liu, R. H., Jacob, J. R., Tennant, B. C., & Hotchkiss, J. H. (1992) · PubMed · Cited by 75 · see citing works
Influence of ascorbic acid dose on N-nitrosoproline formation in humans
Leaf, C. D., Vecchio, A. J., Roe, D. A., & Hotchkiss, J. H. (1987) · Carcinogenesis · doi:10.1093/carcin/8.6.791 · Cited by 74 · see citing works
Carcinoma of the nasal and paranasal regions in rats fed Cantonese salted marine fish.
Huang, D. P., HO, J. H. C., Saw, D., et al. (1978) · PubMed · Cited by 74 · see citing works
Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells
Patten, C. J., Ishizaki, H., Aoyama, T., et al. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90258-x · Cited by 73 · see citing works
Diet, living conditions and nasopharyngeal carcinoma in tunisia—a case‐control study
Jeannel, D., Hubert, A., de Vathaire, F., Ellouz, R., Camoun, M., Salem, M. B., Sancho-Garnier, H., & de Thé, G. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910460316 · Cited by 72 · see citing works
Wang, Y., You, M., Reynolds, S. H., et al. (1990) · PubMed · Cited by 70 · see citing works
Ji, X. B., & Hollocher, T. C. (1988) · Applied and Environmental Microbiology · doi:10.1128/aem.54.7.1791-1794.1988 · Cited by 69 · see citing works
Epidemiological evidence for the role of nitroso compounds in human cancer.
Preston‐Martin, S., & Corréa, P. (1989) · PubMed · Cited by 68 · see citing works
Møller, H., Landt, J., Pedersen, E. M., Jensen, P., Autrup, H. N., & Jensen, O. M. (1989) · PubMed · Cited by 68 · see citing works
Liu, R. H., Baldwin, B. H., Tennant, B. C., et al. (1991) · PubMed · Cited by 68 · see citing works
Teas and tea components as inhibitors of carcinogen formation in model systems and man
STICH, H. F. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90045-j · Cited by 66 · see citing works
Effect of different foods on the acidity of the gastric contents in patients with duodenal ulcer
Lennard-Jones, J. E., & Babouris, N. (1965) · Gut · doi:10.1136/gut.6.2.113 · Cited by 66 · see citing works
Mechanisms of Endogenous Nitrosation
Tannenbaum, S. R. (1988) · Springer eBooks · doi:10.1007/978-1-4757-9640-7_67 · Cited by 64 · see citing works
Alcohol-related cancer risk: A toxico kinetic hypothesis
Anderson, L. M., Chhabra, S. K., Nerurkar, P. V., et al. (1995) · Alcohol · doi:10.1016/0741-8329(94)00089-1 · Cited by 63 · see citing works
Moss, R. A. (1974) · Accounts of Chemical Research · doi:10.1021/ar50084a005 · Cited by 62 · see citing works
Lozano, J.-C., Nakazawa, H., Cros, M., Carbral, R., & Yamasaki, H. (1994) · Molecular Carcinogenesis · doi:10.1002/mc.2940090107 · Cited by 61 · see citing works
Nitrite from inflammatory cells—A cancer risk factor in ulcerative colitis?
Roediger, W. E. W., Lawson, M. J., & Radcliffe, B. C. (1990) · Diseases of the Colon & Rectum · doi:10.1007/bf02139219 · Cited by 61 · see citing works
Lijinsky, W., & Taylor, H. W. (1977) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(77)80196-x · Cited by 60 · see citing works
Aetiology of oesophageal cancer
Craddock, V. M. (1992) · European Journal of Cancer Prevention · doi:10.1097/00008469-199202000-00002 · Cited by 60 · see citing works
Gastric tumorigenesis by a single dose of 4-(hydroxymethyl)benzenediazonium ion of Agaricus bisporus
Tóth, B., Nagel, D. L., & Ross, A. E. (1982) · British Journal of Cancer · doi:10.1038/bjc.1982.218 · Cited by 59 · see citing works
Ohshima, H., Tsuda, M., Adachi, H., Ogura, T., Sügimura, T., & Esumi, H. (1991) · Carcinogenesis · doi:10.1093/carcin/12.7.1217 · Cited by 57 · see citing works
Role of strong ion exchange resins in nitrosamine formation in water
Kimoto, W. I., Dooley, C. J., Carré, J., et al. (1980) · Water Research · doi:10.1016/0043-1354(80)90267-5 · Cited by 57 · see citing works
Is Helicobacter pylori a cause of gastric cancer? An appraisal of the seroepidemiological evidence.
Muñóz, N. (1994) · PubMed · Cited by 57 · see citing works
Genotoxicology of N-Nitroso Compounds
Rao, T. K. R. K., Lijinsky, W., & Epler, J. L. (1984) · Springer eBooks · doi:10.1007/978-1-4684-4595-4 · Cited by 56 · see citing works
Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.
Peterson, L. A., Liu, X.-K., & Hecht, S. S. (1993) · PubMed · Cited by 54 · see citing works
Stillwell, W. G., Glogowski, J. A., Hx, X., Wishnok, J. S., Zavala, D., Montes, G., Correa, P., & Tannenbaum, S. R. (1991) · PubMed · Cited by 54 · see citing works
Helser, M. A., Hotchkiss, J. H., & Roe, D. A. (1992) · Carcinogenesis · doi:10.1093/carcin/13.12.2277 · Cited by 52 · see citing works
Xu, G., & Reed, P. I. (1993) · Carcinogenesis · doi:10.1093/carcin/14.12.2547 · Cited by 52 · see citing works
N-nitrosoproline excretion by rural Nebraskans drinking water of varied nitrate content.
Mirvish, S. S., Grandjean, A. C., Møller, H., Fike, S., Maynard, T., Jones, L., Rosinsky, S., & Nie, G. (1992) · PubMed · Cited by 51 · see citing works
Self-citationOkada, M., & Ishidate, M. (1977) · Xenobiotica · doi:10.3109/00498257709036241 · Cited by 50 · see citing works
Xu, G., Song, P., & Reed, P. I. (1992) · European Journal of Cancer Prevention · doi:10.1097/00008469-199210000-00007 · Cited by 50 · see citing works
Hicks, R. M., James, C., & Webbe, G. (1980) · British Journal of Cancer · doi:10.1038/bjc.1980.308 · Cited by 50 · see citing works
Leaf, C. D., Wishnok, J. S., & Tannenbaum, S. R. (1991) · Carcinogenesis · doi:10.1093/carcin/12.3.537 · Cited by 48 · see citing works
N-nitroso compound formation in human gastric juice.
Kyrtopoulos, S. Α. (1989) · PubMed · Cited by 48 · see citing works
Nitrosamines and related N-nitroso compounds. Chemistry and biochemistry
Stedman, G. (1995) · Endeavour · doi:10.1016/0160-9327(95)90024-1 · Cited by 47 · see citing works
Helicobacter Pylori ‐associated gastritis and the ascorbic acid concentration in gastric juice
Rood, J. C., Ruiz, B. A., Fontham, E. T. H., Malcom, G. T., Hunter, F. M., Sobhan, M., Johnson, W. D., & Correa, P. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514332 · Cited by 46 · see citing works
Zatoński, W. A., Ohshima, H., Przewozniak, K., Drosik, K., Mierzwińska, J., Krygier, M., Chmielarczyk, W., & Bartsch, H. (1989) · International Journal of Cancer · doi:10.1002/ijc.2910440513 · Cited by 45 · see citing works
The epidemiology of cancer of the oesophagus
Cook-Mozaffari, P. (1978) · Nutrition and Cancer · doi:10.1080/01635587909513612 · Cited by 43 · see citing works
Calmels, S., Béréziat, J., Ohshima, H., et al. (1991) · Carcinogenesis · doi:10.1093/carcin/12.3.435 · Cited by 42 · see citing works
Hofe, E. V., Schmerold, I., Lijinsky, W., et al. (1987) · Carcinogenesis · doi:10.1093/carcin/8.9.1337 · Cited by 41 · see citing works
Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite
Lijinsky, W. (1984) · Food and Chemical Toxicology · doi:10.1016/0278-6915(84)90198-4 · Cited by 41 · see citing works
N-nitrosamines in Chinese foods
Song, P., & Hu, J. F. (1988) · Food and Chemical Toxicology · doi:10.1016/0278-6915(88)90120-2 · Cited by 41 · see citing works
Pignatelli, B., Richard, I. M. T., Bourgade, M. C., et al. (1987) · The Analyst · doi:10.1039/an9871200945 · Cited by 41 · see citing works
Banbury Report 12: Nitrosamines and Human Cancer
(1983) · Food and Chemical Toxicology · doi:10.1016/0278-6915(83)90166-7 · Cited by 40 · see citing works
Bulay, O., & Mirvish, S. S. (1979) · PubMed · Cited by 39 · see citing works
Self-citationXu, G., Song, P., & Reed, P. I. (1993) · European Journal of Cancer Prevention · doi:10.1097/00008469-199307000-00007 · Cited by 39 · see citing works
Lown, J. W., Chauhan, S. M. S., Koganty, R. R., et al. (1984) · Journal of the American Chemical Society · doi:10.1021/ja00333a051 · Cited by 38 · see citing works
Nitrosation of dietary precursors.
Shephard, S. E., & Lutz, W. K. (1989) · PubMed · Cited by 38 · see citing works
Greenblatt, M., & Mirvish, S. S. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/50.1.119 · Cited by 37 · see citing works
Self-citationConboy, J. J., & Hotchkiss, J. H. (1989) · The Analyst · doi:10.1039/an9891400155 · Cited by 37 · see citing works
Guttenplan, J. B. (1990) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(90)90161-v · Cited by 36 · see citing works
Mutagens and carcinogens produced by the reaction of environmental aromatic compounds with nitrite.
Wakabayashi, K., Nagao, M., & Sügimura, T. (1989) · PubMed · Cited by 36 · see citing works
Effect of ethanol on nitrosamine metabolism and distribution
SWANN, P. F., Graves, R. J., & Mace, R. (1987) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(87)90008-x · Cited by 35 · see citing works
Schmütte, C., Rideout, W. M., Shen, J., et al. (1994) · Carcinogenesis · doi:10.1093/carcin/15.12.2899 · Cited by 35 · see citing works
Huang, Q. M., Lawson, T. A., Chung, F., et al. (1993) · Carcinogenesis · doi:10.1093/carcin/14.4.749 · Cited by 34 · see citing works
Mirvish, S. S., Huang, Q. M., Chen, S. C., et al. (1993) · Endoscopy · doi:10.1055/s-2007-1010418 · Cited by 33 · see citing works
Self-citationStéfani, E. D., Oreggia, F., Ronco, Á. L., Fierro, L., & Rivero, S. (1994) · PubMed · Cited by 31 · see citing works
Review of methodologies for the determination of nonvolatileN‐nitroso compounds in foods
Sen, N. P., & Kubacki, S. J. (1987) · Food Additives & Contaminants · doi:10.1080/02652038709373646 · Cited by 29 · see citing works
Nutrient intakes among rural Transkeians at risk for oesophageal cancer.
Groenewald, G., Langenhoven, M. L., Beyers, M. J. C., et al. (1981) · PubMed · Cited by 29 · see citing works
Carcinogenicity Test of Six Nitrosamides and a Nitrosocyanamide Administered Orally to Rats 2
Bulay, O., Mlrvish, S. S., Garcia, H., Pelfrène, A. F., Gold, B. I., & Eagen, M. C. (1979) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/62.6.1523 · Cited by 28 · see citing works
.alpha.-Hydroxynitrosamines: transportable metabolites of dialkylnitrosamines
Gold, B. I., & Linder, W. B. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00516a059 · Cited by 28 · see citing works
Aze, Y., Toyoda, K., Furukawa, F., et al. (1993) · Carcinogenesis · doi:10.1093/carcin/14.1.37 · Cited by 28 · see citing works
Nitrosamine and N-nitroso compound chemistry and biochemistry: advances and perspectives[]
Loeppky, R. N. (1994) · Cited by 28 · see citing works
Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni
Badawi, A. F., Cooper, D. P., Mostafa, M. H., et al. (1993) · Carcinogenesis · doi:10.1093/carcin/14.4.653 · Cited by 27 · see citing works
N‐Nitrosamine Ingestion from Consumer‐Cooked Bacon
Vecchio, A. J., Hotchkiss, J. H., & Bisogni, C. A. (1986) · Journal of Food Science · doi:10.1111/j.1365-2621.1986.tb13926.x · Cited by 26 · see citing works
Fujita, Y., Wakabayashi, K., Takayama, S., et al. (1987) · Carcinogenesis · doi:10.1093/carcin/8.4.527 · Cited by 25 · see citing works
Xu, G., & Reed, P. I. (1993) · The Analyst · doi:10.1039/an9931800877 · Cited by 24 · see citing works
Møller, H. (1988) · Cancer Letters · doi:10.1016/0304-3835(88)90157-7 · Cited by 24 · see citing works
Mirvish, S. S., Babcook, D. M., Deshpande, A. D., et al. (1986) · Cancer Letters · doi:10.1016/0304-3835(86)90171-0 · Cited by 23 · see citing works
Self-citationMirvish, S. S., Williamson, J., Babcook, D. M., et al. (1993) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850210307 · Cited by 23 · see citing works
Self-citationMirvish, S. S., Wang, M., Smith, J. W., et al. (1985) · PubMed · Cited by 23 · see citing works
Self-citationMurphy, S. E., & Spina, D. A. (1994) · Carcinogenesis · doi:10.1093/carcin/15.12.2709 · Cited by 22 · see citing works
Sierra, R., Chinnock, A., Ohshima, H., et al. (1994) · PubMed · Cited by 22 · see citing works
Bianchini, F., & Wild, C. P. (1994) · Carcinogenesis · doi:10.1093/carcin/15.6.1137 · Cited by 21 · see citing works
Trace analysis of nitrosated foodstuffs for nitrosamides
Mende, P., Spiegelhalder, B., & Preußmann, R. (1991) · Food and Chemical Toxicology · doi:10.1016/0278-6915(91)90034-5 · Cited by 21 · see citing works
Increased urinary nitrosamine excretion in patients with urinary diversions
Tricker, A. R., Kälble, T., & Preußmann, R. (1989) · Carcinogenesis · doi:10.1093/carcin/10.12.2379 · Cited by 21 · see citing works
Eisenbrand, G., Spiegelhalder, B., Kann, J., et al. (1979) · ChemInform · doi:10.1002/chin.197938327 · Cited by 21 · see citing works
Production of antisera with specificity for malignant melanoma and human fetal skin.
Fritze, D., Kern, D. H., Drogemuller, C. R., et al. (1976) · PubMed · Cited by 20 · see citing works
Tsuda, M., Hirayama, T. T., & Sügimura, T. (1983) · PubMed · Cited by 20 · see citing works
Metabolism of N-nitrosomethyl-n-amylamine by microsomes from human and rat esophagus.
Huang, Q. M., Stoner, G. D., Resau, J., et al. (1992) · PubMed · Cited by 19 · see citing works
Creatinine: a food component that is nitrosated-denitrosated to yield methylurea
Mirvish, S. S., Cairnes, D. A., Hermes, N. H., & Raha, C. R. (1982) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00113a006 · Cited by 19 · see citing works
Self-citationZeng, Y., Ohshima, H., Bouvier, G., et al. (1993) · PubMed · Cited by 19 · see citing works
The EUROGAST Study Group (1994) · Carcinogenesis · doi:10.1093/carcin/15.9.1815 · Cited by 19 · see citing works
Rate constants for the decomposition of a simple alkanediazoate at physiological pH
Hovinen, J., & Fishbein, J. C. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00027a060 · Cited by 18 · see citing works
Helser, M. A., & Hotchkiss, J. H. (1994) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00037a022 · Cited by 18 · see citing works
Organ and cell specificity of DNA methylation by N-nitrosomethylamylamine in rats.
Koenigsmann, M., Schmerold, I., Jeltsch, W., et al. (1988) · PubMed · Cited by 18 · see citing works
Airoldi, L., Magagnotti, C., Bonfanti, M., et al. (1990) · Carcinogenesis · doi:10.1093/carcin/11.8.1437 · Cited by 18 · see citing works
Blocking Nitrosamine Formation
Loeppky, R. N., Bao, Y. T., Bae, J., et al. (1994) · ACS symposium series · doi:10.1021/bk-1994-0553.ch005 · Cited by 18 · see citing works
Structural Modifications and Repair of DNA in Neuro-Oncogenesis by N-Ethyl-N-nitrosourea
Rajewsky, M. F. (1983) · Springer eBooks · doi:10.1007/978-3-642-81947-6_4 · Cited by 17 · see citing works
Ji, C., Mirvish, S. S., Nickols, J. G., et al. (1989) · PubMed · Cited by 17 · see citing works
Self-citationMirvish, S. S., Weisenburger, D. D., Hinrichs, S. H., et al. (1994) · Carcinogenesis · doi:10.1093/carcin/15.5.883 · Cited by 16 · see citing works
Self-citationExcretion of N-mononitrosopiperazine in urine in workers manufacturing piperazine
Bellander, T., �sterdahl, B. G., Hagmar, L., & Skerfving, S. (1988) · International Archives of Occupational and Environmental Health · doi:10.1007/bf00409375 · Cited by 16 · see citing works
Meier, I., Shephard, S. E., & Lutz, W. K. (1990) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(90)90011-y · Cited by 16 · see citing works
Persistence of N-nitrosodiethanolamine contamination in American metal-working lubricants
Keefer, L. K., Goff, U., Stevens, J., & Bennett, E. O. (1990) · Food and Chemical Toxicology · doi:10.1016/0278-6915(90)90124-6 · Cited by 15 · see citing works
Chen, W., Weisburger, J. H., Fiala, Carmella, S. G., Chen, D., Spratt, T. E., & Hecht, S. S. (1995) · Nature · doi:10.1038/374599a0 · Cited by 15 · see citing works
Mirvish, S. S., Karłowski, K., Cairnes, D. A., et al. (1980) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60232a061 · Cited by 15 · see citing works
Self-citationChemistry and biology of nitrosated peptides.
Bc, C. (1989) · PubMed · Cited by 15 · see citing works
Huang, Q. M., Wang, S., Chen, S. C., et al. (1993) · Cancer Letters · doi:10.1016/0304-3835(93)90162-3 · Cited by 14 · see citing works
Tumours induced in Fischer 344 rats by the feeding of disulfiram together with sodium nitrite
Lijinsky, W., & Reuber, M. D. (1980) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(80)90016-4 · Cited by 14 · see citing works
Scarpelli, D. G., & Rao, M. S. (1981) · Cancer · doi:10.1002/1097-0142(19810315)47:6+ · Cited by 14 · see citing works
Craddock, V. M. (1993) · Cambridge University Press eBooks · doi:10.1017/cbo9780511759925 · Cited by 14 · see citing works
Lijinsky, W., & Kovatch, R. M. (1993) · Cancer Letters · doi:10.1016/0304-3835(93)90050-j · Cited by 13 · see citing works
Synthesis of nitrosomethylisoamylamine from isoamylamine and sodium nitrite by fungi
Ji, C., Li, M. H., Li, J. L., et al. (1986) · Carcinogenesis · doi:10.1093/carcin/7.2.301 · Cited by 13 · see citing works
Nitrite-trapping capacity of thioproline in the human body.
Tsuda, M., & Kurashima, Y. (1991) · PubMed · Cited by 13 · see citing works
Cancer of the Esophagus: Approaches to the Etiology
Craddock, V. M. (1993) · Medical Entomology and Zoology · Cited by 12 · see citing works
Helser, M. A. (1991) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(91)90087-l · Cited by 11 · see citing works
Nitrosamine formation via non-prescription drugs?
Nielsen, J. B., & Lings, S. (1994) · Medical Hypotheses · doi:10.1016/0306-9877(94)90129-5 · Cited by 11 · see citing works
N-nitrosodiethanolamine excretion in metal grinders.
Spiegelhalder, B., Müller, J., Drasche, H., et al. (1987) · PubMed · Cited by 11 · see citing works
Tricker, A. R., Kumar, R., Siddiqi, M., et al. (1991) · Carcinogenesis · doi:10.1093/carcin/12.9.1595 · Cited by 10 · see citing works
Kumar, R., Wacker, C.-D., Mende, P., et al. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00031a008 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diet, microorganisms and their metabolites, and colon cancer
O'Keefe, S. J. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.165 · Cited by 1,100 · see citing works
The chemical biology of nitric oxide: Implications in cellular signaling
Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.020 · Cited by 975 · see citing works
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739 · see citing works
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400 · see citing works
Bastide, N. M., Pierre, F. H. F., & Corpet, D. E. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0113 · Cited by 397 · see citing works
Roles of dietary inorganic nitrate in cardiovascular health and disease
Lundberg, J. O., Carlström, M., Larsen, F. J., & Weitzberg, E. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq325 · Cited by 355 · see citing works
Novel Aspects of Dietary Nitrate and Human Health
Weitzberg, E., & Lundberg, J. O. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161159 · Cited by 324 · see citing works
High-Temperature Beverages and Foods and Esophageal Cancer Risk—A Systematic Review
Islami, F., Boffetta, P., Ren, J., Pedoeim, L., Khatib, D., & Kamangar, F. (2009) · International Journal of Cancer · doi:10.1002/ijc.24445 · Cited by 322 · see citing works
Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis
Jaiswal, M., LaRusso, N. F., & Gores, G. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g626 · Cited by 278 · see citing works
Biology of nitrogen oxides in the gastrointestinal tract
Lundberg, J. O., & Weitzberg, E. (2013) · Gut · doi:10.1136/gutjnl-2011-301649 · Cited by 200 · see citing works
Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus
Macfarlane, S., Furrie, E., Macfarlane, G. T., & Dillon, J. F. (2007) · Clinical Infectious Diseases · doi:10.1086/518578 · Cited by 184 · see citing works
Alisson-Silva, F., Kawanishi, K., & Varki, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.07.002 · Cited by 156 · see citing works
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145 · see citing works
Diet-induced endogenous formation of nitroso compounds in the GI tract
Kuhnle, G. G. C., Story, G. W., Reda, T., Mani, A. R., Moore, K. P., Lunn, J. C., & Bingham, S. A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.011 · Cited by 146 · see citing works
The Multifaceted Role of Heme in Cancer
Fiorito, V., Chiabrando, D., Petrillo, S., Bertino, F., & Tolosano, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01540 · Cited by 129 · see citing works
Meat and components of meat and the risk of bladder cancer in the NIH-AARP diet and health study
Ferrucci, L. M., Sinha, R., Ward, M. H., Graubard, B. I., Hollenbeck, A. R., Kilfoy, B. A., Schatzkin, A., Michaud, D. S., & Cross, A. J. (2010) · Cancer · doi:10.1002/cncr.25463 · Cited by 103 · see citing works
Said Abasse, K., Essien, E. E., Abbas, M., Yu, X., Xie, W., Sun, J., Akter, L., & Cote, A. (2022) · Nutrients · doi:10.3390/nu14030666 · Cited by 98 · see citing works
Kimchi and soybean pastes are risk factors of gastric cancer
Nan, H.-M. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i21.3175 · Cited by 95 · see citing works
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94 · see citing works
Iijima, K. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg168 · Cited by 81 · see citing works
Jin, L., Qin, L., Xia, D., Liu, X., Fan, Z., Zhang, C., Gu, L., He, J., Ambudkar, I. S., Deng, D., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.12.015 · Cited by 64 · see citing works
Winter, J. W., Paterson, S., Scobie, G., Wirz, A., Preston, T., & McColl, K. E. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.047 · Cited by 59 · see citing works
Pancreatic Cancer and Exposure to Dietary Nitrate and Nitrite in the NIH-AARP Diet and Health Study
Aschebrook-Kilfoy, B., Cross, A. J., Stolzenberg-Solomon, R. Z., Schatzkin, A., Hollenbeck, A. R., Sinha, R., & Ward, M. H. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr092 · Cited by 53 · see citing works
Aschebrook-Kilfoy, B., Ward, M. H., Gierach, G. L., Schatzkin, A., Hollenbeck, A. R., Sinha, R., & Cross, A. J. (2012) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e328347622f · Cited by 40 · see citing works
Nitrate Exposure and Endogenous Formation of Carcinogenic Nitrosamines in Humans
Vermeer, I. T. M., & van Maanen, J. M. S. (2001) · Reviews on Environmental Health · doi:10.1515/reveh.2001.16.2.105 · Cited by 38 · see citing works
Mirvish, S. S., Grandjean, A. C., Reimers, K. J., Connelly, B. J., Chen, S. C., Morris, C. R., Wang, X., Haorah, J., & Lyden, E. R. (1998) · Nutrition and Cancer · doi:10.1080/01635589809514688 · Cited by 28 · see citing works
Self-citation
- Authors
- Mirvish, S. S.
- Corresponding author
- Mirvish, Sidney S.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 93
- Issue
- 1
- Pages
- 17-48
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2046219406
- Cited by
- 916
- References
- 222
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 18 · 2023: 23 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 29 · 2018: 23 · 2017: 24 · 2016: 36 · 2015: 33 · 2014: 36 · 2013: 33 · 2012: 40
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca035628-11, 5r01ca030593-03)
- National Cancer Institute (R01-CA-30593, R01 CA-35628, UOI-CA-43236)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- N-nitroso compounds, nitrosation, nitrosamines, gastric cancer, esophageal cancer, nasopharyngeal carcinoma, bladder cancer, nitrite esters, vitamin C, polyphenols, nitric oxide, inflammation, tobacco, pediatric leukemia, RAS mutations, TP53 mutation, cancer etiology
- MeSH terms
- Animals, Biotransformation, Urinary Bladder Neoplasms, Carcinogens, Cocarcinogenesis, Environmental Exposure, Esophageal Neoplasms, Food Contamination, Gastrointestinal Neoplasms, Humans, Nasopharyngeal Neoplasms, Nitric Oxide, Nitrosamines, Nitroso Compounds, Genes, ras, Smoking, Stomach Neoplasms, Nitrosation, Genes, p53, Drug-Related Side Effects and Adverse Reactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review