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Cited by 301

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

Open access
Sorolla, Ma Alba, Reverter-Branchat, Gemma, Tamarit, Jordi, Ferrer, Isidre, Ros, Joaquim, Cabiscol, Elisa·2008·Free Radical Biology and Medicine
DOI 10.1016/j.freeradbiomed.2008.05.014
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Abstract

Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG repeats in exon 1 of the huntingtin gene, affecting initially the striatum and progressively the cortex. This work reports a proteomic analysis of human brain postmortem samples obtained from striatum and cortex of patients with HD compared to samples of age- and sex-matched controls. Antioxidant defense proteins that were strongly induced in striatum, but also detectable in cortex, were identified as peroxiredoxins 1, 2, and 6, as well as glutathione peroxidases 1 and 6. The activities of other antioxidant enzymes such as mitochondrial superoxide dismutase and catalase were also increased in HD. Aconitase, a protein involved in energy metabolism, showed decreased activities in striatum of HD patients. Protein carbonyls, used as markers of oxidative stress, were increased in HD, and glial fibrillary acidic protein, aconitase, gamma-enolase, and creatine kinase B were identified as the main targets. Taken together, these results indicate that oxidative stress and damage to specific macromolecules would participate in the disease progression. Also, these data support the rationale for therapeutic strategies that either potentiate antioxidant defenses or avoid oxidative stress generation to delay disease progression.

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Metadata

Authors
Sorolla, M. A., Reverter-Branchat, G., Tamarit, J., Ferrer, I., Ros, J., & Cabiscol, E.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2008-09
Volume
45
Issue
5
Pages
667-678
ISSN
0891-5849
DOI
10.1016/j.freeradbiomed.2008.05.014
OpenAlex
W1971851525
Cited by
301
References
9
FWCI
7.12
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Proteomic and oxidative stress analysis in human brain samples of Huntington disease. https://app.cochat.ai/papers/10.1016/j.freeradbiomed.2008.05.014
The paper
Sorolla, M. A., Reverter-Branchat, G., Tamarit, J., Ferrer, I., Ros, J., & Cabiscol, E. (2008). Proteomic and oxidative stress analysis in human brain samples of Huntington disease. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2008.05.014

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.