Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

Free radicals, metals and antioxidants in oxidative stress-induced cancer

Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452

Oxidative mechanisms in the toxicity of metal ions

Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378

Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology

Matés, J. M. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00306-1 · Cited by 1,540

Cadmium, Environmental Exposure, and Health Outcomes

Satarug, S., Garrett, S. H., Sens, M. A., & Sens, D. A. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901234 · Cited by 1,172

Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein

Uversky, V. N., Li, J., & Fink, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105343200 · Cited by 1,103

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 950

Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review)

Bertin, G., & Averbeck, D. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.001 · Cited by 934

Role of oxidative stress in cadmium toxicity and carcinogenesis

Liu, J., Qu, W., & Kadiiska, M. B. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.01.029 · Cited by 855

Signaling Functions of Reactive Oxygen Species

Forman, H. J., Maiorino, M., & Ursini, F. (2010) · Biochemistry · doi:10.1021/bi9020378 · Cited by 827

Copper in diseases and treatments, and copper‐based anticancer strategies

Tisato, F., Marzano, C., Porchia, M., Pellei, M., & Santini, C. (2009) · Medicinal Research Reviews · doi:10.1002/med.20174 · Cited by 809

Oxidative stress and apoptosis: Impact on cancer therapy

Ozben, T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20874 · Cited by 751

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727

Copper in the brain and Alzheimer’s disease

Hung, Y. H., Bush, A. I., & Cherny, R. A. (2009) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-009-0600-y · Cited by 503

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0304-z · Cited by 470

Multitargeted therapy of cancer by silymarin

Ramasamy, K., & Agarwal, R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.053 · Cited by 443

Oxidative Stress in Developmental Origins of Disease: Teratogenesis, Neurodevelopmental Deficits, and Cancer

Wells, P. G., McCallum, G. P., Chen, C. S., Henderson, J. T., Lee, C. J. J., Perstin, J., Preston, T. J., Wiley, M. J., & Wong, A. W. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn263 · Cited by 430

The stimulation of angiogenesis and collagen deposition by copper

Gérard, C., Bordeleau, L., Barralet, J. E., & Doillon, C. J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.009 · Cited by 420

Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture

López, E., Arce, C., Oset‐Gasque, M. J., Cañadas, S., & González, M. P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.062 · Cited by 402

Environmental-induced oxidative stress in neurodegenerative disorders and aging

Migliore, L., & Coppedè, F. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.013 · Cited by 397

Reactive oxygen species: Destroyers or messengers?

Bartosz, G. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.009 · Cited by 386

Metals and apoptosis: Recent developments

Rana, S. V. S. (2008) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2008.08.002 · Cited by 380

Redox Considerations in Female Reproductive Function and Assisted Reproduction: From Molecular Mechanisms to Health Implications

Agarwal, A. K., Gupta, S., Sekhon, L. H., & Shah, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1964 · Cited by 364

Copper and carcinogenesis

Théophanides, T., & Anastassopoulou, J. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(02)00007-0 · Cited by 354

Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death

Matés, J. M., Pérez‐Gómez, C., de Castro, I. N., Asenjo, M., & Márquez, J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00143-1 · Cited by 353

Multifunctional Activities of Green Tea Catechins in Neuroprotection

Mandel, S. A., Avramovich‐Tirosh, Y., Reznichenko, L., Zheng, H., Weinreb, O., Amit, T., & Youdim, M. B. H. (2005) · Neurosignals · doi:10.1159/000085385 · Cited by 347

Causes of oxidative stress in Alzheimer disease

Zhu, X., Su, B., Wang, X., Smith, M. A., & Perry, G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7218-4 · Cited by 336

COPPER AND ANGIOGENESIS: UNRAVELLING A RELATIONSHIP KEY TO CANCER PROGRESSION

Finney, L. A., Vogt, S., Fukai, T., & Glesne, D. A. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04969.x · Cited by 320

Oxidative Stress: Apoptosis in Neuronal Injury

Loh, K. P., Huang, S. H., de Silva, R., Tan, B., & Zhu, Y. Z. (2006) · Current Alzheimer Research · doi:10.2174/156720506778249515 · Cited by 298

The role of metals in site-specific DNA damage with reference to carcinogenesis1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

Kawanishi, S., Hiraku, Y., Murata, M., & Oikawa, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00779-7 · Cited by 278

Redox Chemistry of Copper–Amyloid‐β: The Generation of Hydroxyl Radical in the Presence of Ascorbate is Linked to Redox‐Potentials and Aggregation State

Guilloreau, L., Combalbert, S., Sournia‐Saquet, A., Mazarguil, H., & Faller, P. (2007) · ChemBioChem · doi:10.1002/cbic.200700111 · Cited by 273

DNA repair in neurons: So if they don’t divide what's to repair?

Fishel, M. L., Vasko, M. R., & Kelley, M. R. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.06.007 · Cited by 263

Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.

Park, J. Y., Shigenaga, M. K., & Ames, B. N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2322 · Cited by 255

A threshold concept for cancer therapy

Kong, Q., Beel, J. A., & Lillehei, K. O. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.0982 · Cited by 250

Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium

Acharya, U. R., Mishra, M., Patro, J., & Panda, M. K. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.10.004 · Cited by 228

Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis

Witkiewicz-Kucharczyk, A., & Bal, W. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.10.018 · Cited by 215

Salivary analysis in oral cancer patients

Bahar, G., Feinmesser, R., Shpitzer, T., Popovtzer, A., & Nagler, R. M. (2006) · Cancer · doi:10.1002/cncr.22386 · Cited by 191

Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

Meloni, G., Sonois, V., Delaine, T., Guilloreau, L., Gillet, A., Teissié, J., Faller, P., & Vašák, M. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.89 · Cited by 190

Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles

Wang, J., Rahman, M. F., Duhart, H. M., Newport, G. D., Patterson, T. A., Murdock, R. C., Hussain, S. M., Schlager, J. J., & Ali, S. F. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.09.005 · Cited by 188

Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP‐1 activation

Zou, W., Yan, M., Xu, W., Huo, H., Sun, L., Zheng, Z., & Liu, X. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1118 · Cited by 185

Neurochemical Targets and Behavioral Effects of Organohalogen Compounds: An Update

Mariussen, E., & Fonnum, F. (2006) · Critical Reviews in Toxicology · doi:10.1080/10408440500534164 · Cited by 175

Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells

Wang, G. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.10.2135 · Cited by 173

Carcinogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in experimental models

Knerr, S., & Schrenk, D. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600006 · Cited by 169

Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines

Davison, K. L., Côté, S., Mader, S., & Miller, W. H. (2003) · Leukemia · doi:10.1038/sj.leu.2402876 · Cited by 165

Molecular mechanisms of cadmium induced mutagenicity

Filipič, M., Fatur, T., & Vudrag, M. (2006) · Human & Experimental Toxicology · doi:10.1191/0960327106ht590oa · Cited by 163

Response of antioxidant enzymes and redox metabolites to cadmium-induced oxidative stress in CRL-1439 normal rat liver cells

Ikediobi, C. O., Badisa, V. L. D., Ayuk‐Takem, L. T., Latinwo, L. M., & West, J. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.14.1.87 · Cited by 157

Activation of Nrf2 in Defense against Cadmium-Induced Oxidative Stress

He, X., Chen, M. G., & Ma, Q. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800019a · Cited by 157

Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals

Faria, M., Carrasco, L., Dı́ez, S., Riva, M. C., Bayona, J. M., & Barata, C. (2008) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.07.012 · Cited by 152

Nanoparticle–chelator conjugates as inhibitors of amyloid-β aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease

Liu, G., Men, P., Kudo, W., Perry, G., & Smith, M. A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.064 · Cited by 148

Reactive oxygen species in melanoma and its therapeutic implications

Wittgen, H. G. M., & van Kempen, L. C. L. T. (2007) · Melanoma Research · doi:10.1097/cmr.0b013e3282f1d312 · Cited by 145

Bioimaging Probes for Reactive Oxygen Species and Reactive Nitrogen Species

Nagano, T. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.r09-66 · Cited by 143

Cell-density-dependent regulation of neural precursor cell function

Limoli, C. L., Rola, R., Giedzinski, E., Mantha, S., Huang, T., & Fike, J. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407065101 · Cited by 137

Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium

Rockwell, P. (2003) · Cellular Signalling · doi:10.1016/j.cellsig.2003.08.006 · Cited by 132

Cadmium-Induced Oxidative Cellular Damage in Human Fetal Lung Fibroblasts (MRC-5 Cells)

Yang, C., Shen, H., Shen, Y., Zhuang, Z. X., & Ong, C. N. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105712 · Cited by 127

Elevated Levels of Urinary 8-Hydroxy-2′-deoxyguanosine in Male Electrical and Electronic Equipment Dismantling Workers Exposed to High Concentrations of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans, Polybrominated Diphenyl Ethers, and Polychlorinated Biphenyls

Wen, S., Yang, F., Gong, Y. J., Zhang, X., Hui, Y., Li, J., Liu, A., Wu, Y., Lu, W.-Q., & Xu, Y. (2008) · Environmental Science & Technology · doi:10.1021/es800044m · Cited by 122

Implications for Risk Assessment of Suggested Nongenotoxic Mechanisms of Chemical Carcinogenesis

Melnick, R. L., Kohn, M. C., & Portier, C. J. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s1123 · Cited by 120

Ro 61–1790, a New Hydrosoluble Endothelin Antagonist: General Pharmacology and Effects on Experimental Cerebral Vasospasm

Roux, S., Breu, V., Giller, T., Neidhart, W. L., Ramuz, H., Coassolo, P., Clozel, J., & Clozel, M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37130-7 · Cited by 116

Effects of cadmium on structure and enzymatic activity of Cu,Zn‐SOD and oxidative status in neural cells

Huang, Y., Shih, C.-M., Huang, C., Lin, C., Chou, C., Tsai, M., Liu, T. P., Chiu, J., & Chen, C. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20772 · Cited by 113

The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells.

Lavigne, J. A., Goodman, J. E., Fonong, T., Odwin, S.-A., He, P., Roberts, D. W., & Yager, J. D. (2001) · PubMed · Cited by 113

Cupric–amyloid β peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical

Dikalov, S., Vitek, M. P., & Mason, R. P. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.004 · Cited by 110

Docosahexaenoic Acid Protects from Amyloid and Dendritic Pathology in an Alzheimer's Disease Mouse Model

Cole, G. M., & Frautschy, S. A. (2006) · Nutrition and Health · doi:10.1177/026010600601800307 · Cited by 110

Biomarkers of oxidative damage to DNA and repair

Loft, S. H., Danielsen, P. H., Mikkelsen, L., Risom, L., Forchhammer, L., & Möller, P. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361071 · Cited by 109

Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor

Li, G., & Osborne, N. N. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.073 · Cited by 108

Induction of oxidative damage by copper-based antineoplastic drugs (Casiopeínas®)

Alemón‐Medina, R., Breña-Valle, M., Muñoz-Sánchez, J. L., Gracia‐Mora, I., & Ruíz-Azuara, L. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0364-9 · Cited by 107

Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells

Stolzing, A., & Grune, T. (2004) · The FASEB Journal · doi:10.1096/fj.03-0374fje · Cited by 107

HIF and reactive oxygen species regulate oxidative phosphorylation in cancer

Hervouet, É., Vrbacká-Čížková, A., Demont, J., Pecinová, A., Pecina, P., Hal, N. L. W. F.-V., Keijer, J., Simonnet, H., Ivánek, R., Kmoch, S., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn125 · Cited by 106

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

Murray, I. A., Morales, J. L., Flaveny, C. A., DiNatale, B. C., Chiaro, C. R., Gowda, K., Amin, S., & Perdew, G. H. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.061788 · Cited by 104

Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds

Safe, S. H. (1997) · Teratogenesis Carcinogenesis and Mutagenesis · doi:10.1002/(sici)1520-6866(1997)17:4/5 · Cited by 102

Cell Apoptosis Induced by Carcinogenic Metals

Chen, F., Vallyathan, V., Castranova, V., & Shi, X. (2001) · Springer eBooks · doi:10.1007/978-1-4615-0793-2_21 · Cited by 101

Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease

Castellani, R. J., Honda, K., Zhu, X., Cash, A., Nunomura, A., Perry, G. L., & Smith, M. A. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.01.002 · Cited by 100

Cell apoptosis induced by carcinogenic metals

Chen, F., Vallyathan, V., Castranova, V., & Shi, X. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1017970330982 · Cited by 98

Delaying the Mitochondrial Decay of Aging

Ames, B. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.073 · Cited by 94

Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma.

Nair, J., Sone, H., Nagao, M., Barbin, A., & Bartsch, H. (1996) · PubMed · Cited by 93

Copper Transfer from Cu–Aβ to Human Serum Albumin Inhibits Aggregation, Radical Production and Reduces Aβ Toxicity

Perrone, L., Mothes-Martin, E., Vignes, M., Mockel, A., Figueroa, C. M., Miquel, M., Maddelein, M., & Faller, P. (2009) · ChemBioChem · doi:10.1002/cbic.200900474 · Cited by 93

Hydroxyl Radical Is Not the Main Reactive Species Involved in the Degradation of DNA Bases by Copper in the Presence of Hydrogen Peroxide

Frelon, S., Douki, T., Favier, A. E., & Cadet, J. (2003) · Chemical Research in Toxicology · doi:10.1021/tx025650q · Cited by 92

Redox-Based Escape Mechanism from Death: The Cancer Lesson

Pani, G., Giannoni, E., Galeotti, T., & Chiarugi, P. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2739 · Cited by 92

Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver

Patel, R. D., Hollingshead, B. D., Omiecinski, C. J., & Perdew, G. H. (2007) · Hepatology · doi:10.1002/hep.21671 · Cited by 90

Contemporary Anticholinesterase Pharmaceuticals of Natural Origin and Their Synthetic Analogues for the Treatment of Alzheimers Disease

Orhan, G., Orhan, I., Subutay-Oztekin, N., Ak, F., & Sener, B. (2009) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488909787002582 · Cited by 90

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines

Lin, P., LIN, C., Chuang, M.-C., CHUANG, M., & LIN, P. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.06.003 · Cited by 89

Modulation of Sirtuins: New Targets for Antiageing

Pallàs, M., Verdaguer, E., Tajes, M., Cuesta, J., & Camins, A. (2008) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488908783421492 · Cited by 88

Evaluation of the in vitro direct and indirect genotoxic effects of cobalt compounds using the alkaline comet assay. Influence of interdonor and interexperimental variability

Boeck, M. D. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.2021 · Cited by 88

ERK and cell death: cadmium toxicity, sustained ERK activation and cell death

Martin, P., & Pognonec, P. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07369.x · Cited by 86

Pharmacokinetics and Molecular Detoxication

Cashman, J. R., Perotti, B. Y. T., Berkman, C. E., & Lin, J. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s123 · Cited by 84

Inhibition of cadmium‐induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium

Yang, C., Tzou, B., Liu, Y., Tsai, M., Shyue, S., & Tzeng, S. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21452 · Cited by 81

Apoptosis and age-dependant induction of nuclear and mitochondrial etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: enhanced DNA damage by dietary curcumin upon copper accumulation

Nair, J., Strand, S., Frank, N., Knauft, J., Wesch, H., Galle, P. R., & Bartsch, H. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi073 · Cited by 81

Over‐expression of antioxidant enzymes protects cultured hippocampal and cortical neurons from necrotic insults

Wang, H., Cheng, E., Brooke, S. M., Chang, P. P., & Sapolsky, R. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02123.x · Cited by 79

A Role for Copper in the Toxicity of Zinc-Deficient Superoxide Dismutase to Motor Neurons in Amyotrophic Lateral Sclerosis

Trumbull, K. A., & Beckman, J. S. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2574 · Cited by 79

Effects of Dexmedetomidine on Regulating Endotoxin-Induced Up-Regulation of Inflammatory Molecules in Murine Macrophages

Lai, Y., Tsai, P.-S., & Huang, C.-J. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.07.010 · Cited by 77

Pathways from glutamine to apoptosis

Matés, J. M. (2006) · Frontiers in bioscience · doi:10.2741/2040 · Cited by 75

Inhibition of B(a)P induced strand breaks in presence of curcumin

Polasa, K., Naidu, A., Ravindranath, I., & Krishnaswamy, K. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.10.016 · Cited by 75

The Aryl Hydrocarbon Receptor Directly Regulates Expression of the Potent Mitogen Epiregulin

Patel, R. D., Kim, D. J., Peters, J. M., & Perdew, G. H. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi344 · Cited by 74

Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats

Tritscher, A. M., Seacat, A. M., Yager, J. D., Groopman, J. D., Miller, B. D., Bell, D. A., Sutter, T. R., & Lucier, G. W. (1996) · Cancer Letters · doi:10.1016/s0304-3835(06)80035-2 · Cited by 72

Cobalt toxicity: Chemical and radiological combined effects on HaCaT keratinocyte cell line

Gault, N., Sandre, C., Poncy, J. L., Moulin, C., Lefaix, J.-L., & Bresson, C. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.08.027 · Cited by 69

Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

Akan, I., Akan, S., Akça, H., Savaş, B., & Özben, T. (2005) · Cancer Cell International · doi:10.1186/1475-2867-5-22 · Cited by 68

Mutagenesis by metal-induced oxygen radicals.

Reid, T. M., Feig, D. I., & Loeb, L. A. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s357 · Cited by 67

DNA damage induced by catecholestrogens in the presence of copper (II): generation of reactive oxygen species and enhancement by NADH

Thibodeau, P. A., & Paquette, B. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00183-5 · Cited by 67

The influence of curcumin and manganese complex of curcumin on cadmium‐induced oxidative damage and trace elements status in tissues of mice

Eybl, V., Kotyzová, D., Lešetický, L., Bludovská, M., & Koutensky, J. (2005) · Journal of Applied Toxicology · doi:10.1002/jat.1124 · Cited by 64

RX 821002 as a Tool for Physiological Investigation of α2‐Adrenoceptors

Clarke, R. W., & Harris, J. E. (2002) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2002.tb00222.x · Cited by 64

Involvement of the endothelin receptor subtype A in neuronal pathogenesis after traumatic brain injury

Sato, M., & Noble‐Haeusslein, L. J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00817-8 · Cited by 61

Recommendations for Standardized Description of and Nomenclature Concerning Oxidatively Damaged Nucleobases in DNA

Cooke, M. S., Loft, S. H., Oliński, R., Evans, M. D., Białkowski, K., Wagner, J. R., Dedon, P. C., Möller, P., Greenberg, M. M., & Cadet, J. (2010) · Chemical Research in Toxicology · doi:10.1021/tx1000706 · Cited by 58

Natural Antioxidants: Therapeutic Prospects for Cancer and Neurological Diseases

Matés, J. M., Segura, J., Alonso, F. J., & Márquez, J. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709789055180 · Cited by 58

Copper-1,10-Phenanthroline-Induced Apoptosis in Liver Carcinoma Bel-7402 Cells Associates with Copper Overload, Reactive Oxygen Species Production, Glutathione Depletion and Oxidative DNA Damage

Cai, X., Pan, N., & Zou, G. (2006) · BioMetals · doi:10.1007/s10534-006-9008-0 · Cited by 57

Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function

Garratt, J. C., Crespi, F., Mason, R. J., & Marsden, C. A. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90204-4 · Cited by 56

Metals and metal compounds in carcinogenesis.

Desoize, B. (2004) · PubMed · Cited by 55

Oxidative DNA Base Damage in Renal, Hepatic, and Pulmonary Chromatin of Rats after Intraperitoneal Injection of Cobalt(II) Acetate

Kasprzak, K. S., Zastawny, T. H., North, S. L., Riggs, C. W., Diwan, B. A., Rice, J. M., & Dizdaroğlu, M. (1994) · Chemical Research in Toxicology · doi:10.1021/tx00039a009 · Cited by 54

Metal inhibition of human N-methylpurine-DNA glycosylase activity in base excision repair

Wang, P., Guliaev, A. B., & Hang, B. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.06.647 · Cited by 53

Can Nutrition Affect Chemical Toxicity

Fürst, A. (2002) · International Journal of Toxicology · doi:10.1080/10915810290096649 · Cited by 52

The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage

Kaindl, U., Eyberg, I., Rohr‐Udilova, N., Heinzle, C. F., & Marian, B. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.002 · Cited by 52

Molecular biology of nickel carcinogenesis: Identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by pecific insoluble nickel compounds

Verma, R., Ramnath, J., Clemens, F., Kaspin, L. C., & Landolph, J. R. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000007276.94488.3d · Cited by 50

Induction of Hepatic 8-Oxo-deoxyguanosine Adducts by 2,3,7,8-Tetrachlorodibenzo- p -dioxin in Sprague−Dawley Rats Is Female-Specific and Estrogen-Dependent

Wyde, M. E., Wong, V. A., Kim, A. H., Lucier, G. W., & Walker, N. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000266j · Cited by 50

The oxidation of glutathione by cobalt/tungsten carbide contributes to hard metal-induced oxidative stress

Fenoglio, I., Corazzari, I., Francia, C., Bodoardo, S., & Fubini, B. (2008) · Free Radical Research · doi:10.1080/10715760802350904 · Cited by 50

Mechanism of action of dioxin-type chemicals, pesticides, and other xenobiotics affecting nutritional indexes

Matsumura, F. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.3.695s · Cited by 49

Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease

Marlatt, M. W., Lee, H., Perry, G. L., Smith, M. A., & Zhu, X. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1493 · Cited by 49

Inflammation, but not hypoxia, mediated HIF-1α activation depends on COX-2

Stasinopoulos, I. A., O’Brien, D. R., & Bhujwalla, Z. M. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.1.7079 · Cited by 49

Inhibition of antimutagenic enzymes, 8-oxo-dGTPases, by carcinogenic metals. Recent developments

Kasprzak, K. S., & Białkowski, K. (2000) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(99)00240-8 · Cited by 47

Characterisation of Cadmium Chloride Induced Molecular and Functional Alterations in Airway Epithelial Cells

Forti, E., Bulgheroni, A., Çetin, Y., Härtung, T., Jennings, P., Pfaller, W., & Prieto, P. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000272060 · Cited by 45

Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells

Yang, S., Misner, B., Chiu, R. J., & Meyskens, F. L. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm128 · Cited by 45

Measurement of oxidatively generated base damage in cellular DNA and urine

Cadet, J., & Poulsen, H. E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.004 · Cited by 44

Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study

Akahoshi, E., Yoshimura, S., Uruno, S., & Ishihara‐Sugano, M. (2009) · Environmental Health · doi:10.1186/1476-069x-8-24 · Cited by 44

Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells

Qian, Y., Zheng, Y., Abraham, L., Ramos, K. S., & Tiffany‐Castiglioni, E. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.11.004 · Cited by 43

The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells

Vondráček, J., Krčmář, P., Procházková, J., Trilecová, L., Gavelová, M., Skálová, L., Szotáková, B., Bunček, M., Radilová, H., Kozubı́k, A., et al. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.03.011 · Cited by 43

Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II)

Porter, D. W. (1997) · Carcinogenesis · doi:10.1093/carcin/18.9.1785 · Cited by 43

Biological oxidants and antioxidants

Packer, L., Cadenas, E., & Jo, D. (1995) · Transplant International · doi:10.1007/bf00336549 · Cited by 43

Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline

Soh, Y. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.06.023 · Cited by 42

Environmental contaminants in pathogenesis of breast cancer.

Mukherjee, S., Koner, B. C., Ray, S., & Ray, A. (2006) · PubMed · Cited by 42

Differential Cell Death Induced by Salsolinol with and without Copper: Possible Role of Reactive Oxygen Species

Kim, H.-J., Soh, Y., Jang, J. H., Lee, J. S., Oh, Y. J., & Surh, Y. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12605-3 · Cited by 40

A Weight-of-Evidence Analysis of the Cancer Dose-Response Characteristics of 2,3,7,8-Tetrachlorodibenzodioxin (TCDD)

Popp, J. A., Crouch, E. A. C., & McConnell, E. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj016 · Cited by 39

Repression of Activated Aryl Hydrocarbon Receptor–Induced Transcriptional Activation by 5α-Dihydrotestosterone in Human Prostate Cancer LNCaP and Human Breast Cancer T47D Cells

Sanada, N., Gotoh, Y., Shimazawa, R., Klinge, C. M., & Kizu, R. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08328fp · Cited by 38

Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line

Mikami, Y., Hisatsune, A., Tashiro, T., Isohama, Y., & Katsuki, H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.002 · Cited by 37

Molecular Carcinogenesis and the Molecular Biology of Human Cancer

(2005) · CRC Press eBooks · doi:10.1201/9780203503430 · Cited by 36

Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds.

Landolph, J. R., Verma, A., Ramnath, J., & Clemens, F. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s5845 · Cited by 36

Cobalt chloride induces neurite outgrowth in rat pheochromocytoma PC-12 cells through regulation of endothelin-2/vasoactive intestinal contractor

Kotake‐Nara, E., Takizawa, S., Quan, J., Wang, H., & Saida, K. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20568 · Cited by 35

Effects of Naphthalene Quinonoids on the Induction of Oxidative DNA Damage and Cytotoxicity in Calf Thymus DNA and in Human Cultured Cells

Lin, P.-H., Pan, W., Kang, Y.-W., Chen, Y.-L., Lin, C.-H., Lee, M.-C., Chou, Y.-H., & Nakamura, J. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050018t · Cited by 34

Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3′-kinase/Akt signaling

Eckers, A., Reimann, K., & Klotz, L. (2008) · BioMetals · doi:10.1007/s10534-008-9167-2 · Cited by 34

Effect of copper on extracellular levels of key pro-inflammatory molecules in hypothalamic GN11 and primary neurons

Spisni, E., Valerii, M. C., Manerba, M., Strillacci, A., Polazzi, E., Toni, M., Griffoni, C., & Tomasi, V. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.03.005 · Cited by 33

Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases

Kamiya, H. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.06.003 · Cited by 32

Copper related toxic effects on cellular protein metabolism in human astrocytes

Merker, K., Hapke, D., Reckzeh, K., Schmidt, H., Lochs, H. H., & Grune, T. (2005) · BioFactors · doi:10.1002/biof.5520240130 · Cited by 32

Interaction of carcinogenic metal compounds with deoxyribonucleic acid repair processes.

Hartwig, A., Schlepegrell, R., Dally, H., & Hartmann, M. (1996) · PubMed · Cited by 32

Copper ions disrupt dopamine metabolism via inhibition of V‐H+‐ATPase: a possible contributing factor to neurotoxicity

Wimalasena, D. S., Wiese, T. J., & Wimalasena, K. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04362.x · Cited by 29

Endothelin-2/Vasoactive Intestinal Contractor: Regulation of Expression via Reactive Oxygen Species Induced by CoCl22, and Biological Activities Including Neurite Outgrowth in PC12 Cells

Kotake‐Nara, E., & Saida, K. (2006) · The Scientific World JOURNAL · doi:10.1100/tsw.2006.37 · Cited by 29

Oxidativer Stress, altersabhängige Zellschädigungen und antioxidative Mechanismen

Gosslau, A., & Rensing, L. (2002) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s003910200018 · Cited by 28

Heavy Metals Modulate Glutamatergic System in Human Platelets

Borges, V. C., Cibin, F. W. S., da Rocha, J. B. T., & Nogueira, C. W. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9231-7 · Cited by 28

Characterization of CoCl2-induced reactive oxygen species (ROS): Inductions of neurite outgrowth and endothelin-2/vasoactive intestinal contractor in PC12 cells by CoCl2 are ROS dependent, but those by MnCl2 are not

Kotake‐Nara, E., & Saida, K. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.06.026 · Cited by 27

Structures of 1,4-Benzodioxane Derivatives from the Seeds of Phytolacca americana and Their Neuritogenic Activity in Primary Cultured Rat Cortical Neurons

Takahasi, H., Yanagi, K., Ueda, M., Nakade, K., & Fukuyama, Y. (2003) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.51.1377 · Cited by 27

Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells

Schreck, I., Chudziak, D., Schneider, S., Seidel, A., Platt, K. L., Oesch, F., & Weiß, C. (2009) · Toxicology · doi:10.1016/j.tox.2009.02.006 · Cited by 26

Catechol-estrogen modified DNA: A better antigen for cancer autoantibody

Khan, W. A., Alam, K., & Moinuddin, M. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.06.006 · Cited by 26

Modulation of Carcinogen Metabolism by Nitric Oxide-Aspirin 2 Is Associated with Suppression of DNA Damage and DNA Adduct Formation

MacDonald, C. J., Cheng, R. Y. S., Roberts, D. D., Wink, D. A., & Yeh, G. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021063 · Cited by 25

Effect of psoralens on Fenton‐like reaction generating reactive oxygen species

Aboul-Enein, H. Y., Kładna, A., Kruk, I., Lichszteld, K., & Michalska, T. (2002) · Biopolymers · doi:10.1002/bip.10285 · Cited by 25

Glutathione and gamma‐glutamyl transferases are involved in the formation of cadmium–glutathione complex

Adamis, P. D. B., Mannarino, S. C., & Eleuthério, E. C. A. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.03.066 · Cited by 24

Role of Free Radicals in Metal-Induced Carcinogenesis

Landolph, J. R. (2018) · Routledge eBooks · doi:10.1201/9780203747605-14 · Cited by 23

Mechanism of Cd2+ on DNA cleavage and Ca2+ on DNA repair in liver of silver crucian carp

Wu, C., Wang, L., Liu, C., Gao, F., Su, M., Wu, X. Y., & Hong, F. (2007) · Fish Physiology and Biochemistry · doi:10.1007/s10695-007-9144-7 · Cited by 22

In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones

Koenig, M. L., & Meyerhoff, J. L. (2003) · Neurotoxicity Research · doi:10.1007/bf03033384 · Cited by 21

Muscarinic activation attenuates abnormal processing of β-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells

Zhu, X., Zhou, W., Cui, Y., Zhu, L., Li, J., Xia, Z., Shao, B., Wang, H., & Chen, H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.080 · Cited by 21

Copper sulfate prevents tyrosine hydroxylase reduced activity and motor deficits in a Parkinson's disease model in mice.

Alcaraz-Zubeldia, M., Boll, M., Montes-López, S., Pérez‐Severiano, F., Martínez‐Lazcano, J. C., Dı́az-Ruiz, A., & Rı́os, C. (2009) · PubMed · Cited by 21

2,3,7,8-Tetrachlorobenzo- p -dioxin Inhibits Proliferation of SK-N-SH Human Neuronal Cells Through Decreased Production of Reactive Oxygen Species

Lee, Y. S., Jin, D., Park, S. H., Han, S. Y., Kim, H. S., Jeong, T. C., Huh, K. Y., & Kim, J. W. (2002) · Free Radical Research · doi:10.1080/1071576021000016517 · Cited by 20

Oxidation and Glycolytic Cleavage of Etheno and Propano DNA Base Adducts

Knutson, C. G., Rubinson, E. H., Akingbade, D., Anderson, C. S., Stec, D. F., Petrova, K. V., Kozekov, I. D., Guengerich, F. P., Rizzo, C. J., & Marnett, L. J. (2009) · Biochemistry · doi:10.1021/bi801654j · Cited by 19

Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues

Lee, Y. (2009) · Oncology Reports · doi:10.3892/or_00000337 · Cited by 19

Metallothionein expression in HaCaT and C6 cell lines exposed to cadmium

Nzengue, Y., Lefèbvre, E., Cadet, J., Favier, A. E., Rachidi, W., Steiman, R. L., & Guiraud, P. (2009) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2009.05.005 · Cited by 18

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in primary rat astroglia: identification of biochemical and cellular targets.

Legare, M. E., Hanneman, W. H., Barhoumi, R., & Tiffany‐Castiglioni, E. (1997) · PubMed · Cited by 18

Gene therapy in the nervous system with superoxide dismutase

Zemlyak, I., Nimon, V., Brooke, S. M., Moore, T., McLaughlin, J. R., & Sapolsky, R. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.109 · Cited by 17

A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats

McCoy, J. G., Strawbridge, C., McMurtrey, K. D., Kane, V. B., & Ward, C. P. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00018-2 · Cited by 16

Copper(II) as an efficient scavenger of singlet molecular oxygen.

Joshi, P. C. (1998) · PubMed · Cited by 15

Genetic Differences in Sensitivity to Alterations of Mandible Structure Caused by the Teratogen 2,3,7,8-Tetrachlorodibenzo- p -Dioxin

Keller, J. M., Zelditch, M. L., Huet, Y. M., & Leamy, L. J. (2008) · Toxicologic Pathology · doi:10.1177/0192623308327409 · Cited by 13

Cadmium exposure in Thai populations from central, northern and northeastern Thailand and the effects of food consumption on cadmium levels.

Apinan, R., Satarug, S., Ruengweerayut, R., Tassaneeyakul, W., & Na‐Bangchang, K. (2009) · PubMed · Cited by 11

Data Mining by Total Ranking Methods: A Case Study on Optimisation of the “Pulp and Bleaching” Process in the Paper Industry

Pavan, M., Todeschini, R., & Orlandi, M. E. (2006) · Annali di Chimica · doi:10.1002/adic.200690004 · Cited by 11

Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase.

Alonso, F. J., Segura, J. A., Lora, J., Lobo, C., Fernandez-Molina, B., Márquez, J., & Matés, J. M. (2005) · PubMed · Cited by 11

4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells

Cheng, Y.-H., Chang, L. W., Cheng, L., Tsai, M., & Lin, P. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.01.024 · Cited by 10

Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery

Nelli, S., Craig, J., & Martin, W. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.033 · Cited by 9

In vitro assessment of the effects of cadmium and zinc on mammalian nerve fibres

Moschou, M., Papaefthimiou, C., Kagiava, A., Antonopoulou, E., & Theophilidis, G. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.01.070 · Cited by 9

Interfacial Metal Flux in Ligand Mixtures. 3. Unexpected Flux Enhancement Due to Kinetic Interplay at the Consuming Surface, Computed for Aquatic Systems

Zhang, Z., & Buffle, J. (2009) · Environmental Science & Technology · doi:10.1021/es9003526 · Cited by 8

Generation of Antioxidant Adenovirus Gene Transfer Vectors Encoding CuZnSOD, MnSOD, and Catalase

Duffy, A. M., O’Brien, T., & McMahon, J. M. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-411-1_27 · Cited by 6

Attenuating effect of melatonin on pyridoxal-stimulated release of adrenomedullary catecholamines in the rat

Budhram, R., & Lau‐Cam, C. A. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.02.017 · Cited by 4

Chemically Induced Morphological and Neoplastic Transformation in C3H/10T1/2 Cl 8 Mouse Embryo Cells

Landolph, J. R. (2005) · CRC Press eBooks · doi:10.1201/9780203503430.ch9 · Cited by 3

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,643

The contribution of environmental exposure to the etiology of autism spectrum disorder

Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509

Potential Biotechnological Strategies for the Cleanup of Heavy Metals and Metalloids

Mosa, K. A., Saadoun, I. M. K., Kumar, K., Helmy, M., & Dhankher, O. P. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00303 · Cited by 448

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin

Barchitta, M., Maugeri, A., Favara, G., Lio, R. M. S., Evola, G., Agodi, A., & Basile, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051119 · Cited by 361

Oxidative stress in apoptosis and cancer: an update

Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0906-3 · Cited by 347

Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: a review.

Buzard, G. S., & Kasprzak, K. S. (2000) · PubMed · Cited by 87

Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage

Nuran Ercal, B. S. P., Hande Gurer-Orhan, B. S. P., & Nukhet Aykin-Burns, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394831 · Cited by 1,944

Metallotoxicant-driven cellular dysregulation: Redox pathways in stress signalling and death program execution

Das, S., Alavala, S., Santaki, S., Yadav, P., Jamalpur, R. P., & Challa, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44299-5.00016-x

Heavy metals and free radical-induced cell death mechanisms

Madkour, L. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-822481-6.00006-2 · Cited by 8

Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Paithankar, J. G., Saini, S., Dwivedi, S., Sharma, A., & Chowdhuri, D. K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128350 · Cited by 611