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Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms
Abstract
Oxidants have critical functions inside healthy and unhealthy cells. Deregulated cell cycle and apoptosis, both regulated by oxidative stress, have been described as hallmarks of mitotic (cancer) and postmitotic (neuronal) cells. This review provides an updated revision of the oxidant effects of some environmental contaminants such as dioxins and the heavy metals cadmium, cobalt, and copper. Dioxins exert their toxic actions by acting on phase I and phase II enzymes, such as cytochromes P450, superoxide dismutase, and glutathione peroxidase, promoting cell proliferation, growth arrest, and apoptosis, affecting cancer homeostasis and neuronal function. Heavy metals manifest cytotoxic effects in various cells and tissues, and tight regulation of metals is essential to the health of organisms. Cadmium modulates gene expression and signal transduction and reduces activities of proteins involved in antioxidant defense, interfering with DNA repair and modifying cancer development and brain function. Cobalt provokes generation of reactive oxygen species and DNA damage in cancer cells and brain tissues, altering proliferation and differentiation and causing apoptosis. Copper is a key metal in cell division processes in both normal and tumor cells. Copper also has been shown to have an important role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.
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“Exposure to heavy metals can detrimentally impact many bodily functions, inducing neurological and behavioral impairment [191–195].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [194]
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Metadata
- Authors
- Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J.
- Affiliations
- Universidad de Málaga (ES)
- Corresponding author
- Matés, José M.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 49
- Issue
- 9
- Pages
- 1328-1341
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2059124139
- Cited by
- 286
- References
- 174
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 14 · 2023: 23 · 2022: 13 · 2021: 18 · 2020: 20 · 2019: 20 · 2018: 11 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 23 · 2013: 25 · 2012: 25
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- dioxins, heavy metals, cadmium, cobalt, copper, reactive oxygen species, oxidative stress, cancer, neurodegenerative diseases, apoptosis, cell cycle, cytochrome P450, superoxide dismutase, glutathione peroxidase, DNA damage, DNA repair, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, environmental pollutants
- MeSH terms
- Animals, Cell Differentiation, Cell Transformation, Neoplastic, Dioxins, Environmental Pollutants, Humans, Neoplasms, Nervous System Diseases, Reactive Oxygen Species, Oxidative Stress, Metals, Heavy, Cell Proliferation
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