Cited by 92Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

Contemporary Anticholinesterase Pharmaceuticals of Natural Origin and Their Synthetic Analogues for the Treatment of Alzheimers Disease

Orhan, Gurdal, Orhan, Ilkay, Subutay-Oztekin, Nese, Ak, Fikri, Sener, Bilge·2009·Recent Patents on CNS Drug Discovery

Abstract

Alzheimer's disease (AD), the most common form of dementia, is a degenerative and progressive neurological disorder characterized by deficit in the cholinergic transmission and formation of senile plaques containing beta-amyloid protein in the brain. Although complete pathology of the disease has not been fully elucidated yet, there are several treatment strategies for AD treatment. The complexity of AD is also due to involvement of several enzymes through its progression. Therefore, the most important therapeutic approach has emerged as inhibition of acetylcholinesterase (AChE), which is the key enzyme in the breakdown of acetylcholine. Another very attractive approach to lower beta-amyloid protein in fibrillar form has been the alpha- and beta-secretase inhibitors. On the other hand, recently, N-methyl-D-aspartate (NMDA) receptor antagonists have become a strong alternative, which has been approved to be effective in treatment of moderate to severe type of AD. Within the past few years, some pharmaceuticals have become available for clinical use; however, none of them have been shown to possess ability to discontinue the disease up to date. Hence, there is obviously a great need for discovery of new drug candidates of natural or synthetic origins for AD treatment. This review will cover AChE-inhibiting pharmaceuticals from plants and their synthetic derivatives including relevant patent literatures which may promise a future hope for AD treatment.

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Crossref · 10.2174/157488909787002582

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Authors
Orhan, G., Orhan, I., Subutay-Oztekin, N., Ak, F., & Sener, B.
Venue
Recent Patents on CNS Drug Discovery
Published
2009-01-01
Volume
4
Issue
1
Pages
43-51
ISSN
1574-8898 (ISSN-L)
OpenAlex
W2167292970
Cited by
90
References
99
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 1 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 9 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 4
FWCI
3.27
Type
journal article
Language
en
Open access
closed
Locations
  • Recent Patents on CNS Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
Alzheimer's disease, acetylcholinesterase inhibitors, natural products, plant-derived drugs, synthetic analogues, amyloid-beta, secretase inhibitors, NMDA receptor antagonists, cholinergic neurotransmission, drug discovery, patents
MeSH terms
Acetylcholinesterase, Alzheimer Disease, Animals, Cholinesterase Inhibitors, Humans

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