The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Role of the enteric microbiota in intestinal homeostasis and inflammation
Open accessAbstract
The mammalian intestine encounters many more microorganisms than any other tissue in the body thus making it the largest and most complex component of the immune system. Indeed, there are greater than 100 trillion (1014) microbes within the healthy human intestine where the total number of genes derived from this diverse microbiome exceeds that of the entire human genome by at least 100-fold. Our coexistence with the gut microbiota represents a dynamic and mutually beneficial relationship that is thought to be a major determinant of health and disease. Because of the potential for intestinal microorganisms to induce local and/or systemic inflammation, the intestinal immune system has developed a number of immune mechanisms to protect the host from pathogenic infections while limiting the inflammatory tissue injury that accompanies these immune responses. Failure to properly regulate intestinal mucosal immunity is thought to be responsible for the inflammatory tissue injury observed in the inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis). An accumulating body of experimental and clinical evidence strongly suggest that IBD results from a dysregulated immune response to components of the normal gut flora in genetically-susceptible individuals. The objective of this review is to present our current understanding of the role that enteric microbiota play in intestinal homeostasis and pathogenesis of chronic intestinal inflammation.
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Cited by
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Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease
Zhang, M., Sun, K., Wu, Y., Yang, Y., Tso, P., & Wu, Z. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00942 · Cited by 347
The Role of Probiotics in Cancer Prevention
Śliżewska, K., Markowiak-Kopeć, P., & Śliżewska, W. (2020) · Cancers · doi:10.3390/cancers13010020 · Cited by 282
Metadata
- Authors
- Koboziev, I., Reinoso Webb, C., Furr, K. L., & Grisham, M. B.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 68
- Pages
- 122-133
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2043291671
- Cited by
- 223
- References
- 33
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- green
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