Oxidative stress response and Nrf2 signaling in aging

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388

Neurodegenerative diseases and oxidative stress

Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · cited 1×

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Inhibition of 12/15-LO ameliorates CVB3-induced myocarditis by activating Nrf2

Ai, F., Zheng, J., Zhang, Y., & Fan, T. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.05.010 · Cited by 21

Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington’s disease

Sjögren, M., Duarte, A. I., McCourt, A. C., Shcherbina, L., Wierup, N., & Björkqvist, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-13713-5 · Cited by 21

Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells

Clementino, M., Kim, D., & Zhang, Z. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz032 · Cited by 21

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

Wang, L., Zuo, X., Ouyang, Z., Qiao, P., & Wang, F. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5591573 · Cited by 21

Knockout of the radical scavenger α1-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight

Bergwik, J., Kristiansson, A., Welinder, C., Göransson, O., Hansson, S. R., Gram, M., Erlandsson, L., & Åkerström, B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.019 · Cited by 21

COP-22 Alleviates d-Galactose–Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice

Ma, Y., Wang, X., Li, X., Chen, X., Teng, Z., Yang, J., Yang, J., & Liu, G. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03976-1 · Cited by 20

Overexpression of miR-506-3p Aggravates DBP-Induced Testicular Oxidative Stress in Rats by Downregulating ANXA5 via Nrf2/HO-1 Signaling Pathway

Tang, M. M., Zhang, L., Zhu, Z. G., Li, R., Wang, S., Wang, W., Qin, Z., & Zhang, W. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4640605 · Cited by 20

Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury

Huang, D., Dai, C., Li, S., & Li, X. (2021) · Aging · doi:10.18632/aging.202437 · Cited by 20

Persistence of improved glucose homeostasis in Gclm null mice with age and cadmium treatment

Schaupp, C. M., Botta, D., White, C. C., Scoville, D., Srinouanprachanh, S. L., Bammler, T. K., MacDonald, J. W., & Kavanagh, T. J. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102213 · Cited by 20

Tetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis

Gao, F., Chen, M., Yu, J., Xu, L., Yu, L., Jiang, H., & Gu, Z. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104957 · Cited by 21

Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways

Ren, G., Lv, W., Ding, Y., Wang, L., Cui, Z., Li, R., Tian, J., & Zhang, C. (2023) · Journal of Ginseng Research · doi:10.1016/j.jgr.2023.01.002 · Cited by 20

Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice

Tuo, H., Li, W., Zhao, W., Zhao, J., Li, D., & Lin, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-51675-7 · Cited by 20

New label‐free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging

Benedetto, A., Bambade, T., Au, C., Tullet, J. M. A., Monkhouse, J. L., Dang, H., Cetnar, K., Chan, B. H. K., Cabreiro, F., & Gems, D. (2019) · Aging Cell · doi:10.1111/acel.12998 · Cited by 23

4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

Bekyarova, G. Y., Tzaneva, M. A., Bratoeva, K. Z., Иванова, И., Kotzev, A. I., Hristova, M., Krastev, D. S., Kindekov, I., & Mileva, M. M. (2019) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2019.1674690 · Cited by 20

Effects of Lespedeza Bicolor Extract on Regulation of AMPK Associated Hepatic Lipid Metabolism in Type 2 Diabetic Mice

Kim, Y., Lee, H., Kim, S. Y., & Lim, Y. (2019) · Antioxidants · doi:10.3390/antiox8120599 · Cited by 21

Methionine augments endogenous antioxidant capacity of rice protein through stimulating MSR antioxidant system and activating Nrf2-ARE pathway in growing and adult rats

Li, H., Cai, L., Liang, M., Wang, Z., Zhang, Y., Wu, Q., & Yang, L. (2020) · European Food Research and Technology · doi:10.1007/s00217-020-03464-5 · Cited by 20

Phosphoglycerate kinase 1 silencing by a novel microRNA microRNA-4523 protects human osteoblasts from dexamethasone through activation of Nrf2 signaling cascade

Liang, J., Zhou, Z., Lin, B., Tan, H., Hu, J., & Tan, M.-S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04250-1 · Cited by 20

Modulación antioxidante y antiinflamatoria del ejercicio físico durante el envejecimiento

Galle, F. A., Martella, D., & Bresciani, G. (2018) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2018.03.003 · Cited by 22

When safeguarding goes wrong: Impact of oxidative stress on protein homeostasis in health and neurodegenerative disorders

Mesika, R., & Reichmann, D. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.11.001 · Cited by 20

Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats

Kukkemane, K., & Jagota, A. (2020) · Biogerontology · doi:10.1007/s10522-020-09875-x · Cited by 19

Age-related alteration in HNE elimination enzymes

Zhang, H., Morgan, T. E., & Forman, H. J. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108749 · Cited by 20

Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas , Cnidium officinale , and Paeonia lactiflora

Kwon, D., Kim, Y. S., Kim, S., Baek, S. H., Kim, H. K., & Lee, H. S. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1900878 · Cited by 19

Airborne PM2.5 pollution: A double-edged sword modulating hepatic lipid metabolism in middle-aged male mice

Hu, R., Zhang, L., Li, Q., Ding, H., Li, R., Gu, W., Chen, R., Zhang, Y., Rajagoplan, S., Zhang, K., et al. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121347 · Cited by 20

A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging

Thomas, C., Erni, R., Wu, J. Y., Fischer, F., Lamers, G., Grigolon, G., Mitchell, S. J., Zarse, K., Carreira, E. M., & Ristow, M. (2023) · Nature Communications · doi:10.1038/s41467-023-43672-7 · Cited by 20

Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension

Khan, M. M., & Kirabo, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105507 · Cited by 19

Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway

Gao, N., Gao, X., Du, M., Xiang, Y., Zuo, H., Huang, R., Wan, W., & Hu, K. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155982 · Cited by 22

Simultaneous exposure to vinylcyclohexene and methylmercury in Drosophila melanogaster: biochemical and molecular analyses

Piccoli, B., Segatto, A., Oliveira, C., da Silva, F. D., Aschner, M., & da Rocha, J. B. T. (2019) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-019-0356-0 · Cited by 16

The antioxidant dieckol reduces damage of oxidative stress‐exposed porcine oocytes and enhances subsequent parthenotes embryo development

Pyeon, D., Lee, S., Yoon, J., Park, H., Park, C., Kim, S., Oh, S., Lee, D., Kim, E., & Park, S. (2021) · Molecular Reproduction and Development · doi:10.1002/mrd.23466 · Cited by 19

Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome

Napoli, E., Flores, A., Mansuri, Y., Hagerman, R. J., & Giulivi, C. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105427 · Cited by 19

New insights into oxidative stress and immune mechanisms involved in age-related macular degeneration tackled by novel therapies

Potilinski, M. C., Tate, P. S., Lorenc, V. E., & Gallo, J. E. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108513 · Cited by 19

Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage

Loan, J. J., Salman, R. A., McColl, B. W., & Hardingham, G. E. (2022) · Biomolecules · doi:10.3390/biom12101438 · Cited by 17

NRF2 and the Moirai: Life and Death Decisions on Cell Fates

Yagishita, Y., Chartoumpekis, D. V., Kensler, T. W., & Wakabayashi, N. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0200 · Cited by 21

Insight of Silkworm Pupa Oil Regulating Oxidative Stress and Lipid Metabolism in Caenorhabditis elegans

Zhao, L., Wu, B., Shuyun, L., Min, D., & Jiang, H. (2022) · Foods · doi:10.3390/foods11244084 · Cited by 20

The Mitochondrial-Derived Peptide (MOTS-c) Interacted with Nrf2 to Defend the Antioxidant System to Protect Dopaminergic Neurons Against Rotenone Exposure

Xiao, J., Zhang, Q., Shan, Y., Ye, F., Zhang, X., Cheng, J. S., Wang, X., Zhao, Y., Dan, G., Chen, M., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03443-3 · Cited by 19

The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence

Han, Y.-K., Liu, Y., Zhang, Y., Wang, W., Lv, T., Huang, J., & Peng, X. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2810250 · Cited by 20

Knockdown of FOXO6 inhibits high glucose–induced oxidative stress and apoptosis in retinal pigment epithelial cells

Zhou, Z., Liu, J., Bi, C.-C., Chen, L., Jiao, Y., & Cui, L. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28252 · Cited by 18

Hibiscus sabdariffa extract protects HT-22 cells from glutamate-induced neurodegeneration by upregulating glutamate transporters and exerts lifespan extension in C. elegans via DAF-16 mediated pathway

Malar, D. S., Prasanth, M. I., Brimson, J. M., Verma, K., Prasansuklab, A., & Tencomnao, T. (2021) · Nutrition and Healthy Aging · doi:10.3233/nha-210131 · Cited by 18

Aucubin slows the development of osteoporosis by inhibiting osteoclast differentiation via the nuclear factor erythroid 2-related factor 2-mediated antioxidation pathway

Zhang, Y., Liu, X. Z., Li, Y., Song, M., Li, Y., Yang, A., Zhang, Y., Wang, D., & Hu, M. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1996614 · Cited by 18

Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health

Sutton, E. R., & Pekovic‐Vaughan, V. (2025) · Antioxidants · doi:10.3390/antiox14091132 · Cited by 20

Feprazone Mitigates IL-1β-Induced Cellular Senescence in Chondrocytes

Huang, Z., Lan, J., & Gao, X. (2021) · ACS Omega · doi:10.1021/acsomega.0c06066 · Cited by 17

Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19

McCord, J. M., Hybertson, B. M., Cota‐Gomez, A., & Gao, B. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.033 · Cited by 18

Substitution of Sugar-Sweetened Beverages for Other Beverages: Can It Be the Next Step Towards Healthy Aging?

Ertuğlu, L. A., Afşar, B., Yıldız, A. B., Demiray, A., Ortíz, A., Covic, A. C., & Kanbay, M. (2021) · Current Nutrition Reports · doi:10.1007/s13668-021-00372-2 · Cited by 17

NRF2 Shortage in Human Skin Fibroblasts Dysregulates Matrisome Gene Expression and Affects Collagen Fibrillogenesis

Salamito, M., Gillet, B., Syx, D., Vaganay, E., Malbouyres, M., Cerutti, C., Tissot, N., Exbrayat-Heritier, C., Perez, P., Jones, C., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.07.034 · Cited by 19

Chronic Exposure to Vinclozolin Induced Fibrosis, Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Mice Kidney

Paola, D. D., D’Amico, R., Genovese, T., Siracusa, R., Cordaro, M., Crupi, R., Peritore, A. F., Gugliandolo, E., Interdonato, L., Impellizzeri, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911296 · Cited by 17

Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response

Chhunchha, B., Kubo, E., Krueger, R. R., & Singh, D. P. (2023) · Antioxidants · doi:10.3390/antiox12010140 · Cited by 18

Antioxidative Role of Heterophagy, Autophagy, and Mitophagy in the Retina and Their Association with the Age-Related Macular Degeneration (AMD) Etiopathogenesis

Nita, M., & Grzybowski, A. E. (2023) · Antioxidants · doi:10.3390/antiox12071368 · Cited by 19

Age-Dependent Changes in Nrf2/Keap1 and Target Antioxidant Protein Expression Correlate to Lipoxidative Adducts, and Are Modulated by Dietary N-3 LCPUFA in the Hippocampus of Mice

Díaz, M. L., Valdés‐Baizabal, C., Pereda, D., & Marín, R. (2024) · Antioxidants · doi:10.3390/antiox13020206 · Cited by 17

Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging

Tranah, G. J., Barnes, H. N., Cawthon, P. M., Coen, P. M., Esser, K. A., Hepple, R. T., Huo, Z., Kramer, P. A., Toledo, F. G. S., Zhang, X., et al. (2024) · Aging Cell · doi:10.1111/acel.14114 · Cited by 16

Redox imbalance in a model of rat mimicking Hutchinson-Gilford progeria syndrome

Chaudhary, M. K., Singh, S., & Rizvi, S. I. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.095 · Cited by 17

6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver

Guo, D., Shen, Y., Li, W., Li, Q., Zhao, Y., Pan, C., Chen, B., Zhong, Y., & Miao, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00320 · Cited by 17

The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 Infection

Tekos, F., Skaperda, Z., Goutzourelas, N., Phelps, D. S., Floros, J., & Kouretas, D. (2020) · Antioxidants · doi:10.3390/antiox9090784 · Cited by 18

The Role of NRF2 in Mycobacterial Infection

Matsuyama, M., Nonaka, M., Nakajima, M., Morishima, Y., Ishii, Y., & Hizawa, N. (2021) · Antioxidants · doi:10.3390/antiox10121861 · Cited by 17

The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies

Manai, F., Govoni, S. M., & Amadio, M. (2022) · Cells · doi:10.3390/cells11244061 · Cited by 18

Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles

Singh, L., Pandey, R., Siddiqi, N. J., & Sharma, B. (2025) · Toxics · doi:10.3390/toxics13010032 · Cited by 16

Targeting Lysosomal Dysfunction and Oxidative Stress in Age-Related Macular Degeneration

Falcão, A. S., Pedro, M. L., Tenreiro, S., & Seabra, M. C. (2025) · Antioxidants · doi:10.3390/antiox14050596 · Cited by 16

PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease

Morroni, F., Sita, G., Graziosi, A., Ravegnini, G., Molteni, R., Paladini, M. S., Dias, K. S. T., dos Santos, A. F., Viegas, C., Camps, I., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00658 · Cited by 17

Smoking Cessation in Mice Does Not Switch off Persistent Lung Inflammation and Does Not Restore the Expression of HDAC2 and SIRT1

Cunto, G. D., Meo, S. D., Bartalesi, B., Cavarra, E., Lungarella, G., & Lucattelli, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169104 · Cited by 16

Omarigliptin Mitigates 6-Hydroxydopamine- or Rotenone-Induced Oxidative Toxicity in PC12 Cells by Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Actions

Gouda, N. A., & Cho, J. (2022) · Antioxidants · doi:10.3390/antiox11101940 · Cited by 17

Impaired NRF2 Inhibits Recovery from Ischemic Reperfusion Injury in the Aging Kidney

Jo, M. J., Kim, J. E., Bae, S. Y., Cho, E., Ahn, S. Y., Kwon, Y., & Ko, G.-J. (2023) · Antioxidants · doi:10.3390/antiox12071440 · Cited by 18

Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells

Chhunchha, B., Kumar, R., Kubo, E., Thakur, P., & Singh, D. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216276 · Cited by 17

Indian Almond (Terminalia catappa Linn.) Leaf Extract Extends Lifespan by Improving Lipid Metabolism and Antioxidant Activity Dependent on AMPK Signaling Pathway in Caenorhabditis elegans under High-Glucose-Diet Conditions

Kim, Y., Lee, S.-B., Cho, M., Choe, S., & Jang, M. (2023) · Antioxidants · doi:10.3390/antiox13010014 · Cited by 17

Sirtuin Proteins and Memory: A Promising Target in Alzheimer’s Disease Therapy?

Fernandez, F., Griffiths, L. R., Sutherland, H. G. E., Cole, M. H., Fitton, J. H., Winberg, P. C., Schweitzer, D. R., Hopkins, L. N., & Meyer, B. J. (2024) · Nutrients · doi:10.3390/nu16234088 · Cited by 17

The Potential Role of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) in Glaucoma: A Review

Wang, M., Li, J., & Zheng, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.921514 · Cited by 16

The Cutaneous Physiological Redox: Essential to Maintain but Difficult to Define

Ron‐Doitch, S., & Kohen, R. (2020) · Antioxidants · doi:10.3390/antiox9100942 · Cited by 16

The Potential Application of Pentacyclic Triterpenoids in the Prevention and Treatment of Retinal Diseases

Cheng, Z., Li, Y., Zhu, X., Wang, K., Ali, Y., Shu, W., Zhang, T., Zhu, L., Murray, M. T., & Zhou, F. (2021) · Planta Medica · doi:10.1055/a-1377-2596 · Cited by 17

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

Sayed, R. K. A., Fernández‐Ortiz, M., Rahim, I., Fernández‐Martínez, J., Aranda‐Martínez, P., Rusanova, I., Martínez-Ruiz, L., Alsaadawy, R. M., Escames, G., & Acuña-Castroviejo, D. (2021) · Antioxidants · doi:10.3390/antiox10081269 · Cited by 17

A Role for NRF2-Signaling in the Treatment and Prevention of Solar Lentigines

Kerns, M. L., Chien, A. L., & Kang, S. (2021) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000008783 · Cited by 16

A selective knockout method for discovery of minor active components from plant extracts: Feasibility and challenges as illustrated by an application to Salvia miltiorrhiza

Li, X., Tang, H., Zhang, L., Yang, L., Li, P., & Chen, J. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.10.011 · Cited by 16

CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats

IuV, N., Klochkov, V., Kavok, N. S., Karpenko, N. A., Yefimova, S. L., Semynozhenko, V. P., Nikitchenko, I. V., & Bozhkov, A. I. (2022) · Biogerontology · doi:10.1007/s10522-022-09987-6 · Cited by 17

Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss

Hou, S., Chen, P., He, J., Chen, J., Zhang, J., Mammano, F., & Yang, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102472 · Cited by 15

Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway

Yamagishi, N., Yamamoto, Y., Nishi, T., Ito, T., & Kanai, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287788 · Cited by 16

Relationship between Composite Dietary Antioxidant Index and Aging

Wang, H., & Chen, Y. (2023) · Healthcare · doi:10.3390/healthcare11202722 · Cited by 15

Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury

Kuo, P., Weng, W., Scofield, B. A., Paraiso, H. C., Yu, I.-C. I., & Yen, J.-H. J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1440592 · Cited by 18

Crataegus aroniaenhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats

Dallak, M. A. (2018) · Pharmaceutical Biology · doi:10.1080/13880209.2018.1523934 · Cited by 15

Celastrol Protects RPE Cells from Oxidative Stress-Induced Cell Death via Activation of Nrf2 Signaling Pathway

Zhou, Y., Zhou, L., Zhou, K., Zhang, J., Shang, F., & Zhang, X. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666190424131704 · Cited by 15

Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells

Yang, J.-L., Sun, M., Yuan, Q., Tang, S., Dong, M., Zhang, R.-D., Liu, Y.-Y., & Mao, L. (2020) · Aging · doi:10.18632/aging.103263 · Cited by 16

The effects of aging on host resistance and disease tolerance to SARS‐CoV‐2 infection

Mok, D. Z. L., Chan, C. Y. Y., Ooi, E. E., & Chan, K. R. (2020) · FEBS Journal · doi:10.1111/febs.15613 · Cited by 15

‘Molecular habituation’ as a potential mechanism of gradual homeostatic loss with age

Guimera, A. M., Welsh, C., Proctor, C. J., McArdle, A., & Shanley, D. P. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.11.010 · Cited by 15

Exercise-Induced FNDC5/Irisin Ameliorates Cognitive Impairment in Aged Mice, Associated with Antioxidant and Neurotrophic Responses

Lee, J. M., Sim, T. H., Kim, S., Choi, Y. J., Lee, J. H., Yeo, S. G., & Kim, Y. (2025) · Antioxidants · doi:10.3390/antiox14101239 · Cited by 19

Mycobacterium tuberculosis: Implications of Ageing on Infection and Maintaining Protection in the Elderly

Bonavida, V., Frame, M., Nguyen, K., Rajurkar, S., & Venketaraman, V. (2022) · Vaccines · doi:10.3390/vaccines10111892 · Cited by 15

Metabolic reprogramming in inflammaging and aging in T cells

Bevilacqua, A., Ho, P., & Franco, F. (2023) · Life Metabolism · doi:10.1093/lifemeta/load028 · Cited by 14

Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster

Taylor, A. L., Dubuisson, O. S., Pandey, P., Zunica, E. R. M., Vandanmagsar, B., Dantas, W. S., Johnson, A. E., Axelrod, C. L., & Kirwan, J. P. (2024) · Aging Cell · doi:10.1111/acel.14107 · Cited by 13

Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages

Aoyama, Y., Yamazaki, H., Nishimua, K., Nomura, M., Shigehiro, T., Suzuki, T., Zang, W., Tatara, Y., Ito, H., Hayashi, Y., et al. (2025) · Blood · doi:10.1182/blood.2024025402 · Cited by 14

Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS‐ Bmal1 −/− Mice

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Involvement of NADPH oxidases and non-muscle myosin light chain in senescence of endothelial progenitor cells in hyperlipidemia

Li, T., Zhang, J.-J., Liu, B., Liu, W., Wu, Y., Xiong, X.-M., Luo, X., Ma, Q., & Peng, J. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1198-y · Cited by 14

Link between cardiac function and the antioxidative defense mechanism in aged rats

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Urban Air Pollution Nanoparticles from Los Angeles: Recently Decreased Neurotoxicity

Zhang, H., D’Agostino, C., Forman, H. J., Cacciottolo, M., Thorwald, M. A., Mack, W. J., Liu, Q., Shkirkova, K., Lamorie‐Foote, K., Sioutas, C., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201577 · Cited by 15

TBHQ alleviates pyroptosis and necroptosis in chicken alveolar epithelial cells induced by fine particulate matter from broiler houses

Xi, M., Shen, D., Dai, P., Han, G., & Li, C. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101593 · Cited by 15

Interface of Aging and Acute Peripheral Neuropathy Induced by Oxaliplatin in Mice: Target-Directed Approaches for Na+, K+—ATPase, Oxidative Stress, and 7-Chloro-4-(phenylselanyl) quinoline Therapy

dos Reis, A. S., Martins, C. C., da Motta, K. P., Paltian, J. J., da Costa, G. P., Alves, D. A. C., Luchese, C., & Wilhelm, E. A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02659-5 · Cited by 14

Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice

Wu, Y., Green, C. L., Wang, G., Yang, D., Li, L., Li, B., Wang, L., Li, M., Li, J., Xu, Y., et al. (2022) · Aging Cell · doi:10.1111/acel.13585 · Cited by 13

Alleviation of Oxidative Damage and Involvement of Nrf2‐ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline

Kang, Y., Yan, W., Fang, H., Zhang, G., Du, Y., Wang, L., Cui, H., & Shi, G. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7908072 · Cited by 14

Catalytic antioxidants for therapeutic medicine

Kubota, R., Asayama, S., & Kawakami, H. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb03365j · Cited by 15

Direct and Indirect Effect of Air Particles Exposure Induce Nrf2-Dependent Cardiomyocyte Cellular Response In Vitro

Orona, N. S., Astort, F., Maglione, G. A., Yakisich, J. S., & Tasat, D. R. (2019) · Cardiovascular Toxicology · doi:10.1007/s12012-019-09530-z · Cited by 14

Systems modelling predicts chronic inflammation and genomic instability prevent effective mitochondrial regulation during biological ageing

Guimera, A. M., Clark, P. A., Wordsworth, J., Anugula, S., Rasmussen, L. J., & Shanley, D. P. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111889 · Cited by 13

Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60

Tejada, S., Sarubbo, F., Jiménez-García, M., Ramis, M. R., Monserrat-Mesquida, M., Quetglas‐Llabrés, M. M., Capó, X., Esteban, S., Sureda, A., & Moranta, D. (2024) · Nutrients · doi:10.3390/nu16030368 · Cited by 14

Mild hyperhomocysteinemia alters oxidative stress profile via Nrf2, inflammation and cholinesterases in cardiovascular system of aged male rats

Prauchner, G. R. K., Júnior, O. V. R., Rieder, A. S., & Wyse, Â. T. D. S. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111028 · Cited by 13

Metformin promotes the survival of random skin flaps via the activation of Nrf2/HO-1 signaling

Chen, Y., Cheng, R., Lü, W., Fan, Y., Ye, Y., Huang, L., Wan, Z., & Zheng, S. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111188 · Cited by 13

New insights into mechanism of ellagic acid alleviating arsenic-induced oxidative stress through MAPK/keap1-Nrf2 signaling pathway response, molecular docking and metabolomics analysis in HepG2 cells

Yu, C., Xu, Y., Zhao, M., Song, P., & Yu, J. H. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117029 · Cited by 13

PAS kinase deficiency reduces aging effects in mice

Dongil, P., Pérez-García, A., Hurtado-Carneiro, V., Herrero-de-Dios, C. M., Álvarez, E., & Sanz, C. (2020) · Aging · doi:10.18632/aging.102745 · Cited by 13

Teachings from COVID‐19 and aging—An oxidative process

Zarbafian, M., Dayan, S. H., & Fabi, S. G. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13751 · Cited by 13

Intracellular antioxidative properties of hydrolysable tannins on animal and human small intestinal enterocyte cell model

Brus, M., Langerholc, T., & Škorjanc, D. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.05.046 · Cited by 1

Lability of the Nrf2/Keap/ARE Cell Defense System in Different Models of Cell Aging and Age-Related Pathologies

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Regulation of NRF2 signaling pathway and the hallmarks of aging: An overview

Medoro, A., Scapagnini, G., & Davinelli, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19247-0.00004-7 · Cited by 1

Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway

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Nrf2: Molecular and epigenetic regulation during aging

Silva‐Palacios, A., Ostolga-Chavarría, M., Zazueta, C., & Königsberg, M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.003 · Cited by 199