Oxidative stress response and Nrf2 signaling in aging

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Mitochondria, Oxidants, and Aging

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Neurodegenerative diseases and oxidative stress

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Lipopolysaccharide induces oxidative stress by triggering MAPK and Nrf2 signalling pathways in mammary glands of dairy cows fed a high-concentrate diet

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Cytoprotective effect of Fufang Lurong Jiangu capsule against hydrogen peroxide-induced oxidative stress in bone marrow stromal cell-derived osteoblasts through the Nrf2/HO-1 signaling pathway

Jin, W., Zhu, X., Yao, F., Xu, X., Chen, X., Luo, Z.-J., Zhao, D., Li, X., Leng, X., & Sun, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109676 · Cited by 44

The role of granulosa cells in oocyte development and aging: Mechanisms and therapeutic opportunities

Wang, H. (2025) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2025.103614 · Cited by 51

NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response

Lin, T.-Y., Cantley, L. C., & DeNicola, G. M. (2016) · InTech eBooks · doi:10.5772/65141 · Cited by 48

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

Marzia Perluigi, A., Tramutola, A., Pagnotta, S. E., Barone, E., & Butterfield, D. A. (2020) · Antioxidants · doi:10.3390/antiox9090779 · Cited by 44

Ramelteon Ameliorates LPS-Induced Hyperpermeability of the Blood-Brain Barrier (BBB) by Activating Nrf2

Liu, Y., Wang, L., Du, N., Yin, X., Shao, H., & Lin, Y. (2021) · Inflammation · doi:10.1007/s10753-021-01451-w · Cited by 43

Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles (‘vehicular smog’)

Pomatto, L. C. D., Cline, M., Woodward, N. C., Pakbin, P., Sioutas, C., Morgan, T. E., Finch, C. E., Forman, H. J., & Davies, K. J. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.04.574 · Cited by 42

Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury

Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2019) · Antioxidants · doi:10.3390/antiox8050119 · Cited by 42

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease

Tsushima, M., Liu, J., Hirao, W., Yamazaki, H., Tomita, H., & Itoh, K. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01188-z · Cited by 42

The Molecular Clock and Neurodegenerative Disease: A Stressful Time

Carter, B., Justin, H. S., Gulick, D., & Gamsby, J. J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.644747 · Cited by 42

Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy

Oshitari, T. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19010439 · Cited by 45

Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract

Roda, E., Luca, F. D., Ratto, D., Priori, E. C., Savino, E., Bottone, M. G., & Rossi, P. (2023) · Biology · doi:10.3390/biology12020196 · Cited by 45

Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

Artamonov, M. Y., Мартусевич, А. К., Pyatakovich, F. A., Minenko, I. A., Dlin, S. V., & LeBaron, T. W. (2023) · Antioxidants · doi:10.3390/antiox12030636 · Cited by 42

Molybdenum nanodots act as antioxidants for photothermal therapy osteoarthritis

Shi, G., Lan, S., Zhang, Q., Wang, J., Shu, F., Hao, Z., Chen, T., Zhu, M., Chen, R., Chen, J., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122909 · Cited by 43

Protective Effects of Sulforaphane Preventing Inflammation and Oxidative Stress to Enhance Metabolic Health: A Narrative Review

Alves, I., Araújo, E. M. Q., Dalgaard, L. T., Singh, S. P., Børsheim, E., & Carvalho, E. (2025) · Nutrients · doi:10.3390/nu17030428 · Cited by 45

The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40 °C) against heat shock-induced apoptosis

Glory, A., & Averill‐Bates, D. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.032 · Cited by 41

MicroRNA-200a activates Nrf2 signaling to protect osteoblasts from dexamethasone

Zhao, S., Mao, L., Wang, S., Chen, F., Ji, F., & Fei, H. (2017) · Oncotarget · doi:10.18632/oncotarget.20452 · Cited by 41

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis

Zeng, N., D’Souza, R. F., Mitchell, C. J., & Cameron‐Smith, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.05.006 · Cited by 42

To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age

Pomatto, L. C. D., Sun, P. Y., & Davies, K. J. A. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.05.006 · Cited by 43

The ageing lung under stress

Korfei, M., MacKenzie, B., & Meiners, S. (2020) · European Respiratory Review · doi:10.1183/16000617.0126-2020 · Cited by 42

Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue

Atamna, H., Atamna, W., Al-Eyd, G., Shanower, G., & Dhahbi, J. M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.09.004 · Cited by 40

REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

Huang, S., Liu, C., Wang, Z., Fu, Z., Britton, W. R., Blomfield, A. K., Kamenecka, T. M., Dunaief, J. L., Solt, L. A., & Chen, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102261 · Cited by 40

Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight

Tahimic, C. G. T., & Globus, R. K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102153 · Cited by 40

Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases

Jeong, N., Jung, J., & Tabassum, R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265543 · Cited by 40

Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway

He, Y., Jiang, K., & Zhao, X. B. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1699831 · Cited by 40

Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention

Timóteo-Ferreira, F., Abreu, D., Mendes, S., Matos, L., Rodrigues, A. R., Almeida, H., & Silva, E. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101345 · Cited by 40

Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2

Mohammad, R. S., Lokhandwala, M. F., & Banday, A. A. (2022) · Antioxidants · doi:10.3390/antiox11010156 · Cited by 41

Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure

Zhang, M., Yu, X., Li, D., Ma, N., Wei, Z., Ci, X., & Zhang, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.810524 · Cited by 42

Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection

Fischer, F., Grigolon, G., Benner, C., & Ristow, M. (2022) · Physiological Reviews · doi:10.1152/physrev.00017.2021 · Cited by 42

Liproxstatin-1 alleviates bleomycin-induced alveolar epithelial cells injury and mice pulmonary fibrosis via attenuating inflammation, reshaping redox equilibrium, and suppressing ROS/p53/α-SMA pathway

Tao, N., Li, K., Liu, J., Fan, G., & Sun, T. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.127 · Cited by 39

Switching of Redox Signaling by Prdx6 Expression Decides Cellular Fate by Hormetic Phenomena Involving Nrf2 and Reactive Oxygen Species

Chhunchha, B., Kubo, E., & Singh, D. P. (2022) · Cells · doi:10.3390/cells11081266 · Cited by 40

NRF2 Activation by Nitrogen Heterocycles: A Review

Egbujor, M. C., Tucci, P., Onyeije, U. C., Emeruwa, C. N., & Saso, L. (2023) · Molecules · doi:10.3390/molecules28062751 · Cited by 39

Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging

Assar, M. E., Angulo, J., Carnicero, J. A. C., Walter, S., García‐García, F. J., López‐Hernández, E., Sánchez-Puelles, J.-M., & Rodríguez‐Mañas, L. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.04.019 · Cited by 39

Transcriptome profiling analysis of senescent gingival fibroblasts in response to Fusobacterium nucleatum infection

Ahn, S. H., Chun, S., Park, C., Lee, J., Lee, S.-W., & Lee, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188755 · Cited by 39

Signal Transduction, Ageing and Disease

Zhang, L. J., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J., & Robbins, P. D. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_9 · Cited by 40

The Aging Liver: Redox Biology and Liver Regeneration

Bellanti, F., & Vendemiale, G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0048 · Cited by 40

Oxidative stress and docosahexaenoic acid injury lead to increased necroptosis and ferroptosis in retinal pigment epithelium

Neiteler, A., Palakkan, A. A., Gallagher, K., & Ross, J. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-47721-5 · Cited by 41

Metal-based superoxide dismutase and catalase mimics reduce oxidative stress biomarkers and extend life span of Saccharomyces cerevisiae

Ribeiro, T. D. P., Fonseca, F. L., de Carvalho, M. D. C., Godinho, R. M. D. C., de Almeida, F. P., Saint’Pierre, T. D., Rey, N. A., Fernandes, C., Horn, A., & Pereira, M. D. (2016) · Biochemical Journal · doi:10.1042/bcj20160480 · Cited by 38

Diminished stress resistance and defective adaptive homeostasis in age-related diseases

Lomeli, N., Bota, D. A., & Davies, K. J. A. (2017) · Clinical Science · doi:10.1042/cs20160982 · Cited by 39

High-Dose Astaxanthin Supplementation Suppresses Antioxidant Enzyme Activity during Moderate-Intensity Swimming Training in Mice

Zhou, Y., Baker, J. S., Chen, X., Wang, Y., Chen, H., Davison, G. W., & Yan, X. (2019) · Nutrients · doi:10.3390/nu11061244 · Cited by 38

Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway

Yu, H., Jiang, X., Dong, F., Zhang, F., Ji, X., Xue, M., Yang, F., Chen, J., Hu, X., & Bao, Z. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112689 · Cited by 39

Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis

Redondo, J., Sarkar, P., Kemp, K., Heesom, K. J., Wilkins, A., Scolding, N. J., & Rice, C. M. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0045 · Cited by 37

Involvement of Nrf2 Activation and NF-kB Pathway Inhibition in the Antioxidant and Anti-Inflammatory Effects of Hesperetin in Activated BV-2 Microglial Cells

Evans, J. A., Mendonca, P., & Soliman, K. F. A. (2023) · Brain Sciences · doi:10.3390/brainsci13081144 · Cited by 39

Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies

Vahidinia, Z., Tameh, A. A., Barati, S., Izadpanah, M., & Hosseini, E. S. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00551-3 · Cited by 37

Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles

Zhang, H., Zhou, L., Yuen, J., Birkner, N. R., Leppert, V. J., O’Day, P. A., & Forman, H. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.002 · Cited by 37

Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing?

Davies, K. J. A., & Forman, H. J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.028 · Cited by 37

Chronic mild Hyperhomocysteinemia impairs energy metabolism, promotes DNA damage and induces a Nrf2 response to oxidative stress in rats brain

dos Santos, T. M., Siebert, C., de Oliveira, M. F., Manfredini, V., & Wyse, Â. T. D. S. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00674-8 · Cited by 37

The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling

Liu, X., DILXAT, T., Shi, Q., Qiu, T., & Lin, J. (2022) · Gene · doi:10.1016/j.gene.2022.146348 · Cited by 34

Recent Advancements in Gene and Stem Cell‐Based Treatment Modalities: Potential Implications in Noise‐Induced Hearing Loss

Eshraghi, A. A., Jung, H. D., & Mittal, R. (2019) · The Anatomical Record · doi:10.1002/ar.24107 · Cited by 37

Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice

Chen, P., Chen, F., Lei, J., & Zhou, B. (2023) · Phytotherapy Research · doi:10.1002/ptr.7848 · Cited by 38

Hexavalent chromium-induced toxic effects on the antioxidant levels, histopathological alterations and expression of Nrf2 and MT2 genes in the branchial tissue of Ctenopharyngodon idellus

Jindal, R., & Handa, K. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.05.027 · Cited by 37

Raspberry extract ameliorates oxidative stress in Caenorhabditis elegans via the SKN-1/Nrf2 pathway

Song, B., Zheng, B., Li, T., & Liu, R. H. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103977 · Cited by 39

Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium

Catanzaro, M., Lanni, C., Basagni, F., Rosini, M., Govoni, S. M., & Amadio, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00844 · Cited by 37

Pathogenic and therapeutic role for NRF2 signaling in ultraviolet light–induced skin pigmentation

Kerns, M. L., Miller, R. J., Mazhar, M., Byrd, A. S., Archer, N. K., Pinsker, B. L., Lew, L., Dillen, C. A., Wang, R., Miller, L. S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.139342 · Cited by 36

Cellular senescence in liver diseases: From mechanisms to therapies

Ge, T., Shao, Y., Bao, X., Xu, W., & Lu, C. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110522 · Cited by 37

SC79 protects dopaminergic neurons from oxidative stress

Xu, Y., Gao, Y., & Yang, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.23538 · Cited by 35

The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease

Zhao, Y., Qiong-Zhang, Zhang, J., Lou, Z., Zu, H.-B., Wang, Z., Wei-cheng, Z., Kai-Yao, & Xiao, B. (2018) · Aging and Disease · doi:10.14336/ad.2017.1028 · Cited by 35

Role of oxidative stress in cardiotoxicity of antineoplastic drugs

Zhang, X., Zhu, Y., Dong, S., Zhang, A., Lu, Y., Li, Y., Lv, S., & Zhang, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.06.001 · Cited by 35

Sargassum fusiforme Fucoidan SP2 Extends the Lifespan of Drosophila melanogaster by Upregulating the Nrf2-Mediated Antioxidant Signaling Pathway

Zhang, Y., Xu, M., Hu, C., Liu, A., Chen, J., Gu, C., Zhang, X., You, C., Tong, H., Wu, M., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8918914 · Cited by 35

Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice

Cui, L., Shi, L., Li, D., Li, X., Su, X., Chen, L., Jiang, Q., Jiang, M., Luo, J., Ji, A., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00199 · Cited by 33

Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion

Menshikov, M. Y., Zubkova, E., Stafeev, I., & Parfyonova, Y. V. (2021) · Biomedicines · doi:10.3390/biomedicines9091178 · Cited by 36

Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Fu, Z., & Zhang, J. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2100420 · Cited by 40

The Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in Neurodegenerative Diseases

Zoungrana, L. I., Krause‐Hauch, M., Wang, H., Fatmi, M. K., Bates, L., Li, Z., Kulkarni, P., Ren, D., & Li, J. (2022) · Cells · doi:10.3390/cells11132048 · Cited by 37

Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials

Dai, S., Tian, Z., Zhao, D., Liang, Y. J., Liu, M., Liu, Z., Hou, S., & Yang, Y. (2022) · Antioxidants · doi:10.3390/antiox11071360 · Cited by 37

Role of thyroid hormones-induced oxidative stress on cardiovascular physiology

Arcos, M. L. B. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130239 · Cited by 35

The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2–mediated antioxidant protection

Li, Y., Zhu, X., Wang, K., Zhu, L., Murray, M. T., & Zhou, F. (2022) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgac036 · Cited by 37

Cysteine restriction‐specific effects of sulfur amino acid restriction on lipid metabolism

Nichenametla, S. N., Mattocks, D. A. L., Cooke, D., Midya, V., Malloy, V. L., Mansilla, W. D., Øvrebø, B., Turner, C., Bastani, N. E., Sokolová, J., et al. (2022) · Aging Cell · doi:10.1111/acel.13739 · Cited by 33

Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging

Serebryannyy, L., & Misteli, T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201706061 · Cited by 37

Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster

Nunes, R. G. D. S., Pereira, P. S., Elekofehinti, O. O., Fidelis, K. R., da Silva, C. S., Ibrahim, M., Barros, L. M., da Cunha, F. A. B., Lukong, K. E., de Menezes, I. R. A., et al. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.03.017 · Cited by 35

Xanthohumol Analogues as Potent Nrf2 Activators against Oxidative Stress Mediated Damages of PC12 Cells

Bai, F., Zhang, B., Hou, Y., Yao, J., Xu, Q., Xu, J., & Fang, J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00171 · Cited by 34

Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster

Dwivedi, V., & Lakhotia, S. C. (2016) · Journal of Biosciences · doi:10.1007/s12038-016-9641-x · Cited by 34

Semisynthetic quercetin-quinone mitigates BV-2 microglia activation through modulation of Nrf2 pathway

Škandík, M., Mrvová, N., Bezek, Š., & Račková, L. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.030 · Cited by 35

The treatment of Goji berry (Lycium barbarum) improves the neuroplasticity of the prefrontal cortex and hippocampus in aged rats

Ruíz-Salinas, A. K., Vázquez‐Roque, R. A., Díaz, A., Pulido, G., Treviño, S., Florán, B., & Flores, G. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108416 · Cited by 33

Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents – Implications for oxidative UV damage

Kremslehner, C., Miller, A., Nica, R., Nagelreiter, I., Narzt, M., Golabi, B., Vorstandlechner, V., Mildner, M., Lachner, J., Tschachler, E., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101583 · Cited by 34

An NRF2 Perspective on Stem Cells and Ageing

Dodson, M. B., Anandhan, A., Zhang, D. D., & Madhavan, L. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.690686 · Cited by 35

Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice

Zhang, P., Jin, Y., Xia, W., Wang, X., & Zhou, Z. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.03.002 · Cited by 34

Introduction to Special Issue on ‘Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine

Mann, G. E., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.002 · Cited by 34

AMPK Enhances Transcription of Selected Nrf2 Target Genes via Negative Regulation of Bach1

Fischhuber, K., Matzinger, M., & Heiß, E. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00628 · Cited by 36

Dimethyl Fumarate Triggers the Antioxidant Defense System in Human Retinal Endothelial Cells through Nrf2 Activation

Manai, F., & Amadio, M. (2022) · Antioxidants · doi:10.3390/antiox11101924 · Cited by 33

Statins in Chronic Kidney Disease—Effects on Atherosclerosis and Cellular Senescence

Fularski, P., Krzemińska, J., Lewandowska, N., Młynarska, E., Saar, M., Wronka, M., Rysz, J., & Franczyk, B. (2023) · Cells · doi:10.3390/cells12131679 · Cited by 33

Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity

Bak, J., Kim, H. J., Kim, S.-Y., & Choi, Y. (2016) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2016.20.3.279 · Cited by 33

Tuning the proteasome to brighten the end of the journey

Mayor, T., Sharon, M., & Glickman, M. H. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00198.2016 · Cited by 32

Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction

Pomatto, L. C. D., Dill, T., Carboneau, L., Levan, S., Kato, J. I., Mercken, E. M., Pearson, K. J., Bernier, M., & de Cabo, R. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.005 · Cited by 32

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Wang, M.-X., Zhao, J., Zhang, H., Li, K., Niu, L., Wang, Y., & Zheng, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9410952 · Cited by 33

Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans

Ostrom, E. L., & Traustadóttir, T. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.08.016 · Cited by 36

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

Lewandowska, M., Sajdak, S., Więckowska, B., Manevska, N., & Lubiński, J. (2020) · Nutrients · doi:10.3390/nu12092838 · Cited by 33

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts

Zheng, Y., Yang, J., Tang, P., Zhu, Y., Chen, Z., She, C., Chen, G., Cao, P., & Xu, X. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03962-8 · Cited by 33

Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3–Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury

Luo, C., Ding, W., Yang, C., Zhang, W., Liu, X., & Deng, H. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00167 · Cited by 33

Genetic Polymorphisms in Oxidative Stress and Inflammatory Pathways as Potential Biomarkers in Alzheimer’s Disease and Dementia

Vogrinc, D., Kramberger, M. G., Emeršič, A., Čučnik, S., Goričar, K., & Dolžan, V. (2023) · Antioxidants · doi:10.3390/antiox12020316 · Cited by 38

Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice

Lohr, K., Pachl, F., Gholami, A. M., Geillinger, K. E., Daniel, H., Küster, B., & Klingenspor, M. (2016) · Physiological Reports · doi:10.14814/phy2.12988 · Cited by 33

Zuogui Pills alleviate cyclophosphamide-induced ovarian aging by reducing oxidative stress and restoring the stemness of oogonial stem cells through the Nrf2/HO-1 signaling pathway

Li, Z., Liang, Y., Wang, Y., Lin, Y., Zeng, L., Zhang, Y., & Zhu, L. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118505 · Cited by 32

Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence

Tang, W., Wang, K., Feng, Y., Tsui, K., Singh, K. K., Stout, M. B., Wang, S., & Wu, M. (2025) · Life Medicine · doi:10.1093/lifemedi/lnaf004 · Cited by 37

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells

Zhang, H., Zhou, L., Davies, K. J. A., & Forman, H. J. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108074 · Cited by 31

Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells

Kopacz, A., Klóska, D., Proniewski, B., Cysewski, D., Personnic, N., Piechota-Polańczyk, A., Kaczara, P., Zakrzewska, A., Forman, H. J., Dulak, J., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101304 · Cited by 34

Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages

Guo, C., Davies, M. J., & Hawkins, C. L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101666 · Cited by 33

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease

Ahuja, M., Kaidery, N. A., Dutta, D., Attucks, O. C., Kazakov, E. H., Gazaryan, I. G., Matsumoto, M., Igarashi, K., Sharma, S. M., & Thomas, B. (2022) · Antioxidants · doi:10.3390/antiox11091780 · Cited by 34

The role of Andrographolide in the prevention and treatment of liver diseases

Qin, X., Wang, X., Tian, M., Dong, Z., Wang, J., Wang, C., & Huang, Q. (2023) · Phytomedicine · doi:10.1016/j.phymed.2022.154537 · Cited by 32

Anti-aging activity and their mechanisms of natural food-derived peptides: current advancements

Li, J., Wang, J., Zhang, N., Li, Y., Cai, Z., Li, G., Liu, Z., Liu, Z., Wang, Y., Shao, X., et al. (2023) · Food Innovation and Advances · doi:10.48130/fia-2023-0028 · Cited by 34

Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling

Roberts, J. A., Rainbow, R. D., & Sharma, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076723 · Cited by 35

Modeling complex age-related eye disease

Becker, S., L'Ecuyer, Z., Jones, B. W., Zouache, M. A., McDonnell, F. S., & Vinberg, F. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101247 · Cited by 34

Intracellular antioxidative properties of hydrolysable tannins on animal and human small intestinal enterocyte cell model

Brus, M., Langerholc, T., & Škorjanc, D. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.05.046 · Cited by 1

Lability of the Nrf2/Keap/ARE Cell Defense System in Different Models of Cell Aging and Age-Related Pathologies

Shilovsky, G. A. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922010060 · Cited by 24

Regulation of NRF2 signaling pathway and the hallmarks of aging: An overview

Medoro, A., Scapagnini, G., & Davinelli, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19247-0.00004-7 · Cited by 1

Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway

Shih, P., & Yen, G. (2006) · Biogerontology · doi:10.1007/s10522-006-9033-y · Cited by 185

Nrf2: Molecular and epigenetic regulation during aging

Silva‐Palacios, A., Ostolga-Chavarría, M., Zazueta, C., & Königsberg, M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.003 · Cited by 199