Cited by 804Genomics, phytochemicals, and oxidative stressGenetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

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Oxidative stress response and Nrf2 signaling in aging

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Zhang, Hongqiao, Davies, Kelvin J.A., Forman, Henry Jay·2015·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2015.05.036PMC PMC4628850

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Abstract

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins, also decline. Importantly, the adaptive response to oxidative stress declines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels, including transcription, posttranslation, and interactions with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging.

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5 retracted

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Authors: Zhang, H., Davies, K. J. A., & Forman, H. J.
Affiliations: University of Southern California (US)
University of California, Merced (US)
Corresponding author: Forman, Henry Jay
ORCID: Zhang, Hongqiao
Davies, Kelvin J.A.
Forman, Henry Jay
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2015-11
Volume: 88
Issue: Pt B
Pages: 314-336
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2015.05.036
PMC: PMC4628850
OpenAlex: W2207241376
Cited by: 804
References: 429
Citations by year: 2026: 50 · 2025: 56 · 2024: 75 · 2023: 94 · 2022: 111 · 2021: 92 · 2020: 103 · 2019: 76 · 2018: 56 · 2017: 47 · 2016: 32 · 2015: 12
FWCI: 4.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: U.S. NIH (R01-ES023864, R01-ES003598)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, aging, Nrf2 signaling, antioxidant response element, antioxidant enzymes, proteasome, age-related decline, post-translational regulation, age-related diseases
MeSH terms: Aging, Animals, Antioxidants, Gene Expression Regulation, Humans, Signal Transduction, Oxidative Stress, NF-E2-Related Factor 2

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Oxidative stress response and Nrf2 signaling in aging

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