Cited by 997Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stressGlutathione Transferases and Polymorphisms

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

Molecular basis of the Keap1–Nrf2 system

Open access

Suzuki, Takafumi, Yamamoto, Masayuki·2015·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2015.06.006

Open this paper in CoChat — free account

Abstract

Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. Nrf2 induces the expression of detoxification and antioxidant enzymes, and Keap1 (Kelch-like ECH-associated protein 1), an adaptor subunit of Cullin 3-based E3 ubiquitin ligase, regulates Nrf2 activity. Keap1 also acts as a sensor for oxidative and electrophilic stresses. Keap1 retains multiple sensor cysteine residues that detect various stress stimuli. Increasing attention has been paid to the roles that Nrf2 plays in the protection of our bodies against drug toxicity and stress-induced diseases. On the other hand, Nrf2 is found to promote both oncogenesis and cancer cell resistance against chemotherapeutic drugs. Thus, although Nrf2 acts to protect our body from deleterious stresses, cancer cells hijack the Nrf2 activity to support their malignant growth. Nrf2 has emerged as a new therapeutic target, and both inducers and inhibitors of Nrf2 are awaited. Studies challenging the molecular basis of the Keap1-Nrf2 system functions are now critically important to improve translational studies of the system. Indeed, recent studies identified cross talk between Nrf2 and other signaling pathways, which provides new insights into the mechanisms by which the Keap1-Nrf2 system serves as a potent regulator of our health and disease.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2015.06.006

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Self-citation
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.-S., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,288
Self-citation
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,210
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947
Self-citation
Nrf2–Keap1 defines a physiologically important stress response mechanism
Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725
Self-citation
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
Zhang, D. D., & Hannink, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8137-8151.2003 · Cited by 1,480
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395
Self-citation

Show all 84 references

Sorted by citations

Items 901–997 of 997

The Lack of Nrf2 Causes Hepatocyte Dedifferentiation and Reduced Albumin Production in an Experimental Extrahepatic Cholestasis ModelPreprint
Wang, G., Garcia, V., Lee, J., Yanum, J. A., Jiang, H., & Dai, G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.26.441515
N-carbamylglutamate and L-arginine Supplementation Improve the Intestinal Oxidative Resistance of the Intrauterine Growth-retarded Ovine FetusesPreprint
Zhang, H., Ma, Y., Wang, M., Elsabagh, M., & Wang, H. (2020) · doi:10.21203/rs.3.rs-95710/v1
Pengaruh Pemberian Serbuk Rimpang Kunyit (Curcuma longa L.) terhadap Jumlah Folikel Ovarium Tikus Putih (Ratus norvegicus) Premenopause
Suprihatin, T., Rahayu, S., Rifa’i, M., & Widyarti, S. (2020) · Buletin Anatomi dan Fisiologi · doi:10.14710/baf.5.2.2020.190-197
Two Faces of Nrf2 in Cancer
Yildiz, M., & Seğmen, H. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102753
Modulatory Effects of Cilostazol; an Nrf2/HO-1 activator against NAFLD in Rats Confirmed by Molecular Docking and FTIR StudiesPreprint
Sedik, A. A., & Amer, A. A. (2022) · Research Square · doi:10.21203/rs.3.rs-1328467/v2
Extension of Healthy Life Span of Dialysis Patients in the Era of a 100-Year Life
Inaba, M., & Mori, K. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-2345-3
Faculty Opinions recommendation of Small Maf proteins (MafF, MafG, MafK): History, structure and function.
Lipton, S. A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726273509.793538961
Faculty Opinions recommendation of Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of bach1.
Fisher, P. B., & Emdad, L. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736054359.793562930
Life in an Aerobic World
(2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803013-4.00018-1
Conjugation and Transport Processes
Coleman, M. D. (2020) · Wiley eBooks · doi:10.1002/9781119658016.ch6
Enzyme Regulation
Ding, X., & Zhang, Q.-Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95619-8
Análise dos mecanismos pró-inflamatórios do ácido úrico solúvel: efeito sobre proteínas sensíveis à modulação redox e sobre a polarização de células THP-1
Gomes, C. J. C. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2021.tde-17012022-123152
Autophagy in the Intestinal Stem Cells
Göncü, E. (2022) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-031-17362-2_7
MITOCHONDRIA-TARGETED ANTIOXIDANT SKQ1 REGULATES OF SIGNAL SYSTEM KEAP1/NRF2/ARE AND APOPTOSIS IN THE LEUKOCYTES OF BLOOD UNDER OXIDATIVE STRESS
Gutsenko, O. I., Корниенко, И. В., Ananyan, A. A., Milutina, N. P., & Внуков, В. В. (2022) · Russian Journal of Biological Physics and Chemisrty · doi:10.29039/rusjbpc.2022.0569
Effect of trans-resveratrol on oxidative stress biomarkers associated with atherosclerosis
Santana, T. M. (2022) · doi:10.11606/d.9.2022.tde-27102022-170736
Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Acai Berries and Pistachios and Cashews as Natural Food Sources
Paola, R. D., Cuzzocrea, S., Fusco, R., & Cordaro, M. (2023) · Biochemistry · doi:10.5772/intechopen.109239
Comparative Analysis of the Mutation and Expression Profile of the Cytoprotective NRF2/ KEAP1/P62/SQSTM1 Signaling Pathway in Different Glioma Subtypes: An In Silico Study
Akın, D. F., & Aktaş, S. H. (2023) · Namık Kemal Tıp Dergisi · doi:10.4274/nkmj.galenos.2023.74745
The role of NRF-2 in renal damage in cardiopulmonary bypass
Padak, M. (2023) · Eurasian Clinical and Analytical Medicine · doi:10.4328/ecam.10038
Reducing neurodegeneration and oxidative damage in Alzheimer's disease: Role of the Nrf2 pathway activation by natural compounds
Villavicencio-Tejo, F., & Quintanilla, R. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90052-2.00003-2
Intestinal redox regulation and inflammatory bowel disease
Iwaki, H., & Motohashi, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19247-0.00015-1
Targeting the NF-E2-related factor 2 pathway for overcoming leukemia
Harifi-Mood, M. S., Daroudi, M., Darroudi, M., Naseri, K., Samarghandian, S., & Farkhondeh, T. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127594
Iron Metabolism and Ferroptosis
Zheng, H., & Toyokuni, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-39171-2_2
CXX-3, a Norditerpene Lactones From Podocarpus nakaii , Inhibits Cancer Cell Viability by Suppressing the NRF2/KEAP1 Antioxidant Pathway
Yuan, J., Gao, H., Zhou, D., Wang, Y., Shen, F., Chen, Y., & Zhu, R. (2023) · Natural Product Communications · doi:10.1177/1934578x231214129
Progress of Itaconate in the Treatment of Renal Diseases
曹, 心. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.142322
NRF2'nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü
Kaleler, İ., & Yaylım, İ. (2024) · Haliç Üniversitesi Fen Bilimleri Dergisi · doi:10.46373/hafebid.1442953
Effects of Two Indigenous Bacillus Supplementation on the Growth, Immunity, Antioxidant and Antibacterial Capacity of Rhynchocypris LagowskiiPreprint
Ji-hao, G., Lei, X., Wang, X., Yang, Z., Lin, L., Zhu, W., Li, S., & Chen, Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4776055
Additional file 1 of TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
Teng, X., Yang, Y., Chen, Z., Wang, J., Wang, X., Zheng, Y., Wang, C., Wang, Y., Zhu, Z., Ding, X., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812634
The induction of metallothionein by sulforaphane reduces iron toxicity via Nrf2
Elvandari, A. P., Siswanto, F. M., & Imaoka, S. (2024) · Journal of Applied Biology & Biotechnology · doi:10.7324/jabb.2024.193124
Splicing junction-based classifier for the detection of abnormal constitutive activation of the KEAP1-NRF2 system
Mateos, R. N., Winardi, W., Chiba, K., Okada, A., Suzuki, A., Mitsuishi, Y., & Shiraishi, Y. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00475-w
Effects of lipopolysaccharide administration on thymus damage, antioxidant capacity and immune function in weaned piglets
Bai, L., Jiang, Y., Li, X., Yu, W., Zhu, W., Zhao, G., Yang, T., Zhou, Y., Li, J., & Li, Y. (2025) · Journal of Veterinary Research · doi:10.2478/jvetres-2025-0018
The Inhibition of Txnrd1 by Methylglyoxal Impairs the Intracellular Control of Mycobacterium TuberculosisPreprint
Li, H., Liu, R., Kathamuthu, G. R., Gencheva, R., Scholz, A.-L., Alzrigat, M., Coppo, L., Arnér, E. S. J., & Rottenberg, M. E. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5240783
Endocrine therapy induces oxidative stress in ER+ breast cancer that sensitizes persister cells to ferroptosisPreprint
Tau, S. S., Friedman, M., Roberts, A. M., Ferridge, L. R., Kleist, S. A., Cressey, L. E., Kettenbach, A. N., Shoemaker, C. J., & Miller, T. W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.18.665614
In Silico and In Vitro Studies of Anti-Inflammatory, Anti-Oxidative Stress, and Anti-Apoptosis Effect of 7-Octenoic Acid Derived from Moringa oleifera Lam., on LPS-Induced Monocyte-Derived Macrophages (MDM)
Srimuang, K., Buakaew, W., Thongsri, Y., Daowtak, K., Potup, P., Ferrante, A., & Usuwanthim, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188911
Impaired Hemostasis and the Role of Oxidative Stress-Induced Signaling in Thrombotic Disorders—Where We Stand Today
Georgiou‐Siafis, S. K., & Kotsi, P. (2025) · Receptors · doi:10.3390/receptors4040021
Identification and Verification of Immune Metabolism–Related Biomarkers and Immune Infiltration Landscape for Pediatric Opsoclonus Myoclonus Ataxia Syndrome in Neuroblastoma
Li, M., & Li, J. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70610
Transcription factor NRF2: New therapeutic approach to modify Parkinson's disease progression
Rojo, A. I., Esteras, N., Cuadrado, A., & Lastres‐Becker, I. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-21992-4.00025-7
Regulome-SNP and Novel Risk Markers of CHD Susceptibility in the Yanbian AreaPreprint
Yang, E., Jin, X., Liu, X., Dong, C.-Y., Cai, W.-X., Sun, S.-Y., Sun, Z., Li, Y.-Z., Jin, J., & Jin, G. (2025) · Research Square · doi:10.21203/rs.3.rs-7698288/v1
Additional file 2 of Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NF-κB pathway
Baig, N., Sultan, R., & Qureshi, S. A. (2022) · Figshare · doi:10.6084/m9.figshare.21602004
Additional file 1 of Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NF-κB pathway
Baig, N., Sultan, R., & Qureshi, S. A. (2022) · Figshare · doi:10.6084/m9.figshare.21602001
Additional file 3 of TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
Xu, T., Yang, Y., Chen, Z., Wang, J., Wang, X., Zheng, Y., Wang, C., Wang, Y., Zhu, Z., Ding, X., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812640
Additional file 1 of Dissecting molecular mechanisms underlying H2O2-induced apoptosis of mouse bone marrow mesenchymal stem cell: role of Mst1 inhibition
Zhang, Q., Cheng, X., Zhang, H., Zhang, T., Wang, Z., Zhang, W., & Yu, W. (2020) · Figshare · doi:10.6084/m9.figshare.13357940
Additional file 1 of The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature
Da'as, S. I., Ahmed, I., Hasan, W., Abdelrahman, D., ALIYEV, E. E., Nisar, S., Bhat, A. A., Joglekar, M. V., Hardikar, A. A., Fakhro, K. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26572801
Additional file 1 of High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi
Zhang, A., Li, H., Song, Q., Cui, Y., Zhang, Y., Wang, X., Li, Z., & Hou, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24515851
Additional file 1 of Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy
Xia, D., Zhang, X.-R., Ma, Y.-L., Zhao, Z.-J., Zhao, R., & Wang, Y.-Y. (2020) · Figshare · doi:10.6084/m9.figshare.12744138
Additional file 2 of TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
Xu, T., Yang, Y., Chen, Z., Wang, J., Wang, X., Zheng, Y., Wang, C., Wang, Y., Zhu, Z., Ding, X., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812637
Additional file 4 of TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
Xu, T., Yang, Y., Chen, Z., Wang, J., Wang, X., Zheng, Y., Wang, C., Wang, Y., Zhu, Z., Ding, X., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812643
Additional file 4 of High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi
Zhang, A., Li, H., Song, Q., Cui, Y., Zhang, Y., Wang, X., Li, Z., & Hou, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26636565
Additional file 3 of High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi
Zhang, A., Li, H., Song, Q., Cui, Y., Zhang, Y., Wang, X., Li, Z., & Hou, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26636562
Additional file 2 of High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi
Zhang, A., Li, H., Song, Q., Cui, Y., Zhang, Y., Wang, X., Li, Z., & Hou, Y. (2024) · Figshare · doi:10.6084/m9.figshare.24516103
Investigating gender differences in Alzheimer's disease
Fouad, G. I., Ando, H., & Ichihara, G. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877251410204 · Cited by 2
Diacerein protects against Ovariectomy-Induced bone loss via reversal of NRF2 epigenetic suppression
Qiao, L., Shen, T., Ben, Y., Dong, J., Liu, B., Chen, X., & Jiang, Q. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117748
Augmenting Nrf2 signaling pathway promotes adipocyte differentiation from human embryonic stem cells
Park, M. H., Gil, D., Han, H., & Kim, J.-H. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.114917
Design and optimisation of meta-substituted bis(arylsulfonamido)benzene inhibitors through a molecular hybridisation strategy targeting the Keap1-Nrf2 protein-protein interaction
Lee, S., Ali, A. R., Abed, D. A., & Hu, L. (2026) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2026.2622777
ROS-Mediated Cellular Signaling Pathways in Metabolic Disorders
Gunasekaran, S. K., Gobinath, M., Roychowdhury, P., Maideen, N. M. P., & Kuppusamy, G. (2026) · Springer eBooks · doi:10.1007/978-3-032-11752-6_4
Lycopene Attenuates Hexavalent Chromium-Induced Hepatotoxicity in Mice by Modulating the Nrf2 Signaling Pathway and the Unfolded Protein Response
Zhang, X., Zhang, Q.-M., Xia, L.-B., Ge, K., Talukder, M., She, D.-Y., & Bi, S.-S. (2026) · Biological Trace Element Research · doi:10.1007/s12011-026-05038-0
Enhancing Tumour Radiosensitivity by Targeting Nrf2 Antioxidant System
Golyshev, G., Tikunova, K. V., Deeni, Y., & Goltsov, A. N. (2026) · Medical Radiology and radiation safety · doi:10.33266/1024-6177-2026-71-5-20-32
Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition
Mi, Y., Wang, R., Qian, J., Liu, Z., Li, Y., Fan, H., Wang, L., Kuai, H., Xiong, F., Wang, H., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158147
Les allergies cutanées aux fragrances : mécanisme d'action et rôle du facteur de transcription Nrf2. Du modèle 2D au modèle 3D.
Raffalli, C. (2018) · theses.fr (ABES) · doi:10.70675/4900e006zd72bz460czbce9z30cd5e7312bc
A Hetero-multivalent Covalent Strategy for Enhanced Pulmonary Fibrosis TherapyPreprint
Ge, G., Zhu, G., Deng, Y., Wu, H., Zhang, H., Zhu, G., Zeng, H., Li, N., Wang, L., Fan, Y., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9244913/v1
Dietary yeast extract mitigates the negative effects of reduced fishmeal diet on growth and metabolism in mud crab (Scylla paramamosain)
Zou, Y., Peng, H., Huang, C., Zhou, B., Huang, K., Zhang, Y., Gu, J., Li, X. D., Zhu, T., Zhao, W., et al. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2026.103609
Grape seed proanthocyanidins supplementation attenuates diquat-induced intestinal barrier damage in weaned pigs
Zhang, Y., He, X., Zhao, Q., Li, H., Qin, R., Zuo, W., & Han, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1828376 · Cited by 1
STARMAP: A 3D-informed framework for mapping functional regions in proteins to regulatory and cellular phenotypesPreprint
Shukla, K., Castro, J., Cheng, D., Holley, L., & Brunk, E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.05.723010
Perm1 enhances Nrf2-driven antioxidant defense through Keap1 oxidation during myocardial ischemia/reperfusion injury
Oka, S., Huang, C.-Y., Matsushita, M., Titus, A. S., Nakada, Y., Mukai, R., Veera, S., Mourad, Y., Yehia, G., Romanienko, P. J., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.204132
Modulation of morphine tolerance and dependence by pyrroloquinoline quinone in mice: Insights into mechanistic bridge from N-methyl-D-aspartate receptors-calcium/calmodulin-dependent protein kinase II signaling to oxidative neuroinflammation
Nicola, M. A., Hefny, F. H., Morsy, R. M. I., Abdel‐Maksoud, F. M., Gamea, M. G., & Hamdy, M. M. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.104956
Lycopene supplementation during pregnancy and lactation attenuates thermally oxidized cooking oil-induced hepatic and cerebral damage in rat offspring: A comprehensive histomorphometric and molecular analysis
Jusuf, A. A., Fadilah, & Nirwanti, N. A. (2026) · Toxicology Reports · doi:10.1016/j.toxrep.2026.102290
A review on Nrf2 and antioxidant metalloproteins
Hossain, A. M. S., Qudratovna, Q. M., Kholnazarov, B., Odaka, A., Nakane, D., & Akitsu, T. (2026) · European Journal of Chemistry · doi:10.5155/eurjchem.17.2.176-187.2773
Evaluation of the Nrf2-Keap1 Pathway in Patients with Acute Cerebral Ischemic Disease
Alkan, G., Koçtürk, F., Karakus, A., Taysi, M. E., & Tayşi, S. (2026) · Medicina · doi:10.3390/medicina62071371
Metabolomics-guided quantification reveals antioxidant discrepancies of Sargassum yezoense in chemical and cellular systems
Baek, S., Miao, Y., Cao, L., Chun, O. K., & Lee, S. G. (2026) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-026-04697-w
Hepatitis C Virus Enhances Lysosome‐Associated Membrane Protein 2 A Transcription Through Nuclear Factor Erythroid 2‐Related Factor 2 to Support Viral Replication
Xu, Z., Matsui, C., Septianastiti, M. A., Puspitasari, F., Deng, L., Abe, T., & Shoji, I. (2026) · Microbiology and Immunology · doi:10.1111/1348-0421.70077
Effect of moderate-intensity aerobic exercise on early oxidative stress and muscle atrophy in SAMP8 mice through modulation of the DAO/SRR and Nrf2/Keap1 pathways
Tong, X., Xue, J., Chen, Z., Luo, R., Huang, Z., Chen, F., Liu, Y., Xiao, J., Jiang, J., Wang, Z., et al. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112760
Food-derived antioxidant peptides as modulators of endogenous redox defense: Mechanisms, recovery kinetics, and translational evidence
Zhang, H. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109644
Pre-transport dietary chitosan improves the physiological robustness of juvenile largemouth bass (Micropterus salmoides) by modulating antioxidant and inflammatory responses
Zhao, H.-Z., Chang, Y.-L., Wang, C., He, Y.-Y., Zhao, Y., Dong, Y.-C., Huang, X.-X., & Zhong, G.-F. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111620
Poly(itaconic acid) nanoparticles alleviate inflammation and multiorgan injury in sepsis by promoting nuclear factor erythroid 2-related factor 2 nuclear translocation and macrophage reprogramming
Zhang, H., Wang, Y., Deng, T., Peng, J., Ye, X., Zeng, X., Zhu, J., Huang, L., Zheng, X., Li, Y., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.08.029
Air pollution and undernutrition induce rat alveolar macrophages functional dysregulation and compromise their response to a viral challenge
Masci, I., Lezón, C. E., Kurtz, M., & Tasat, D. R. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.105138
Translational Insights into α-Synuclein Aggregation and Proteostasis Dysfunction in Parkinson’s Disease
Paul, S., Roy, A., Bhattacharya, P., Boruah, D. C., & Borah, A. (2026) · Current Pharmacology Reports · doi:10.1007/s40495-026-00474-x
USP35-mediated NRF2 deubiquitination attenuates experimental cryptorchidism-induced testicular damage and H2O2-induced apoptosis and oxidative stress in spermatogonia
Liu, X., Sun, J., Mao, C., Cao, Y., Deng, Q., & Li, G.-Y. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05707-7
Nrf2–Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias
Irfan, M., Taha, M., Asghar, S. M. F., & Raza, M. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.71091
A narrative review of emerging chemoprotective agents for chemotherapy-induced toxicity: nanoformulated natural products, dual COX-2/TNF-α inhibitors, and Nrf2 modulators
Ezerioha, C. E., Uahomo, P. O., Chidi-Ezerioha, P. A., Akpan, G. W., & Chukundah, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1907919
Oxidative Stress in Animals: A Systematic Analysis from Signaling Pathways to Biological Effects
Chang, L., Liu, C., & Huang, G. (2026) · Life · doi:10.3390/life16091516
Bidirectional crosstalk between the catalytic and moonlighting functions of human dipeptidyl peptidase 3: potential physiological implications
Matić, A., Šupljika, F., Petohleb, L., Paić, A. T., Kindl, D. C., Horvat, G., Barbarić, L., Oskomić, M., Matovina, M., & Tomić, A. (2026) · RSC Advances · doi:10.1039/d6ra05272j
Dual promoter architecture of NFE2L2 underlies isoform-specific translational control of NRF2
Sznarkowska, A., Urban-Wójciuk, Z., Dziadosz-Brzezińska, A., Cieśla, M., Kusiński, S., Wakimian, K., Szabelska-Beręsewicz, A., Chruściel, E., Papak, I., Marek-Trzonkowska, N., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104405
Subtype-Conditioned NRF2–KEAP1 Signaling in Breast Cancer: A Narrative Review and Hypothesis-Generating Framework from Chemoprevention to Therapy Resistance
Choi, H. Y., Kwon, H., & Hah, Y. (2026) · Antioxidants · doi:10.3390/antiox15101223
HuaTanJiangQi formula regulates Nrf2-mediated CYP2J2/EETs/NF-κB axis to alleviate glucocorticoid resistance in COPD
Guangduo, H. A. N., Xinlong, L. I., Zhuang, F., Liu, S., Wentao, Z. H. U., Wei, F. A. N. G., 童加冰, & Wang, D. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122438
Nrf2 overexpression attenuates TGF-β-induced EMT-like changes and ferroptosis-related stress in lung epithelial cells
Wu, C., Feng, Y., Zhou, Y., Zhu, X., Dai, Q., Ye, Z., & Dong, Z. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.104045
Artemisia vulgaris and sabinene ameliorate gastric ulceration and its recurrence through modulation of acid secretion, oxidative stress, and inflammatory cytokines: an in vivo and in silico study
Borba, A. L. T., Freschi, K., Miorando, D., Maccagnan, J. C., Steffler, A. M., Vecchia, C. A. D., Buzatto, M. V., Giacomelli, I. R., Dentz, A. L. V., Marcelino, A. P. N., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122484
Targeting oxidative stress and neuroinflammation: Analgesic effects of 4-(phenylsulfanyl)butan-2-one on chronic constriction injury-induced peripheral neuropathic pain in rats
Cheng, H., Chen, N., Yang, S.-N., Li, P.-J., Jean, Y.-H., Shih, P., Huang, S.-Y., Chen, W.-F., Sung, C.-S., & Wen, Z.-H. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106272
Selective NRF2 target induction despite falling NFE2L2 transcription across the MASLD spectrum: implications for marginal donor grafts and KEAP1-targeted therapy
Campbell, S., O’Reilly, R., Ahmed, O., McElheron, M., Chapman, W. C., & O’Farrelly, C. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.10.038
BindingDB Entry 50011439: Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
BindingDB (2022) · UC San Diego · doi:10.7270/q2vd7329
BindingDB Entry 50048123: Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.
BindingDB (2018) · UC San Diego · doi:10.7270/q2pc34cb
BindingDB Entry 50001541: Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency.
BindingDB (2020) · UC San Diego · doi:10.7270/q2pk0jnt
BindingDB Entry 50001567: Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.
BindingDB (2020) · UC San Diego · doi:10.7270/q2qc0629
BindingDB Entry 50018333: Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
BindingDB (2024) · UC San Diego · doi:10.7270/q2b85dbt
BindingDB Entry 50019506: Briarane-type diterpenoids, the inhibitors of osteoclast formation by interrupting Keap1-Nrf2 interaction and activating Nrf2 pathway.
BindingDB (2024) · UC San Diego · doi:10.7270/q26d5zc1
BindingDB Entry 50019911: Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling.
BindingDB (2024) · UC San Diego · doi:10.7270/q2z60tf4
Cyanidin-3-O-Glucoside in Anthocyanin-Rich Fraction Combined with Atorvastatin Mitigates Kidney Injury via Attenuating Renal Lipotoxicity and Oxidative Stress and Preserving Mitochondrial Function in Obese Rats
Lalichatsakul, C., Phatthapong, P., Pengrattanachot, N., Sutthasupha, P., Laorodphun, P., Nakrat, S., Sookwong, P., Mahatheeranont, S., & Lungkaphin, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219462
NRF2 in hypertrophic scarring: A stage-dependent redox hub poised between resolution and persistence
Thangboonjit, W., Pluempreecha, M., Soingam, T., & Panich, U. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104460
The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis
Smith, P. K., West, N. P., Preez, S. D., Sampson, H. A., Hellings, P. W., Price, D. B., O’Mahony, L., Venter, C., Akdiş, C. A., & Yosipovitch, G. (2026) · Allergy · doi:10.1111/all.70532

Authors: Suzuki, T., & Yamamoto, M.
Affiliations: Tohoku University (JP)
Corresponding author: Yamamoto, Masayuki
ORCID: Suzuki, Takafumi
Yamamoto, Masayuki
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2015-11
Volume: 88
Issue: Pt B
Pages: 93-100
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2015.06.006
OpenAlex: W952491933
Cited by: 995
References: 84
Citations by year: 2026: 62 · 2025: 89 · 2024: 83 · 2023: 102 · 2022: 116 · 2021: 104 · 2020: 118 · 2019: 88 · 2018: 78 · 2017: 82 · 2016: 62 · 2015: 10
FWCI: 7.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 360 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Free Radical Biology and Medicine (acceptedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Japan Science and Technology Agency
Japan Society for the Promotion of Science (26460354, 2611010, 24249015, 25112502)
Takeda Science Foundation
Naito Foundation
Core Research for Evolutional Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Keywords: Keap1, Nrf2, oxidative stress sensing, electrophilic stress, chemoresistance, carcinogenesis, Nrf2 inhibitors, Nrf2 inducers, therapeutic target
MeSH terms: Animals, Humans, Signal Transduction, Intracellular Signaling Peptides and Proteins, NF-E2-Related Factor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular basis of the Keap1–Nrf2 system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks