Molecular basis of the Keap1–Nrf2 system

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.-S., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,288

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,210

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

Zhang, D. D., & Hannink, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8137-8151.2003 · Cited by 1,480

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395

Effect of chlorogenic acid on lipid metabolism in 3T3-L1 cells induced by oxidative stress

Liu, L., Zhang, C., Zhai, M., Yu, T., Pei, M., Du, P., Li, A., Yan, J., Li, C., & Zhang, G. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102330 · Cited by 22

The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2

Higa, Y., Hiasa, M., Tenshin, H., Nakaue, E., Tanaka, M. H., Kim, S., Nakagawa, M., Shimizu, S., Tanimoto, K., Teramachi, J., et al. (2023) · Antioxidants · doi:10.3390/antiox12010133 · Cited by 22

Differential tissue regulation of nrf2/keap1 crosstalk in response to Aeromonas infection in Nile tilapia: a comparative study

Elbialy, Z. I., Salah, A. S., Elsheshtawy, A., Elkatatny, N. M., Fouad, A. M., & Abo‐Al‐Ela, H. G. (2023) · Aquaculture International · doi:10.1007/s10499-023-01175-8 · Cited by 22

Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling

Zheng, K., Zhang, Q., Sheng, Z.-Q., Li, Y., & Lu, H.-H. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495711 · Cited by 22

The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial

Tavakoli, A., Akhgarjand, C., Ansar, H., Houjaghani, H., Khormani, A., Djafarian, K., Rostamian, A., Ranjbar, M., & Farsani, G. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-86734-0 · Cited by 25

Heme oxygenase-1 as a potential therapeutic target in rheumatic diseases

Liu, Y., Lin, Z., He, S., & Zuo, J. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.12.033 · Cited by 21

Short-term effects of deoxynivalenol, T-2 toxin, fumonisin B1 or ochratoxin on lipid peroxidation and glutathione redox system and its regulatory genes in common carp (Cyprinus carpio L.) liver

Kövesi, B., Kulcsár, S., Zándoki, E., Szabó‐Fodor, J., Mézes, M., Balogh, K., Ancsin, Z., & Pelyhe, C. (2020) · Fish Physiology and Biochemistry · doi:10.1007/s10695-020-00845-1 · Cited by 21

Four‐Octyl Itaconate Protects Chondrocytes against H2O2‐Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling

Zhang, P., Wang, X., Peng, Q., Jin, Y., Shi, G., Fan, Z., & Zhou, Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2206167 · Cited by 21

Molecular mechanisms of autophagy and implications in liver diseases

Wu, Y., Tan, H. W. S., Lin, J.-Y., Shen, H., Wang, H., & Lu, G. X. (2023) · Liver Research · doi:10.1016/j.livres.2023.02.002 · Cited by 24

Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis

Fan, P., Meng, H., Hao, W., Zheng, Y., Li, H., Zhang, Z., Du, L., Guo, X., Wang, D., Wang, Y., et al. (2023) · Food & Function · doi:10.1039/d3fo00967j · Cited by 20

SIRT6 : A potential therapeutic target for diabetic cardiomyopathy

Wu, T., Qu, Y., Xu, S., Wang, Y., Liu, X., & Ma, D. (2023) · The FASEB Journal · doi:10.1096/fj.202301012r · Cited by 23

Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication

Ariffianto, A., Deng, L., Abe, T., Matsui, C., Ito, M., Ryo, A., Aly, H. H., Watashi, K., Suzuki, T., Mizokami, M., et al. (2023) · Journal of Virology · doi:10.1128/jvi.01287-23 · Cited by 22

Metal profiling in coronary ischemia-reperfusion injury: Implications for KEAP1/NRF2 regulated redox signaling

Yang, F., & Smith, M. J. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.013 · Cited by 25

Apoptosis Induced by the Curcumin Analogue EF-24 Is Neither Mediated by Oxidative Stress-Related Mechanisms nor Affected by Expression of Main Drug Transporters ABCB1 and ABCG2 in Human Leukemia Cells

Skoupá, N., Doležel, P., Ruzickova, E., & Mlejnek, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112289 · Cited by 21

PML nuclear bodies, membrane-less domains acting as ROS sensors?

Niwa‐Kawakita, M., Wu, H.-C., de Thé, H., & Lallemand-Breitenbach, V. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.11.007 · Cited by 21

Effects of heat stress on the liver of the Chinese giant salamander Andrias davidianus: Histopathological changes and expression characterization of Nrf2-mediated antioxidant pathway genes

Wang, C., Zhou, Y.-L., Zhu, Q.-H., Zhou, Z., Gu, W.-B., Liu, Z.-P., Wang, L.-Z., & Shu, M.-A. (2018) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2018.07.016 · Cited by 22

Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects

Liu, D., Xue, J., Liu, Y., Gu, H., Wei, X., Ma, W., Luo, W., Ma, L., Jia, S., Dong, N., et al. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.09.005 · Cited by 23

Bamboo Stems (Phyllostachys nigra variety henosis) Containing Polyphenol Mixtures Activate Nrf2 and Attenuate Phenylhydrazine-Induced Oxidative Stress and Liver Injury

Yang, J. H., Choi, M., Na, C.-S., Cho, S. S., Kim, J. H., Ku, S., Cho, I. J., Shin, H., & Ki, S. H. (2019) · Nutrients · doi:10.3390/nu11010114 · Cited by 21

Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation

Yokosawa, T., Yamada, M., Noguchi, T., Suzuki, S., Hirata, Y., & Matsuzawa, A. (2019) · The Journal of Antibiotics · doi:10.1038/s41429-019-0216-6 · Cited by 21

FAM96B inhibits the senescence of dental pulp stem cells

Liang, H., Li, W., Yang, H., Cao, Y., Ge, L., Shi, R., Fan, Z., Dong, R., & Zhang, C. (2020) · Cell Biology International · doi:10.1002/cbin.11319 · Cited by 21

Antioxidant and Anti-Inflammatory Mechanisms of Lipophilic Fractions from Polyscias fruticosa Leaves Based on Network Pharmacology, In Silico, and In Vitro Approaches

Rarison, R. H. G., Truong, V., Yoon, B.-H., Park, J., & Jeong, W. (2023) · Foods · doi:10.3390/foods12193643 · Cited by 20

Histone deacetylases and inhibitors in diabetes mellitus and its complications

Wang, L., Bai, Y., Cao, Z., Guo, Z., Lian, Y., Liu, P., Zeng, Y., Lyu, W., & Chen, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117010 · Cited by 24

microRNA-4532 inhibition protects human lens epithelial cells from ultra-violet-induced oxidative injury via activating SIRT6-Nrf2 signaling

Sun, G., Huang, D. F., Li, K., & Jiang, Q. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.026 · Cited by 20

Cullin3 aggravates the inflammatory response of periodontal ligament stem cells via regulation of SHH signaling and Nrf2

Chen, W., Su, J., Cai, S., & Shi, C. (2021) · Bioengineered · doi:10.1080/21655979.2021.1943603 · Cited by 20

Nrf2 in the Field of Dentistry with Special Attention to NLRP3

Schieffer, L., Manzl, C., Schatz, C., Haybaeck, J., & Crismani, A. G. (2022) · Antioxidants · doi:10.3390/antiox11010149 · Cited by 20

Tetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis

Gao, F., Chen, M., Yu, J., Xu, L., Yu, L., Jiang, H., & Gu, Z. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104957 · Cited by 21

Keap-NRF2 signaling contributes to the Notch1 protected heart against ischemic reperfusion injury via regulating mitochondrial ROS generation and bioenergetics

Xu, H., Wan, X., Zhu, R.-R., Liu, J., Liu, J., & Zhou, X. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.63297 · Cited by 20

Pectolinarigenin Induces Antioxidant Enzymes through Nrf2/ARE Pathway in HepG2 Cells

Shiraiwa, M., Kitakaze, T., Yamashita, Y., Ukawa, Y., Mukai, K., & Ashida, H. (2022) · Antioxidants · doi:10.3390/antiox11040675 · Cited by 20

Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages

Zhou, J., Fang, F., Qi, J., Li, T., Zhang, L., Liu, H., Lv, J., Xu, T., Wu, F., Song, C., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.274 · Cited by 20

Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response

Zhang, W., Xu, M., Wen, S., Wang, L., Zhang, K., Zhang, C., Zou, H., Gu, J., Liu, X., Bian, J., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114239 · Cited by 21

The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance

Alhaddad, L., Osipov, A. N., & Leonov, S. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113577 · Cited by 21

S-allylmercaptocysteine improves nonalcoholic steatohepatitis by enhancing AHR/NRF2-mediated drug metabolising enzymes and reducing NF-κB/IκBα and NLRP3/6-mediated inflammation

Yu, Q., Lee, Y.-Y., Xia, Z., Liong, E. C., Xiao, J., & Tipoe, G. L. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02305-1 · Cited by 20

Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway

Han, J., Shi, X., Zheng, Z., Zhang, B., Shi, F., Jiang, L., & Xu, J. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s184245 · Cited by 20

Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells

Tawarayama, H., Suzuki, N., Inoue-Yanagimachi, M., Himori, N., Tsuda, S., Sato, K., Ida, T., Akaike, T., Kunikata, H., & Nakazawa, T. (2020) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2020.1833224 · Cited by 19

Discovery of caffeoylisocitric acid as a Keap1-dependent Nrf2 activator and its effects in mesangial cells under high glucose

Yao, H., Zhang, W., Yang, F., Ai, F., Du, D., & Li, Y. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1998025 · Cited by 19

Micronutrients and Renal Outcomes: A Prospective Cohort Study

Chen, C., Chiu, C., Wu, I., Hsu, H.-J., Chen, Y.-T., Hsu, C.-K., Pan, H., Lee, C., & Sun, C. (2022) · Nutrients · doi:10.3390/nu14153063 · Cited by 19

Ginkgo biloba extracts (GBE) protect human RPE cells from t-BHP-induced oxidative stress and necrosis by activating the Nrf2-mediated antioxidant defence

Li, Y., Zhu, X., Wang, K., Zhu, L., Murray, M. T., & Zhou, F. (2022) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgac069 · Cited by 22

Oxymatrine ameliorates osteoarthritis via the Nrf2/NF-κB axis in vitro and in vivo

Zhou, K., Liu, D., Jin, Y., Xia, W., Zhang, P., & Zhou, Z. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110539 · Cited by 19

Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia

Yamada, M., Warabi, E., Oishi, H., Lira, V. A., & Okutsu, M. (2023) · The FASEB Journal · doi:10.1096/fj.202300349r · Cited by 19

Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets☆

Ramsden, R., & Gallagher, E. (2016) · Redox Biology · doi:10.1016/j.redox.2016.07.001 · Cited by 19

Prediction of Binding Energy of Keap1 Interaction Motifs in the Nrf2 Antioxidant Pathway and Design of Potential High-Affinity Peptides

Karttunen, M., Choy, W., & Cino, E. A. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b03295 · Cited by 19

Protective effect of inducible aldo-keto reductases on 4-hydroxynonenal- induced hepatotoxicity

Li, D., Gu, Z., Zhang, J., & Ma, S. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.012 · Cited by 19

The Nrf2 activator MIND4‐17 protects retinal ganglion cells from high glucose‐induced oxidative injury

Chen, N., Li, Y., Huang, N. J., Yao, J., Luo, W., & Jiang, Q. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29619 · Cited by 19

Emodin resists to Cyprinid herpesvirus 3 replication via the pathways of Nrf2/Keap1-ARE and NF-κB in the ornamental koi carp (Cyprinus carpio haematopterus)

Wang, Z., Zheng, N., Liang, J., Wang, Q., Xiujie, Z., Wang, H., Yuan, H., Zhang, R., Guo, S., Liu, Y., et al. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109023 · Cited by 19

Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options

Jiang, T., & He, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.851257 · Cited by 19

Role of nuclear factor erythroid 2-related factor 2 (Nrf2) in female and male fertility

Valipour, J., Taghizadeh, F., Esfahani, R., Ramesh, M., & Rastegar, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29752 · Cited by 19

Regulation of KCNMA1 transcription by Nrf2 in coronary arterial smooth muscle cells

Sun, X., Qian, L.-L., Li, Y., Pfiefer, T. M., Wang, X.-L., Lee, H.-C., & Lü, T. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.03.001 · Cited by 18

Ginsenoside Rh3 activates Nrf2 signaling and protects endometrial cells from oxygen and glucose deprivation-reoxygenation

Wang, X.-M., She, C., Li, Q., Zhang, D., Xu, J., Li, M., Li, P., & Xu, H. (2020) · Aging · doi:10.18632/aging.103009 · Cited by 18

Increased supply of methionine during a heat-stress challenge in lactating holstein cows alters mammary tissue mTOR signaling and its response to lipopolysaccharide

Coleman, D. N., Vailati-Riboni, M., Pate, R. T., Aboragah, A. A., Luchini, D. N., Cardoso, F. C., & Loor, J. J. (2022) · Journal of Animal Science · doi:10.1093/jas/skac175 · Cited by 18

Proanthocyanidins Activate Nrf2/ARE Signaling Pathway in Intestinal Epithelial Cells by Inhibiting the Ubiquitinated Degradation of Nrf2

Yang, S., Meng, L., Yunlong, D., He, T., Yao, S., & Li, P. (2022) · BioMed Research International · doi:10.1155/2022/8562795 · Cited by 19

Potential therapeutic effects of Chinese meteria medica in mitigating drug-induced acute kidney injury

Li, J., Li, T., Li, Z., Song, Z., & Gong, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1153297 · Cited by 18

The Effect of Preventing Oxidative Stress and Its Mechanisms in the Extract from Sonchus brachyotus DC. Based on the Nrf2-Keap1-ARE Signaling Pathway

Zhang, M.-J., Sun, W., Yang, J., Shi, D., Dai, X., & Li, X. (2023) · Antioxidants · doi:10.3390/antiox12091677 · Cited by 18

Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway

Talebi, M., Sadoughi, M. M., Ayatollahi, S. A., Ainy, E., Kiani, R., Zali, A., & Miri, M. M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115805 · Cited by 20

Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo

Zhao, L., Zhang, Z., Li, P., Gao, Y., & Shi, Y. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02813-x · Cited by 18

Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain

Luo, Y., Châtre, L., Melhem, S., Al-Dahmani, Z. M., Homer, N. Z. M., Miedema, A., Deelman, L. E., Groves, M. R., Feelisch, M., Morton, N. M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102965 · Cited by 18

Targeting Nrf2 to treat thyroid cancer

Gong, Z., Xue, L., Li, H., Fan, S., van Hasselt, C. A., Li, D., Zeng, X., Tong, M. C. F., & Chen, G. G. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116324 · Cited by 18

DNMT inhibitor, 5-aza-2′-deoxycytidine mitigates di(2-ethylhexyl) phthalate-induced aggravation of psoriasiform inflammation in mice via reduction in global DNA methylation in dermal and peripheral compartments

Alfardan, A. S., Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., Alqinyah, M., Attia, S. M., El‐Sherbeeny, A. M., Al-Harbi, M. M., Al‐Shabanah, O. A., Ibrahim, K. E., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112503 · Cited by 18

Insights into the Pathogenic Secondary Symptoms Caused by the Primary Loss of Dystrophin

Forcina, L., Pelosi, L., Miano, C., & Musarò, A. (2017) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk2040044 · Cited by 18

Redox cell signaling and hepatic progenitor cells

di Bello, G., Vendemiale, G., & Bellanti, F. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.09.004 · Cited by 18

Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway

Chen, L., Wang, J., Cai, X., Chen, S., Zhang, J., Li, B., Chen, W., Guo, X., Luo, H., & Chen, J. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105516 · Cited by 19

In Vitro and In Vivo Protective Effects of Lentil (Lens culinaris) Extract against Oxidative Stress-Induced Hepatotoxicity

Jung, Y.-S., Lee, S. H., Chun, S. Y., Kim, D. H., Jang, B. I., Han, M., & Lee, S. (2021) · Molecules · doi:10.3390/molecules27010059 · Cited by 18

Redox Homeostasis and Immune Alterations in Coronavirus Disease-19

Bellanti, F., Buglio, A. L., & Vendemiale, G. (2022) · Biology · doi:10.3390/biology11020159 · Cited by 18

Astaxanthin enhances antioxidant capacity to alleviate thermal stress-induced liver inflammation in largemouth bass (Micropterus salmoides): a multi-omics insight into glutathione metabolism remodeling

Sun, Y., Zong, W., Wang, J., He, J., Zhang, J., & Han, T. (2025) · Frontiers in Marine Science · doi:10.3389/fmars.2025.1595039 · Cited by 17

Oral isoniazid causes oxidative stress, oocyte deterioration and infertility in mice

Qiao, P., Zhang, Y., Yang, Y., Meng, R., Xu, Z., Jiang, X., Zhang, Y., Zhang, C., & Su, J. (2021) · Toxicology · doi:10.1016/j.tox.2021.152749 · Cited by 17

The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione

Kinoshita, C., & Aoyama, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084245 · Cited by 19

Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19

McCord, J. M., Hybertson, B. M., Cota‐Gomez, A., & Gao, B. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.033 · Cited by 18

The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling

Gao, Y., Liu, W., Su, X., Li, X., Yu, F., & Zhang, N. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3959390 · Cited by 17

Effects of PUFA-Rich Dietary Strategies on Ruminants’ Mammary Gland Gene Network: A Nutrigenomics Review

Kyriakaki, P., Zisis, F., Pappas, A. C., Mavrommatis, A., & Tsiplakou, E. (2022) · Metabolites · doi:10.3390/metabo13010044 · Cited by 17

Antioxidative Role of Heterophagy, Autophagy, and Mitophagy in the Retina and Their Association with the Age-Related Macular Degeneration (AMD) Etiopathogenesis

Nita, M., & Grzybowski, A. E. (2023) · Antioxidants · doi:10.3390/antiox12071368 · Cited by 19

Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway

Xu, H., Deng, R., Li, E. T. S., Shen, J., & Wang, M. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104019 · Cited by 17

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging

Shimizu, S., Mimura, J., Hasegawa, T., Shimizu, E., Imoto, S., Tsushima, M., Kasai, S., Yamazaki, H., Ushida, Y., Suganuma, H., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236834 · Cited by 17

DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway

Qiu, L.-J., Ma, Z., Li, X., Deng, Y., Duan, G., Zhao, L., Xu, X.-W., Xiao, L., Liu, H., Zhu, Z., et al. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa110 · Cited by 17

Theaflavin Attenuates TBHP-Induced Endothelial Cells Oxidative Stress by Activating PI3K/AKT/Nrf2 and Accelerates Wound Healing in Rats

Chen, D., Wu, Z., Wu, L., Jiang, J., & Hu, G. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.830574 · Cited by 17

Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress

Guo, S., Fei, H., Ji, F., Chen, F., Xie, Y., & Wang, S. (2017) · Oncotarget · doi:10.18632/oncotarget.22360 · Cited by 17

Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation

Wen, M., Liu, M.-M., Zhang, Y., Qiao, B., Luo, T., Liu, G., Li, D., & Zhou, B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144630 · Cited by 17

Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice

Lee, S. J., Kim, J. E., Choi, Y. J., Gong, J. E., Park, S. H., Douangdeuane, B., Souliya, O., Park, J. M., Lee, H. S., Kim, B.-H., et al. (2021) · Antioxidants · doi:10.3390/antiox10050791 · Cited by 16

Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer

Katsuoka, F., Otsuki, A., Hatanaka, N., Okuyama, H., & Yamamoto, M. P. (2022) · Molecular and Cellular Biology · doi:10.1128/mcb.00520-21 · Cited by 16

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

Boretti, A. A. (2022) · Natural Product Communications · doi:10.1177/1934578x221144579 · Cited by 16

MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer

Hu, B., Chen, R., Jiang, M., Xiong, S., Xie, A., Liu, X., & Fu, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087608 · Cited by 16

Oxytetracycline-induced oxidative liver damage by disturbed mitochondrial dynamics and impaired enzyme antioxidants in largemouth bass (Micropterus salmoides)

Li, T., Jin, M., Huang, L., Zhang, Y., Zong, J., Shan, H., Kang, H., Xu, M., Liu, H., Zhao, Y., et al. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106616 · Cited by 17

Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine

Guan, T., Li, N., Xu, X., Xiong, D., Wang, B., Xiao, L., Yang, W., Chu, G., Yusuf, A., Zhang, J., et al. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109928 · Cited by 16

Protection against HEMA-Induced Mitochondrial Injury In Vitro by Nrf2 Activation

Jiao, Y., Niu, T., Liu, H., Tay, F. R., & Chen, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3501059 · Cited by 16

Compound 13 activates AMPK-Nrf2 signaling to protect neuronal cells from oxygen glucose deprivation-reoxygenation

Mo, Y., Zhu, J., Jiang, A., Zhao, J., Ye, L., & Han, B. (2019) · Aging · doi:10.18632/aging.102534 · Cited by 15

The Potential Role of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) in Glaucoma: A Review

Wang, M., Li, J., & Zheng, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.921514 · Cited by 16

Keap1-targeting microRNA-941 protects endometrial cells from oxygen and glucose deprivation-re-oxygenation via activation of Nrf2 signaling

Li, S., Cheng, W., Li, Y., Xu, H., Han, H., Li, P., & Zhang, D.-X. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0526-0 · Cited by 16

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats

Busceti, C. L., Cotugno, M., Bianchi, F., Forte, M., Stanzione, R., Marchitti, S., Battaglia, G., Nicoletti, F., Fornai, F., & Rubattu, S. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124289 · Cited by 16

Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection

Sun, Q., Shen, X., Ma, J., Lou, H., & Zhang, Q. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.07.026 · Cited by 16

CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes

Yang, Y., Li, J., Zhang, L., Lin, Z., Xiao, H., Sun, X., Zhang, M., Liu, P., & Huang, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105333 · Cited by 16

Glaucocalyxin A Ameliorates Hypoxia/Reoxygenation-Induced Injury in Human Renal Proximal Tubular Epithelial Cell Line HK-2 Cells

Hosohata, K., Jin, D., & Takai, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010446 · Cited by 16

Role of transcriptional factor Nrf2 in the acute lung injury of mice.

Kong, M., Mao, J., Luo, B., & Qin, Z. (2015) · PubMed Central · Cited by 16

Nuclear Factor Erythroid 2–Related Factor 2 Deficiency Results in Amplification of the Liver Fat-Lowering Effect of Estrogen

Rui, W., Zou, Y., Lee, J., Nambiar, S. M., Lin, J., Zhang, L., Yang, Y., & Dai, G. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.231316 · Cited by 16

Interplay between Nrf2 and NF-κB in Neuroinflammatory Diseases

Liddell, J. R. (2017) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000489 · Cited by 16

Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2

Jung, J. Y., Park, S. M., Ko, H. L., Lee, J. R., Park, C. A., Byun, S. H., Ku, S., Cho, I. J., & Kim, S. C. (2018) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x18500246 · Cited by 16

Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes

Yamato, O., Tsuneyoshi, T., Ushijima, M., Jikihara, H., & Yabuki, A. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1699-2 · Cited by 16

Neuropilin-2–expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling

Kumar, A., Goel, H. L., Silva, C. A., Wang, T., Geng, Y., Wang, M., Goel, S., Hu, K., Li, R., Zhu, L. J., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci181368 · Cited by 16

Possible antidepressant mechanism of acupuncture: targeting neuroplasticity

Xu, N., He, Y., Wei, Y.-N., Bai, L., & Wang, L. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1512073 · Cited by 20

Understanding the Reciprocal Interplay Between Antibiotics and Host Immune System: How Can We Improve the Anti-Mycobacterial Activity of Current Drugs to Better Control Tuberculosis?

Park, H.-E., Lee, W., Shin, M., & Shin, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.703060 · Cited by 16

Heme oxygenase-1, carbon monoxide, and malaria – The interplay of chemistry and biology

Pena, A. C., & Pamplona, A. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214285 · Cited by 17

Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts

Zhao, J., Tang, P., Zhou, Z., Xu, G., Li, Q., Li, K.-R., & Zheng, Y. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01146-7 · Cited by 15

Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia/reoxygenation

Yang, F., Smith, M. J., Griffiths, A., Morrell, A. P., Chapple, S. J., Siow, R. C. M., Stewart, T. J., Maret, W., & Mann, G. E. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102777 · Cited by 15

Molecular Basis of the KEAP1-NRF2 Signaling Pathway

Suzuki, T., Takahashi, J. A., & Yamamoto, M. P. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.0028 · Cited by 320

Overview of redox regulation by Keap1–Nrf2 system in toxicology and cancer

Suzuki, M., Otsuki, A., Keleku-Lukwete, N., & Yamamoto, M. P. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.10.001 · Cited by 62

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

Suzuki, T., & Yamamoto, M. P. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.800169 · Cited by 412

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

Taguchi, K., Motohashi, H., & Yamamoto, M. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01473.x · Cited by 1,478

The Keap1–Nrf2 system as an in vivo sensor for electrophiles

Uruno, A., & Motohashi, H. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.02.007 · Cited by 187