Molecular basis of the Keap1–Nrf2 system

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.-S., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,288

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,210

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

Zhang, D. D., & Hannink, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8137-8151.2003 · Cited by 1,480

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395

Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway

Yamagishi, N., Yamamoto, Y., Nishi, T., Ito, T., & Kanai, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287788 · Cited by 16

Regulation of Keap1-Nrf2 axis in temporal lobe epilepsy—hippocampal sclerosis patients may limit the seizure outcomes

Madhamanchi, K., Madhamanchi, P., Narne, P., Jayalakshmi, S., Panigrahi, M. K., Patil, A., & Babu, P. P. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06936-0 · Cited by 15

Allantopyrone A activates Keap1–Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death

Uesugi, S., Muroi, M., Kondoh, Y., Shiono, Y., Osada, H., & Kimura, K. (2016) · The Journal of Antibiotics · doi:10.1038/ja.2016.99 · Cited by 15

microRNA-19a protects osteoblasts from dexamethasone via targeting TSC1

Liu, G., Chen, F., Ji, F., Fei, H., Xie, Y., & Wang, S. (2017) · Oncotarget · doi:10.18632/oncotarget.23326 · Cited by 15

Protective Effects of Trimetazidine in Retarding Selenite-Induced Lens Opacification

Fang, W., Ye, Q., Yao, Y., Xiu, Y., Gu, F., & Zhu, Y. (2019) · Current Eye Research · doi:10.1080/02713683.2019.1633359 · Cited by 16

Hepatoprotective Effect of Neoagarooligosaccharide via Activation of Nrf2 and Enhanced Antioxidant Efficacy

Yang, J. H., Na, C.-S., Cho, S. S., Kim, K. M., Lee, J. H., Chen, X.-Q., Ku, S., Cho, I. J., Kim, E. J., Lee, J. H., et al. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00697 · Cited by 15

Diphenyl diselenide is as effective as Ebselen in a juvenile rat model of cisplatin-induced nephrotoxicity

Fulco, B. C. W., Jung, J. T. K., Chagas, P. M., Rosa, S. G., Prado, V. C., & Nogueira, C. W. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126482 · Cited by 15

N -Carbamylglutamate and l -arginine supplementation improve hepatic antioxidant status in intrauterine growth-retarded suckling lambs

Zhang, H., Jin, Y., Wang, M., Loor, J. J., & Wang, H. (2020) · RSC Advances · doi:10.1039/c9ra09316h · Cited by 15

Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells

Yang, J.-L., Sun, M., Yuan, Q., Tang, S., Dong, M., Zhang, R.-D., Liu, Y.-Y., & Mao, L. (2020) · Aging · doi:10.18632/aging.103263 · Cited by 16

Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells

Ward, A. O., Sala‐Newby, G. B., Ladak, S. S., Angelini, G. D., Caputo, M., Suleiman, M. S., Evans, P. C., George, S. J., & Zakkar, M. (2021) · Perfusion · doi:10.1177/02676591211012571 · Cited by 15

Comparative transcriptome analysis between the short-term stress and long-term adaptation of the Ruditapes philippinarum in response to benzo[a]pyrene

Wang, H., Pan, L., Xu, R., Miao, J., Si, L., & Pan, L. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.08.020 · Cited by 15

SENP6‐Mediated deSUMOylation of Nrf2 Exacerbates Neuronal Oxidative Stress Following Cerebral Ischemia and Reperfusion Injury

Xia, Q., Que, M., Zhan, G., Zhang, L., Zhang, X., Zhao, Y., Zhou, H., Zheng, L., Mao, M., & Li, X. (2024) · Advanced Science · doi:10.1002/advs.202410410 · Cited by 14

Target Nuclear Factor Erythroid 2‐Related Factor 2 in Pulmonary Hypertension: Molecular Insight into Application

Qin, Y., Qiao, Y., Wang, D., Li, L., Li, M., Yan, G., & Tang, C. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7845503 · Cited by 14

Diallyl Disulfide Blocks Cigarette Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Tumorigenesis via Activation of the Nrf2 Antioxidant System and Suppression of NF-κB Inflammatory Response

Tian, J., Zhao, W., Wu, Y., Shi, Y., Yu, J., Zhang, W., Xing, C., Zhuang, C., & Qu, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c02007 · Cited by 15

The application of nanoparticles based on ferroptosis in cancer therapy

Li, Y., Wei, C., Yan, J., Li, F., Chen, B., Sun, Y., Luo, K., He, B., & Liang, Y. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb02308g · Cited by 14

Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-κB/PPAR-α/NLRP3 pathways

Zhou, M., Cao, Y., Xie, S., Xiang, Y., Li, M., Yang, H., & Dong, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111872 · Cited by 14

The Rich Evolutionary History of the Reactive Oxygen Species Metabolic Arsenal Shapes Its Mechanistic Plasticity at the Onset of Metazoan Regeneration

Vullien, A., Amiel, A., Baduel, L., Diken, D., Renaud, C., Krasovec, G., Vervoort, M., Röttinger, É., & Gazave, E. (2024) · Molecular Biology and Evolution · doi:10.1093/molbev/msae254 · Cited by 14

Short-term effects of T-2 toxin or deoxynivalenol on lipid peroxidation and the glutathione system in common carp

Pelyhe, C., Kövesi, B., Zándoki, E., Kovács, B., Szabó‐Fodor, J., Mézes, M., & Balogh, K. (2016) · Acta Veterinaria Hungarica · doi:10.1556/004.2016.042 · Cited by 14

How exercise induces oxidative eustress

Cobley, J. N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00023-7 · Cited by 14

Nuclear factor erythroid 2‐related factor 2 in human papillomavirus‐related cancers

Cruz‐Gregorio, A., Aranda‐Rivera, A. K., & Pedraza‐Chaverrí, J. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2308 · Cited by 14

Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice

Wang, Y., Xiang, Y., Wang, R., Li, X., Wang, J., Yu, S., & Zhang, Y. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.04.035 · Cited by 13

The possible repositioning of an oral anti-arthritic drug, auranofin, for Nrf2-activating therapy: The demonstration of Nrf2-dependent anti-oxidative action using a zebrafish model

Fuse, Y., Endo, Y., Araoi, S., Daitoku, H., Suzuki, H., Kato, M., & Kobayashi, M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.022 · Cited by 14

The protective effects of the miR-129-5p/keap-1/Nrf2 axis on Ang II-induced cardiomyocyte hypertrophy

Ye, H., Xu, G., Zhang, D., & Wang, R. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-8079 · Cited by 13

The regulatory mechanisms of mitophagy and oxidative stress in androgenetic alopecia

Bi, D., Hu, Y., Hua, S., Liu, J., & Guo, S. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111862 · Cited by 13

The Role of P62 /Nrf2/Keap1 Signaling Pathway in Lead‐Induced Neurological Dysfunction

Peng, D., Wei, P., Li, Z., Wei, R., Li, H., & Li, S. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70566 · Cited by 14

The Effects of Ginsenosides on the Nrf2 Signaling Pathway

Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-73234-9_20 · Cited by 13

BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway

Li, T., Geng, Z., Zhang, J., Xu, L., & Zhu, X. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.299 · Cited by 13

A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages

Shen, X., Chen, H., Zhang, H., Luo, L., Wen, T., Liu, L., Hu, Q., & Wang, L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110965 · Cited by 13

Worsening of imiquimod-induced psoriasiform inflammation in mice by environmental pollutant, di-(2-ethylhexyl) phthalate through dysregulation in IL-17A and Nrf2/iNOS signaling in peripheral myeloid and CD4 + T cells

Alfardan, A. S., Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., Alqinyah, M., Attia, S. M., Sarawi, W. S., Alanazi, A. Z., Alhazzani, K., & Ibrahim, K. E. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111293 · Cited by 13

Curcumin mitigates ochratoxin A-induced oxidative stress and alters gene expression in broiler chicken liver and kidney

Kövesi, B., Worlanyo, A. P., Kulcsár, S., Ancsin, Z., Erdélyi, M., Zándoki, E., Mézes, M., & Balogh, K. (2024) · Acta Veterinaria Hungarica · doi:10.1556/004.2024.01016 · Cited by 13

Muscle‐derived IL‐1β regulates EcSOD expression via the NBR1‐p62‐Nrf2 pathway in muscle during cancer cachexia

Yamada, M., Warabi, E., Oishi, H., Lira, V. A., & Okutsu, M. (2024) · The Journal of Physiology · doi:10.1113/jp286460 · Cited by 13

Changes of lipid peroxidation and glutathione redox system, and expression of glutathione peroxidase regulatory genes as effect of short-term aflatoxin B1 exposure in common carp

Kövesi, B., Pelyhe, C., Zándoki, E., Mézes, M., & Balogh, K. (2018) · Toxicon · doi:10.1016/j.toxicon.2018.02.003 · Cited by 13

The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells

Simon‐Molas, H., Sánchez‐de‐Diego, C., Navarro‐Sabaté, À., Castaño, E., Ventura, F., Bartrons, R., & Manzano, À. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031905 · Cited by 13

Cyclic Peptides in Neurological Disorders: The Case of Cyclo(His-Pro)

Bellezza, I., Peirce, M. J., & Minelli, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814905-8.00010-1 · Cited by 13

Unravelling Immunity: Understanding Inflammatory Pathways as Key Players in Immune Response and Disease Progression

Ghara, A., Matada, G. S. P., Sah, R. K., Sneha, S., Boneka, S. S., Paik, A., Majumder, S., Pramanick, P., & Metikurki, B. (2025) · Current Molecular Biology Reports · doi:10.1007/s40610-025-00167-2 · Cited by 12

Targeting the Nrf2/HO-1 aixs: A therapeutic strategy against regulated cell death in Alzheimer’s disease

Wang, Z., Feng, W., Li, X., Yun, X., Wu, S., Du, L., & Wang, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103035 · Cited by 15

HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

Sala-Gaston, J., Pedrazza, L., Ramírez, J., Martinez-Martinez, A., Rawlins, L. E., Baple, E. L., Crosby, A. H., Mayor, U., Ventura, F., & Rosa, J. L. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04586-7 · Cited by 13

Identification of Nrf2/Keap1 pathway and its transcriptional regulation of antioxidant genes after exposure to microcystins in freshwater mussel Cristaria plicata

Wu, J., Liu, W., Hou, S., Wang, Y., Fang, H., Luo, S., Yang, L., & Wen, C. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104629 · Cited by 12

PAK2/beta-catenin/c-Myc/PKM2 signal transduction suppresses ovarian granulosa cell apoptosis in polycystic ovary syndrome

Miao, H., Hu, S., Ye, L., Zhang, M., Jing, X., & Hong, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.08.004 · Cited by 12

Oligosaccharides from black ginseng innovatively prepared by low‐temperature steam‐heating process ameliorate cognitive impairment in Alzheimer's disease mice via the Keap‐1/Nrf2 pathway

Xu, W., Yu, P., Shao, S., Xie, Z., Wu, Y., Liu, J., Xu, T., Cai, G., & Yang, H. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13394 · Cited by 12

The Role of NRF2 in Trinucleotide Repeat Expansion Disorders

Chang, K., & Chen, C. (2024) · Antioxidants · doi:10.3390/antiox13060649 · Cited by 12

Cardamonin protects against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1

Nan, W., Yin, J., Hao, W., Meng, H., Wu, J., Yin, X., & Wu, H. (2024) · Food & Function · doi:10.1039/d4fo03543g · Cited by 13

Exploring the association between aging, ferroptosis, and common age-related diseases

Mavaddatiyan, L., Naeini, S. H., Khodabandeh, S., Hosseini, F., Skelton, R. J. P., Azizi, V., & Talkhabi, M. (2025) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2025.105877 · Cited by 14

Adipose stem cell-derived nanovesicles for cardioprotection: production and identification of therapeutic components

Huang, C., Chng, W. H., Neupane, Y. R., Lai, Y., Cui, W., Yang, M., Wolfram, J., Chong, S. Y., Yu, X., Zhang, S., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113989 · Cited by 12

Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte‐Specific c‐met Deletion during the Progression of NASH

Ramadori, P., Drescher, H. K., Erschfeld, S., Fragoulis, A., Kensler, T. W., Wruck, C. J., Cubero, F. J., Trautwein, C., Streetz, K. L., & Kroy, D. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3420286 · Cited by 12

Applying an Electrophilicity-Based Strategy to Develop a Novel Nrf2 Activator Inspired from Dietary [6]-Shogaol

Du, Y., Zheng, Y.-L., Ji, Y., Dai, F., Hu, Y.-J., & Zhou, B. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02442 · Cited by 12

Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus

Lü, T., & Lee, H.-C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.750618 · Cited by 12

A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2

Qiu, L., Wang, M., Zhu, Y., Xiang, Y., & Zhang, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082150 · Cited by 12

Effect of short-term sterigmatocystin exposure on lipid peroxidation and glutathione redox system and expression of glutathione redox system regulatory genes in common carp liver

Kövesi, B., Pelyhe, C., Zándoki, E., Mézes, M., & Balogh, K. (2019) · Toxicon · doi:10.1016/j.toxicon.2019.03.001 · Cited by 12

Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β

Wen, J., Li, X., Zheng, S., & Xiao, Y. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146946 · Cited by 12

Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NF-κB pathway

Baig, N., Sultan, R., & Qureshi, S. A. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03776-x · Cited by 14

High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi

Zhang, A., Li, H., Song, Q., Cui, Y., Zhang, Y., Wang, X., Li, Z., & Hou, Y. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01952-7 · Cited by 11

Hepatoprotective effects of Radix Bupleuri extract on aflatoxin B1-induced liver injury in ducks

Feng, T., Li, S., Wang, P., Zhu, D., Xu, Z., Wang, L., Li, J., Kulyar, M. F., & Shen, Y. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116781 · Cited by 11

Computational Analysis and Experimental Data Exploring the Role of Hesperetin in Ameliorating ADHD and SIRT1/Nrf2/Keap1/OH-1 Signaling

Mokhtar, H. I., El‐Fadeal, N. M. A., El‐Sayed, R. M., Hegazy, A., El-Kherbetawy, M. K., Hamad, A. G., ElSayed, M. H., & Zaitone, S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179284 · Cited by 11

GSTA3 regulates TGF- β 1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K–Keap1/Nrf2 pathway

Xiao, Y., Zhang, Z., Fu, Y., Shan, H., Cui, S., & Wu, J. (2019) · Journal of International Medical Research · doi:10.1177/0300060519876796 · Cited by 11

Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats

Wang, Z., Cai, L., Li, H., Liang, M., Zhang, Y., Wu, Q., & Yang, L. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13180 · Cited by 11

BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma

Kang, J.-S., Nam, L. B., Yoo, O.-K., Lee, K., Suh, Y., Kim, D., Kim, W. K., Lim, C., Lee, H., & Keum, Y. (2022) · Antioxidants · doi:10.3390/antiox11010114 · Cited by 11

Identification of Phytogenic Compounds with Antioxidant Action That Protect Porcine Intestinal Epithelial Cells from Hydrogen Peroxide Induced Oxidative Damage

Wang, J., Chen, M., Wang, S., Chu, X., & Ji, H. (2022) · Antioxidants · doi:10.3390/antiox11112134 · Cited by 11

Maresin1: A multifunctional regulator in inflammatory bone diseases

Zhang, Z., Ji, C., Wang, M., Wang, M., She, X., Song, D., Xu, X., & Zhang, D. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110308 · Cited by 13

Glyoxalase I is a novel target for the prevention of metabolic derangement

Miranda, E. R., & Haus, J. M. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108524 · Cited by 11

Neuroligin-3 protects retinal cells from H2O2-induced cell death via activation of Nrf2 signaling

Li, X., Huang, D. F., Yu, Q., Yang, J., & Yao, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.141 · Cited by 11

Toxicity of organochalcogens in human leukocytes is associated, but not directly related with reactive species production, apoptosis and changes in antioxidant gene expression

Bueno, D., Meinerz, D. F., Waczuk, E. P., de Souza, D., & da Rocha, J. B. T. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1536824 · Cited by 11

2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside alleviated the acute hepatotoxicity and DNA damage in diethylnitrosamine-contaminated mice

Yu, W., Zhao, J., Li, W., Zheng, Y.-P., Zhu, J., Liu, J., Liu, R., Wang, Z., Wang, X., & Hai, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117274 · Cited by 11

Effects of apple polyphenols on myofiber-type transformation in longissimus dorsi muscle of finishing pigs

Chen, X., Jia, G., Liu, G., Zhao, H. Y., & Huang, Z. (2020) · Animal Biotechnology · doi:10.1080/10495398.2020.1735405 · Cited by 11

Evaluation of the role of Nrf2/Keap1 pathway‑associated novel mutations and gene expression on antioxidant status in patients with deep vein thrombosis

Akın, D. F., Eroğlu, T., İlk, S., Eğin, Y., & Kankılıç, T. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8790 · Cited by 11

Cerebellar Blood Flow and Gene Expression in Crossed Cerebellar Diaschisis after Transient Middle Cerebral Artery Occlusion in Rats

Kidani, N., Hishikawa, T., Hiramatsu, M., Nishihiro, S., Kin, K., Takahashi, Y., Murai, S., Sugiu, K., Yasuhara, T., Miyazaki, I., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114137 · Cited by 11

Knockdown of ALK7 inhibits high glucose‐induced oxidative stress and apoptosis in retinal pigment epithelial cells

Shi, Q., Dong, X., Zhang, M., Cheng, Y.-H., & Pei, C. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13189 · Cited by 11

Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation

Bai, J., Jia, P., Zhang, Y., Wang, K., & Wu, G. (2021) · Human & Experimental Toxicology · doi:10.1177/0960327121996032 · Cited by 11

The Effects of Mixed Fusarium Mycotoxins at EU-Permitted Feed Levels on Weaned Piglets’ Tissue Lipids

Ali, O., Mézes, M., Balogh, K., Kovács, M., & Szabó, A. (2021) · Toxins · doi:10.3390/toxins13070444 · Cited by 11

NRF2: An emerging role in neural stem cell regulation and neurogenesis

Boorman, E., Killick, R., Aarsland, D., Zunszain, P. A., & Mann, G. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.301 · Cited by 12

Mechanism of Emulsified Isoflurane Postconditioning–Induced Activation of the Nrf2–Antioxidant Response Element Signaling Pathway During Myocardial Ischemia-Reperfusion: The Relationship With Reactive Oxygen Species

Chen, W., Chen, X.-Y., Wang, Y., Wang, H., Zhou, W., & Yu, T. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000668 · Cited by 11

Evaluating the Antioxidant Properties of the Ancient-Crop Tef (Eragrostis tef) Grain Extracts in THP-1 Monocytes

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