Yamamoto, Masayuki

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 3,634

Targeting the KEAP1-NRF2 system to prevent kidney disease progression

Nezu, M., Suzuki, N., & Yamamoto, M. (2017) · American Journal of Nephrology

Genomics, phytochemicals, and oxidative stressAcute Kidney Injury Research

Cited by 3,447

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressUbiquitin and proteasome pathways

Cited by 2,224

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 2,124

The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

Yamamoto, M., Kensler, T. W., & Motohashi, H. (2018) · Physiological Reviews

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,968

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,947

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., Hayashi, M., Sekine, H., Tanaka, N., Moriguchi, T., Motohashi, H., Nakayama, K., et al. (2016) · Nature Communications

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 1,878

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M., & Winterbourn, C. (2022) · Nature Reviews Molecular Cell Biology

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,735

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,725

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

Taguchi, K., Motohashi, H., & Yamamoto, M. (2011) · Genes to Cells

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,478

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 1,395

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

McMahon, M., Itoh, K., Yamamoto, M., & Hayes, J. D. (2003) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,141

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 1,102

Molecular basis of the Keap1–Nrf2 system

Suzuki, T., & Yamamoto, M. (2015) · Free Radical Biology and Medicine

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 995

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 986

The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., et al. (2021) · Nature

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 972

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Ida, T., Sawa, T., Ihara, H., Tsuchiya, Y., Watanabe, Y., Kumagai, Y., Suematsu, M., Motohashi, H., Fujii, S., Matsunaga, T., et al. (2014) · Proceedings of the National Academy of Sciences

Sulfur Compounds in BiologyRedox biology and oxidative stress

Cited by 934

Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

Tong, K. I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T., & Yamamoto, M. (2006) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressProtein Structure and Dynamics

Cited by 759

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 735

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Shibata, T., Ohta, T., Tong, K. I., Kokubu, A., Odogawa, R., Tsuta, K., Asamura, H., Yamamoto, M., & Hirohashi, S. (2008) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 728

Toward clinical application of the Keap1-Nrf2 pathway

Suzuki, T., Motohashi, H., & Yamamoto, M. (2013) · Trends in Pharmacological Sciences

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 680

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal

Heme Oxygenase-1 and Carbon MonoxideGenomics, phytochemicals, and oxidative stress

Cited by 637

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine

Asthma and respiratory diseasesGenomics, phytochemicals, and oxidative stress

Cited by 580

The KEAP1–NRF2 System in Cancer

Taguchi, K., & Yamamoto, M. (2017) · Frontiers in Oncology

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 527