The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“High fluoride doses can lead to DNA damage, mitochondrial damage, endoplasmic reticulum (ER) stress, and apoptotic death, thereby impairing ameloblast function and disrupting the normal synthesis and secretion of enamel-associated proteins via the impairment of normal ER function [10–13].”
From Saliva microbiome alterations in dental fluorosis population (2023) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Sirtuins as regulators of metabolism and healthspan
Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008
Genomic Instability in Mice Lacking Histone H2AX
Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology · doi:10.1038/ncb1004 · Cited by 989
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319774 · Cited by 401
Research works printed but not linked: 62
- CDC, 2001, Recommendations for using fluoride to prevent and control dental caries in the United States. Centers for Disease Control and Prevention, MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control, 50, 1
- Dean, 1936, Some Epidemiological Aspects of Chronic Endemic Dental Fluorosis, American journal of public health and the nation’s health, 26, 567, 10.2105/AJPH.26.6.567 · DOI
- Boivin, 1989, Skeletal fluorosis: histomorphometric analysis of bone changes and bone fluoride content in 29 patients, Bone, 10, 89, 10.1016/8756-3282(89)90004-5 · DOI
- Zager, 1997, Inorganic fluoride. Divergent effects on human proximal tubular cell viability, The American journal of pathology, 150, 735
- Thrane, 2001, Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK, Toxicological sciences: an official journal of the Society of Toxicology, 61, 83, 10.1093/toxsci/61.1.83 · DOI
- Ghosh, 2002, Testicular toxicity in sodium fluoride treated rats: association with oxidative stress, Reproductive toxicology, 16, 385, 10.1016/S0890-6238(02)00038-2 · DOI
- Sun, 2011, Fluoride-induced apoptosis and gene expression profiling in mice sperm in vivo, Archives of toxicology, 85, 1441, 10.1007/s00204-011-0672-7 · DOI
- DenBesten, 1999, Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements, Community dentistry and oral epidemiology, 27, 41, 10.1111/j.1600-0528.1999.tb01990.x · DOI
- Kotecha, 2012, Prevalence of dental fluorosis & dental caries in association with high levels of drinking water fluoride content in a district of Gujarat, India, The Indian journal of medical research, 135, 873
- Beltran-Aguilar, 2010, Prevalence and severity of dental fluorosis in the United States, 1999–2004, NCHS data brief, 1
- Hu, 2007, Enamel formation and amelogenesis imperfecta, Cells, tissues, organs, 186, 78, 10.1159/000102683 · DOI
- Smith, 1996, Developmental changes in the pH of enamel fluid and its effects on matrix-resident proteinases, Advances in dental research, 10, 159, 10.1177/08959374960100020701 · DOI
- Sharma, 2010, The acid test of fluoride: how pH modulates toxicity, PloS one, 5, e10895, 10.1371/journal.pone.0010895 · DOI
- Ito, 2009, ER-stress caused by accumulated intracistanal granules activates autophagy through a different signal pathway from unfolded protein response in exocrine pancreas cells of rats exposed to fluoride, Archives of toxicology, 83, 151, 10.1007/s00204-008-0341-7 · DOI
- Kubota, 2005, Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation, The Journal of biological chemistry, 280, 23194, 10.1074/jbc.M503288200 · DOI
- Sharma, 2008, Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion, Environmental health perspectives, 116, 1142, 10.1289/ehp.11375 · DOI
- Suzuki, 2014, Uncoupling protein-2 is an antioxidant that is up-regulated in the enamel organ of fluoride-treated rats, Connective tissue research, 55, 25, 10.3109/03008207.2014.923854 · DOI
- Izquierdo-Vega, 2008, Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss, Toxicology and applied pharmacology, 230, 352, 10.1016/j.taap.2008.03.008 · DOI
- Garcia-Montalvo, 2009, Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress, Toxicology, 263, 75, 10.1016/j.tox.2009.06.008 · DOI
- Mailloux, 2011, Uncoupling proteins and the control of mitochondrial reactive oxygen species production, Free radical biology & medicine, 51, 1106, 10.1016/j.freeradbiomed.2011.06.022 · DOI
- Sluss, 2006, H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation, Molecular cell, 23, 152, 10.1016/j.molcel.2006.07.001 · DOI
- Suzuki, 2014, Sirtuin1 and autophagy protect cells from fluoride-induced cell stress, Biochimica et biophysica acta, 1842, 245, 10.1016/j.bbadis.2013.11.023 · DOI
- Landry, 2000, The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases, Proceedings of the National Academy of Sciences of the United States of America, 97, 5807, 10.1073/pnas.110148297 · DOI · Paper page
- Smith, 2000, A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family., Proceedings of the National Academy of Sciences of the United States of America, 97, 6658, 10.1073/pnas.97.12.6658 · DOI · Paper page
- Nemoto, 2004, Nutrient availability regulates SIRT1 through a forkhead-dependent pathway, Science, 306, 2105, 10.1126/science.1101731 · DOI
- Blander, 2004, The Sir2 family of protein deacetylases, Annual review of biochemistry, 73, 417, 10.1146/annurev.biochem.73.011303.073651 · DOI
- Salminen, 2013, Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process, International journal of molecular sciences, 14, 3834, 10.3390/ijms14023834 · DOI
- Nogueiras, 2012, Sirtuin 1 and sirtuin 3: physiological modulators of metabolism, Physiological reviews, 92, 1479, 10.1152/physrev.00022.2011 · DOI
- Hayashida, 2010, Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice, Molecular and cellular biochemistry, 339, 285, 10.1007/s11010-010-0391-z · DOI
- Han, 2010, SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence, Nucleic acids research, 38, 7458, 10.1093/nar/gkq609 · DOI
- Noriega, 2011, CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability, EMBO reports, 12, 1069, 10.1038/embor.2011.151 · DOI
- Nasrin, 2009, JNK1 phosphorylates SIRT1 and promotes its enzymatic activity, PloS one, 4, e8414, 10.1371/journal.pone.0008414 · DOI
- Chen, 1992, Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ, Archives of oral biology, 37, 771, 10.1016/0003-9969(92)90110-T · DOI
- Pfaffl, 2001, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic acids research, 29, e45, 10.1093/nar/29.9.e45 · DOI · Paper page
- Yang, 2007, Antioxidants tiron and N-acetyl-l-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway, Free radical biology & medicine, 42, 1369, 10.1016/j.freeradbiomed.2007.01.036 · DOI
- Guan, 2010, N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway, Molecular carcinogenesis, 49, 68, 10.1002/mc.20578 · DOI
- Ma, 2014, DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells, Biochimica et biophysica acta, 1842, 1088, 10.1016/j.bbadis.2014.04.002 · DOI
- Fordyce, 2007, A health risk assessment for fluoride in Central Europe, Environmental geochemistry and health, 29, 83, 10.1007/s10653-006-9076-7 · DOI
- Everett, 2011, Fluoride’s effects on the formation of teeth and bones, and the influence of genetics., Journal of dental research, 90, 552, 10.1177/0022034510384626 · DOI
- Sauerheber, 2013, Physiologic conditions affect toxicity of ingested industrial fluoride, Journal of environmental and public health, 2013, 439490, 10.1155/2013/439490 · DOI
- Chouhan, 2008, Effects of fluoride on the tissue oxidative stress and apoptosis in rats: biochemical assays supported by IR spectroscopy data, Toxicology, 254, 61, 10.1016/j.tox.2008.09.008 · DOI
- Flora, 2012, A possible mechanism for combined arsenic and fluoride induced cellular and DNA damage in mice, Metallomics: integrated biometal science, 4, 78, 10.1039/C1MT00118C · DOI
- Wright, 1996, Protein characterization of fluorosed human enamel, Journal of dental research, 75, 1936, 10.1177/00220345960750120401 · DOI
- Ogata, 2006, Autophagy is activated for cell survival after endoplasmic reticulum stress, Molecular and cellular biology, 26, 9220, 10.1128/MCB.01453-06 · DOI · Paper page
- He, 2006, DNA damage, apoptosis and cell cycle changes induced by fluoride in rat oral mucosal cells and hepatocytes, World journal of gastroenterology: WJG, 12, 1144, 10.3748/wjg.v12.i7.1144 · DOI
- J, 2013, Evaluation of multi-endpoint assay to detect genotoxicity and oxidative stress in mice exposed to sodium fluoride, Mutation research, 751, 59, 10.1016/j.mrgentox.2012.11.006 · DOI
- Ribeiro, 2004, No relationship between subchronic fluoride intake and DNA damage in Wistar rats, Caries research, 38, 576, 10.1159/000080590 · DOI
- Slamenova, 1992, Cytotoxicity and genotoxicity testing of sodium fluoride on Chinese hamster V79 cells and human EUE cells, Mutation research, 279, 109, 10.1016/0165-1218(92)90252-U · DOI
- Shanthakumari, 2004, Effect of fluoride intoxication on lipidperoxidation and antioxidant status in experimental rats, Toxicology, 204, 219, 10.1016/j.tox.2004.06.058 · DOI
- Rao, 2011, Morphometry of buccal mucosal cells in fluorosis--a new paradigm, Human & experimental toxicology, 30, 1761, 10.1177/0960327111400109 · DOI
- Pal, 2014, Protective effect of resveratrol on fluoride induced alteration in protein and nucleic acid metabolism, DNA damage and biogenic amines in rat brain, Environmental toxicology and pharmacology, 38, 684, 10.1016/j.etap.2014.07.009 · DOI
- Flora, 2009, Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain, Journal of the neurological sciences, 285, 198, 10.1016/j.jns.2009.07.001 · DOI
- Bruner, 2000, Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA, Nature, 403, 859, 10.1038/35002510 · DOI · Paper page
- Bravard, 2006, Redox regulation of human OGG1 activity in response to cellular oxidative stress, Molecular and cellular biology, 26, 7430, 10.1128/MCB.00624-06 · DOI
- Cortina, 2005, Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria, Experimental eye research, 81, 742, 10.1016/j.exer.2005.04.017 · DOI
- Saitoh, 2001, Enhancement of OGG1 protein AP lyase activity by increase of APEX protein, Mutation research, 486, 31, 10.1016/S0921-8777(01)00078-7 · DOI
- Jin, 2015, Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia, Molecular medicine reports, 11, 4079, 10.3892/mmr.2015.3339 · DOI
- Kershaw, 2012, Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1, Mutagenesis, 27, 501, 10.1093/mutage/ges012 · DOI
- Kaur, 2014, Cellular accumulation of Cys326-OGG1 protein complexes under conditions of oxidative stress, Biochemical and biophysical research communications, 447, 12, 10.1016/j.bbrc.2014.03.044 · DOI
- Luczak, 2013, Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II), Free radical biology & medicine, 65, 262, 10.1016/j.freeradbiomed.2013.06.028 · DOI
- Jin, 2013, Antioxidant N-acetylcysteine protects pancreatic beta-cells against aldosterone-induced oxidative stress and apoptosis in female db/db mice and insulin-producing MIN6 cells, Endocrinology, 154, 4068, 10.1210/en.2013-1115 · DOI
- Ji, 2013, N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes, Asian journal of andrology, 15, 290, 10.1038/aja.2012.129 · DOI
Cited by
Sorted by citations
Wang, D., Cao, L., Zhou, X., Wang, G., Ma, Y., Hao, X., & Fan, H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129381 · Cited by 186
Saliva microbiome alterations in dental fluorosis population
Liu, S., Song, Q., Zhang, C., Li, M., Li, Z., Liu, Y., Xu, L., Xie, X., Zhao, L., Zhang, R., et al. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2180927 · Cited by 24
Metadata
- Authors
- Suzuki, M., Bandoski, C., & Bartlett, J. D.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 89
- Pages
- 369-378
- ISSN
- 0891-5849
- PMC
- PMC4684823
- Cited by
- 216
- References
- 6
- Language
- en
- Funders
- National Health Research Institutes (R01DE018106)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling. https://app.cochat.ai/papers/10.1016/j.freeradbiomed.2015.08.015
- The paper
- Suzuki, M., Bandoski, C., & Bartlett, J. D. (2015). Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2015.08.015