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Nanotechnology-Based Drug Delivery Systems for Honokiol: Enhancing Therapeutic Potential and Overcoming Limitations

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Mitophagy in ischemic heart disease: molecular mechanisms and clinical management

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Extracellular vesicles: opening up a new perspective for the diagnosis and treatment of mitochondrial dysfunction

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Aloe‐Emodin Improves Mitophagy in Alzheimer's Disease via Activating the AMPK / PGC ‐1α/ SIRT3 Signaling Pathway

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Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora

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New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress

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Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3

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Prolonged fluoride exposure induces spatial-memory deficit and hippocampal dysfunction by inhibiting small heat shock protein 22 in mice

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Research progress of dihydromyricetin in the treatment of diabetes mellitus

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Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis

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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

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Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis

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Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship

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Inhibition of Sirt3 activates the cGAS-STING pathway to aggravate hepatocyte damage in hepatic ischemia–reperfusion injury mice

Kong, E., Zhang, Y., Geng, X., Zhao, Y., Yue, W. L., & Feng, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111474 · Cited by 25 · see citing works

NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis

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Advances in SIRT3 involvement in regulating autophagy-related mechanisms

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Roles of SIRT3 in aging and aging-related diseases

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Mitochondrial DNA release mediated by TFAM deficiency promotes copper-induced mitochondrial innate immune response via cGAS-STING signalling in chicken hepatocytes

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Lentinan-loaded GelMA hydrogel accelerates diabetic wound healing through enhanced angiogenesis and immune microenvironment modulation

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Herbal/Natural Compounds Resist Hallmarks of Brain Aging: From Molecular Mechanisms to Therapeutic Strategies

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A review on SIRT3 and its natural small molecule activators as a potential Preventive and therapeutic target

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Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models

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BDE-47 flame retardant exposure induces microglial pyroptosis and cognitive deficits by activating the mtROS-NLRP3 axis via Sirt3 downregulation and is salvaged by honokiol

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Kaixinsan regulates neuronal mitochondrial homeostasis to improve the cognitive function of Alzheimer's disease by activating CaMKKβ-AMPK-PGC-1α signaling axis

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GLT ‐1 downregulation in hippocampal astrocytes induced by type 2 diabetes contributes to postoperative cognitive dysfunction in adult mice

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Gel@CAT-L hydrogel mediates mitochondrial unfolded protein response to regulate reactive oxygen species and mitochondrial homeostasis in osteoarthritis

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The role and therapeutic potential of SIRTs in sepsis

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Probiotic Limosilactobacillus reuteri DSM 17938 Alleviates Acute Liver Injury by Activating the AMPK Signaling via Gut Microbiota–Derived Propionate

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Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer

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Research progress on the role of mitochondria in the process of hepatic ischemia-reperfusion injury

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Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise

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Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease

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The study of honokiol as a natural product-based antimicrobial agent and its potential interaction with FtsZ protein

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Polyphenols targeting multiple molecular targets and pathways for the treatment of vitiligo

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Honokiol Targeting SIRT3 : From Molecular Mechanisms to Therapeutic Opportunities

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Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis

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Honokiol ameliorates silica-induced lung fibrosis by inhibiting macrophage pyroptosis via modulating cGAS/STING signaling

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Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway

Wu, H. K., Feng, L., Wu, H., Wang, L., Xu, H., & Fu, F. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117622 · Cited by 15 · see citing works

Natural products intervene in non-alcoholic fatty liver disease by regulating the AMPK signaling pathway: preclinical evidence and mechanism

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The lactate metabolism and protein lactylation in epilepsy

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Fluoride induces immune-inflammatory disorder in the kidneys via histone lysine crotonylation in vivo

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SIRT3 Represses Vascular Remodeling via Reducing Mitochondrial Ac-CoA Accumulation in Vascular Smooth Muscle Cells

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ZLN005, a PGC-1α Activator, Protects the Liver against Ischemia–Reperfusion Injury and the Progression of Hepatic Metastases

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Unraveling the mechanism of quercetin alleviating BHPF-induced apoptosis in epithelioma papulosum cyprini cells: SIRT3-mediated mitophagy

Chen, S., Wang, Y., Chen, K., Xing, X., Jiang, Q., & Xu, T. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109907 · Cited by 13 · see citing works

One-pot interpenetrating epoxy thermosets from renewable dual biomass to high performance

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Phenotypic screening identified polydatin alleviating cartilage degeneration by modulating SIRT3-dependent mitochondrial dysfunction

Mao, A., Fu, Y., Zhang, M., Wu, J., & Wu, M. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156948 · Cited by 12 · see citing works

Lactucopicrin promotes fatty acid β‐oxidation and attenuates lipid accumulation through adenosine monophosphate‐activated protein kinase activation in free fatty acid‐induced human hepatoblastoma cancer cells

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Vine tea (Ampelopsis grossedentata) ameliorates chronic alcohol-induced hepatic steatosis, oxidative stress, and inflammation via YTHDF2/PGC-1α/SIRT3 axis

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Unraveling the roles of mitochondrial sirtuins in aging-related diseases: From mechanistic insights to therapeutic strategies

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USP14 modulates cell pyroptosis and ameliorates doxorubicin-induced cardiotoxicity by deubiquitinating and stabilizing SIRT3

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Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction

Geng, J., Yuan, Q., Ni, C., Zhang, Y., Liu, X., Zhu, X., Hao, X., Liang, G., Wang, D., & Fan, H. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118396 · Cited by 11 · see citing works

Cryptotanshinone attenuates lactate-induced nucleus pulposus cells injury by modulating the STAT3/SIRT3 signaling axis

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Osteocalcin Ameliorates CUMS ‐Induced Depressive‐Like Behaviors by Reducing Mitochondrial Damage in Hippocampal Neurons

Chen, H., Mao, J., Wang, M., Zhang, Q., Zheng, R., Zhang, Z., Lv, Q., Liu, Q., Wu, Y., & Ma, X. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70530 · Cited by 12 · see citing works

Cellular energy supply for promoting vascular remodeling of small-diameter vascular grafts: a preliminary study of a new strategy for vascular graft development

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Mitochondria-targeted nanoparticles based on glycated oat protein for enhanced curcumin bioavailability and antioxidant activity

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The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradation

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Design of self-assembled micelles based on natural dual-targeting strategies and evaluation of their anti-liver cancer effects as drug delivery systems

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PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons

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Protective effect of honokiol on cadmium-induced liver injury in chickens

Huang, X., Yuan, J., Gu, J., Abbas, Y., Yuan, Y., Liu, Z., Zou, H., & Bian, J. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104066 · Cited by 9 · see citing works

Molecular and immunohistochemical alterations in fluoride-induced neurological impediment in adult rats

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TET1 mitigates prenatal fluoride-induced cognition impairment by modulating Bcl2 DNA hydroxymethylation level

Cai, Y., Zeng, X., Wu, M., Chen, H., Sun, M., & Yang, H. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01174-w · Cited by 9 · see citing works

Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic–reperfusion injury by targeting the NOX2/AMPK pathway

Chen, Y., Guan, B., Lu, J., Yan, X., Huang, C., Qiu, Y., Li, X., Sun, X., Chen, L., Li, W., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1623846 · Cited by 9 · see citing works

Excessive Lysosomal Stress Response and Consequently Impaired Autophagy Contribute to Fluoride-Induced Developmental Neurotoxicity

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SiO2 NP promotes allergic gastritis induced by degranulation of mouse MC9 cell through AQP4-mediated impairment of SIRT3-TFAM deacetylation and mitochondrial autophagy

Lei, Y., Wang, X., Wu, H., Gao, M., Xu, T., & Lin, H. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.139721 · Cited by 8 · see citing works

Therapeutic Potential of Polyphenols in Cellular Reversal of Patho‐Mechanisms of Alzheimer's Disease Using In Vitro and In Vivo Models: A Comprehensive Review

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Fluoride Induces Neurocytotoxicity by Disrupting Lysosomal Iron Metabolism and Membrane Permeability

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Melatonin attenuates scopolamine‐induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway

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Naringin alleviates fluoride-induced neurological impairment: A focus on the regulation of energy metabolism mediated by mitochondrial permeability transition pore

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Fluoride: a double-edged sword in public health and environmental toxicology

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Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA–miRNA–mRNA Interdependent Networks

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Role of the AMPK/PGC-1α/SIRT3-Mediated Mitochondrial Dysfunction in the Neurotoxicity of Methanol

Han, X., Peng, M., Wang, X., Hu, Y., Li, G., Song, Y., Lv, Y., & Chen, N. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05431-1 · Cited by 7 · see citing works

Injectable biodegradable and micelle-incorporated dynamic adhesive hydrogels with sustained honokiol release for postoperative antiadhesion via the combination of a physical barrier and peritoneal mesothelial cell activation

Wu, Y., Zhuo, S., Zhang, Z., Zhao, R., Liu, D., Lin, B., Shi, M., Guo, B., & Zhao, X. (2025) · Science China Technological Sciences · doi:10.1007/s11431-025-3131-y · Cited by 7 · see citing works

Adiponectin receptor agonist AdipoRon alleviates memory impairment in the hippocampus of septic mice

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Electroacupuncture as a promising therapeutic strategy for doxorubicin-induced heart failure: Insights into the PI3K/AKT/mTOR/ULK1 and AMPK /mTOR /ULK1 pathways

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Multiple Mechanisms and Therapeutic Strategies for the Involvement of AMPK in the Development of Alzheimer’s Disease

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Honokiol-Loaded ZIF-90 Nanoparticles Modified with Polydopamine for Antitumor Therapy

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Mechanisms Underlying Memory Impairment Induced by Fructose

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Chondroitin sulfate protects against synaptic impairment caused by fluorosis through the Erk1/2-MMP-9 signaling pathway

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Ameliorative Effects of Urolithin A Against Cadmium-Induced NLRP3-Mediated Pyroptosis and Cognitive Deficits Via Regulating Aryl Hydrocarbon Receptor Signaling

Zhu, Y., Yuan, Q., Geng, J., Hu, J., Zhao, P., Yan, Y., Hu, M. Y., Liu, X., Zhu, X., Wang, D., et al. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04858-w · Cited by 5 · see citing works

Levistilide A from Ligusticum chuanxiong alleviates LPS-induced depression- and anxiety-like behaviors by promoting mitophagy through the SIRT3/PINK1/Parkin pathway

Meng, J., Wei, P., Yang, H., Chen, L., Peng, C., Dai, O., Zhou, Q., & Xiong, L. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.121146 · Cited by 5 · see citing works

Targeting frataxin deficiency in DRG neurons and fibroblasts: omaveloxolone restores metabolic and iron balance to reduce ferroptosis

Portillo-Carrasquer, M., Sanz‐Alcázar, A., Sánchez-López, B., Delaspre, F., Pazos-Gil, M., Oliveira-Jorge, L., Castells‐Roca, L., Tamarit, J., Ros, J., & Cabiscol, E. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119031 · Cited by 5 · see citing works

Revealing the role of honokiol in human glioma cells by RNA-seq analysis

Guo, Y., Liu, X., XU, Q., ZHOU, X., Liu, J., XU, Y., LU, Y., & LIU, H. (2024) · Biocell · doi:10.32604/biocell.2024.049748 · Cited by 5 · see citing works

Revitalizing mitochondrial function and empowering spinal cord recovery using copper-catalyzed Pdots

Zhao, B., Wang, F., Sun, J., Gao, J., Zhao, L., Shen, Z., Li, Z., Wang, Y., Wang, Y., Li, D., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.148264 · Cited by 5 · see citing works

Engineering nature's defense: Phosphorylated Scutellaria baicalensis Georgi polysaccharide rescue mitochondrial dysfunction and hepatic damage in DHAV-1-infected ducklings

Hu, M., Guan, S., Fu, X., Wang, K., Gu, B., Liu, X., Liu, X., Yan, Z., Chen, Z., & Liu, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147710 · Cited by 4 · see citing works

Interaction between home and community-based services and PM2.5 on cognition: A prospective cohort study of Chinese elderly

Zhang, H., Ni, R., Cao, Y., Chen, Y., Fang, W., Hu, W., & Pan, G. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116048 · Cited by 4 · see citing works

Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver

Xing, Y., Ge, J., Wang, Y., Zhou, X., Yuan, Z., Lv, M., Zhao, M., Liu, L., Gong, D., Geng, T., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137222 · Cited by 4 · see citing works

Sirtuin 3-mediated deacetylation of superoxide dismutase 2 ameliorates sodium fluoride-induced mitochondrial dysfunction in porcine oocytes

Qi, X.-Y., Yuan, J.-D., Liu, Z., Jiang, X.-Q., Zhang, Q., Zhang, S.-L., Zhao, L., Ke, L.-Y., Zhang, C.-Y., Li, Y., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168306 · Cited by 17 · see citing works

Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response

Hou, M., Bao, W., Gao, Y., Chen, J., & Song, G. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109741 · Cited by 56 · see citing works

Sirt3-mediated mitochondrial dysfunction is involved in fluoride-induced cognitive deficits

Wang, D., Cao, L., Pan, S., Wang, G., Wang, L., Cao, N., & Hao, X. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112665 · Cited by 43 · see citing works

SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

Ye, J., Chen, L., Lu, Y., Lei, S., Peng, M., & Xia, Z. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13053 · Cited by 104 · see citing works

Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH‐SY5Y cells

Tang, Z., Lai, C., Luo, J., Ding, Y., Chen, Q., & Guan, Z. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22705 · Cited by 26 · see citing works