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Transient Receptor Potential Ankyrin 1 Channel Expression on Peripheral Blood Leukocytes from Rheumatoid Arthritic Patients and Correlation with Pain and Disability

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Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: Transformation into a neoplastic-like phenotype

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Cell-Free NADPH Oxidase Activation Assays: “In Vitro Veritas”

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Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1

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Receptor mediated disruption of retinal pigment epithelium function in acute glycated-albumin exposure

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Behaviour of human osteoblastic cells cultured on plasma‐sprayed titanium implants in the presence of nicotine

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The combined effects of sidestream smoke extracts and glycated serum albumin on endothelial cells and platelets

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Genotoxicity testing of extracts of a Swedish moist oral snuff

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Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses

Antognelli, C., Gambelunghe, A., Buono, C., Murgia, N., Talesa, V. N., & Muzi, G. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.08.002 · Cited by 23 · see citing works

Complex osteoclastogenic inductive effects of nicotine over hydroxyapatite

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Recent advances in understanding the roles of transglutaminase 2 in alcoholic steatohepatitis

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Induction of Cross-Linking and Silencing of Sp1 by Transglutaminase during Liver Injury in ASH and NASH via Different ER Stress Pathways

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A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls

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Nicotine Reduces the Cytotoxic Effect of Glycated Proteins on Microglial Cells

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Effect of nicotine in matrix mineralization by human bone marrow and Saos‐2 cells cultured on the surface of plasma‐sprayed titanium implants

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Low level nicotine: A novel approach to reduce osteoporosis incidence

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Comparison of the effects of nicotine upon the transcellular electrical resistance and sucrose permeability of human ECV304/rat C6 co-cultures and human CaCo2 cells

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Protective effects of honokiol against methylglyoxal-induced osteoblast damage

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Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target

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Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity

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Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators

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Associations between smoke exposure and osteoporosis or osteopenia in a US NHANES population of elderly individuals

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Diabetes mellitus promotes susceptibility to periodontitis—novel insight into the molecular mechanisms

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The role of RAGE in host pathology and crosstalk between RAGE and TLR4 in innate immune signal transduction pathways

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Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke

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Osteoporosis in COPD patients: Risk factors and pulmonary rehabilitation

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An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis

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Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer

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Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis: Role of Advanced Glycation End Products

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Osteonectin regulates the extracellular matrix mineralization of osteoblasts through P38 signaling pathway

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Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme

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Cytotoxicity of universal dental adhesive systems: Assessment in vitro assays on human gingival fibroblasts

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Extrapulmonary Comorbidities Associated with Chronic Obstructive Pulmonary Disease: A Review

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Carbonyl Stress in Red Blood Cells and Hemoglobin

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Heat‐not‐burn tobacco (IQOS), oral fibroblasts and keratinocytes: cytotoxicity, morphological analysis, apoptosis and cellular cycle. An in vitro study

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Bisphosphonates Reduce Smoking-Induced Osteoporotic-Like Alterations by Regulating RANKL/OPG in an Osteoblast and Osteoclast Co-Culture Model

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Antioxidant Properties of Cerium Oxide Nanoparticles Prevent Retinal Neovascular Alterations In Vitro and In Vivo

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Prevalence and Risk Factors of Osteoporosis: A Cross-Sectional Study in a Tertiary Center

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Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

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Combined Treatment of Monopolar and Bipolar Radiofrequency Increases Skin Elasticity by Decreasing the Accumulation of Advanced Glycated End Products in Aged Animal Skin

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Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro

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Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis

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A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts

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Nontobacco Nicotine Dependence and Rates of Periprosthetic Joint Infection and Other Postoperative Complications in Shoulder Arthroplasty: A Retrospective Analysis

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Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases

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The impact of E-cigarette vaping and vapour constituents on bone health

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Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations

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Morpho-functional effects of different universal dental adhesives on human gingival fibroblasts: an in vitro study

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E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model

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Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity

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Testosterone and Follicle Stimulating Hormone–Dependent Glyoxalase 1 Up-Regulation Sustains the Viability of Porcine Sertoli Cells through the Control of Hydroimidazolone– and Argpyrimidine-Mediated NF-κB Pathway

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Curcumin Prevents Diabetic Osteoporosis through Promoting Osteogenesis and Angiogenesis Coupling via NF-κB Signaling

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The RAGE signaling in osteoporosis

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Methylglyoxal activates osteoclasts through JNK pathway leading to osteoporosis

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Do E-cigarettes and vaping have a lower risk of osteoporosis, nonunion, and infection than tobacco smoking?

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Role of Advanced Glycation End-Products and Other Ligands for AGE Receptors in Thyroid Cancer Progression

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Influence of nicotine on orthodontic tooth movement: A systematic review of experimental studies in rats

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Role of toll-like receptor 4 in the regulation of the cell death pathway and neuroinflammation

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Metastatic Prostate Cancer Cells Secrete Methylglyoxal-Derived MG-H1 to Reprogram Human Osteoblasts into a Dedifferentiated, Malignant-like Phenotype: A Possible Novel Player in Prostate Cancer Bone Metastases

Antognelli, C., Marinucci, L., Frosini, R., Macchioni, L., & Talesa, V. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910191 · Cited by 20 · see citing works

Alpha7 Nicotinic Acetylcholine Receptor Mediates Nicotine-induced Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma HepG2 Cells

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α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells

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Redox-Sensitive Glyoxalase 1 Up-Regulation Is Crucial for Protecting Human Lung Cells from Gold Nanoparticles Toxicity

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Predicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish Experiments

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The Effects of Nicotine- and Cigarette-Related Products on Osteogenesis, Bone Formation, and Bone Mineralization: A Systematic Review

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Assessment of advanced glycation end products in the peri‐implant sulcular fluid among moderate cigarette‐smokers and nonsmokers with peri‐implantitis

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Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts

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Molecular Assessment of Methylglyoxal-Induced Toxicity and Therapeutic Approaches in Various Diseases: Exploring the Interplay with the Glyoxalase System

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Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels

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The impact of electronic cigarettes on the outcomes of total joint arthroplasty

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Vaping Trends and Outcomes in Primary Total Joint Arthroplasty Patients: An Analysis of 21,341 Patients

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Tobacco heating system has less impact on bone metabolism than cigarette smoke

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Toxicity and underlying mechanism of the toxic dinoflagellate Gambierdiscus caribaeus to the fish Oryzias melastigma

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Smoking index and COPD duration as potential risk factors for development of osteoporosis in patients with non-small cell lung cancer – A retrospective case control study evaluated by CT Hounsfield unit

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Nicotine as a female reproductive toxicant—A review

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Expression of REGγ in atherosclerotic plaques and promotes endothelial cells apoptosis via the cyclophilin A pathway indicates functional implications in atherogenesis

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Chebulic Acid Prevents Methylglyoxal-Induced Mitochondrial Dysfunction in INS-1 Pancreatic β-Cells

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Effects of nicotine on porcine pre-pupertal sertoli cells: An in vitro study

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Bone Marrow Adiposity Assessed by HRpQCT Is Related to Fracture Risk and Bone Mineral Density in Older Swedish Women

Zoulakis, M., Axelsson, K. F., Litsne, H., Johansson, L., & Lorentzon, M. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf216 · Cited by 9 · see citing works

Antiglycative Activity and RAGE Expression in Rett Syndrome

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E-Cigarette Usage and Arthritis in the United States, a Nationwide Cross-Sectional Survey

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Action of a deproteinized xenogenic biomaterial in the process of bone repair in rats submitted to inhalation of cigarette smoke

Buchaim, D. V., Bueno, P. C. D. S., Andreo, J. C., Roque, D. D., Roque, J. S., Zilio, M. G., Salatin, J. A., Kawano, N., Furlanette, G., & Buchaim, R. L. (2018) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-865020180040000004 · Cited by 8 · see citing works

Formation of advanced glycation end‐products in glycation of silver carp myofibrillar protein with glucose: Relationship with its chemical indicators

Ren, Y., Mao, Z., Zhang, Q., Dong, S., Zha, F., & Chen, B. (2022) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16136 · Cited by 8 · see citing works

PTEN/PKM2/ERα-Driven Glyoxalase 1 Overexpression Sustains PC3 Prostate Cancer Cell Growth Through MG-H1/RAGE Pathway Desensitization Leading to H2O2-Dependent KRIT1 Downregulation

Manfredelli, D., Torcoli, C., Pariano, M., Bellezza, G., Baroni, T., Talesa, V. N., Sidoni, A., & Antognelli, C. (2025) · Antioxidants · doi:10.3390/antiox14091120 · Cited by 7 · see citing works

Association between Maternal Smoking during Pregnancy and Missing Teeth in Adolescents

Kang, J. N., Yasuda, Y. U., Ogawa, T., Sato, M., Yamagata, Z., Fujiwara, T., & Moriyama, K. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16224536 · Cited by 7 · see citing works

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein S1 Induces Methylglyoxal-Derived Hydroimidazolone/Receptor for Advanced Glycation End Products (MG-H1/RAGE) Activation to Promote Inflammation in Human Bronchial BEAS-2B Cells

Manfredelli, D., Pariano, M., Costantini, C., Graziani, A., Bozza, S., Romani, L. R., Puccetti, P., Talesa, V. N., & Antognelli, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914868 · Cited by 7 · see citing works

Associations among health-related quality of life, mental resilience and social support in patients early after surgery for osteoporotic vertebral compression fractures: a longitudinal study

Wang, A., Wu, C., Tang, D., Zhao, J., Yang, S., Fang, H. Q., & Jiang, L. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-084781 · Cited by 7 · see citing works

E-cigarette aerosol exposure effect on bone biomechanical properties in murine models

Morgan, M., Farra, Y. M., Vergara-Anglim, A., Bellini, C. M., Oakes, J. M., & Shefelbine, S. J. (2023) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2023.111879 · Cited by 6 · see citing works

Insights into the pathogenesis of nicotine addiction. Could a salivary biosensor be useful in Nicotine Replacement Therapy (NRT)?

Băbțan, A.-M., Petrescu, N. B., Ionel, A., Boşca, A. B., Uriciuc, W. A., Feurdean, C. N., Mirica, C., Bordea, I. R., Miclaus, V., Ruxanda, F., et al. (2019) · Journal of Mind and Medical Sciences · doi:10.22543/7674.62.p196209 · Cited by 6 · see citing works

Tobacco and Alternative Nicotine Products and Their Regulation

Neuberger, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-57499-4_124 · Cited by 8 · see citing works

Role of saturated and unsaturated fatty acids on dicarbonyl–albumin derived advanced glycation end products in vitro

Peake, B., Ghetia, M., Gerber, C., Costabile, M., & Deo, P. (2021) · Amino Acids · doi:10.1007/s00726-021-03069-6 · Cited by 5 · see citing works

The dual role of nicotine in the development and progression of hepatocellular carcinoma

Li, Z., Ding, H., Hu, Y., Zhang, Z., & Wang, H. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117256 · Cited by 4 · see citing works

The mediating role of inflammation in the association between cotinine levels and remnant cholesterol: a cross-sectional study

Lai, T., Su, Z., Tian, G., Sun, J., & Hu, K. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02372-x · Cited by 3 · see citing works

Non-tobacco nicotine dependence increases risk of complications following lumbar spine decompression and fusion

Spitzer, C., Romoff, M. R., Brunette, M., Peterson, M. K., Ton, A. T., Le, R. K., Sharma, A. K., Chan, J. P., Wu, H., Hashmi, S. K., et al. (2025) · North American Spine Society Journal (NASSJ) · doi:10.1016/j.xnsj.2025.100790 · Cited by 3 · see citing works

Non-tobacco nicotine dependence and rates of perioperative complications in operatively treated unicondylar tibial plateau fractures: A retrospective, propensity-matched cohort analysis

Eghtedari, C. F., Good, L., Florentino, S. A., Berk, A. N., Adelstein, J. M., Hirpara, A., Wetzel, R. J., Ochenjele, G., & Napora, J. K. (2025) · Injury · doi:10.1016/j.injury.2025.112889 · Cited by 3 · see citing works

Inflammatory impact of cigarette smoking on bone function and structure; a review of evidence

Shahbaz, Y., Shirmohammadi, R., Shamsghahfarokhi, S., Esfahani, H., Forghan, M., Jelodar, H. E., Ashrafi, L., & Mousavi, M. (2025) · Journal of Parathyroid Disease · doi:10.34172/jpd.2025.13302 · Cited by 3 · see citing works

Association between the serum cotinine and trabecular bone score in the adult population: A cross-sectional study

Bao, S., Jimu, W., Mu, N., Yan, F., Xing, S., & Zhou, Z. (2024) · Tobacco Induced Diseases · doi:10.18332/tid/194680 · Cited by 3 · see citing works

Impact of Nicotine Dependence on Postoperative Outcomes in Pilon Fracture Open Reduction and Internal Fixation: A Comparative Cohort Analysis

Wang, J., Cambre, B. N., Cho, D. H., Dugan, A. L. M., Panchbhavi, V., Wang, A. S., & Panchbhavi, V. K. (2025) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000003085 · Cited by 3 · see citing works

A Mechanistic Review of Nicotine Toxicity with Recent Updates

Ahmadi, Z. (2019) · International Journal of Biochemistry & Physiology · doi:10.23880/ijbp-16000155 · Cited by 3 · see citing works

Analysis of the toxicity and mechanisms of osteoporosis caused by cigarette toxicants using network toxicology and molecular docking techniques

Xie, W., Song, C., Hao, P., Li, F., Hou, X., Chen, J., Liu, Z., & Wang, Z. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.180414 · Cited by 2 · see citing works

The effect of non-tobacco nicotine on bone healing: a systematic review and application to total joint arthroplasty

Travis, L. M., Cacciatore, J. C., Schuster, J. A., Khan, F. A., Stern, J. M., Moore, M. R., Hneiny, L., Hernandez, V. H., & McNamara, C. (2026) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-026-06733-3 · Cited by 2 · see citing works

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Pramoda, G., Shivhare, K., Gupta, P. K., Sahebkar, A., Kesharwani, P., & Shukla, R. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71155 · Cited by 2 · see citing works

Tobacco and Alternative Nicotine Products and Their Regulation

Neuberger, M. (2020) · Springer eBooks · doi:10.1007/978-3-642-36206-4_124-1 · Cited by 2 · see citing works

Complex interactions between nicotine and resveratrol in the Drosophila melanogaster wing spot test

Velazquez-Ulloa, N. A., Heres-Pulido, M. E., Santos-Cruz, L. F., Durán-Díaz, Á., Castañeda-Partida, L., Browning, A., Carmona-Alvarado, C., Estrada-Guzmán, J. C., Ferderer, G., Garfias, M., et al. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09744 · Cited by 2 · see citing works

Boron’s Role in B16-F10 Melanoma: Cytotoxic, Antioxidant, Apoptotic, and Anti-inflammatory Effects

Varol, M., Subaşı, B., Gündüz, M. K., & Yerlikaya, A. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04750-7 · Cited by 1 · see citing works

Postoperative Outcomes After Ankle Fracture ORIF in Patients With Documented Nicotine and/or Cannabis Use: An Observational Analysis

Le, Y., Rowshan, A. P., Fleuriscar, J., Hsu, N. N., & Aiyer, A. A. (2025) · Foot & Ankle International · doi:10.1177/10711007251393661 · Cited by 1 · see citing works

Smoked nicotine dependence elevates risk of nonunion and revision surgery following bimalleolar ankle fracture ORIF: a propensity‑matched 90‑day and 2‑year TriNetX analysis

Wang, J., Nguyen, P., Iyer, S., Patel, A., Panchbhavi, V., Patel, S., & Panchbhavi, V. K. (2025) · European Journal of Orthopaedic Surgery & Traumatology · doi:10.1007/s00590-025-04644-3 · Cited by 2 · see citing works

Unraveling the mechanisms of nicotine-induced osteoporosis via network toxicology, bioinformatics, and molecular docking

Xu, S. H., Wang, G., Liu, J., Zhang, X., Dong, X., Liang, J. H., & Bai, T. (2026) · Tobacco Induced Diseases · doi:10.18332/tid/215177 · Cited by 1 · see citing works

Exploring the radiosensitizing potential of AZD8931: a pilot study on the human LoVo colorectal cancer cell line

Antognelli, C., Palumbo, I., Piattoni, S., Calzuola, M., Papa, B. D., Talesa, V. N., & Aristei, C. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1820610 · Cited by 1 · see citing works

First Ecuadorian statement consensus for the evaluation and treatment of osteoporosis

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Research Progress of Related Factors and Prevention of Surgical Site Infection after Spinal Surgery

沈, 万. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1381803

Associations among early health-related quality of life, mental resilience, and social support in patients after surgery for osteoporotic vertebral compression fractures: a longitudinal studyPreprint

Wang, A., Tang, D., Zhao, J., Yang, S., Fang, H., & Jiang, L. (2024) · Research Square · doi:10.21203/rs.3.rs-3922990/v1

Evaluation of Tobacco heating system (THS) during closed lower limb fracture healing in trauma smokers’ patientsPreprint

Herbst, M., Aspera-Werz, R. H., Braun, B. J., Schulz, K., Rollmann, M. F. R., Histing, T., & Nussler, A. K. (2024) · Research Square · doi:10.21203/rs.3.rs-4241378/v1

Evaluation of the Tobacco Heating System (THS) During Closed Lower Limb Fracture Healing in Trauma Smokers’ PatientsPreprint

Herbst, M., Aspera-Werz, R. H., Braun, B. J., Schulz, K., Rollmann, M. F. R., Histing, T., & Nussler, A. K. (2024) · Qeios · doi:10.32388/de0eae

Evaluation of the Tobacco Heating System (THS) During Closed Lower Limb Fracture Healing in Trauma Smokers’ PatientsPreprint

Herbst, M., Aspera-Werz, R. H., Braun, B. J., Schulz, K., Rollmann, M. F. R., Histing, T., & Nussler, A. K. (2024) · Qeios · doi:10.32388/de0eae.2

Association of a Body Shape Index with Bone Mineral Density and Osteoporosis Among U.S. Adults: Evidence from NHANES

Niu, H.-G., Hu, G.-K., Li, T., Guo, Z. J., Hu, Y., Gong, Y.-K., Ye, G., Chen, D.-J., An, J., & Gao, W. (2025) · Calcified Tissue International · doi:10.1007/s00223-025-01386-6

Narrative review: pathological mechanisms of smoking-related chronic periodontitis effects of nicotine on periodontal ligament stem cell function

Xu, J., Huang, W., & Hu, X. (2025) · All Life · doi:10.1080/26895293.2025.2601461

NonTobacco Nicotine Dependence Is Associated With Increased Fracture Risk in Adolescents and Young Adults

Zhang, J., Meydan, Y., Chen, B., & Barsi, J. M. (2026) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000003220 · Cited by 1 · see citing works

Effects of nicotine on the metabolism and gene expression profile of Sprague‑Dawley rat primary osteoblasts

Liang, D., Wang, K., Tang, Z., Liu, R., Zeng, F., Cheng, M., Lian, Q., & Wu, H. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8884 · Cited by 21 · see citing works

Peroxisome proliferator-activated receptor delta agonist attenuates nicotine suppression effect on human mesenchymal stem cell-derived osteogenesis and involves increased expression of heme oxygenase-1

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Complex osteoclastogenic inductive effects of nicotine over hydroxyapatite

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Nicotine induced proliferation and cytokine release in osteoblastic cells

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EFFECT OF NICOTINE ON OSTEOCLASTOGENESIS

Pfeifer, P. C., & Yee, J. A. (2003) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200305001-00681