The role of RAGE in host pathology and crosstalk between RAGE and TLR4 in innate immune signal transduction pathways

Prantner, Daniel; Nallar, Shreeram; Vogel, Stefanie N.

doi:10.1096/fj.202002136r

Cited by 93Advanced Glycation End Products researchImmune Response and InflammationInflammation biomarkers and pathways

The role of RAGE in host pathology and crosstalk between RAGE and TLR4 in innate immune signal transduction pathways

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Prantner, Daniel, Nallar, Shreeram, Vogel, Stefanie N.·2020·The FASEB Journal

DOI 10.1096/fj.202002136rPMC PMC8121140

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Abstract

Although the innate immune receptor protein, Receptor for Advanced Glycation End products (RAGE), has been extensively studied, there has been renewed interest in RAGE for its potential role in sepsis, along with a host of other inflammatory diseases of chronic, noninfectious origin. In contrast to other innate immune receptors, for example, Toll‐like receptors (TLRs), that recognize ligands derived from pathogenic organisms that are collectively known as “pathogen‐associated molecular patterns” (PAMPs) or host‐derived “damage‐associated molecular patterns” (DAMPs), RAGE has been shown to recognize a broad collection of DAMPs exclusively. Historically, these DAMPs have been shown to be pro‐inflammatory in nature. Early studies indicated that the adaptor molecule, MyD88, might be important for this change. More recent studies have explored further the mechanisms underlying this inflammatory change. Overall, the newer results have shown that there is extensive crosstalk between RAGE and TLRs. The three canonical RAGE ligands, Advanced Glycation End products (AGEs), HMGB1, and S100 proteins, have all been shown to activate both TLRs and RAGE to varying degrees in order to induce inflammation in in vitro models. As with any field that delves deeply into innate signaling, obstacles of reagent purity may be a cause of some of the discrepancies in the literature, and we have found that commercial antibodies that have been widely used exhibit a high degree of nonspecificity. Nonetheless, the weight of published evidence has led us to speculate that RAGE may be physically interacting with TLRs on the cell surface to elicit inflammation via MyD88‐dependent signaling.

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Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation
Evankovich, J. W., Lear, T., McKelvey, A. C., Dunn, S. R., Londino, J. D., Liu, Y., Chen, B. B., & Mallampalli, R. K. (2017) · The FASEB Journal · doi:10.1096/fj.201700031r · Cited by 20 · see citing works
Antifibrotic properties of receptor for advanced glycation end products in idiopathic pulmonary fibrosis
Ding, H. J., Ji, X., Chen, R., Ma, T., Tang, Z., Fen, Y., & Cai, H. (2015) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2015.10.010 · Cited by 19 · see citing works
Chronic Alcohol Ingestion Impairs Rat Alveolar Macrophage Phagocytosis via Disruption of RAGE Signaling
Staitieh, B. S., Egea, E. E., Fan, X., Amah, A., & Guidot, D. M. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2017.12.013 · Cited by 18 · see citing works
Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo
Lee, Y. R., Park, M. S., Joo, H. K., Kim, K. M., Kim, J. R., Jeon, B. H., & Choi, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-27025-9 · Cited by 18 · see citing works
Limited Role of the Receptor for Advanced Glycation End Products during Streptococcus pneumoniae Bacteremia
Achouiti, A., de Vos, A. F., de Beer, R., Florquin, S., Veer, C. V. ′., & van der Poll, T. (2013) · Journal of Innate Immunity · doi:10.1159/000348739 · Cited by 17 · see citing works
Profilin-1 contributes to cardiac injury induced by advanced glycation end-products in rats
Yang, D., Liu, W., Ma, L., Wang, Y., Ma, J., Jiang, M., Deng, X., Huang, F., Yang, T., & Chen, M. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7446 · Cited by 17 · see citing works
HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa -Infected Mice
Ekanayaka, S. A., McClellan, S. A., Peng, X., Barrett, R. P., Francis, R., & Hazlett, L. D. (2018) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2018.0073 · Cited by 16 · see citing works
Gene doubling increases glyoxalase 1 expression in RAGE knockout mice
Bartling, B., Zunkel, K., Al‐Robaiy, S., Dehghani, F., & Simm, A. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.129438 · Cited by 13 · see citing works
Association between RAGE variants and the susceptibility to atherosclerotic lesions in Chinese Han population
Zhang, X., Cheng, M., Tong, F., & Su, X. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7163 · Cited by 10 · see citing works
Aging‐associated genes and let‐7 microRNAs: a contribution to myogenic program dysregulation in oculopharyngeal muscular dystrophy
Cappelletti, C., Galbardi, B., Bruttini, M., Salerno, F., Canioni, E., Pasanisi, M. B., Rodolico, C., Brizzi, T., Mora, M., Renieri, A., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201801577rr · Cited by 10 · see citing works
Antiglycative Activity and RAGE Expression in Rett Syndrome
Cordone, V., Pecorelli, A., Benedusi, M., Santini, S. J., Falone, S., Hayek, J., Amicarelli, F., & Valacchi, G. (2019) · Cells · doi:10.3390/cells8020161 · Cited by 9 · see citing works
Advanced glycation endproducts induce self- and cross-tolerance in monocytes
Uhle, F., Weiterer, S., Siegler, B. H., Brenner, T., Lichtenstern, C., & Weigand, M. A. (2017) · Inflammation Research · doi:10.1007/s00011-017-1076-9 · Cited by 6 · see citing works
Increased pulmonary vascular expression of receptor for advanced glycation end products (RAGE) in experimental congenital diaphragmatic hernia
Hofmann, A., Friedmacher, F., Takahashi, T., Gosemann, J., & Puri, P. S. (2015) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2015.02.024 · Cited by 5 · see citing works
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA
Sirois, C. M., Jin, T., Miller, A. L., Bertheloot, D., Nakamura, H., Horvath, G. L., Mian, A., Jiang, J., Schrum, J. E., Bossaller, L., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.2012020104182014c · Cited by 4 · see citing works
Understanding heterogeneity in the host response to Staphylococcus aureus infection for prognostic biomarker discovery
Dinoso, J. B., Gutierrez, J., Choy, D., Kummerfeld, S., Baruch, A., Chambers, H., & Rosenberger, C. (2014) · Critical Care · doi:10.1186/cc14017 · Cited by 2 · see citing works

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The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes
Erusalimsky, J. D. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101958 · Cited by 131 · see citing works
PAMPs and DAMPs in Sepsis: A Review of Their Molecular Features and Potential Clinical Implications
Cicchinelli, S., Pignataro, G., Gemma, S., Piccioni, A., Picozzi, D., Ojetti, V., Franceschi, F., & Candelli, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020962 · Cited by 128 · see citing works
The Role of Extracellular HSP70 in the Function of Tumor-Associated Immune Cells
Linder, M., & von Strandmann, E. P. (2021) · Cancers · doi:10.3390/cancers13184721 · Cited by 81 · see citing works
TIRAP in the Mechanism of Inflammation
Rajpoot, S., Wary, K. K., Ibbott, R., Liu, D., Saqib, U., Thurston, T. L. M., & Baig, M. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697588 · Cited by 79 · see citing works
Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases
Guarneri, F., Custurone, P., Papaianni, V., & Gangemi, S. (2021) · Antioxidants · doi:10.3390/antiox10010082 · Cited by 65 · see citing works
Inhibitory pattern recognition receptors
Rumpret, M., von Richthofen, H. J., Peperzak, V., & Meyaard, L. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211463 · Cited by 51 · see citing works
A Narrative Review of Key Risk Factors for Severe Illness Following SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus Infection
Branche, A. R., Ramesh, M. S., & Francis, B. M. (2024) · Infectious Diseases and Therapy · doi:10.1007/s40121-024-01081-3 · Cited by 49 · see citing works
Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy
Dharmarajan, S., Carrillo, C., Qi, Z., Wilson, J. M., Baucum, A. J., Sorenson, C. M., Sheibani, N., & Belecky‐Adams, T. L. (2023) · Diabetologia · doi:10.1007/s00125-023-05995-4 · Cited by 44 · see citing works
Leveling Up the Controversial Role of Neutrophils in Cancer: When the Complexity Becomes Entangled
Sionov, R. V. (2021) · Cells · doi:10.3390/cells10092486 · Cited by 42 · see citing works
Emodin alleviates sepsis‐mediated lung injury via inhibition and reduction of NF ‐ kB and HMGB1 pathways mediated by SIRT1
Liu, F., Gu, T., & Wei, D. (2021) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12476 · Cited by 41 · see citing works
Pleiotropic Actions of Aldehyde Reductase (AKR1A)
Fujii, J., Homma, T., Miyata, S., & Takahashi, M. (2021) · Metabolites · doi:10.3390/metabo11060343 · Cited by 42 · see citing works
Innate Immunity: A Balance between Disease and Adaption to Stress
Faenza, I., & Blalock, W. L. (2022) · Biomolecules · doi:10.3390/biom12050737 · Cited by 34 · see citing works
Calprotectin: The Link Between Acute Lung Injury and Gastrointestinal Injury in Covid-19: Ban or Boon
Alexiou, A. T., Batiha, G. E., Al-Kuraishy, H. M., Al-Gareeb, A. I., & Al‐Niemi, M. S. (2022) · Current Protein and Peptide Science · doi:10.2174/1389203723666220610124303 · Cited by 33 · see citing works
Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation
Gopalakrishnan, A., Joseph, J., Shirey, K. A., Keegan, A. D., Boukhvalova, M. S., Vogel, S. N., & Blanco, J. C. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968336 · Cited by 33 · see citing works
Self-citation
Granisetron attenuates liver injury and inflammation in a rat model of cecal ligation and puncture-induced sepsis
Abo‐Youssef, A. M., Mohammad, M. K., Abo‐Saif, A. A., & Messiha, B. A. S. (2021) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2021.08.005 · Cited by 32 · see citing works
Dietary advanced glycation end-products promote food allergy by disrupting intestinal barrier and enhancing Th2 immunity
Zhang, Q., Yu, G., Jiang, Y., Shi, H. N., Yang, X., Gao, Z., Wang, Q., Sun, J., Wang, C., Li, Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60235-0 · Cited by 31 · see citing works
Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-κB and HMGB1 signaling pathways in rats
Lebda, M. A., Elmassry, I. H., Taha, N., & Elfeky, M. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16309-9 · Cited by 30 · see citing works
Role of pattern recognition receptors in chemotherapy-induced neuropathic pain
Araldi, D., Khomula, E. V., Bonet, I. J. M., Bogen, O., Green, P. G., & Levine, J. D. (2023) · Brain · doi:10.1093/brain/awad339 · Cited by 29 · see citing works
The Receptor for Advanced Glycation Endproducts (RAGE) and Its Ligands S100A8/A9 and High Mobility Group Box Protein 1 (HMGB1) Are Key Regulators of Myeloid-Derived Suppressor Cells
Ostrand‐Rosenberg, S., Huecksteadt, T. P., & Sanders, K. A. (2023) · Cancers · doi:10.3390/cancers15041026 · Cited by 27 · see citing works
Is it all the RAGE ? Defining the role of the receptor for advanced glycation end products in Parkinson's disease
Gasparotto, J., Somensi, N., Girardi, C. S., Bittencourt, R. R., de Oliveira, L. M., Hoefel, L. P. L., Scheibel, I. M., Peixoto, D. O., Moreira, J. C. F., Outeiro, T. F., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15890 · Cited by 26 · see citing works
Enhanced intra-articular therapy for rheumatoid arthritis using click-crosslinked hyaluronic acid hydrogels loaded with toll-like receptor antagonizing peptides
Lee, S. W., Seo, J., Kim, Y. H., Ju, H. J., Kim, S., Ji, Y. B., Lee, H. B., Kim, H. S., Choi, S., & Kim, H. S. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.10.023 · Cited by 25 · see citing works
RAGE and αVβ3-integrin are essential for suPAR signaling in podocytes
Kim, E. Y., & Dryer, S. E. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166186 · Cited by 23 · see citing works
The Novel MyD88 Inhibitor TJ-M2010-5 Protects Against Hepatic Ischemia-reperfusion Injury by Suppressing Pyroptosis in Mice
Zou, Z., Shang, R., Zhou, L., Du, D., Yang, Y., Xie, Y., Li, Z., Zhao, M., Jiang, F., Zhang, L., et al. (2022) · Transplantation · doi:10.1097/tp.0000000000004317 · Cited by 21 · see citing works
RAGE–TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages
Yan, L., Li, Y., Tan, T., Qi, J., Fang, J. S., Guo, H., Ren, Z., Gou, L., Geng, Y., Cui, H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087007 · Cited by 21 · see citing works
Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish
Petrie-Hanson, L., & Peterman, A. E. (. (2022) · Pathogens · doi:10.3390/pathogens11101140 · Cited by 19 · see citing works
Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy
Yang, X., Jia, R., Hu, F., Fan, W., Lin, T., Zhang, X., Xu, C., Ruan, S., Jiang, C., Li, Y., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01100-9 · Cited by 17 · see citing works
The Prolonged Activation of the p65 Subunit of the NF-Kappa-B Nuclear Factor Sustains the Persistent Effect of Advanced Glycation End Products on Inflammatory Sensitization in Macrophages
de Assis, S. I. S., Amendola, L., Okamoto, M. M., Ferreira, G. D. S., Iborra, R. T., Santos, D. R., Santana, M. D. F. M., Santana, K. G., Corrêa‐Giannella, M. L., Barbeiro, D. F., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052713 · Cited by 17 · see citing works
Dysregulation of Host–Pathogen Interactions in Sepsis: Host-Related Factors
Joosten, S. C. M., Wiersinga, W. J., & van der Poll, T. (2024) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0044-1787554 · Cited by 15 · see citing works
Ferritinophagy in inflammatory and autoimmune diseases: Mechanistic insights and therapeutic potentials
Wang, Y. Q., Li, Y., Jiang, J., Hong, Y., Gao, S., & Hua, C. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103954 · Cited by 15 · see citing works
Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring
Govindarajah, V., Sakabe, M., Good, S., Solomon, M. P., Arasu, A., Chen, N., Zhang, X., Grimes, H. L., Kendler, A., Xin, M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci169730 · Cited by 15 · see citing works
Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice
Kitaoka, S., Tomohiro, A., Ukeshima, S., Liu, K., Wake, H., Kimura, S. H., Yamamoto, Y., Nishibori, M., & Furuyashiki, T. (2023) · Cells · doi:10.3390/cells12131789 · Cited by 15 · see citing works
Role of RAGE and its ligand HMGB1 in the development of COPD
Chen, L., Sun, X., & Zhong, X. (2022) · Postgraduate Medicine · doi:10.1080/00325481.2022.2124087 · Cited by 14 · see citing works
Combining bioinformatics and multiomics strategies to investigate the key microbiota and active components of Liupao tea ameliorating hyperlipidemia
Zhou, H., Wang, X., She, Z., Huang, L., Wei, H., Yang, S., Wei, Z., Chen, H., Yang, B. H., Hu, Z., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118438 · Cited by 14 · see citing works
Mitigation of sepsis-induced liver injury by Clemastine via modulating GSDMD/NLRP-3/Caspase-1/NF-κB signalling pathways
Abdelnaser, M., Attya, M. E., Elrehany, M. A., & Fathy, M. (2025) · European journal of medical research · doi:10.1186/s40001-025-02982-w · Cited by 14 · see citing works
Potential antiviral activities of chrysin against hepatitis B virus
Bhat, S. A., Hasan, S. K., Parray, Z. A., Siddiqui, Z. I., Ansari, S., Anwer, A., Khan, S., Amir, F., Mehmankhah, M., Islam, A., et al. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00531-6 · Cited by 13 · see citing works
Quantitative Assessment of Intracellular Effectors and Cellular Response in RAGE Activation
Deepu, V., Rai, V., & Agrawal, D. K. (2024) · Archives of Internal Medicine Research · doi:10.26502/aimr.0168 · Cited by 14 · see citing works
Effect of Mesenchymal Stem Cell–Derived Extracellular Vesicles Induced by Advanced Glycation End Products on Energy Metabolism in Vascular Endothelial Cells
Liang, J., Cheng, S., Song, Q.-D., Tang, Y., Wang, Q., Chen, H., Feng, J., Yang, L., Li, S., Wang, Z., et al. (2024) · Kidney International Reports · doi:10.1016/j.ekir.2024.10.015 · Cited by 12 · see citing works
Fibronectin Functions as a Selective Agonist for Distinct Toll-like Receptors in Triple-Negative Breast Cancer
Ambesi, A., Maddali, P., & McKeown‐Longo, P. J. (2022) · Cells · doi:10.3390/cells11132074 · Cited by 11 · see citing works
Rhein alleviates advanced glycation end products (AGEs)-induced inflammatory injury of diabetic cardiomyopathy in vitro and in vivo models
Zhao, S., Zhao, H., Wang, B., Shao, C., Pan, W., & Li, S. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01741-7 · Cited by 11 · see citing works
1,2,4-Triazine derivatives as agents for the prevention of AGE-RAGE-mediated inflammatory cascade in THP-1 monocytes: An approach to prevent inflammation-induced late diabetic complications
Jahan, H., Tufail, P., Shamim, S., Khan, K. M., Gennari, M. M., Pizzi, M., & Choudhary, M. I. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113145 · Cited by 10 · see citing works
Sulfated Hyperbranched and Linear Polyglycerols Modulate HMGB1 and Morphological Plasticity in Neural Cells
Maysinger, D., Zhang, I., Wu, P. Y., Kagelmacher, M., Luo, H. D., Kizhakkedathu, J. N., Dernedde, J., Ballauff, M., Haag, R., Shobo, A., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00558 · Cited by 11 · see citing works
A Nonlethal Murine Flame Burn Model Leads to a Transient Reduction in Host Defenses and Enhanced Susceptibility to Lethal Pseudomonas aeruginosa Infection
Brammer, J., Choi, M., Baliban, S. M., Kambouris, A. R., Fiskum, G. M., Chao, W., Lopez, K., Miller, C. H. T., Al‐Abed, Y., Vogel, S. N., et al. (2021) · Infection and Immunity · doi:10.1128/iai.00091-21 · Cited by 9 · see citing works
Self-citation
Computational Deciphering of the Role of S100A8 and S100A9 Proteins and Their Changes in the Structure Assembly Influences Their Interaction with TLR4, RAGE, and CD36
Paramasivam, S., Selvan, P. S., & Ekambaram, S. P. (2024) · The Protein Journal · doi:10.1007/s10930-024-10186-0 · Cited by 8 · see citing works
High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone
Butcher, L., Zaldua, J.-C., Carnicero, J. A. C., Hawkins, K. M., Whitley, J., Mothukuri, R., Evans, P. A., Morris, K., Pillai, S., & Erusalimsky, J. D. (2022) · Respiratory Research · doi:10.1186/s12931-022-02220-5 · Cited by 8 · see citing works
Naturally occurring HMGB1 inhibitor delineating the anti-hepatitis B virus mechanism of glycyrrhizin via in vitro and in silico studies
Bhat, S. A., Siddiqui, Z. I., Parray, Z. A., Sultan, A., Afroz, M., Azam, S. A., Farooqui, S. R., & Kazim, S. N. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.119029 · Cited by 7 · see citing works
Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment
Guebel, D. V., Torres, N. V., & Acebes, Á. (2021) · Biology Open · doi:10.1242/bio.057950 · Cited by 6 · see citing works
A review on clinical implications of S100 proteins in lung diseases
Raveendran, V. V., Al-Qattan, S. M., & Mutairy, E. A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1618772 · Cited by 6 · see citing works
Virtual Probing on the Influence of Ca2+ and Zn2+ Bound S100A8 and S100A9 Proteins Towards their Interaction Against Pattern Recognition Receptors Aggravating Rheumatoid Arthritis
Paramasivam, S., Murugesan, J., Vedagiri, H., Perumal, S. S., & Ekambaram, S. P. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01600-6 · Cited by 6 · see citing works
DNA‐Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice
Koga, Y., Sotokawauchi, A., Higashimoto, Y., Nishino, Y., Hashizume, N., Kakuma, T., Akiba, J., Tanaka, Y., Matsui, T., Yagi, M., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9932311 · Cited by 6 · see citing works
The role of HMGB1 on SiC NPs-induced inflammation response in lung epithelial-macrophage co-culture system
Chen, X., Zhang, L., Yu, C., Duan, A., Jiao, B., Chen, Y., Dai, Y., & Li, B. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114762 · Cited by 5 · see citing works
Induction of Antimicrobial Protein S100A15 Expression by Oral Microbial Pathogens Is Toll-like Receptors-Dependent Activation of c-Jun-N-Terminal Kinase (JNK), p38, and NF-κB Pathways
Selimović, D., Kharouf, N., Carrouel, F., Hassan, S.-Y., Flanagan, T. W., Hassan, S.-L., Megahed, M., Haïkel, Y., Santourlidis, S., & Hassan, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065348 · Cited by 5 · see citing works
Pyridoxamine protects human granulosa cells against advanced glycation end-products-induced steroidogenesis disturbances
Mirani, M., Bahmanpour, S., Masjedi, F., Derakhshan, Z., Dara, M., Nasr‐Esfahani, M. H., & Tabei, K. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08723-8 · Cited by 5 · see citing works
Damage Associated Molecular Patterns (DAMPs) Mediate the Foreign Body Response to Poly(ethylene glycol) Diacrylate Hydrogels via Toll like Receptors
Thompson, B. J., Saleh, L. S., Carillion, E. L., Alper, S., & Bryant, S. J. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01984 · Cited by 5 · see citing works
RAGE signaling pathway in glioblastoma and cognitive decline: Insights into inflammatory mechanisms and therapeutic implications
Raj, J. A. T., John, G., Ghanekar, S., Thiruselvan, G. K., Shah, J., Ande, D., Chatterjee, A., & Goda, J. S. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150026 · Cited by 4 · see citing works
MUC1 and MUC4 expression are inversely correlated and trigger immunological response and transport pathways in adult-type diffuse gliomas
Machado, G. C., & Ferrer, V. P. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.109730 · Cited by 4 · see citing works
Nutrient regulation of inflammatory signalling in obesity and vascular disease
Palmer, T. M., & Salt, I. P. (2021) · Clinical Science · doi:10.1042/cs20190768 · Cited by 3 · see citing works
High Glucose Promotes Invasion of Fusobacterium nucleatum and Inflammatory Responses in Human Bronchial Fibroblasts
Nomura, T., Tanaka, Y., Yaguchi, M., Shinozaki‐Kuwahara, N., & Nomoto, T. (2024) · International Journal of Oral-Medical Sciences · doi:10.5466/ijoms.22.165 · Cited by 3 · see citing works
AGEs-RAGE-KCa3.1 pathway mediates palmitic acid-induced migration of PBMCs from patients with type 2 diabetes
Zhang, Y., Ma, X., Zhao, X., Li, J.-J., Ma, S., Pang, Z., Xu, J., Du, X., Deng, X., & Wang, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14823 · Cited by 3 · see citing works
Inflammation and bone marrow fibrosis: novel immunotherapeutic targets
Calledda, F. R., Malara, A., & Balduini, A. (2023) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000778 · Cited by 3 · see citing works
The TLR4/NF-κB signaling pathway-mediated type 2 skewing of T helper cell in cough variant asthma was counteracted by ethanol extract of Anacyclus pyrethrum root
Zheng, J., Zhang, R., Liu, C.-J., Yang, H., & Jin, X. (2023) · Immunobiology · doi:10.1016/j.imbio.2023.152379 · Cited by 3 · see citing works
Nanocurcumin alleviate inflammation and oxidative stress in LPS-induced mastitis model via activation of Nrf2 and suppressing TLR4 mediated NF-κB and HMGB1 signaling pathwaysPreprint
Lebda, M. A., Elmassry, I. H., Taha, N., & Elfeky, M. (2021) · Research Square · doi:10.21203/rs.3.rs-447345/v1 · Cited by 3 · see citing works
The S100A11-RAGE/TLR4 axis activation mediates inflammatory response and epithelial integrity against Toxoplasma gondii infection in a human placental explant model
Guerrero-Muñoz, J., Liempi, A. I., Fernández-Moya, A., Araneda-Rojas, S., Mendoza, C., Seguy, F., Cáceres-Rojas, G., Gleisner, M. A., Kemmerling, U., & Castillo, C. (2025) · Placenta · doi:10.1016/j.placenta.2025.05.008 · Cited by 2 · see citing works
Hyperglycemia exacerbates placental inflammation induced by Porphyromonas gingivali s‐lipopolysaccharide
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Systemic inflammatory markers of visceral leishmaniasis treatment response in East Africa
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Authors: Prantner, D., Nallar, S., & Vogel, S. N.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Vogel, Stefanie N.
ORCID: Prantner, Daniel
Nallar, Shreeram
Vogel, Stefanie N.
Venue: The FASEB Journal
Publisher: Wiley
Published: 2020-11
Volume: 34
Issue: 12
Pages: 15659-15674
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.202002136r
PMC: PMC8121140
OpenAlex: W3096351980
Cited by: 92
References: 160
Citations by year: 2026: 14 · 2025: 12 · 2024: 16 · 2023: 22 · 2022: 11 · 2021: 16
FWCI: 1.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AI123371, AI125215, S10 OD025101)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: receptor for advanced glycation end products, RAGE, TLR4, innate immune signaling, damage-associated molecular patterns, advanced glycation end products, HMGB1, S-100 protein, MyD88, receptor cross-talk, sepsis, inflammation
MeSH terms: Receptor for Advanced Glycation End Products, Animals, Humans, Immunity, Innate, Inflammation, Signal Transduction, Toll-Like Receptor 4

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The role of RAGE in host pathology and crosstalk between RAGE and TLR4 in innate immune signal transduction pathways

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