The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The tumor suppressor protein p53 and the ferroptosis network
Open accessAbstract
ABSTRACT Ferroptosis is a form of lipid peroxidation‐induced cell death that can be regulated in many ways, from altering the activity of antioxidant enzymes to the level of transcription factors. The p53 tumor suppressor is 'the guardian of the genome' that participates in the control of cell survival and division under various stresses. Beyond its effects on apoptosis, autophagy, and cell cycle, p53 also regulates ferroptosis either through a transcriptional or posttranslational mechanism. On one hand, p53 can enhance ferroptosis by inhibiting the expression of SLC7A11 (solute carrier family 7 member 11) or by enhancing that of SAT1 (spermidine/spermine N1‐acetyltransferase 1) and GLS2 (glutaminase 2). On the other hand, p53 suppresses ferroptosis through the direct inhibition of DPP4 (dipeptidyl peptidase 4) activity or by the induction of CDKN1A/p21 (cyclin dependent kinase inhibitor 1 A) expression. Here, we review recent discoveries and emerging trends in the study of the ferroptosis network and highlight the context‐dependent impact of p53 on ferroptosis and oxidative stress. Graphical abstract Figure. No Caption available. HighlightsFerroptosis is a form of regulated cell death.p53 plays a dual role in ferroptosis.p53 enhances ferroptosis through targeting SLC7A11, SAT1 or GLS2.p53 suppresses ferroptosis through targeting DPP4 or CDKN1A.Activation of autophagy promotes ferroptosis.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Self-citationGalluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Self-citationRole of nrf2 in oxidative stress and toxicity
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Self-citationFerroptosis as a p53-mediated activity during tumour suppression
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p21 in cancer: Intricate networks and multiple activities
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Autophagy promotes ferroptosis by degradation of ferritin
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Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
Self-citationThe multiple mechanisms that regulate p53 activity and cell fate
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The emerging role of ferroptosis in inflammation
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Mitochondria regulation in ferroptosis
Wang, H., Liu, C., Zhao, Y., & Gao, G. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2019.151058 · Cited by 650
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
Battaglia, A. M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F., & Biamonte, F. (2020) · Cells · doi:10.3390/cells9061505 · Cited by 561
Metadata
- Authors
- Kang, R., Kroemer, G., & Tang, D.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 133
- Pages
- 162-168
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2804789540
- Cited by
- 698
- References
- 37
- FWCI
- 22.83
- Type
- journal article
- Language
- en
- Open access
- green
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