Plastic modifications induced by object recognition memory processing
Open accessAbstract
Long-term potentiation (LTP) phenomenon is widely accepted as a cellular model of memory consolidation. Object recognition (OR) is a particularly useful way of studying declarative memory in rodents because it makes use of their innate preference for novel over familiar objects. In this study, mice had electrodes implanted in the hippocampal Schaffer collaterals-pyramidal CA1 pathway and were trained for OR. Field EPSPs evoked at the CA3-CA1 synapse were recorded at the moment of training and at different times thereafter. LTP-like synaptic enhancement was found 6 h posttraining. A testing session was conducted 24 h after training, in the presence of one familiar and one novel object. Hippocampal synaptic facilitation was observed during exploration of familiar and novel objects. A short depotentiation period was observed early after the test and was followed by a later phase of synaptic efficacy enhancement. Here, we show that OR memory consolidation is accompanied by transient potentiation in the hippocampal CA3-CA1 synapses, while reconsolidation of this memory requires a short-lasting phase of depotentiation that could account for its well described vulnerability. The late synaptic enhancement phase, on the other hand, would be a consequence of memory restabilization.
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Hippocampal CA1 firing rates were enhanced during NOP testing and NOP consolidation is related to an increase of hippocampal CA3-CA1 synaptic efficacy.
“Hippocampal CA1 firing rates were enhanced during NOP testing (Cohen et al., 2013) and NOP consolidation is related to an increase of the hippocampal CA3-CA1 synaptic efficacy (Clarke et al., 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Clarke et al., 2010
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“In addition, NOR produces in vivo LTP in mice (Clarke et al., 2010).”
BackgroundResultInfluentialThe role of histamine receptors in the consolidation of object recognition memory
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- Authors
- Clarke, J. R., Cammarota, M., Gruart, A., Izquierdo, I., & Delgado-García, J. M.
- Affiliations
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Centro de Memória, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, 90610-000 Porto Alegre, Rio Grande do Sul, Brazil; and
- Universidad Pablo de Olavide (ES)
- División de Neurociencias, Universidad Pablo de Olavide, 41013 Sevilla, Spain
- Corresponding author
- Izquierdo, Iván
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-01-25
- Volume
- 107
- Issue
- 6
- Pages
- 2652-2657
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2823877
- OpenAlex
- W2002369606
- Cited by
- 273
- References
- 45
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 14 · 2023: 12 · 2022: 22 · 2021: 16 · 2020: 23 · 2019: 16 · 2018: 16 · 2017: 20 · 2016: 20 · 2015: 16 · 2014: 24 · 2013: 24 · 2012: 19
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission (201714)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Ministerio de Ciencia e Innovación
- Universidade Federal do Rio Grande do Sul
- Junta de Andalucía (BIO-122)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- object recognition memory, memory consolidation, memory reconsolidation, depotentiation, long-term potentiation, hippocampal CA3-CA1 synapses, Schaffer collaterals, field EPSP, synaptic plasticity, novel object preference, mice
- MeSH terms
- Animals, Electroencephalography, Hippocampus, Memory, Mice, Inbred C57BL, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Dizocilpine Maleate, Long-Term Potentiation, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Recognition, Psychology, Mice
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