Oxidative Stress and Cognitive Alterations Induced by Cancer Chemotherapy Drugs: A Scoping Review
Open accessAbstract
Cognitive impairment is one of the most deleterious effects of chemotherapy treatment in cancer patients, and this problem sometimes remains even after chemotherapy ends. Common classes of chemotherapy-based regimens such as anthracyclines, taxanes, and platinum derivatives can induce both oxidative stress in the blood and in the brain, and these effects can be reproduced in neuronal and glia cell cultures. In rodent models, both the acute and repeated administration of doxorubicin or adriamycin (anthracyclines) or cisplatin impairs cognitive functions, as shown by their diminished performance in different learning and memory behavioural tasks. Administration of compounds with strong antioxidant effects such as N-acetylcysteine, gamma-glutamyl cysteine ethyl ester, polydatin, caffeic acid phenethyl ester, and 2-mercaptoethane sulfonate sodium (MESNA) counteract both oxidative stress and cognitive alterations induced by chemotherapeutic drugs. These antioxidant molecules provide the scientific basis to design clinical trials in patients with the aim of reducing the oxidative stress and cognitive alterations, among other probable central nervous system changes, elicited by chemotherapy in cancer patients. In particular, N-acetylcysteine and MESNA are currently used in clinical settings and are therefore attracting scientific attention.
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- Authors
- Cauli, O.
- Affiliations
- Universitat de València (ES)
- Corresponding author
- Cauli, Omar
- ORCID
- Cauli, Omar
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2021-07-13
- Volume
- 10
- Issue
- 7
- Pages
- 1116
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC8301189
- OpenAlex
- W3180588892
- Cited by
- 60
- References
- 7
- Citations by year
- 2026: 20 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 7 · 2021: 4
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
- Keywords
- chemotherapy-induced cognitive impairment, oxidative stress, anthracyclines, doxorubicin, cisplatin, taxanes, platinum derivatives, antioxidant drugs, N-acetylcysteine, mesna, cognitive function, learning and memory
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