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Cited by 75

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Hematopoietic stem cell self-renewal

Akala, Omobolaji O, Clarke, Michael F·2006·Current Opinion in Genetics & Development
DOI 10.1016/j.gde.2006.08.011
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Abstract

Recent studies have begun to elucidate the mechanisms controlling hematopoietic stem cell (HSC) self-renewal. Self-renewal requires the integration of survival signals and proliferation controls with the maintenance of an undifferentiated state. This demands a complex crosstalk between extrinsic signals from the microenvironment and the cell-intrinsic regulators of self-renewal. The Polycomb protein Bmi1 is absolutely required for the maintenance of both adult HSCs and neural stem cells. Evidence from studies in murine and human embryonic stem cells indicates that Polycomb group proteins play a dynamic role in concert with master transcriptional regulators in actively maintaining an undifferentiated state, suggesting that this mechanism applies to multiple types of stem cell. Recently, various new players that regulate HSC maintenance (e.g. Mcl1, Tel/Etv6, Gfi1, Pten and Stat5) have been identified. In order to better understand HSC self-renewal, we need to understand how these pathways are coordinated.

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Crossref · 10.1016/j.gde.2006.08.011

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Citations

Cites

Research works printed but not linked: 37

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Cited by

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Metadata

Authors
Akala, O. O., & Clarke, M. F.
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2006-10
Volume
16
Issue
5
Pages
496-501
ISSN
0959-437X
DOI
10.1016/j.gde.2006.08.011
Cited by
75
References
8
Language
en
Licence

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