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Cited by 1,113

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

Yilmaz, Ömer H., Valdez, Riccardo, Theisen, Brian K., Guo, Wei, Ferguson, David O., Wu, Hong, Morrison, Sean J.·2006·Nature
DOI 10.1038/nature04703
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Crossref · 10.1038/nature04703

Cites

8 of 8 references verified0 citation errors · 0 not checkable

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  • Rapamycin may be particularly beneficial against cancer stem cells, and has been shown to deplete leukemia-initiating cells and inhibit both self-renewal and differentiation of stem cells derived from infantile hemangioma.

    “Rapamycin may be particularly beneficial against cancer stem cells, and has been shown to deplete leukemia-initiating cells and inhibit both self-renewal and differentiation of stem cells derived from infantile hemangioma 91,92.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [91]

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 34

  1. Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105–111 (2001) · DOI · Paper page
  2. Pardal, R., Clarke, M. F. & Morrison, S. J. Applying the principles of stem-cell biology to cancer. Nature Rev. Cancer 3, 895–902 (2003) · DOI
  3. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983–3988 (2003) · DOI
  4. Singh, S. K. et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5821–5828 (2003)
  5. Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730–737 (1997) · DOI
  6. Warner, J. K., Wang, J. C., Hope, K. J., Jin, L. & Dick, J. E. Concepts of human leukemic development. Oncogene 23, 7164–7177 (2004) · DOI
  7. Lessard, J. & Sauvageau, G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255–260 (2003) · DOI · Paper page
  8. Hemmati, H. D. et al. Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl Acad. Sci. USA 100, 15178–15183 (2003) · DOI
  9. Molofsky, A. V., Pardal, R. & Morrison, S. J. Diverse mechanisms regulate stem cell self-renewal. Curr. Opin. Cell Biol. 16, 700–707 (2004) · DOI
  10. Taipale, J. & Beachy, P. A. The Hedgehog and Wnt signalling pathways in cancer. Nature 411, 349–354 (2001) · DOI
  11. Molofsky, A. V. et al. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev. 19, 1432–1437 (2005) · DOI
  12. Di Cristofano, A. & Pandolfi, P. P. The multiple roles of PTEN in tumor suppression. Cell 100, 387–390 (2000) · DOI · Paper page
  13. Aggerholm, A., Gronbaek, K., Guldberg, P. & Hokland, P. Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders. Eur. J. Haematol. 65, 109–113 (2000) · DOI
  14. Roman-Gomez, J. et al. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood 104, 2492–2498 (2004) · DOI
  15. Dahia, P. L. et al. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies. Hum. Mol. Genet. 8, 185–193 (1999) · DOI
  16. Cheong, J. W. et al. Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome. Br. J. Haematol. 122, 454–456 (2003) · DOI
  17. Hock, H. et al. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 18, 2336–2341 (2004) · DOI
  18. Kühn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427–1429 (1995) · DOI · Paper page
  19. Kogan, S. C. et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 100, 238–245 (2002) · DOI · Paper page
  20. Christensen, J. L. & Weissman, I. L. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc. Natl Acad. Sci. USA 98, 14541–14546 (2001) · DOI
  21. Kiel, M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C. & Morrison, S. J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109–1121 (2005) · DOI · Paper page
  22. Yilmaz, O. H., Kiel, M. J. & Morrison, S. J. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107, 924–930 (2005) · DOI
  23. Smith, L. G., Weissman, I. L. & Heimfeld, S. Clonal analysis of hematopoietic stem-cell differentiation in vivo. Proc. Natl Acad. Sci. USA 88, 2788–2792 (1991) · DOI
  24. Inoki, K., Corradetti, M. N. & Guan, K. L. Dysregulation of the TSC–mTOR pathway in human disease. Nature Genet. 37, 19–24 (2005) · DOI
  25. Podsypanina, K. et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc. Natl Acad. Sci. USA 98, 10320–10325 (2001) · DOI
  26. Neshat, M. S. et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc. Natl Acad. Sci. USA 98, 10314–10319 (2001) · DOI
  27. Recher, C. et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 105, 2527–2534 (2005) · DOI
  28. Avellino, R. et al. Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. Blood 106, 1400–1406 (2005) · DOI
  29. Teachey, D. T. et al. The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood 107, 1149–1155 (2006) · DOI
  30. Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804–1808 (2000) · DOI · Paper page
  31. Groszer, M. et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186–2189 (2001) · DOI · Paper page
  32. Molofsky, A. V. et al. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425, 962–967 (2003) · DOI
  33. Morrison, S. J. & Weissman, I. L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1, 661–673 (1994) · DOI
  34. Smith, L. H. & Clayton, M. L. Distribution of injected 59Fe in mice. Exp. Hematol. 20, 82–86 (1970)

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Metadata

Authors
Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2006-04-05
Volume
441
Issue
7092
Pages
475-482
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature04703
Cited by
1,113
References
8
Language
en
Licence
www.springer.com/tdm (tdm)

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