Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration
Abstract
Self-renewal of hematopoietic stem cells (HSCs) is key to their reconstituting ability, but the signaling pathways that regulate this process remain poorly understood. Here we show that transduction of adult mouse bone marrow cells with a constitutively activated form of Stat3 (Stat3-C) increased their regenerative activity in lethally irradiated recipients. Conversely, transduction of these cells with a dominant-negative form of Stat3 suppressed their regenerative activity. Serial transplantation and clonal tracking of the HSC progeny regenerated in vivo from STAT3-C-transduced HSCs demonstrated that the major effect of forced expression of STAT3-C was to enhance HSC self-renewal during the initial phase of hematopoietic recovery. This acquired potential for enhanced self-renewal divisions then became latent, but was reactivated when the cells were transferred to new irradiated recipients. Increased levels of activated STAT3 were also found to be associated with greater preservation of primitive hematopoietic cells in short-term cultures. These results indicate a novel biphasic regulation of HSC self-renewal in vivo in which activated STAT3 promotes HSC self-renewal under stimulated, but not homeostatic, conditions. STAT3 may thus be an important regulator of hematopoietic regeneration and a novel target for HSC engineering.
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Hematopoietic progenitor-specific STAT3 knockout leaves basal hematopoiesis unaltered but impairs stem cell regeneration after 5-FU.
“Unaltered basal hematopoiesis; impaired stem cell regeneration after 5-FU”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Chung et al., 2006
Cites
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790 · see citing works
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159 · see citing works
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871 · see citing works
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808 · see citing works
"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711 · see citing works
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.Preprint
Niwa, H., Burdon, T., Chambers, I., & Smith, A. G. (1998) · Genes & Development · doi:10.1101/gad.12.13.2048 · Cited by 1,673 · see citing works
A Stem Cell Molecular Signature
Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R. (2002) · Science · doi:10.1126/science.1073823 · Cited by 1,543 · see citing works
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works
Hematopoietic Stem Cell Quiescence Maintained by p21 <sup>cip1/waf1</sup>
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339 · see citing works
Levy, D., & Lee, C.-K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15650 · Cited by 925 · see citing works
Developmental potential and dynamic behavior of hematopoietic stem cells
Lemischka, I. R., Raulet, D. H., & Mulligan, R. C. (1986) · Cell · doi:10.1016/0092-8674(86)90566-0 · Cited by 880 · see citing works
The Stat family in cytokine signaling
Ihle, J. N. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00199-x · Cited by 713 · see citing works
HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo
Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00697-9 · Cited by 700 · see citing works
Dick, J. E., Magli, M. C., Huszar, D., Phillips, R. A., & Bernstein, A. (1985) · Cell · doi:10.1016/s0092-8674(85)80102-1 · Cited by 637 · see citing works
Sauvageau, G., Þorsteinsdóttir, U., Eaves, C. J., Lawrence, H. J., Largman, C., Lansdorp, P. M., & Humphries, R. K. (1995) · Genes & Development · doi:10.1101/gad.9.14.1753 · Cited by 586 · see citing works
Self-citationTebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine · doi:10.1038/nm763 · Cited by 474 · see citing works
Szilvassy, S. J., Humphries, R. K., Lansdorp, P. M., Eaves, A. C., & Eaves, C. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8736 · Cited by 450 · see citing works
Self-citationO’Farrell, A.-M., Liu, Y., Moore, K. W., & Mui, A. L. ‐. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.1006 · Cited by 439 · see citing works
Essential role of STAT3 for embryonic stem cell pluripotency
Raz, R., Lee, C., Cannizzaro, L. A., D’Eustachio, P., & Levy, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2846 · Cited by 399 · see citing works
Welte, T., Zhang, S. S. M., Wang, T., Zhang, Z., Hesslein, D. G. T., Yin, Z., Kano, A., Iwamoto, Y., Li, E., Craft, J. E., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237137100 · Cited by 381 · see citing works
Rapid activation of the stat3 transcription complex in liver regeneration
Cressman, D. E., Diamond, R. H., & Taub, R. (1995) · Hepatology · doi:10.1002/hep.1840210531 · Cited by 314 · see citing works
From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs
Terskikh, A. V., Easterday, M. C., Li, L., Hood, L., Kornblum, H. I., Geschwind, D. H., & Weissman, I. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131200898 · Cited by 288 · see citing works
Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes
Kunisada, K., Tone, E., Fujio, Y., Matsui, H., Yamauchi‐Takihara, K., & Kishimoto, T. (1998) · Circulation · doi:10.1161/01.cir.98.4.346 · Cited by 236 · see citing works
HER‐2/ <i>neu</i> Signal Transduction in Human Breast and Ovarian Cancer
Reese, D. M., & Slamon, D. J. (1997) · STEM CELLS · doi:10.1002/stem.150001 · Cited by 229 · see citing works
Serine Phosphorylation and Negative Regulation of Stat3 by JNK
Lim, C. P., & Cao, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.31055 · Cited by 225 · see citing works
Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion
Iscove, N. N., & Nawa, K. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00341-1 · Cited by 214 · see citing works
Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)
Jain, N., Zhang, T., Fong, S., Lim, C. P., & Cao, X. (1998) · Oncogene · doi:10.1038/sj.onc.1202238 · Cited by 213 · see citing works
Kato, Y., Iwama, A., Tadokoro, Y., Shimoda, K., Minoguchi, M., Akira, S., Tanaka, M., Miyajima, A., Kitamura, T., & Nakauchi, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042541 · Cited by 178 · see citing works
Notch signalling in hematopoiesis
Ohishi, K., Katayama, N., Shiku, H., et al. (2003) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00183-0 · Cited by 174 · see citing works
Þorsteinsdóttir, U., Sauvageau, G., & Humphries, R. K. (1999) · Blood · doi:10.1182/blood.v94.8.2605.420k19_2605_2612 · Cited by 154 · see citing works
Audet, J., Miller, C., Rose‐John, S., Piret, J. M., & Eaves, C. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1757 · Cited by 137 · see citing works
Self-citationCombined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration
Peters, M., Blinn, G., Jostock, T., Schirmacher, P., Büschenfelde, K. M. Z., Galle, P. R., & Rose–John, S. (2000) · Gastroenterology · doi:10.1053/gast.2000.20236 · Cited by 129 · see citing works
Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation
Schuringa, J.-J., Schepers, H., Vellenga, E., & Kruijer, W. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02354-7 · Cited by 124 · see citing works
Roles of Stat3 and ERK in G‐CSF Signaling
Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Kakumitsu, H., Yoshie, M., Yamamoto, M., Takeda, K., Matsuda, T., Akira, S., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0173a · Cited by 65 · see citing works
Oh, I., & Eaves, C. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205592 · Cited by 57 · see citing works
Self-citationHematopoietic stem cells: Inferences from in vivo assays
Eaves, C. J., Miller, C., Cashman, J. D., Conneally, E., Petzer, A. L., Zandstra, P. W., & Eaves, A. (1997) · Stem Cells · doi:10.1002/stem.5530150802 · Cited by 50 · see citing works
Self-citationOntogenic emergence of definitive hematopoietic stem cells
Dzierzak, E. A. (2003) · Current Opinion in Hematology · doi:10.1097/00062752-200305000-00006 · Cited by 49 · see citing works
Hematopoietic Stem Cell Protocols
(2002) · Methods in molecular medicine · doi:10.1385/159259140x · Cited by 42 · see citing works
Szilvassy, S. J., Nicolini, F. E., Eaves, C. J., & Miller, C. (2003) · Humana Press eBooks · doi:10.1385/1-59259-140-x:167 · Cited by 25 · see citing works
Self-citationOh, I., Fabry, M. E., Humphries, R. K., et al. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.02.001 · Cited by 23 · see citing works
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- Schuringa JJ, Schepers H, Vellenga E, Kruijer W. Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation. FEBS Lett.2001;495: 71-76. · DOI · Paper page
Cited by
Sorted by citations
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
STAT3, stem cells, cancer stem cells and p63
Galoczová, M., Coates, P. J., & Vojtěšek, B. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0078-0 · Cited by 266 · see citing works
Foshay, K. M., & Gallicano, G. I. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.016 · Cited by 225 · see citing works
Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function
Melillo, J. A., Song, L., Bhagat, G., Blazquez, A. B., Plumlee, C. R., Lee, C., Berin, C., Reizis, B., & Schindler, C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902960 · Cited by 225 · see citing works
Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein
Debnath, B., Xu, S., & Neamati, N. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300207s · Cited by 205 · see citing works
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age
Mann, M., Mehta, A., de Boer, C. G., Kowalczyk, M. S., Lee, K., Haldeman, P., Rogel, N., Knecht, A. R., Farouq, D., Regev, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.056 · Cited by 188 · see citing works
Yu, S., Luo, F., Xu, Y., Zhang, Y., & Jin, L. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.905370 · Cited by 189 · see citing works
Regulation of Hematopoietic Stem Cells by the Steel Factor/KIT Signaling Pathway
Kent, D. G., Copley, M. R., Benz, C., Dykstra, B. J., Bowie, M. B., & Eaves, C. J. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5134 · Cited by 179 · see citing works
Self-citationZhang, F., Thornhill, S., Howe, S., Ulaganathan, M., Schambach, A., Sinclair, J., Kinnon, C., Gaspar, H. B., Antoniou, M., & Thrasher, A. (2007) · Blood · doi:10.1182/blood-2006-12-060814 · Cited by 191 · see citing works
Corniola, R. S., Tassabehji, N. M., Hare, J. T., Sharma, G. M., & Levenson, C. W. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.040 · Cited by 168 · see citing works
Chen, M.-W., Yang, S.-T., Chien, M., Hua, K., Wu, C., Hsiao, S. M., Lin, H., Hsiao, M., Su, J.-L., & Wei, L. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1115 · Cited by 150 · see citing works
Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles
Razavi, Z. S., Tajiknia, V., Majidi, S., Ghandali, M., Mirzaei, H. R., Rahimian, N., Hamblin, M. R., & Mirzaei, H. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103192 · Cited by 132 · see citing works
Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs
Guezguez, B., Campbell, C. J. V., Boyd, A. L., Karanu, F., Casado, F. L., Cresce, C. D., Collins, T. J., Shapovalova, Z., Xenocostas, A., & Bhatia, M. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.015 · Cited by 124 · see citing works
Alvarado, L. J., Huntsman, H. D., Cheng, H., et al. (2019) · Blood · doi:10.1182/blood-2018-11-884486 · Cited by 122 · see citing works
Wei, W., Tweardy, D. J., Zhang, M., Zhang, X., Landua, J. D., Petrovic, I., Bu, W., Roarty, K. P., Hilsenbeck, S. G., Rosen, J. M., et al. (2014) · Stem Cells · doi:10.1002/stem.1752 · Cited by 110 · see citing works
Li, S., Ali, S., Duan, X., Liu, S., Du, J., Liu, C., Dai, H., Zhou, M., Zhou, L., Yang, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.051 · Cited by 95 · see citing works
Hematopoietic stem cells: generation and self-renewal
Huang, X., Cho, S., & Spangrude, G. J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402225 · Cited by 109 · see citing works
Hematopoietic stem cell self-renewal
Akala, O. O., & Clarke, M. F. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.08.011 · Cited by 97 · see citing works
Jenkins, B. J., Roberts, A. W., Greenhill, C., Najdovska, M., Lundgren–May, T., Robb, L. G., Grail, D., & Ernst, M. (2006) · Blood · doi:10.1182/blood-2006-08-040352 · Cited by 90 · see citing works
Zhou, Q., Chen, P., Di, G., Zhang, Y., Wang, Y., Qi, X., Duan, H., & Xie, L. (2014) · Stem Cells · doi:10.1002/stem.1942 · Cited by 85 · see citing works
JAK-STAT in Early Hematopoiesis and Leukemia
Fasouli, E. S., & Katsantoni, E. Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.669363 · Cited by 81 · see citing works
Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers
Brachet‐Botineau, M., Polomski, M., Neubauer, H. A., Juen, L., Hédou, D., Viaud‐Massuard, M., Prié, G., & Gouilleux, F. (2020) · Cancers · doi:10.3390/cancers12010240 · Cited by 75 · see citing works
Kim, J., Kang, Y., Park, G., Kim, M., Park, Y.-O., Kim, H., Leem, S., Chu, I., Lee, J.-S., Jho, E., et al. (2009) · Stem Cells · doi:10.1002/stem.52 · Cited by 75 · see citing works
Self-citationOh, K., Ko, E., Kim, H. S., Park, A. K., Moon, H., Noh, D., & Lee, D. (2011) · Breast Cancer Research · doi:10.1186/bcr3034 · Cited by 75 · see citing works
Murakami, S., Suzuki, T., Harigae, H., Roméo, P., Yamamoto, M. P., & Motohashi, H. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00086-17 · Cited by 71 · see citing works
Tubi, L. Q., Nunes, S. C., Brancalion, A., Breatta, E. D., Manni, S., Mandato, E., Zaffino, F., Macaccaro, P., Carrino, M., Gianesin, K., et al. (2016) · Leukemia · doi:10.1038/leu.2016.209 · Cited by 69 · see citing works
Zhu, H., Xiao, F., Wang, G., Wei, X., Jiang, L., Chen, Y., Zhu, L., Wang, H., Diao, Y., Wang, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.041 · Cited by 69 · see citing works
Crozatier, M., & Vincent, A. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007351 · Cited by 68 · see citing works
Kent, D. G., Dykstra, B. J., Cheyne, J., Ma, E., & Eaves, C. J. (2008) · Blood · doi:10.1182/blood-2007-10-117820 · Cited by 63 · see citing works
Self-citationCell signaling pathways as molecular targets to eliminate AML stem cells
Rodrigues, A. C., Costa, R. G. A., Silva, S. L. R., Dias, I. R. S. B., Dias, R. B., & Bezerra, D. P. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103277 · Cited by 59 · see citing works
A Novel Function of Interleukin‐10 Promoting Self‐Renewal of Hematopoietic Stem Cells
Kang, Y., Yang, S., Park, G., Cho, B., Min, C., Kim, T., Lee, J. S., & Oh, I. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0002 · Cited by 57 · see citing works
Self-citationRole of STAT3 in Transformation and Drug Resistance in CML
Nair, R. R., Tolentino, J. H. G., & Hazlehurst, L. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00030 · Cited by 56 · see citing works
JAK-STAT Signaling in Stem Cells
Stine, R. R., & Matunis, E. L. (2013) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-007-6621-1_14 · Cited by 56 · see citing works
The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor
Ecker, A. (2009) · Frontiers in bioscience · doi:10.2741/3425 · Cited by 48 · see citing works
The Drosophila lymph gland is an ideal model for studying hematopoiesis
Yu, S., Luo, F., & Jin, L. H. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.11.017 · Cited by 46 · see citing works
Chung, Y. S., Kim, H. J., Kim, T.-M., Hong, S.-H., Kwon, K.-R., An, S., Park, J.-H., Lee, S., & Oh, I.-H. (2009) · Blood · doi:10.1182/blood-2009-01-197780 · Cited by 43 · see citing works
Self-citationCatalase Inhibits Ionizing Radiation-Induced Apoptosis in Hematopoietic Stem and Progenitor Cells
Xiao, X., Luo, H., Vanek, K. N., LaRue, A. C., Schulte, B. A., & Wang, G. Y. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0402 · Cited by 42 · see citing works
Cheng, Y., Lin, K.-H., Young, T., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0234 · Cited by 41 · see citing works
Unraveling the complex regulation of stem cells: implications for aging and cancer
Oakley, E. J., & Zant, G. E. V. (2007) · Leukemia · doi:10.1038/sj.leu.2404530 · Cited by 42 · see citing works
Loss of p300 accelerates MDS-associated leukemogenesis
Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S. M., Hamard, P.-J., Ando, K., et al. (2016) · Leukemia · doi:10.1038/leu.2016.347 · Cited by 41 · see citing works
STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia
Bruserud, Ø., Nepstad, I., Hauge, M., Hatfield, K. J., & Reikvam, H. (2014) · Expert Review of Hematology · doi:10.1586/17474086.2015.971005 · Cited by 39 · see citing works
Gu, H., Chen, C., Hao, X., Su, N., Huang, D., Zou, Y., Lin, S., Chen, X., Zheng, D., Liu, L., et al. (2020) · Blood · doi:10.1182/blood.2019003940 · Cited by 37 · see citing works
Regulation of hematopoietic cell development and function by Stat3
Pamela, A. H. (2009) · Frontiers in bioscience · doi:10.2741/3597 · Cited by 36 · see citing works
Zhao, X., Cheng, Z., & Wang, J. (2018) · Medical Science Monitor · doi:10.12659/msm.911194 · Cited by 35 · see citing works
Novel aspects of parenchymal–mesenchymal interactions: from cell types to molecules and beyond
Blüguermann, C., Wu, L., Petrigliano, F. A., McAllister, D. R., Miriuka, S., & Evseenko, D. A. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.2950 · Cited by 35 · see citing works
STAT transcription factors in normal and cancer stem cells.
Dorritie, K., Redner, R., & Johnson, D. E. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.05.004 · Cited by 34 · see citing works
Iso, Y., Rao, K., Poole, C. N., et al. (2013) · Stem Cells · doi:10.1002/stem.1546 · Cited by 32 · see citing works
The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent
Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., & Argenton, F. (2020) · Development · doi:10.1242/dev.188987 · Cited by 30 · see citing works
Role of STAT3 and GATA-1 interactions in γ-globin gene expression
Xiao, Y., Kodeboyina, S., Liu, L., Dzandu, J. K., Sangerman, J., Ofori-Acquah, S. F., & Pace, B. S. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.05.004 · Cited by 31 · see citing works
Васин, М. В. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-414 · Cited by 31 · see citing works
Disruption of Bis Leads to the Deterioration of the Vascular Niche for Hematopoietic Stem Cells
Kwon, K.-R., Ahn, J., Kim, M., et al. (2009) · Stem Cells · doi:10.1002/stem.285 · Cited by 29 · see citing works
Self-citationOh, K., Moon, H., Lee, D., & Yoo, Y.-B. (2015) · Laboratory Animal Research · doi:10.5625/lar.2015.31.4.188 · Cited by 28 · see citing works
Miao, R., Chun, H., Feng, X., Gomes, A. C., Choi, J., & Pereira, J. P. (2022) · Nature Communications · doi:10.1038/s41467-022-32228-w · Cited by 27 · see citing works
Al-Asmari, A. K., Riyasdeen, A., & Islam, M. (2017) · Integrative Cancer Therapies · doi:10.1177/1534735417704949 · Cited by 25 · see citing works
STAT3 inhibition as a therapeutic strategy for leukemia
Kanna, R., Choudhary, G. S., Ramachandra, N., et al. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1397668 · Cited by 25 · see citing works
Ahn, J.-Y., Park, G., Shim, J.-S., et al. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.2.014 · Cited by 25 · see citing works
Self-citationWei, J., Herrler, T., Liu, K., Han, D., Yang, M., Dai, C., & Li, Q. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0186 · Cited by 21 · see citing works
Hong, S., Yang, S., Kim, T., Shim, J., Lee, H., Lee, G., Park, B., Nam, S. W., Ryoo, Z. Y., & Oh, I. (2014) · Stem Cells · doi:10.1002/stem.1631 · Cited by 21 · see citing works
Self-citationInsulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages
Xia, P., Wang, S., Du, Y., Huang, G.-L., Satoh, T., Akira, S., & Fan, Z.-S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150618 · Cited by 18 · see citing works
Cul4A is required for hematopoietic stem-cell engraftment and self-renewal
Li, B., Jia, N., Waning, D. L., Yang, F., Haneline, L. S., & Chun, K. T. (2007) · Blood · doi:10.1182/blood-2006-12-064154 · Cited by 20 · see citing works
Hsueh, Y., Chen, H., Chu, W., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6103 · Cited by 20 · see citing works
Zhu, H., Guo, H., Sun, N., Xiao, R., Ji, B., Jiang, R., Dong, F., Yao, C., Wang, X., Li, R., et al. (2025) · Advanced Science · doi:10.1002/advs.202509383 · Cited by 21 · see citing works
Zhang, H., Li, H. S., Hillmer, E. J., Zhao, Y., Chrisikos, T. T., Hu, H., Wu, X. Y., Thompson, E. J., Clise-Dwyer, K., Millerchip, K. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713889115 · Cited by 18 · see citing works
Li, Y., Wang, J., Li, Y., et al. (2019) · Veterinary Microbiology · doi:10.1016/j.vetmic.2019.02.027 · Cited by 17 · see citing works
Kim, J. H., Lee, H., Choi, H., Kim, J., Chu, I., Leem, S., & Oh, I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168036 · Cited by 17 · see citing works
Self-citationInhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo
Thulin, M. H., Määttä, J. A., Linder, A., et al. (2021) · The Prostate · doi:10.1002/pros.24125 · Cited by 17 · see citing works
Saka, K., Kawahara, M., Ueda, H., et al. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24421 · Cited by 16 · see citing works
The Use of Normal Stem Cells and Cancer Stem Cells for Potential Anti-Cancer Therapeutic Strategy
Han, S.-W., Kim, Y. Y., Kang, W. K., Kim, H.-C., Ku, S., Kang, B.-C., & Yun, J.-W. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-018-0128-8 · Cited by 15 · see citing works
Chronic inflammation promotes cancer progression as a second hit
Burócziová, M., Grusanovic, S., Vanickova, K., et al. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.09.002 · Cited by 14 · see citing works
Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy
Lee, D., Wang, Y., Kalaitzidis, D., Ramachandran, J., Eda, H., Sykes, D. B., Raje, N. S., & Scadden, D. T. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84620 · Cited by 13 · see citing works
Li, F., Xi, X., Xu, L., et al. (2022) · Current Cancer Drug Targets · doi:10.2174/1568009623666221024103834 · Cited by 10 · see citing works
Ishizuka, S., Lai, C., Otsu, M., et al. (2018) · ACS Synthetic Biology · doi:10.1021/acssynbio.8b00163 · Cited by 10 · see citing works
Wang, H., Wu, Z., Liu, Y., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114852 · Cited by 9 · see citing works
Regulation of the self-renewal ability of tissue stem cells by tumor-related genes
Naka, K., Ohmura, M., & Hirao, A. (2007) · Cancer Biomarkers · doi:10.3233/cbm-2007-34-504 · Cited by 9 · see citing works
STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1
Wakabayashi, Y., Miyatsuka, T., Miura, M., Himuro, M., Taguchi, T., Iida, H., Nishida, Y., Fujitani, Y., & Watada, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-25941-5 · Cited by 8 · see citing works
Tsyrulnyk, A. O., & Moriggl, R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-182-6_19 · Cited by 7 · see citing works
Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting
Masuda, J., Kawamoto, H., Strober, W., Takayama, E., Mizutani, A., Murakami, H., Ikawa, T., Kitani, A., Maeno, N., Shigehiro, T., et al. (2016) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-016-2187-4 · Cited by 6 · see citing works
Wang, Q., Han, Y., Li, L., & Qian, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00042-3 · Cited by 7 · see citing works
Moore, M. A. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-227-8_30 · Cited by 5 · see citing works
Saka, K., Kawahara, M., Teng, J., et al. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.09.012 · Cited by 5 · see citing works
Gasparoli, L., Virely, C., Tsakaneli, A., Che, N., Edwards, D., Bartram, J. L., Hubank, M. J. F., Pal, D., Heidenreich, O. T., Martens, J. H. A., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.283613 · Cited by 4 · see citing works
The Maintaining and Directed Differentiation of Hematopoietic Stem Cells Under Microgravity
Wang, P., Qian, J., Tian, H., & Zhao, Y. X. (2019) · Research for development · doi:10.1007/978-981-13-6325-2_9 · Cited by 4 · see citing works
Stem Cells, Hypoxia and Hypoxia-Inducible Factors
Watt, S. M., Tsaknakis, G., Forde, S. P., & Carpenter, L. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-227-8_18 · Cited by 4 · see citing works
Zhang, X., Qiao, Z., Guan, B., Wang, F., Shen, X., Shu, H. G., Shan, Y., Cong, Y., Xing, S. J., & Yu, Z.-Y. (2024) · Molecules · doi:10.3390/molecules29040816 · Cited by 3 · see citing works
Caputo, L., Stamenkovic, C., Tierney, M. T., Cecchini, A., Nicolau, M., Guarnaccia, G., Barajas, J. R., Falzarano, M. S., Bassel‐Duby, R., Ferlini, A., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102692 · Cited by 3 · see citing works
STAT1 inhibition promotes oxidative stress to sustain leukemia stem cell maintenance
Han, X., Wang, K., Zhu, S., et al. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111652 · Cited by 3 · see citing works
Scorpion venom polypeptide accelerate irradiated hematopoietic cells proliferation
He, Y., Kong, T., & Dong, W. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.02.012 · Cited by 3 · see citing works
Hematopoietic Stem Cell Biology
Rossmann, M. P., Orkin, S. H., & Chute, J. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35762-3.00009-3 · Cited by 3 · see citing works
Deng, G., Wang, J., Men, C., et al. (2025) · Collagen and Leather · doi:10.1186/s42825-024-00188-0 · Cited by 2 · see citing works
Moore, M. A. S. (2007) · Elsevier eBooks · doi:10.1016/b978-012370615-7/50053-6 · Cited by 2 · see citing works
Mouse Embryonic Stem Cells Express Functional Toll Like Receptor 2.
Taylor, T. M., Kim, Y., Derbigny, W. A., et al. (2009) · Blood · doi:10.1182/blood.v114.22.1473.1473 · Cited by 2 · see citing works
Moore, M. A. S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00047-1 · Cited by 2 · see citing works
Méndez‐Ferrer, S., & Fang, Z. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00237-6 · Cited by 2 · see citing works
Networks Establishing Hematopoietic Stem Cell Multipotency and Self-Renewal
Abdelhay, E. S. F. W., Pizzatti, L., & Binato, R. (2012) · InTech eBooks · doi:10.5772/32211 · Cited by 1 · see citing works
Maintenance and expansion of hematopoietic stem cells in vitro using genetic methods
Wu, Z. (2011) · doi:10.32657/10356/47581 · Cited by 1 · see citing works
STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activityPreprint
Patel, B., Zhou, Y., Babcock, R. L., Ma, F., Zal, M. A., Kumar, D., Medik, Y. B., Kahn, L. M., Pineda, J. E., Park, E. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.10.528069 · Cited by 1 · see citing works
Cardiovascular therapeutics derived from the paracrine biology of adult human progenitor cells
Poole, C. N. (n.d.) · ProQuest Demo Repository
- Authors
- Chung, Y.-J., Park, B.-B., Kang, Y.-J., Kim, T.-M., Eaves, C. J., & Oh, I.-H.
- Affiliations
- BC Cancer Agency (CA)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-08-15
- Volume
- 108
- Issue
- 4
- Pages
- 1208-1215
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2166180289
- Semantic Scholar
- 5d35bdca0b6f9dfa9fac5e3966d0a3779f0ec0a0
- Cited by
- 107
- References
- 40
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 4
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- STAT3, hematopoietic stem cells, self-renewal, hematopoietic regeneration, STAT3 activation, dominant-negative STAT3, bone marrow transplantation, irradiation, clonal tracking, serial transplantation
- MeSH terms
- Animals, Cell Division, Cells, Cultured, Enzyme Activation, Gene Expression Regulation, Hematopoietic Stem Cells, Mice, Transgenic, Regeneration, Transduction, Genetic, Whole-Body Irradiation, Signal Transduction, Bone Marrow Transplantation, STAT3 Transcription Factor, Mice
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