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The molecular determinants of de novo nucleotide biosynthesis in cancer cells
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Tumor cells increase the use of anabolic pathways to satisfy the metabolic requirements associated with a high growth rate. Transformed cells take up and metabolize nutrients such as glucose and glutamine at high levels that support anabolic growth. Oncogenic signaling through the PI3K/Akt and Myc pathways directly control glucose and glutamine uptake, respectively. In order to achieve elevated rates of nucleotide biosynthesis, neoplastic cells must divert carbon from PI3K/Akt-induced glycolytic flux into the nonoxidative branch of the pentose phosphate pathway to generate ribose-5-phosphate. This redirection of glucose catabolism appears to be regulated by cytoplasmic tyrosine kinases. Myc-induced glutamine metabolism also increases the abundance and activity of different rate-limiting enzymes that produce the molecular precursors required for de novo nucleotide synthesis. In this review, we will focus on recent progress in understanding how glucose and glutamine metabolism is redirected by oncogenes in order to support de novo nucleotide biosynthesis during proliferation and how metabolic reprogramming can be potentially exploited in the development of new cancer therapies.
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“Cytosolic glutamine supports nucleotide biosynthesis, which is essential for rapidly proliferating cells30.”
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Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Self-citationKim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Self-citationHIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Self-citationHypoxia signalling in cancer and approaches to enforce tumour regression
Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676
Molecular imaging of cancer with positron emission tomography
Gambhir, S. S. (2002) · Nature reviews. Cancer · doi:10.1038/nrc882 · Cited by 1,658
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Mattaini, K. R., & Heiden, M. G. V. (2012) · Science · doi:10.1126/science.1227513 · Cited by 19
Jimenez‐Duran, G., Kozole, J., Heap, R. E., Dickinson, E. R., Kwiatkowski, C. R., Zappacosta, F., Annan, R. S., Galwey, N. W., Nichols, E.-M., Modis, L. K., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918551 · Cited by 18
Folate Metabolism in Hepatocellular Carcinoma. What Do We Know So Far?
Quevedo-Ocampo, J., Escobedo-Calvario, A., Souza-Arroyo, V., Miranda-Labra, R. U., Bucio-Ortiz, L., Gutiérrez-Ruíz, M., Chávez-Rodríguez, L., & Gómez-Quiroz, L. (2022) · Technology in Cancer Research and Treatment · doi:10.1177/15330338221144446 · Cited by 17
Alt, J., Potter, M. C., Rojas, C. J., & Slusher, B. S. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.01.001 · Cited by 18
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van der Knaap, J. A., & Verrijzer, C. P. (2025) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030122-044718 · Cited by 17
Nayeen, M. J., Katinas, J. M., Magdum, T., Shah, K., Wong-Roushar, J., O’Connor, C. E., Fifer, A. N., Wallace-Povirk, A., Hou, Z., Matherly, L. H., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00763 · Cited by 17
Glucose Metabolism in Breast Cancer and its Implication in Cancer Therapy
Li, N., Tan, W., Li, J., Li, P., Lee, S., Wang, Y., & Gong, Y. (2011) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2011.22022 · Cited by 17
Lyu, Z., Chen, Y., Guo, X., Zhou, F., Yan, Z., Xing, J., An, J., & Zhang, H. (2016) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2016.05.001 · Cited by 17
Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer
Tarazi, D., & Maynes, J. T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092225 · Cited by 16
Wallace-Povirk, A., Rubinsak, L. A., Malysa, A., Dzinic, S. H., Ravindra, M. P., Schneider, M. J., Glassbrook, J. E., O’Connor, C. E., Hou, Z., Kim, S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-14788-5 · Cited by 16
Tian, D., Liang, L., Zhao, X., Zheng, M., Cao, X., Qin, H., Wang, C., Liang, Y., & Han, H. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.04.008 · Cited by 16
The Complex Roles of Redox and Antioxidant Biology in CancerPreprint
Hayashi, M., Okazaki, K., Papgiannakopoulos, T., & Motohashi, H. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041546 · Cited by 16
Nucleic acid metabolism: the key therapeutic target for myeloid tumors
Yabushita, T., & Goyama, S. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104693 · Cited by 15
Proteomics of Aqueous Humor as a Source of Disease Biomarkers in Retinoblastoma
Galardi, A., Stathopoulos, C., Colletti, M., Lavarello, C., Russo, I., Cozza, R., Romanzo, A., Carcaboso, A. M., Locatelli, F., Petretto, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113458 · Cited by 15
Li, Y., Zhu, L., Mao, J., Zheng, H., Hu, Z., Yang, S., Mao, T., Zhou, T., Cao, P., Wu, H., et al. (2024) · MedComm · doi:10.1002/mco2.483 · Cited by 15
Zhang, M., Chai, Y., Brumbaugh, J., Liu, X., Rabii, R., Feng, S., Misuno, K., Messadi, D. V., & Hu, S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-223 · Cited by 15
Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress
Kotov, I. N., Olst, E. S., Knobel, P. A., van der Meulen‐Muileman, I. H., Felley‐Bosco, E., van Beusechem, V. W., Smit, E. F., Stahel, R. A., & Marti, T. M. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.07.008 · Cited by 15
Kr-POK (ZBTB7c) regulates cancer cell proliferation through glutamine metabolism
Hur, M., Yoon, J.-H., Kim, M., Ko, H., & Jeon, B. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.05.005 · Cited by 14
Du, L., Zhang, Y., Luo, J., He, C., Lang, J., & Cao, X. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00737-1 · Cited by 15
Voronkova, M. A., Hansen, H. L., Cooper, M. P., Miller, J. I., Sukumar, N., Geldenhuys, W. J., Robart, A. R., & Webb, B. A. (2023) · Biochemical Journal · doi:10.1042/bcj20230207 · Cited by 14
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives
Kal, S., Mahata, S., Jati, S., & Mahata, S. K. (2023) · Peptides · doi:10.1016/j.peptides.2023.171147 · Cited by 15
Xu, S., Tian, Y., Hu, Y., Zhang, N., Hu, S., Song, D., Wu, Z., Wang, Y., Cui, Y., & Tang, H. (2016) · Scientific Reports · doi:10.1038/srep28057 · Cited by 14
Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy
Mu, C., Korenchan, D. E., Wang, S., Wilson, D. M., & Flavell, R. R. (2021) · Molecular Imaging and Biology · doi:10.1007/s11307-020-01570-0 · Cited by 14
Iorio, P. D., Beggiato, S., Ronci, M., Nedel, C. B., Tasca, C. I., & Zuccarini, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653549 · Cited by 14
Oburoglu, L., Mansell, E., & Woods, N. (2021) · Scientific Reports · doi:10.1038/s41598-021-97194-7 · Cited by 14
Advances in the Study of Metabolic Reprogramming in Gastric Cancer
Rong, Y., Teng, Y., & Zhou, X. (2025) · Cancer Medicine · doi:10.1002/cam4.70948 · Cited by 13
Alnatour, M., Alazzo, A., Ghaemmaghami, A. M., Kim, D., & Alexander, C. (2019) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2019.100036 · Cited by 13
Wallace-Povirk, A., Tong, N., Wong-Roushar, J., O’Connor, C. E., Zhou, X., Hou, Z., Bao, X., Garcia, G. E., Li, J., Kim, S., et al. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116093 · Cited by 13
Recent advances in nanomedicine for metabolism-targeted cancer therapy
Da, J., Di, X., Xie, Y., Li, J., Zhang, L., & Liu, Y. (2024) · Chemical Communications · doi:10.1039/d3cc05858a · Cited by 12
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Xu, Y., Li, M., Lin, M., Cui, D., & Xie, J. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s443482 · Cited by 11
Dai, Q., Xie, P., Tan, H., Zhang, J., Wang, F., Lei, B., & Cai, Z. (2024) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.4c00048 · Cited by 12
Nakane, K., Yagi, K., Yajima, S., Nomura, S., Sugimoto, M., & Seto, Y. (2024) · Cancer Science · doi:10.1111/cas.16256 · Cited by 12
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Tan, J., Zhou, S., Zhang, W. Y., Yang, B., Zhong, G., Huang, J. H., Hu, H., Han, F., & Luo, M. (2022) · Cancer Science · doi:10.1111/cas.15453 · Cited by 12
An, F., Zhang, Z., Xia, M., & XING, L. (2015) · Oncology Reports · doi:10.3892/or.2015.4150 · Cited by 12
Peixoto, J., Janaki‐Raman, S., Schlicker, L., Schmitz, W., Walz, S., Winkelkotte, A. M., Herold‐Mende, C. C., Soares, P., Schulze, A., & Lima, J. P. (2021) · Cancers · doi:10.3390/cancers13061327 · Cited by 12
Xie, J., Liu, J., Chen, X., & Zeng, C. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1333822 · Cited by 11
Li, C., Yan, Z., Cao, X., Zhang, X., & Yang, L. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0783-y · Cited by 11
HPRT1 activity loss is associated with resistance to thiopurine in ALL
Yang, F., Fang, H., Wang, D., Chen, Y., Zhai, Y., Zhou, B. S., & Li, H. (2017) · Oncotarget · doi:10.18632/oncotarget.23405 · Cited by 11
Li, C., Wen, L., Dong, J., Li, L., Huang, J., Yang, J., Liang, T., Li, T., Xia, Z., & Chen, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1072806 · Cited by 10
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Tangudu, N. K., Buj, R., Wang, H., Wang, J., Cole, A. R., Uboveja, A., Fang, R. S., Amalric, A., Yang, B., Chatoff, A. G., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0450 · Cited by 13
Analysis of substrate binding in individual active sites of bifunctional human ATIC
Witkowska, D., Cox, H. L., Hall, T. C., Wildsmith, G. C., Machin, D. C., & Webb, M. E. (2017) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2017.10.005 · Cited by 10
Ying, D., Zhang, G., Huang, H., Tan, W., & Cai, H. (2024) · Biotechnology Progress · doi:10.1002/btpr.3464 · Cited by 9
Mikawa, T., Kameda, M., Ikari, S., Shibata, E., Liu, S., Miyagawa, S., Ono, K., Ito, T., Yoshizawa, A., Sugimoto, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02502-6 · Cited by 10
Pyruvate Kinase M2 Role in Cardiovascular Repair
Rihan, M., Zangi, L., & Magadum, A. (2025) · Cells · doi:10.3390/cells14201623 · Cited by 8
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma
Xiong, G., Feng, Y., Yi, X., Zhang, X., Li, X., Yang, L., Yi, Z., Sai, B., Yang, Z., Zhang, Q., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.989263 · Cited by 8
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Milburn, M. V., Lawton, K. A., McDunn, J. E., Ryals, J. A., & Guo, L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1689-0_12 · Cited by 8
Li, J., Liu, J., Wang, R., Chen, H., Cui, L., Zhao, M., He, F., Wang, Y., & Liu, P. (2020) · PubMed Central · Cited by 8
Tong, N., Wong-Roushar, J., Wallace-Povirk, A., Shah, Y. V., Nyman, M. C., Katinas, J. M., Schneider, M. J., O’Connor, C. E., Bao, X., Kim, S., et al. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00020 · Cited by 8
Chaiyawat, P., Phanphaisarn, A., Sirikaew, N., Klangjorhor, J., Thepbundit, V., Teeyakasem, P., Phinyo, P., Pruksakorn, D., & Settakorn, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-90456-4 · Cited by 8
Ma, M., Hu, R., Huang, Q., Zhong, X., Li, J., Lv, M., Yi, J., Sun, J., Fan, K., Xu, Y., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107811 · Cited by 7
Molecular biological investigation of temozolomide and KC7F2 combination in U87MG glioma cell line
Abbaszade, Z., Bağca, B. G., & Avcı, Ç. B. (2021) · Gene · doi:10.1016/j.gene.2021.145445 · Cited by 7
Kuny, C. V., & Kalejta, R. F. (2016) · Journal of Virology · doi:10.1128/jvi.00731-16 · Cited by 7
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Muciño-Olmos, E. A., Vázquez-Jiménez, A., López-Esparza, D. E., Maldonado, V., Valverde, M., & Reséndis-Antonio, O. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.582396 · Cited by 7
Singh, P., Ali, S. A., Kumar, S., & Mohanty, A. K. (2023) · Journal of Proteomics · doi:10.1016/j.jprot.2023.104981 · Cited by 6
Scaffold-mediated switching of lymphoma metabolism in culture
Bhatt, R., Ravi, D., Evens, A. M., & Parekkadan, B. (2022) · Cancer & Metabolism · doi:10.1186/s40170-022-00291-y · Cited by 6
Evidence against a Major Role for TKTL-1 in Hypoxic and Normoxic Cancer Cells
Mayer, A., von Wallbrunn, A., & Vaupel, P. W. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7756-4_17 · Cited by 6
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Denko, N. C. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2014.930345 · Cited by 6
Role of pH in Regulating Cancer Pyrimidine Synthesis
Alqahtani, S. S., Koltai, T., Ibrahim, M. E., Bashir, A. H. H., Alhoufie, S. T. S., Ahmed, S. B. M., Molfetta, D. D., Carvalho, T. M. A., Cardone, R. A., Reshkin, S. J., et al. (2022) · Journal of Xenobiotics · doi:10.3390/jox12030014 · Cited by 5
FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis
Monsalve, A., Canals, I., & Oburoglu, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1039636 · Cited by 5
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Mourokh, L. G., & Friedman, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052835 · Cited by 5
Ruscetti, M. A., & Wu, H. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6828-8_4 · Cited by 6
Micronutrient regulation of the DNA methylome
Leesang, T. E., Lyon, P. D., Pinzone, J., & Cimmino, L. (2024) · Frontiers in Epigenetics and Epigenomics · doi:10.3389/freae.2024.1409355 · Cited by 5
Enomoto, T., Tone, N., Ishii, T., Hirono, H., Oi, A., Hirono, Y., Ikka, T., & Yamashita, H. (2025) · Plant Direct · doi:10.1002/pld3.70084 · Cited by 4
Jawla, N., Kar, R., Patil, V. S., & Arimbasseri, G. A. (2024) · Immunology · doi:10.1111/imm.13860 · Cited by 4
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Ruan, X., Xiong, Y., Li, X., Yang, E., & Wang, J. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00793-5 · Cited by 4
Santos-Jiménez, J. D. L., Campos-Sandoval, J. A., Rosales, T. I., Ko, B., Alonso, F. J., Márquez, J., DeBerardinis, R. J., & Matés, J. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010427 · Cited by 4
Kinetic mechanism and some properties of glucose-6-phosphate dehydrogenase from sheep brain cortex
Ulusu, N. N., & Sengezer, C. (2012) · Turkish Journal of Biochemistry · doi:10.5505/tjb.2012.83007 · Cited by 4
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Lu, W., & Huang, P. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_5 · Cited by 4
Metabolic Reprogramming and Molecular Rewiring in Cancer: Therapeutic Opportunities
Meiliana, A., Dewi, N. M., & Wijaya, A. (2021) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v13i2.1598 · Cited by 3
Immune checkpoint inhibition: a future guided by radiology
Khan, F., Jones, K. I., & Lyon, P. C. (2023) · British Journal of Radiology · doi:10.1259/bjr.20220565 · Cited by 4
Li, S., Yang, Z., Zhang, H., Peng, M., & Ma, H. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02330 · Cited by 4
Arrighi, N., Bodei, S., Zani, D., Simeone, C., Cunico, S. C., Spano, P., & Sigala, S. (2012) · Urologia Journal · doi:10.5301/ru.2012.9272 · Cited by 4
Kou, L., Qi, H., Jiang, Y., Liu, Q., & Sun, J. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119078 · Cited by 3
Serum untargeted metabolomics analysis of colorectal cancer
Yi, Y., Cao, Y., Guo, Y., Cui, Y., Han, C., & Sun, W. (2025) · BMC Cancer · doi:10.1186/s12885-025-15433-w · Cited by 3
Li, Z., Song, N., Deng, Y., Zhang, Q., Hu, F., Lu, Y., Chen, J., Xiao, P., Yan, A., Li, J., et al. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102642 · Cited by 3
Dhandapani, S., Choi, H.-S., Chung, H., Perumalsamy, H., Wang, R., Balusamy, S. R., Natarajan, S., Park, J., & Kim, Y. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00221 · Cited by 3
Zhang, X., Li, E., Kuang, Y., Gai, Y., Feng, Y., Huang, Y., Wei, Z., Niu, J., Yu, S., Yang, Z., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07618-9 · Cited by 4
Systems-Level Analysis of Cancer Metabolism
Gameiro, P. A., Metallo, C. M., & Stephanopoulos, G. N. (2012) · Springer eBooks · doi:10.1007/978-94-007-4534-6_11 · Cited by 3
Hossain, M. S. (2014) · American Journal of BioScience · doi:10.11648/j.ajbio.20140206.16 · Cited by 3
T Lymphocyte Metabolic Features and Techniques to Modulate Them
Викторовна, В. В., & Владимирович, Ш. К. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923110159 · Cited by 3
Biology – cancer metabolic phenotype
Čuperlović‐Culf, M. (2013) · Elsevier eBooks · doi:10.1533/9781908818263.15 · Cited by 3
Pettersson, U. (2019) · Upsala Journal of Medical Sciences · doi:10.1080/03009734.2019.1613698 · Cited by 3
Methionine coordinates a hierarchically organized anabolic program enabling proliferationPreprint
Walvekar, A. S., Srinivasan, R., Gupta, R., & Laxman, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/249367 · Cited by 3
Chen, D., Li, H., Zhang, H., Li, Q., Huang, Y., & Liu, H. (2020) · doi:10.21203/rs.3.rs-96109/v1 · Cited by 3
Muzammal, M., Fatima, S., Gul, A., Qayum, J., Farid, A., Ahmad, S., Shah, W., & Khan, M. A. (2023) · Journal of Taibah University for Science · doi:10.1080/16583655.2023.2262753 · Cited by 2
Lei, H., Lin, Z., Chen, X., Mou, K., Xu, F., Zheng, Y., & Xie, L. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.02.030 · Cited by 2
Wang, C., Zhang, B., Cong, Y., Du, X., Chen, S., Visser, L., Ruiz-Moreno, A. J., Zhang, L., Reggiori, F., Dömling, A. S. S., et al. (2024) · ChemMedChem · doi:10.1002/cmdc.202300688 · Cited by 2
Metabolic Imbalance Associated Mitophagy in Tumor Cells: Genesis and Implications
Chaurasia, M., Misra, S., Bhatt, A. N., Das, A., Dwarakanath, B. S. R., & Sharma, K. (2015) · Journal of cancer research updates · doi:10.6000/1929-2279.2015.04.02.8 · Cited by 2
Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy
Thakur, R. K., & Kumari, N. (2025) · Springer eBooks · doi:10.1007/978-981-96-7336-0_9 · Cited by 1
Hypoxia-driven microRNA-27b underlies pathologic cardiac endoreplication in heart disease
Mirtschink, P., Yuan, T., Bischof, C., Pham, M. D., Zhu, C., Ware, A. P., Mao, Y., Wu, M., Rogg, E.-M., Bottermann, K., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02656-x · Cited by 1
Regulation of Cancer Cell Metabolism by Hypoxia
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Xu, S., Spencer, C. M., & Munger, J. C. (2015) · Journal of Virology · doi:10.1128/jvi.03671-14 · Cited by 1
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Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Li, A., Zhang, W., Song, H., Zhang, M., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3387658 · Cited by 1
Metadata
- Authors
- Tong, X., Zhao, F., & Thompson, C. B.
- Affiliations
- Abramson Cancer Center (US)
- Corresponding author
- Tong, Xuemei
- Zhao, Fangping
- Thompson, Craig B
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 19
- Issue
- 1
- Pages
- 32-37
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC2707261
- OpenAlex
- W2002869675
- Cited by
- 351
- References
- 56
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 22 · 2023: 20 · 2022: 22 · 2021: 24 · 2020: 32 · 2019: 20 · 2018: 18 · 2017: 15 · 2016: 17 · 2015: 26 · 2014: 17 · 2013: 15 · 2012: 33
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA092660)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- cancer metabolism, metabolic reprogramming, PI3K/Akt signaling, c-Myc, glucose metabolism, glutamine metabolism, pentose phosphate pathway, ribose-5-phosphate, glycolysis, oncogenic signaling, cancer therapy
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Glucose, Glutamine, Glycolysis, Humans, Models, Biological, Neoplasms, Pentose Phosphate Pathway, Ribosemonophosphates, Proto-Oncogene Proteins c-myc, Protein Serine-Threonine Kinases, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Proto-Oncogene Proteins c-akt
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