Cited by 1,018Cancer, Hypoxia, and MetabolismCancer, Lipids, and MetabolismCancer and biochemical research

Brick by brick: metabolism and tumor cell growth

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DeBerardinis, Ralph J, Sayed, Nabil, Ditsworth, Dara, Thompson, Craig B·2008·Current Opinion in Genetics & Development

Abstract

Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the 'Warburg effect'). But the biosynthetic activities required to create daughter cells are equally important for tumor growth, and recent studies are now bringing these pathways into focus. In this review, we discuss how tumor cells achieve high rates of nucleotide and fatty acid synthesis, how oncogenes and tumor suppressors influence these activities, and how glutamine metabolism enables macromolecular synthesis in proliferating cells.

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Crossref · 10.1016/j.gde.2008.02.003

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  • In proliferating cells, mitochondria adopt an additional role as a biosynthetic hub, converting pyruvate and other metabolites into intermediates for protein and fatty acid biosynthesis.

    “In proliferating cells, mitochondria adopt an additional role as a biosynthetic hub, converting pyruvate and other metabolites into metabolic intermediates involved in protein and fatty acid biosynthesis (44).”

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  1. [26]Stryer L, Berg JM, Tymoczko JL. Biochemistry. 5th. 2002. [Google Scholar]

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Authors
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B.
Affiliations
  • Abramson Cancer Center (US)
  • Children's Hospital of Philadelphia (US)
Corresponding author
Thompson, Craig B
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2008-02
Volume
18
Issue
1
Pages
54-61
ISSN
0959-437X (ISSN-L)
OpenAlex
W2162016905
Cited by
1,018
References
64
Citations by year
2026: 6 · 2025: 25 · 2024: 27 · 2023: 45 · 2022: 51 · 2021: 71 · 2020: 36 · 2019: 40 · 2018: 57 · 2017: 68 · 2016: 71 · 2015: 72 · 2014: 79 · 2013: 76 · 2012: 93
FWCI
4.50
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Genetics & Development (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (P01CA104838)
  • National Institute of Diabetes and Digestive and Kidney Diseases (K08DK072565)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
cancer metabolism, tumor growth, Warburg effect, glycolysis, oxidative phosphorylation, nucleotide synthesis, fatty acid synthesis, glutamine metabolism, oncogenes, tumor suppressor, macromolecular synthesis, biosynthesis
MeSH terms
Fatty Acids, Glutamine, Glycolysis, Humans, Lipids, Models, Biological, Neoplasms, Ribosemonophosphates, Cell Proliferation

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