Brick by brick: metabolism and tumor cell growth
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Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the 'Warburg effect'). But the biosynthetic activities required to create daughter cells are equally important for tumor growth, and recent studies are now bringing these pathways into focus. In this review, we discuss how tumor cells achieve high rates of nucleotide and fatty acid synthesis, how oncogenes and tumor suppressors influence these activities, and how glutamine metabolism enables macromolecular synthesis in proliferating cells.
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In proliferating cells, mitochondria adopt an additional role as a biosynthetic hub, converting pyruvate and other metabolites into intermediates for protein and fatty acid biosynthesis.
“In proliferating cells, mitochondria adopt an additional role as a biosynthetic hub, converting pyruvate and other metabolites into metabolic intermediates involved in protein and fatty acid biosynthesis (44).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [44]
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“In contrast to contracting skeletal muscle’s requirements to support moderate to intense endurance activity, tumor cells use glucose, glutamine, and other metabolic substrates to meet not only energetic requirements but also the biosynthetic needs for cell growth and nucleic acid synthesis for rapid cell division (53).”
BackgroundRen, L., Hong, S.-H., Chen, Q.-R., Briggs, J., Cassavaugh, J., Srinivasan, S., Lizardo, M. M., Mendoza, A., Xia, A. Y., Avadhani, N., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-0210 · Cited by 50 · see citing works
Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells
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- Authors
- DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B.
- Affiliations
- Abramson Cancer Center (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Thompson, Craig B
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 18
- Issue
- 1
- Pages
- 54-61
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC2476215
- OpenAlex
- W2162016905
- Cited by
- 1,018
- References
- 64
- Citations by year
- 2026: 6 · 2025: 25 · 2024: 27 · 2023: 45 · 2022: 51 · 2021: 71 · 2020: 36 · 2019: 40 · 2018: 57 · 2017: 68 · 2016: 71 · 2015: 72 · 2014: 79 · 2013: 76 · 2012: 93
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P01CA104838)
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK072565)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- cancer metabolism, tumor growth, Warburg effect, glycolysis, oxidative phosphorylation, nucleotide synthesis, fatty acid synthesis, glutamine metabolism, oncogenes, tumor suppressor, macromolecular synthesis, biosynthesis
- MeSH terms
- Fatty Acids, Glutamine, Glycolysis, Humans, Lipids, Models, Biological, Neoplasms, Ribosemonophosphates, Cell Proliferation
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