The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Role of N6-methyladenosine modification in cancer
Open accessAbstract
As the most abundant internal modification in eukaryotic messenger RNAs identified, N6-methyladenosine (m6A) has been shown recently to play essential roles in various normal bioprocesses. Evidence is emerging that m6A modification and its regulatory proteins also play critical roles in various cancers including leukemia, brain tumor, breast cancer and lung cancer, etc. For instance, FTO, the first m6A demethylase identified, has been reported recently to play an oncogenic role in leukemia and glioblastoma. ALKBH5 (another m6A demethylase) has been reported to exert a tumor-promoting function in glioblastoma and breast cancer. METTL3 (a major m6A methyltransferase) likely plays distinct roles between glioblastoma and lung cancer. Here we discuss the recent progress and future prospects in study of m6A machinery in cancer.
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N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
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DNMT3A Mutations in Acute Myeloid Leukemia
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YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
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Mutation in TET2 in Myeloid Cancers
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Cited by
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Huang, H., Weng, H., Zhou, K., Wu, T., Zhao, B. S., Sun, M., Chen, Z., Deng, X., Xiao, G., Auer, F., et al. (2019) · Nature · doi:10.1038/s41586-019-1016-7 · Cited by 677
Self-citationMultiple functions of m6A RNA methylation in cancer
Pan, Y., Ma, P., Liu, Y., Li, W., & Shu, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0590-8 · Cited by 312
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation
Kan, R. L., Chen, J., & Sallam, T. (2022) · Trends in Genetics · doi:10.1016/j.tig.2021.06.014 · Cited by 308
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Metadata
- Authors
- Deng, X., Su, R., Feng, X., Wei, M., & Chen, J.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 48
- Pages
- 1-7
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2761347085
- Cited by
- 200
- References
- 11
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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