The origins of cancer cell dormancy
Open accessAbstract
Cancer cell dormancy has emerged as an important nongenetic driver of drug resistance. Dormant cells are characterized by a reversible cell cycle exit. They represent a reservoir for eventual cancer relapse, and upon reactivation, can fuel metastatic disease. Although dormant cells were originally believed to emerge from a drug-resistant pre-existing cancer subpopulation, this notion has been recently challenged. Here, we review recent evidence indicating that dormancy represents an adaptive strategy employed by cancer cells to avoid the cytotoxic effects of antitumor therapy. Furthermore, we outline the molecular pathways engaged by cancer cells to enter dormancy upon drug exposure, with a focus on cellular senescence as a driver of dormancy.
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In oncogenic processes that abrogate dormancy of senescent cells and push them toward malignant transformation, the resulting cancer cells may already have been pre-selected to evade immune recognition.
“In oncogenic processes that abrogate dormancy of such senescent cells, pushing them toward malignant transformation, 256 the resulting cancer cells may already have been pre-selected to evade immune recognition.”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [256]
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Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works
- Authors
- Morales-Valencia, J., & David, G.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- David, Gregory
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 74
- Pages
- 101914
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC9156570
- OpenAlex
- W4225127877
- Cited by
- 25
- References
- 59
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 4
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NYSDOH (C36617GG)
- New York State Stem Cell Science (C322560GG)
- National Institutes of Health
- NCI (CA246416)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- cancer cell dormancy, drug resistance, tumor recurrence, metastasis, cellular senescence, cancer therapy
- MeSH terms
- Antineoplastic Agents, Humans, Neoplasms, Neoplastic Stem Cells, Tumor Microenvironment
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