Cited by 495Hepatocellular Carcinoma Treatment and PrognosisMedical Imaging Techniques and ApplicationsMRI in cancer diagnosis

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Advances in the early diagnosis of hepatocellular carcinoma

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Wang, Weiyi, Wei, Chao·2020·Genes & Diseases

DOI 10.1016/j.gendis.2020.01.014PMC PMC7452544

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Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers globally. In contrast to the declining death rates observed for all other common cancers such as breast, lung, and prostate cancers, the death rates for HCC continue to increase by ~2-3% per year because HCC is frequently diagnosed late and there is no curative therapy for an advanced HCC. The early diagnosis of HCC is truly a big challenge. Over the past years, the early diagnosis of HCC has relied on surveillance with ultrasonography (US) and serological assessments of alpha-fetoprotein (AFP). However, the specificity and sensitivity of US/AFP is not satisfactory enough to detect early onset HCC. Recent technological advancements offer hope for early HCC diagnosis. Herein, we review the progress made in HCC diagnostics, with a focus on emerging imaging techniques and biomarkers for early disease diagnosis.

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Authors: Wang, W., & Wei, C.
Corresponding author: Wei, Chao
ORCID: Wang, Weiyi
Wei, Chao
Venue: Genes & Diseases
Publisher: Elsevier BV
Published: 2020-09
Volume: 7
Issue: 3
Pages: 308-319
ISSN: 2352-3042 (ISSN-L)
DOI: 10.1016/j.gendis.2020.01.014
PMC: PMC7452544
OpenAlex: W3003360914
Cited by: 492
References: 179
Citations by year: 2026: 56 · 2025: 107 · 2024: 126 · 2023: 108 · 2022: 74 · 2021: 19 · 2020: 2
FWCI: 6.76
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Genes & Diseases (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
Keywords: hepatocellular carcinoma, early diagnosis, alpha-fetoprotein, ultrasonography, cancer surveillance, imaging modalities, biomarkers, sensitivity and specificity

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Advances in the early diagnosis of hepatocellular carcinoma

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