The prevalence of diabetes mellitus and abnormal glucose metabolism in the inpatient psychiatric setting: a systematic review and meta-analysis
Open accessAbstract
Objective To systematically determine the prevalence of diabetes mellitus (DM), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) in psychiatric inpatients and explore the impact of patient and study variables on prevalence estimates. Method We searched EMBASE, PsychINFO, Medline and CENTRAL from database inception until 1st December 2015. We included studies of any design reporting prevalence of abnormal glucose metabolism in any adult psychiatric inpatients. We conducted a random effects meta-analysis to generate pooled prevalence estimates. Chi-square tests compared differences within categorical variables (inpatient setting, continent of study and patient diagnostic category) and Spearman's correlation analyses assessed the impact of linear variables (age, year of data collection and study quality). Study quality was assessed using an adapted Newcastle-Ottawa Scale. Results 36 study reports representing 42 unique cohorts were included. Across all studies prevalence of unspecified type DM was 10% (95%CI: 9-12), of T1DM was 1% (0-1), of T2DM was 9% (6-13), of IFG 18% (8-28), and of IGT was 22% (16-28). These estimates were not affected by study quality. Conclusions All estimates are higher compared to the general population. Mental health professionals should be aware of this elevated prevalence to improve screening and management of abnormal glucose metabolism.
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Zonisamide has limited evidence for use in second-generation antipsychotic-induced weight gain.
“Limited evidence for use in in secondgeneration antipsychotic induced weight gain.84”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [84]
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- Authors
- Roberts, E., Jones, L., Blackman, A., Dewhurst, T., Matcham, F., Kan, C., Mustafa, O., Thomas, T., Siddiqi, N., Ismail, K., & Price, H.
- Affiliations
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- King's College Hospital (GB)
- Bradford District Care NHS Foundation Trust (GB)
- Southern Health NHS Foundation Trust (GB)
- Corresponding author
- Roberts, Emmert
- ORCID
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 45
- Pages
- 76-84
- ISSN
- 0163-8343 (ISSN-L)
- OpenAlex
- W2572226087
- Cited by
- 23
- References
- 61
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute for Health and Care Research (ACF-2014-17-009, 15/70/26, CL-2017-17-003, RP-DG-1214-10002)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- diabetes mellitus, impaired fasting glucose, impaired glucose tolerance, abnormal glucose metabolism, psychiatric inpatients, prevalence, type 1 diabetes, type 2 diabetes, diabetes screening, mental illness
- MeSH terms
- Mental Disorders, Hospitals, Psychiatric, Humans, Comorbidity, Glucose Metabolism Disorders
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