Physical comorbidities increase the risk of psychiatric comorbidity in immune-mediated inflammatory disease
Abstract
Objective We tested the association between physical comorbidity and incident depression, anxiety disorder and bipolar disorder in three immune-mediated inflammatory diseases (IMID): inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA) versus age-, sex- and geographically-matched controls.Methods Using population-based administrative data we identified 6119 persons with IBD, 3514 persons with MS, 10,206 persons with RA and 97,727 matched controls. We identified incident cases of depression, anxiety disorder and bipolar disorder in these populations. We evaluated the association of physical comorbidities with incident psychiatric comorbidity using Cox regression, adjusting for sociodemographic factors and index year.Results The risk of incident depression, anxiety disorders and bipolar disorder was higher in each IMID cohort versus their matched cohorts. The risk of incident psychiatric comorbidity increased with an increasing number of physical comorbidities for each psychiatric comorbidity evaluated, across all IMID. Adjustment for physical comorbidity did not attenuate the increased risk of psychiatric comorbidity in the IMID cohorts versus their matched cohorts.Conclusion The increased incidence of psychiatric comorbidity in IMID versus matched general population cohorts is not accounted for by their increased prevalence of physical comorbidities. However, within IMID cohorts, physical comorbidity increases the risk of psychiatric comorbidity.
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In an IBD cohort, patients exhibited a high incidence of psychological distress and comorbidities, including depression, anxiety disorders, and bipolar disorder.
“In an IBD cohort, patients exhibited a high incidence of psychological distress and comorbidities, including depression, anxiety disorders, and bipolar disorder (57).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [57]
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- Authors
- Marrie, R. A., Walld, R., Bolton, J. M., Sareen, J., Walker, J. R., Patten, S. B., Singer, A., Lix, L. M., Hitchon, C. A., El-Gabalawy, R., Katz, A., Fisk, J. D., & Bernstein, C. N.
- Affiliations
- University of Manitoba (CA)
- University of Calgary (CA)
- Dalhousie University (CA)
- Corresponding author
- Marrie, Ruth Ann
- ORCID
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 51
- Pages
- 71-78
- ISSN
- 0163-8343 (ISSN-L)
- OpenAlex
- W2784230895
- Cited by
- 31
- References
- 65
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 2
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Manitoba
- Crohn's and Colitis Canada
- Canadian Institutes of Health Research (THC-135234, 333252)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- somatic comorbidity, psychiatric comorbidity, immune-mediated inflammatory diseases, depression, anxiety disorders, bipolar disorder, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, comorbidity burden
- MeSH terms
- Adolescent, Adult, Aged, Anxiety Disorders, Bipolar Disorder, Depressive Disorder, Female, Humans, Male, Manitoba, Middle Aged, Multiple Sclerosis, Rheumatic Fever, Risk, Inflammatory Bowel Diseases, Comorbidity, Young Adult
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