Mental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance
Open accessAbstract
BACKGROUND: While mental comorbidity is considered common in multiple sclerosis (MS), its impact is poorly defined; methods are needed to support studies of mental comorbidity. We validated and applied administrative case definitions for any mental comorbidities in MS. METHODS: Using administrative health data we identified persons with MS and a matched general population cohort. Administrative case definitions for any mental comorbidity, any mood disorder, depression, anxiety, bipolar disorder and schizophrenia were developed and validated against medical records using a a kappa statistic (k). Using these definitions we estimated the prevalence of these comorbidities in the study populations. RESULTS: Compared to medical records, administrative definitions showed moderate agreement for any mental comorbidity, mood disorders and depression (all k ≥ 0.49), fair agreement for anxiety (k = 0.23) and bipolar disorder (k = 0.30), and near perfect agreement for schizophrenia (k = 1.0). The age-standardized prevalence of all mental comorbidities was higher in the MS than in the general populations: depression (31.7% vs. 20.5%), anxiety (35.6% vs. 29.6%), and bipolar disorder (5.83% vs. 3.45%), except for schizophrenia (0.93% vs. 0.93%). CONCLUSIONS: Administrative data are a valid means of surveillance of mental comorbidity in MS. The prevalence of mental comorbidities, except schizophrenia, is increased in MS compared to the general population.
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Numerous studies show that anxiety is almost as common as depression in persons with multiple sclerosis.
“numerous studies show that anxiety is almost as common as depression in persons with MS”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Marrie et al., 2013
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Sexual Dysfunction Seems to Trigger Depression in Female Multiple Sclerosis Patients
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Neurology Issues in Schizophrenia
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Noradrenaline transmission reducing drugs may protect against a broad range of diseases.
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Incidence of Mood or Anxiety Disorders in Children of Parents with Multiple Sclerosis
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Effect of Exercise Interventions on Anxiety in People with Multiple Sclerosis
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Clinical Profile of Persons with Multiple Sclerosis Across the Continuum of Care
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Re-Examination of Classic Risk Factors for Suicidal Behavior in the Psychiatric Population
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Psychiatric comorbidity in multiple sclerosis: It’s not the genes
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- Authors
- for the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis, Marrie, R. A., Fisk, J. D., Yu, B. N., Leung, S., Elliott, L., Caetano, P., Warren, S., Evans, C., Wolfson, C., Svenson, L. W., Tremlett, H., Blanchard, J. F., & Patten, S. B.
- Affiliations
- University of Manitoba (CA)
- Health Sciences Centre (CA)
- Dalhousie University (CA)
- University of Alberta (CA)
- University of Saskatchewan (CA)
- Alberta Health (CA)
- Research Institute of the McGill University Health Centre (CA)
- Corresponding author
- Marrie, Ruth Ann
- ORCID
- Venue
- BMC Neurology
- Published
- 2013-02-06
- Volume
- 13
- Issue
- 1
- Pages
- 16-16
- ISSN
- 1471-2377 (ISSN-L)
- PMC
- PMC3599013
- OpenAlex
- W2011332759
- Cited by
- 163
- References
- 34
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 11 · 2018: 15 · 2017: 12 · 2016: 16 · 2015: 19 · 2014: 11 · 2013: 2
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- cIRcle (University of British Columbia) (submittedVersion, cc-by)
- Mspace (University of Manitoba) (submittedVersion)
- Open Collections
- Funders
- United States Agency for International Development
- Bill and Melinda Gates Foundation
- Amgen
- Pfizer
- AstraZeneca
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alberta Health Services
- Health Sciences Centre Foundation
- McGill University
- European Committee for Treatment and Research in Multiple Sclerosis
- Manitoba Health Research Council
- Canadian Health Services Research Foundation
- Public Health Agency of Canada
- University of Alberta
- Michael Smith Health Research BC (MOP-93646, RG 4202-A-2)
- Multiple Sclerosis Society of Canada (MOP-93646, RG 4202-A-2)
- Multiple Sclerosis Society
- Public Health Agency
- Dalhousie University
- University of British Columbia
- Schweizerische Multiple Sklerose Gesellschaft
- Alberta Innovates
- Servier
- H. Lundbeck A/S
- Bayer Canada
- Canadian Institutes of Health Research (RG 4202-A-2, (MOP: #93646, 190898)
- Social Sciences and Humanities Research Council of Canada (93646)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Health Professions › Health Information Management › Medical Coding and Health Information
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- multiple sclerosis, psychiatric comorbidity, administrative data validation, case definition, depression, anxiety, bipolar disorder, schizophrenia, mood disorders, prevalence, population-based surveillance
- MeSH terms
- Adult, Mental Disorders, Canada, Female, Humans, Male, Medical Records, Middle Aged, Multiple Sclerosis, Population Surveillance, Reproducibility of Results, Cohort Studies, Comorbidity, Prevalence, Young Adult
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