Interaction of auditory and pain pathways: effects of stimulus intensity, hearing loss and opioid signaling
Open accessAbstract
Moderate intensity sounds can reduce pain sensitivity (i.e., audio-analgesia) whereas intense sounds can induce aural pain, evidence of multisensory interaction between auditory and pain pathways. To explore auditory-pain pathway interactions, we used the tail-flick (TF) test to assess thermal tail-pain sensitivity by measuring the latency of a rat to remove its tail from 52 °C water. In Experiment 1, TF latencies were measured in ambient noise and broadband noise (BBN) presented from 80 to 120 dB SPL. TF latencies gradually increased from ambient to 90 dB SPL (audio-analgesia), but then declined. At 120 dB, TF latencies were significantly shorter than normal, evidence for audio-hyperalgesia near the aural threshold for pain. In Experiment II, the opioid pain pathway was modified by treating rats with a high dose of fentanyl known to induce post-treatment hyperalgesia. TF latencies in ambient noise were normal 10-days post-fentanyl. However, TF latencies became shorter than normal from 90 to 110 dB indicating that fentanyl pre-treatment had converted audio-analgesia to audio-hyperalgesia. In Experiment III, we tested the hypothesis that hearing loss could alter pain sensitivity by unilaterally exposing rats to an intense noise that induced a significant hearing loss. TF latencies in ambient noise gradually declined from 1- to 4-weeks post-exposure indicating that noise-induced hearing loss had increased pain sensitivity. Our results suggest that auditory and pain pathways interact in ways that depend on intensity, hearing loss and opioid pain signaling, results potentially relevant to pain hyperacusis.
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Interactions between the auditory and pain pathways may be mediated in part by opioid signaling, consistent with the excellent pain relief from oxycodone reported by one participant.
“Moreover, interactions between the auditory and pain pathways may be mediated, in part, by opioid signaling34, consistent with the excellent pain relief from oxycodone that one participant reported (Table 3).”
From Clinical phenotype and management of sound-induced pain: Insights from adults with pain hyperacusis (2025) · cites this paper as [34]
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Cepeda, M. S., Carr, D. B., Lau, J., & Álvarez, H. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004843.pub2 · Cited by 432 · see citing works
RetractedPain regulation by non-neuronal cells and inflammation
Ji, R.-R., Chamessian, A., & Zhang, Y.-Q. (2016) · Science · doi:10.1126/science.aaf8924 · Cited by 1,314 · see citing works
Organization of endogenous opiate and nonopiate pain control systems
Watkins, L. R., & Mayer, D. J. (1982) · Science · doi:10.1126/science.6281891 · Cited by 791 · see citing works
Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception
Mogil, J. S., Wilson, S. G., Bon, K., Eun Lee, S., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., et al. (1999) · Pain · doi:10.1016/s0304-3959(98)00197-3 · Cited by 656 · see citing works
Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine
Célèrier, E., Rivat, C., Jun, Y., Laulin, J.-P., Larcher, A., Reynier, P., & Simonnet, G. (2000) · Anesthesiology · doi:10.1097/00000542-200002000-00029 · Cited by 584 · see citing works
Thrills in response to music and other stimuli
Goldstein, A. (1980) · Physiological Psychology · doi:10.3758/bf03326460 · Cited by 534 · see citing works
Janssen, P. A., Cj, N., & Jg, D. (1963) · PubMed · Cited by 522 · see citing works
The dorsal posterior insula subserves a fundamental role in human pain
Segerdahl, A. R., Mezue, M., Okell, T. W., Farrar, J. T., & Tracey, I. (2015) · Nature Neuroscience · doi:10.1038/nn.3969 · Cited by 393 · see citing works
Crossmodal binding through neural coherence: implications for multisensory processing
Senkowski, D., Schneider, T. R., Foxe, J. J., & Engel, A. K. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.05.002 · Cited by 383 · see citing works
Ledoux, J. E., Ruggiero, D. A., Forest, R., Stornetta, R., & Reis, D. J. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902640110 · Cited by 373 · see citing works
Update on Nonpharmacologic Approaches to Relieve Labor Pain and Prevent Suffering
Simkin, P., & Bolding, A. (2004) · Journal of Midwifery & Women s Health · doi:10.1016/j.jmwh.2004.07.007 · Cited by 342 · see citing works
A review of hyperacusis and future directions: Part I. Definitions and manifestations
Tyler, R. S., Pienkowski, M., Roncancio, E. R., Jun, H. J., Brozoski, T., Dauman, N., Coelho, C. B., Andersson, G., Keiner, A. J., Cacace, A. T., et al. (2014) · American Journal of Audiology · doi:10.1044/2014_aja-14-0010 · Cited by 329 · see citing works
Célèrier, E., Laulin, J.-P., Corcuff, J.-B., Le Moal, M., & Simonnet, G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04074.2001 · Cited by 315 · see citing works
Knipper, M., van Dijk, P., Nunes, I., Rüttiger, L., & Zimmermann, U. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.002 · Cited by 307 · see citing works
Microglia and neuropathic pain
Inoue, K., & Tsuda, M. (2009) · Glia · doi:10.1002/glia.20871 · Cited by 291 · see citing works
Genetic predictors for acute experimental cold and heat pain sensitivity in humans
Kim, H., Mittal, D. P., Iadarola, M. J., & Dionne, R. A. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2005.036079 · Cited by 206 · see citing works
Salicylate increases the gain of the central auditory system
Sun, W., Lu, J., Stolzberg, D. J., Gray, L., Deng, A., Lobariñas, E., & Salvi, R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.024 · Cited by 200 · see citing works
Self-citationShore, S. E., Koehler, S. D., Oldakowski, M., Hughes, L. F., & Syed, S. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05983.x · Cited by 196 · see citing works
Shore, S. E. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04142.x · Cited by 194 · see citing works
Fentanyl Enhancement of Carrageenan-induced Long-lasting Hyperalgesia in Rats
Rivat, C., Laulin, J., Corcuff, J., Célèrier, E., Pain, L., & Simonnet, G. (2002) · Anesthesiology · doi:10.1097/00000542-200202000-00025 · Cited by 181 · see citing works
Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain
Taves, S., Berta, T., Chen, G., & Ji, R. (2013) · Neural Plasticity · doi:10.1155/2013/753656 · Cited by 179 · see citing works
A comparison of the effects of preferred music, arithmetic and humour on cold pressor pain
Mitchell, L., MacDonald, R., & Brodie, E. E. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.03.005 · Cited by 178 · see citing works
Dobek, C. E., Beynon, M. E., Bosma, R. L., & Stroman, P. W. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.07.006 · Cited by 177 · see citing works
Noise trauma impairs neurogenesis in the rat hippocampus
Kraus, K. S., Mitra, S., Jiménez, Z., Hinduja, S., Ding, D., Jiang, H., Gray, L., Lobariñas, E., Sun, W., & Salvi, R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.071 · Cited by 174 · see citing works
Self-citationIson, J., Allen, P., & O'Neill, W. (2007) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-007-0098-3 · Cited by 173 · see citing works
The Mu-Opioid Receptor and the NMDA Receptor Associate in PAG Neurons: Implications in Pain Control
Rodríguez-Muñoz, M., Sánchez‐Blázquez, P., Vicente‐Sánchez, A., Berrocoso, E., & Garzón, J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.155 · Cited by 170 · see citing works
The medial division of the medial geniculate body of the cat: implications for thalamic organization
Winer, J., & Morest, D. K. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-12-02629.1983 · Cited by 169 · see citing works
Dehmel, S., Pradhan, S., Koehler, S. D., Bledsoe, S. C., & Shore, S. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-11.2012 · Cited by 165 · see citing works
Long-lasting increased pain sensitivity in rat following exposure to heroin for the first time
Laulin, J., Larcher, A., Célèrier, E., Moal, M. L., & Simonnet, G. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00083.x · Cited by 156 · cited 2× · see citing works
“This long-lasting opiate-induced hyperalgesia could be blocked by NMDA-antagonists (Laulin et al., 1998; Rivat et al., 2002).”
BackgroundAudiometric Characteristics of Hyperacusis Patients
Sheldrake, J. B., Diehl, P. U., & Schaette, R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00105 · Cited by 155 · see citing works
Zhou, J., & Shore, S. E. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20343 · Cited by 141 · see citing works
Opioid-induced Hyperalgesia in a Murine Model of Postoperative Pain
Célèrier, E., González, J. R., Maldonado, R. J., Cabañero, D., & Puig, M. M. (2006) · Anesthesiology · doi:10.1097/00000542-200603000-00023 · Cited by 137 · see citing works
Adult deafness induces somatosensory conversion of ferret auditory cortex
Allman, B. L., Keniston, L., & Meredith, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809483106 · Cited by 130 · see citing works
Unilateral Photophobia or Phonophobia in Migraine Compared With Trigeminal Autonomic Cephalalgias
Irimia, P., Cittadini, E., Paemeleire, K., Cohen, A. S., & Goadsby, P. J. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01565.x · Cited by 129 · see citing works
Preventing Occupational Hearing Loss-A Practical Guide
Glaser, R. H. (1997) · Ear and Hearing · doi:10.1097/00003446-199708000-00015 · Cited by 128 · see citing works
Sherlock, L. P., & Formby, C. (2005) · Journal of the American Academy of Audiology · doi:10.3766/jaaa.16.2.4 · Cited by 127 · see citing works
The estrous cycle and estrogen modulate stress-induced analgesia.
Ryan, S. M., & Maier, S. F. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.3.371 · Cited by 124 · see citing works
Auditory analgesia in dental operations
Gardner, W. J., & Licklider, J. C. R. (1959) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1959.0251 · Cited by 123 · see citing works
Potentiated Opioid Analgesia in Norepinephrine Transporter Knock-Out Mice
Bohn, L., Xu, F., Gainetdinov, R. R., & Caron, M. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09040.2000 · Cited by 122 · see citing works
Aazh, H., McFerran, D. J., Salvi, R., Prasher, D. K., Jastreboff, M., & Jastreboff, P. (2014) · Noise and Health · doi:10.4103/1463-1741.132100 · Cited by 117 · see citing works
Self-citationMcNally, G. P., Pigg, M., & Weidemann, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1828-04.2004 · Cited by 117 · see citing works
Efferent projections of the gracile nucleus in the cat
Berkley, K. J., & Hand, P. J. (1978) · Brain Research · doi:10.1016/0006-8993(78)90406-7 · Cited by 109 · see citing works
The estrous cycle and estrogen modulate stress-induced analgesia.
Ryan, S. M., & Maier, S. F. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.3.371 · Cited by 109 · see citing works
Long-Term Opioid Use in Non-Cancer Pain
Häuser, W., Bock, F., Engeser, P., Tölle, T. R., Willweber-Strumpf, A., & Petzke, F. W. (2014) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2014.0732 · Cited by 100 · see citing works
Brain correlates of stress-induced analgesia
Yilmaz, P., Diers, M., Diener, S. J., Rance, M., Wessa, M., & Flor, H. (2010) · Pain · doi:10.1016/j.pain.2010.08.016 · Cited by 99 · see citing works
Acquired hearing loss and brain plasticity
Eggermont, J. J. (2016) · Hearing Research · doi:10.1016/j.heares.2016.05.008 · Cited by 99 · see citing works
Somatosensory Projections to Cochlear Nucleus Are Upregulated after Unilateral Deafness
Zeng, C., Yang, Z., Shreve, L., Bledsoe, S. C., & Shore, S. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2598-12.2012 · Cited by 97 · see citing works
Hyperacusis in patients with complex regional pain syndrome related dystonia
de Klaver, M. J. M., van Rijn, M. A., Marinus, J., Soede, W., de Laat, J. A. P. M., & van Hilten, J. J. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.111609 · Cited by 96 · see citing works
Visual influences on ferret auditory cortex
Bizley, J. K., & King, A. J. (2009) · Hearing Research · doi:10.1016/j.heares.2009.06.017 · Cited by 89 · see citing works
Stricker, P. A., Muhly, W. T., Jantzen, E. C., Li, Y., Jawad, A. F., Long, A. S., Polansky, M., & Cook‐Sather, S. D. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001722 · Cited by 89 · see citing works
Migraine, vertigo and migrainous vertigo: Links between vestibular and pain mechanisms
Balaban, C. D. (2011) · Journal of Vestibular Research · doi:10.3233/ves-2011-0428 · Cited by 88 · see citing works
Physiological brainstem mechanisms of trigeminal nociception: An fMRI study at 3T
Schulte, L. H., Sprenger, C., & May, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.023 · Cited by 83 · see citing works
Pavlovian conditioning of opioid and nonopioid pain inhibitory mechanisms in humans
Flor, H., Birbaumer, N., Schulz, R., Grüsser, S. M., & Mucha, R. F. (2002) · European Journal of Pain · doi:10.1016/s1090-3801(02)00043-5 · Cited by 80 · see citing works
Jain, R., & Shore, S. E. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.077 · Cited by 78 · see citing works
Neural systems for the expression of hypoalgesia during nonassociative fear.
Bellgowan, P. S. F., & Helmstetter, F. J. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.727 · Cited by 76 · see citing works
Benison, A. M., Chumachenko, S. Y., Harrison, J. A., Maier, S. F., Falci, S. P., Watkins, L. R., & Barth, D. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0076-11.2011 · Cited by 73 · see citing works
Li, H., & Mizuno, N. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00082-5 · Cited by 72 · see citing works
Endogenous opioids regulate moment-to-moment neuronal communication and excitability
Winters, B. L., Gregoriou, G. C., Kissiwaa, S. A., Wells, O., Medagoda, D. I., Hermes, S. M., Burford, N. T., Alt, A. J., Aicher, S. A., & Bagley, E. E. (2017) · Nature Communications · doi:10.1038/ncomms14611 · Cited by 71 · see citing works
Chronic Opioid Use in Fibromyalgia Syndrome
Painter, J. T., & Crofford, L. J. (2013) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0b013e3182863447 · Cited by 70 · see citing works
Hyperacusis in chronic pain: neural interactions between the auditory and nociceptive systems
Suhnan, A. P., Finch, P. M., & Drummond, P. D. (2017) · International Journal of Audiology · doi:10.1080/14992027.2017.1346303 · Cited by 69 · see citing works
Neural systems for the expression of hypoalgesia during nonassociative fear.
Bellgowan, P. S. F., & Helmstetter, F. J. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.4.727 · Cited by 69 · see citing works
Li, J., Xie, W., Strong, J. A., Guo, Q., & Zhang, J. (2010) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e318203087f · Cited by 67 · see citing works
Bellgowan, P. S. F., & Helmstetter, F. J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00057-2 · Cited by 65 · see citing works
Multi-sensory integration in brainstem and auditory cortex
Basura, G. J., Koehler, S. D., & Shore, S. E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.037 · Cited by 63 · see citing works
Gabapentin Prevents Delayed and Long-lasting Hyperalgesia Induced by Fentanyl in Rats
Elstraete, A. C. V., Sitbon, P., Mazoit, J., & Benhamou, D. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318164cf85 · Cited by 62 · see citing works
Kraus, K. S., Ding, D., Jiang, H., Lobarinas, E., Sun, W., & Salvi, R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.056 · Cited by 61 · see citing works
Self-citationTonic tensor tympani syndrome in tinnitus and hyperacusis patients: A multi-clinic prevalence study
Westcott, M., Sanchez, T., Sharples, T., Diges, I., Saba, C., Dineen, R., McNeill, C., Chiam, A., & O′Keefe, M. (2013) · Noise and Health · doi:10.4103/1463-1741.110295 · Cited by 59 · see citing works
Buprenorphine-induced hyperalgesia in the rat
Wala, E. P., & Holtman, J. R. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.083 · Cited by 59 · see citing works
Collaterals of primate spinothalamic tract neurons to the periaqueductal gray
Zhang, D., Carlton, S. M., Sorkin, L. S., & Willis, W. D. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902960208 · Cited by 57 · see citing works
Early Hearing-Impairment Results in Crossmodal Reorganization of Ferret Core Auditory Cortex
Meredith, M. A., & Allman, B. L. (2012) · Neural Plasticity · doi:10.1155/2012/601591 · Cited by 56 · see citing works
Effects of acoustic trauma on the auditory system of the rat: The role of microglia
Baizer, J. S., Wong, K. M., Manohar, S., Hayes, S. H., Ding, D., Dingman, R., & Salvi, R. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.004 · Cited by 53 · see citing works
Self-citationCyclooxygenase‐2 (Cox‐2) in injured human nerve and a rat model of nerve injury
Durrenberger, P. F., Facer, P., Gray, R., Chessell, I. P., Naylor, A., Bountra, C., Banati, R. B., Birch, R., & Anand, P. (2004) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2004.09104.x · Cited by 51 · see citing works
Preventing occupational hearing loss - a practical guide.
(1996) · doi:10.26616/nioshpub96110 · Cited by 50 · see citing works
Reconnecting neuronal networks in the auditory brainstem following unilateral deafening
Illing, R., Kraus, K. S., & Meidinger, M. A. (2005) · Hearing Research · doi:10.1016/j.heares.2005.01.016 · Cited by 49 · see citing works
Meredith, M. A., Clemo, H. R., Corley, S. B., Chabot, N., & Lomber, S. G. (2015) · Hearing Research · doi:10.1016/j.heares.2015.12.007 · Cited by 49 · see citing works
N’Gouemo, P., & Faingold, C. L. (1999) · Epilepsy Research · doi:10.1016/s0920-1211(98)00128-4 · Cited by 47 · see citing works
Ready for action: a role for the human midbrain in responding to infant vocalizations
Parsons, C. E., Young, K. S., Joensson, M., Brattico, E., Hyam, J. A., Stein, A. L., Green, A. L., Aziz, T. Z., & Kringelbach, M. L. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst076 · Cited by 45 · see citing works
Quintão, N. L. M., da Silva, G., Antonialli, C. S., Rocha, L. W., Filho, V. C., & Cicció, J. F. (2010) · Planta Medica · doi:10.1055/s-0029-1240891 · Cited by 43 · see citing works
An Integrative Model Accounting for the Symptom Cluster Triggered After an Acoustic Shock
Noreña, A. J., Fournier, P., Londero, A., Ponsot, D., & Charpentier, N. (2018) · Trends in Hearing · doi:10.1177/2331216518801725 · Cited by 42 · see citing works
Macías, Á. R., González, J. C. F., Manrique, M. J., Pérez, C. M., Garcia-Ibanez, L., Español, C. C., Coudert-Koall, C., & Killian, M. J. P. (2018) · Audiology and Neurotology · doi:10.1159/000488755 · Cited by 42 · see citing works
Wang, H., Chen, J., Xu, X., Sun, W., Chen, X., Zhao, F., Luo, M., Liu, C., Guo, Y., Xie, W., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000417 · Cited by 42 · see citing works
Manohar, S., Spoth, J., Radziwon, K. E., Auerbach, B. D., & Salvi, R. (2017) · Hearing Research · doi:10.1016/j.heares.2017.07.001 · Cited by 39 · see citing works
Self-citationCrossmodal bias of visual input on pain perception and pain-induced beta activity
Pomper, U., Höfle, M., Hauck, M., Kathmann, N., Engel, A. K., & Senkowski, D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.040 · Cited by 38 · see citing works
Central hyperacusis with phonophobia in multiple sclerosis
Weber, H. G., Pfadenhauer, K., Stöhr, M., & Rösler, A. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms814oa · Cited by 36 · see citing works
Foo, H., & Helmstetter, F. J. (1999) · Pain · doi:10.1016/s0304-3959(99)00125-6 · Cited by 35 · see citing works
Hypoalgesia in response to sensitization during acute noise stress.
Helmstetter, F. J., & Bellgowan, P. S. F. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.177 · Cited by 35 · see citing works
Abnormal Auditory Gain in Hyperacusis: Investigation with a Computational Model
Diehl, P. U., & Schaette, R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00157 · Cited by 34 · see citing works
Zd, B. (2000) · PubMed · Cited by 33 · see citing works
Selective opioid δ agonists elicit antinociceptive supraspinal/spinal synergy in the rat
Kovelowski, C. J., Bian, D., Hruby, V. J., Lai, J. Y., Ossipov, M. H., & Porreca, F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01803-x · Cited by 33 · see citing works
Lu, C., Ye, F., Luo, Q., Tao, Y., & Shu, H. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002601 · Cited by 33 · see citing works
Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling
Manohar, S., Dahar, K., Adler, H. J., Dalian, D., & Salvi, R. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.07.005 · Cited by 31 · see citing works
Self-citationHypoalgesia in response to sensitization during acute noise stress.
Helmstetter, F. J., & Bellgowan, P. S. F. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.177 · Cited by 30 · see citing works
Reisch, A., Illing, R., & Laszig, R. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.016 · Cited by 27 · see citing works
Sensitization or tolerance to morphine effects after repeated stresses
Benedek, G., & Szikszay, M. (1985) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(85)90189-7 · Cited by 24 · see citing works
Fournier, P., Schönwiesner, M., & Hébert, S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.007 · Cited by 20 · see citing works
Analgesia following startle-eliciting stimuli
Cranney, J. (1988) · Psychobiology · doi:10.3758/bf03327301 · Cited by 18 · see citing works
Special Issue on microglia and chronic pain
Hulsebosch, C. E. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.009 · Cited by 18 · see citing works
Synaptic Reorganization Response in the Cochlear Nucleus Following Intense Noise Exposure
Manohar, S., Ramchander, P. V., Salvi, R., & Seigel, G. M. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.023 · Cited by 17 · see citing works
Self-citationCongenital deafness is associated with specific somatosensory deficits in adolescents
Moshourab, R. A., Bégay, V., Wetzel, C., Walcher, J., Middleton, S. J., Gross, M., & Lewin, G. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-04074-0 · Cited by 16 · see citing works
Kappa opioid receptors participate in nerve growth factor-induced hyperalgesia
Apfel, S. C., Newel, M., Dormia, C., & Kessler, J. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00209-2 · Cited by 15 · see citing works
Reactive microglia after taste nerve injury: comparison to nerve injury models of chronic pain
Bartel, D. L., & Finger, T. E. (2013) · F1000Research · doi:10.12688/f1000research.2-65.v1 · Cited by 15 · see citing works
Non-opiate analgesia following stressful acoustic stimulation
Szikszay, M., Benedek, G., & Hideg, J. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90185-4 · Cited by 14 · see citing works
Analgesic effect of environmental noise: a possible stress response in rats.
Shankar, N., Awasthy, N., Mago, H., & Tandon, O. P. (1999) · PubMed · Cited by 13 · see citing works
Audiotaped relaxation, implosion, and rehearsal for the treatment of patients with dental phobia.
Lg, H. (1992) · PubMed · Cited by 10 · see citing works
Halladay, L. R., & Blair, H. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.045 · Cited by 10 · see citing works
Tamari, J. W., Naccache, A., To'mey, G. F., & Jabbur, S. J. (1974) · Experimental Neurology · doi:10.1016/0014-4886(74)90168-x · Cited by 9 · see citing works
A search for a mesencephalic periaqueductal gray-cochlear nucleus connection.
Radmilovich, M., Bertolotto, C., Jl, P., Pedemonte, M., & Velluti, R. A. (1991) · PubMed · Cited by 9 · see citing works
Effect of Audioanalgesia in 6- to 12-year-old Children during Dental Treatment Procedure
Ramar, K., Hariharavel, V. P., Sinnaduri, G., Sambath, G., Zohni, F., & Alagu, P. J. (2016) · The Journal of Contemporary Dental Practice · doi:10.5005/jp-journals-10024-1973 · Cited by 9 · see citing works
Marone, J. G. (1968) · Psychological Reports · doi:10.2466/pr0.1968.22.3c.1055 · Cited by 6 · see citing works
Microglia take control in chronic pain
Lewis, S. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3442 · Cited by 4 · see citing works
Blass, B. C. (1975) · Journal of the American Podiatric Medical Association · doi:10.7547/87507315-65-10-963 · Cited by 4 · see citing works
Alterations in morphine-induced analgesia in mice exposed to pain, light or sound.
Mw, S., & Fr, D. (1973) · PubMed · Cited by 2 · see citing works
A "Sound" approach to analgesia.
Lj, H. (1970) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Gierke HEV, Davis H, Eldredge DH, Hardy JD 1953 Aural pain produced by sound In Benox Report, An Exploratory Study of the Biological Effects of noise. Project NR 144079. Office of Naval Research. University of Chicago Press.
- Moller AR, (Ed.) 2007 Neurophysiologic Abnormaliteis in Autism. Nova Science Publishers.
Cited by
Sorted by citations
Hyperacusis: Loudness intolerance, fear, annoyance and pain
Salvi, R., Chen, G., & Manohar, S. (2022) · Hearing Research · doi:10.1016/j.heares.2022.108648 · Cited by 32 · see citing works
Self-citationYou, S., Xu, F., Wu, Y., Qin, S., Shu, B., Chen, Y., Chen, Y., Huang, H., & Duan, G. (2023) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2023.111286 · Cited by 30 · see citing works
You, S., Xu, F., Zhu, X., Qin, S., Zheng, X., Tao, C., Wu, Y., Chen, Y., Shu, B., Huang, H., et al. (2023) · International Journal of Surgery · doi:10.1097/js9.0000000000000672 · Cited by 21 · see citing works
Zhang, J., Pang, L., Yang, C., Fan, Y., Zhao, B., & Cao, X. (2024) · Buildings · doi:10.3390/buildings14041100 · Cited by 20 · see citing works
Clinical phenotype and management of sound-induced pain: Insights from adults with pain hyperacusis
Jahn, K. N., Kashiwagura, S. T., & Yousuf, M. S. (2025) · The Journal of Pain · doi:10.1016/j.jpain.2024.104741 · Cited by 10 · see citing works
Cross-modal cortical circuit for sound sensitivity in neuropathic pain
Mao, Y., Zhang, M., Peng, X., Liu, Y., Liu, Y., Xia, Q., Luo, B., Chen, L., Zhang, Z., Wang, Y., et al. (2025) · Current Biology · doi:10.1016/j.cub.2024.12.044 · Cited by 8 · see citing works
Opening a window into the riddle of misophonia, sensory over-responsiveness, and pain
Kaufman, A. E., Weissman‐Fogel, I., Rosenthal, M. Z., Kaplan‐Neeman, R., & Bar‐Shalita, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.907585 · Cited by 5 · see citing works
Bilateral sensorineural hearing loss after opioid overdose in an adolescent male
Richard, K. E., Smetak, M. R., Peterson, A., Phillips, J., & Virgin, F. W. (2022) · Ear Nose & Throat Journal · doi:10.1177/01455613221129932 · Cited by 3 · see citing works
Gastrodin Ameliorates Learning and Memory Impairments Caused by Long-Term Noise Exposure
Wu, L., Liu, Y., Zhou, H., Cao, Z., & Yu, J. (2024) · Noise and Health · doi:10.4103/nah.nah_76_24 · Cited by 3 · see citing works
Sound hypersensitivity phenotypes and sound hypersensitivity disorder
Lopez-Escamez, J. A., Ridder, D. D., Jahn, K. N., Langguth, B., Sedley, W., Song, J., & Vanneste, S. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106796 · Cited by 2 · see citing works
Seicol, B. J., Valles, A., Kohler, A., Glowatzki, E., & Wood, M. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.30.679579 · Cited by 2 · see citing works
Salvi, R., Chen, G., Liu, X., Auerbach, B. D., Ding, D., Chen, Y., & Manohar, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-35647-6_23 · Cited by 1 · see citing works
Self-citationMohammadi, S., Ezzati, E., Mahooti, R., Kavyannejad, F., Paran, M. S., & Kavyannejad, R. (2025) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2025.100480 · Cited by 1 · see citing works
Fan, C., Duan, J., Cao, S., & Zhang, M. (2025) · Noise and Health · doi:10.4103/nah.nah_104_25 · Cited by 1 · see citing works
Lu, M., Chen, M., Peng, H., Ou, J., & Wu, X. (2026) · Noise and Health · doi:10.4103/nah.nah_204_25 · Cited by 1 · see citing works
RetractedCreating Discomfort Maps via Hand-held Human Feedback Interface for Robotic Shoulder Physiotherapy
Ravenberg, J., Belli, I., Prendergast, J. M., Seth, A., & Peternel, L. (2024) · IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) · doi:10.1109/iros58592.2024.10801858 · Cited by 1 · see citing works
Noise exposure in pain management: harmful disruptions to therapeutic sound
Hamza, O., Giff, A. E., Hanshaw, B., Basharat, A., & Issa, M. (2026) · Pain Medicine · doi:10.1093/pm/pnag026
Yang, L., Cai, W., Zhou, H., & Jie, H. (2026) · Noise and Health · doi:10.4103/nah.nah_121_25
Pain as muse: How creative acts flourish in the shadow of struggle
Khalil, R., Frühholz, S., & Landry, M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106650
Jia, T., Peng, Y.-T., Sun, Y., Cui, Y., Gu, X., Yang, L., Zhang, S., Cao, J., Xiao, C., & Zhou, C. (2026) · Nature Communications · doi:10.1038/s41467-026-73205-x
Li, X. W., Guo, X., & Fu, X. (2026) · Healthcare · doi:10.3390/healthcare14142223
- Authors
- Manohar, S., Adler, H. J., Radziwon, K., & Salvi, R.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Salvi, Richard
- Venue
- Hearing Research
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 393
- Pages
- 108012
- ISSN
- 0378-5955 (ISSN-L)
- PMC
- PMC7338237
- OpenAlex
- W3033232462
- Cited by
- 21
- References
- 110
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 3
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hearing Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Hearing Health Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- multisensory interaction, stimulus intensity, noise-induced hearing loss, opioid signaling, fentanyl, tail-flick test, thermal pain sensitivity
- MeSH terms
- Analgesics, Opioid, Animals, Auditory Threshold, Deafness, Fentanyl, Hearing Loss, Noise-Induced, Hyperalgesia, Pain, Hearing Loss, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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