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Cited by 373Multisensory perception and integrationTactile and Sensory InteractionsNeuroscience and Music Perception

Topographic organization of convergent projections to the thalamus from the inferior colliculus and spinal cord in the rat

Ledoux, Joseph E., Ruggiero, David A., Forest, Ronni, Stornetta, Ruth, Reis, Donald J.·1987·Journal of Comparative Neurology
DOI 10.1002/cne.902640110
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Abstract

The purpose of this study was to identify thalamic areas receiving convergent sensory inputs from acoustic and spinal projection systems in the rat. The topographic distribution of afferents to the thalamus from the inferior colliculus and spinal cord was examined by using WGA-HRP as an anterograde axonal tracer. Following injections in the inferior colliculus, terminal labeling was present in ventral, medial, and dorsal divisions of the medial genicuate body (MGB) and in adjacent areas of the posterior thalamus, including the posterior limitans nucleus, the posterior intralaminar nucleus, the marginal zone, the peripeduncular region, the lateral or parvicellular part of the subparafascicular nucleus, and a region intercalated between the posterior limitans nucleus and the suprageniculate nucleus. In the caudal thalamus spinal projections remained in the reticular formation medial to the collicular terminal field. At intermediate levels of the MG, however, the spinal projection began to overlap the collicular field, terminating in the medial division of the MG and in the posterior intralaminar nucleus, the marginal zone, the lateral subparafascicular nucleus, and the area between the suprageniculate and posterior limitans nuclei. More rostrally, the convergent field expanded to include aspects of the dorsal MG division. The extent to which afferent projections to the thalamus from the inferior colliculus and spinal cord converge is thus graded in the caudorostral plane, with the greatest overlap occurring at the level of the rostral third of the MGB. These observations identify potential areas of acoustic and somesthetic integration and may account for observations of neuronal plasticity in the thalamus in response to the pairing of acoustic and somesthetic inputs.

Integrity signals

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Crossref · 10.1002/cne.902640110

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  • Tracing studies in rodents have shown that the PIL receives inputs from sensory regions such as the inferior and superior colliculus, auditory cortex, and spinal cord and projects to socially relevant brain regions including the PVH, lateral septum, MPOA, and medial amygdala.

    “Tracing studies conducted in rodents have provided anatomical support for this theory, demonstrating that the PIL receives inputs from sensory regions such as the inferior and superior colliculus, auditory cortex, and spinal cord (3, 7-10) and projects to socially relevant brain regions including the paraventricular nucleus of the hypothalamus (PVH), the lateral septum, medial preoptic area (MPOA)”

    From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [8]

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Authors
Ledoux, J. E., Ruggiero, D. A., Forest, R., Stornetta, R., & Reis, D. J.
Affiliations
Cornell University (US)
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1987-10
Volume
264
Issue
1
Pages
123-146
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902640110
OpenAlex
W2012943765
Cited by
373
References
67
Citations by year
2026: 10 · 2025: 4 · 2024: 14 · 2023: 9 · 2022: 6 · 2021: 4 · 2020: 14 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 3
FWCI
10.05
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6218 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL-18974)
  • National Institute of Mental Health (MH38774)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Keywords
thalamus, inferior colliculus, spinal cord, thalamic afferents, topographic organization, medial geniculate body, suprageniculate nucleus, reticular formation, neuroplasticity, rats
MeSH terms
Afferent Pathways, Animals, Auditory Pathways, Brain Mapping, Geniculate Bodies, Horseradish Peroxidase, Inferior Colliculi, Male, Rats, Inbred Strains, Spinothalamic Tracts, Thalamus, Wheat Germ Agglutinins, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate, Rats

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