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Cited by 232Probiotics and Fermented FoodsGut microbiota and healthReproductive tract infections research

Probiotics, their prophylactic and therapeutic applications in human health development: A review of the literature

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Tegegne, Bantayehu Addis, Kebede, Bekalu·2022·Heliyon
DOI 10.1016/j.heliyon.2022.e09725PMC PMC9240980
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Abstract

Antibiotics do not differentiate between good and bad germs, disrupting normal microflora and causing vitamin deficiency in the human body. They also kill healthy bacteria in the gut and genital tract on a large scale, weakening the host's defense mechanism. Probiotics are a colony of bacteria that live in our intestines and are regarded as a metabolic 'organ' due to their beneficial effects on human health, including metabolism and immunological function. They are used in clinical settings to prevent and treat conditions such as diarrhoea, colon cancer, hypertension, diabetes, acute pancreatitis, Helicobacter pylori infection, ventilator-associated pneumonia, migraine and autism. Probiotics may modify immunological activity by increasing innate and adaptive immune responses, altering microbial habitat in the intestine, improving gut barrier function, competitive adherence to the mucosa and epithelium, and producing antimicrobial compounds. The aim of this study is to index that further in depth researches to be conducted on probiotics pivotal role in the prophylaxis and therapeutic usage for a variety of disease that may or may not have treatment alternatives. Key words such as probiotics, microbiota, prophylactics, and therapeutic applications were searched extensively in research databases such as PubMed, PubMed Central (PMC), Scopus, Web of Science, Research Gate, Google Scholar, and Cochrane Library. This concise narrative review article summarized primarily the history, selection, mechanism/mode of action, recent advances in prophylactic and therapeutic applications, and future directions in the use of probiotics for prophylactic and therapeutic applications.

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Authors
Tegegne, B. A., & Kebede, B.
Affiliations
Debre Markos University (ET)
Corresponding author
Tegegne, Bantayehu Addis
ORCID
Venue
Heliyon
Publisher
Elsevier BV
Published
2022-06
Volume
8
Issue
6
Pages
e09725
ISSN
2405-8440 (ISSN-L)
DOI
10.1016/j.heliyon.2022.e09725
PMC
PMC9240980
OpenAlex
W4283277553
Cited by
232
References
3
Citations by year
2026: 42 · 2025: 71 · 2024: 56 · 2023: 55 · 2022: 8
FWCI
4.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Heliyon (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
probiotics, gut microbiota, antibiotic-induced dysbiosis, probiotic prophylaxis, probiotic therapy, immunomodulation, intestinal barrier, Helicobacter pylori infection, diarrhea, colon cancer, hypertension, diabetes mellitus, acute pancreatitis, ventilator-associated pneumonia, migraine, autism spectrum disorder, antimicrobial agents, mechanism of action

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