Cited by 761Gut microbiota and healthClostridium difficile and Clostridium perfringens researchAntibiotic Resistance in Bacteria

The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

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Kim, Sohn, Covington, April, Pamer, Eric G.·2017·Immunological Reviews

Abstract

Summary: The human gastrointestinal tract hosts a diverse network of microorganisms, collectively known as the microbiota that plays an important role in health and disease. For instance, the intestinal microbiota can prevent invading microbes from colonizing the gastrointestinal tract, a phenomenon known as colonization resistance. Perturbations to the microbiota, such as antibiotic administration, can alter microbial composition and result in the loss of colonization resistance. Consequently, the host may be rendered susceptible to colonization by a pathogen. This is a particularly relevant concern in the hospital setting, where antibiotic use and antibiotic‐resistant pathogen exposure are more frequent. Many nosocomial infections arise from gastrointestinal colonization. Due to their resistance to antibiotics, treatment is often very challenging. However, recent studies have demonstrated that manipulating the commensal microbiota can prevent and treat various infections in the intestine. In this review, we discuss the members of the microbiota, as well as the mechanisms, that govern colonization resistance against specific pathogens. We also review the effects of antibiotics on the microbiota, as well as the unique epidemiology of immunocompromised patients that renders them a particularly high‐risk population to intestinal nosocomial infections.

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  1. [48]Dale DC Myelosuppresion Sonis ST Keefe DM Pathobiology of Cancer Regimen-Related Toxicities New York, NY Springer 2013

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Authors
Kim, S., Covington, A., & Pamer, E. G.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Pamer, Eric G.
Venue
Immunological Reviews
Publisher
Wiley
Published
2017-08-30
Volume
279
Issue
1
Pages
90-105
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W2753747201
Cited by
741
References
147
Citations by year
2026: 49 · 2025: 67 · 2024: 112 · 2023: 95 · 2022: 136 · 2021: 117 · 2020: 69 · 2019: 68 · 2018: 27 · 2017: 1
FWCI
4.22
Type
journal article
Language
en
Open access
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (P01CA023766, P30CA008748)
  • National Institute of General Medical Sciences (T32GM007739)
  • National Institute of Allergy and Infectious Diseases (R01AI095706, U01AI124275, R01AI042135)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords
gut microbiota, colonization resistance, antibiotics, enteric pathogens, nosocomial infections, antibiotic resistance, immunocompromised patients, commensal microbiota, intestinal colonization
MeSH terms
Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Bacterial Infections, Cross Infection, Drug Resistance, Humans, Immunocompromised Host, Host-Pathogen Interactions, Dysbiosis

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