A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors
Open accessPublished version of a preprint
Abstract
Dimensional reduction analysis of available data for white matter of the brain allows to locate the normal (homeostatic), Glioblastoma and Alzheimer's disease attractors in gene expression space and to identify paths related to transitions like carcinogenesis or Alzheimer's disease onset. A predefined path for aging is also apparent, which is consistent with the hypothesis of programmatic aging. In addition, reasonable assumptions about the relative strengths of attractors allow to draw a schematic landscape of fitness: a Wright's diagram. These simple diagrams reproduce known relations between aging, Glioblastoma and Alzheimer's disease, and rise interesting questions like the possible connection between programmatic aging and Glioblastoma in this tissue. We anticipate that similar multiple diagrams in other tissues could be useful in the understanding of the biology of apparently unrelated diseases or disorders, and in the discovery of unexpected clues for their treatment.
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Cites
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- Authors
- Nieves, J., Gil, G., & Gonzalez, A.
- Affiliations
- Instituto de Cibernética Matemática y Física (CU)
- Corresponding author
- Nieves, Joan
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2025-02
- Volume
- 11
- Issue
- 4
- Pages
- e42445
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC11867265
- OpenAlex
- W4407133599
- Cited by
- 0
- References
- 8
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Alzheimer's disease, glioblastoma, attractors, white matter, dimensional reduction, carcinogenesis, aging, fitness landscape, disease onset
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