Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

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The DNA sequence of human chromosome 21

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An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

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Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

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Amyloid, the presenilins and Alzheimer’s disease

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Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

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Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome

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A copy number variation map of the human genome

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

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The genetic epidemiology of neurodegenerative disease

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Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

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Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

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BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

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Take five—BACE and the γ‐secretase quartet conduct Alzheimer's amyloid β‐peptide generation

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Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration

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The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

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Copy number variants, diseases and gene expression

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Molecular mapping of alzheimer‐type dementia in Down's syndrome

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APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

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Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

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The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

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Cerebral amyloid angiopathy and cognitive function: The HAAS autopsy study

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Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

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Causative and susceptibility genes for Alzheimer’s disease: a review

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Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

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Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.

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Molecular genetic analysis of Down syndrome

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Highly conserved and disease‐specific patterns of carboxyterminally truncated Aβ peptides 1–37/38/39 in addition to 1–40/42 in Alzheimer's disease and in patients with chronic neuroinflammation

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Atypical aging in down syndrome

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Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

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Genomic organization of the human amyloid beta-protein precursor gene

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Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation

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Age-Related Distribution of Neuropathologic Changes in the Cerebral Cortex of Patients With Down's Syndrome

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Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

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Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein

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APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain

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Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25–35

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Down's Syndrome: Up‐Regulation of β‐Amyloid Protein Precursor and τ mRNAs and Their Defective Coordination

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Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

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Dense-Core Senile Plaques in the Flemish Variant of Alzheimer's Disease Are Vasocentric

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APP Gene Family Alternative Splicing Generates Functionally Related Isoformsa

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Genomic organization of the human-amyloid beta-protein precursor gene

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A novel AβPP mutation exclusively associated with cerebral amyloid angiopathy

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Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease

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Molecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic ResonancePreprint

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β-Amyloid Prions and the Pathobiology of Alzheimer’s DiseasePreprint

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APP at a glance

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A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene

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Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features

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Multiple pterygium syndrome

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Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population

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INTRAFAMILIAL DIVERSITY OF PHENOTYPE ASSOCIATED WITH APP DUPLICATION

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Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer’s disease pathogenesis

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Down syndrome: Toward a molecular definition of the phenotype

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Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals

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Good gene, bad gene: New APP variant may be both

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Entorhinal cortex of aged subjects with Down's syndrome shows severe neuronal loss caused by neurofibrillary pathology

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Mutation screening of patients with Alzheimer disease identifies APP locus duplication in a Swedish patient

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Studies on the first described Alzheimer's disease amyloid β mutant, the Dutch variant

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The Amyloid .BETA. Protein Precursor Mutations Linked to Familial Alzheimer's Disease Alter Processing in a Way That Fosters Amyloid Deposition.

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Structural and Chemical Biology of Presenilin ComplexesPreprint

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Volume 179, Number 3, September 30, 1991

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

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Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

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Pathology of Neurodegenerative Diseases

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Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy

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Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier

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Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids

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Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

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Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration

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Alzheimer’s Disease: Exploring the Landscape of Cognitive Decline

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Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

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The genetic landscape of Alzheimer disease

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Genetic architecture of Alzheimer's disease

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Alzheimer's disease failed clinical trials

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Microglia in Alzheimer’s Disease in the Context of Tau Pathology

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NLRP3 inflammasome signalling in Alzheimer's disease

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The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer’s Disease in SH-SY5Y cells

Guyon, A., Rousseau, J., Lamothe, G., & Tremblay, J. P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237122 · Cited by 20 · see citing works