Genomic and Proteomic Analysis of Myocarditis and Dilated Cardiomyopathy

Cooper, Leslie T.; Onuma, Oyere K.; Sagar, Sandeep; Oberg, Ann L.; Mahoney, Douglas W.; Asmann, Yan W.; Liu, Peter

doi:10.1016/j.hfc.2009.08.012

Cited by 30Viral Infections and Immunology ResearchCardiomyopathy and Myosin StudiesCardiac Fibrosis and Remodeling

Genomic and Proteomic Analysis of Myocarditis and Dilated Cardiomyopathy

Cooper, Leslie T., Onuma, Oyere K., Sagar, Sandeep, Oberg, Ann L., Mahoney, Douglas W., Asmann, Yan W., Liu, Peter·2010·Heart Failure Clinics

DOI 10.1016/j.hfc.2009.08.012

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Abstract

Myocarditis is defined as an inflammation of the myocardium that results in injury to the cardiac myocytes. Myocarditis is also thought to be a common cause of dilated cardiomyopathy (DCM) from evidence of viral persistence in the myocardium in patients with idiopathic DCM. Genome and proteome screening techniques that do not require mechanistic knowledge of disease pathogenesis have recently begun to reveal disease-specific profiles. These studies are now yielding novel mechanisms, biomarkers, and potential therapeutic targets. This article reviews several examples of noncandidate genomic and proteomic screening, as well as the potential strengths and pitfalls of these strategies for the evaluation of myocarditis and nonischemic DCM.

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All 3 pathways of complement are upregulated in the serum of patients with myocarditis and predict progression to DCM.
“All 3 pathways of complement are upregulated in the serum of patients with myocarditis and predict progression to DCM. 154”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [154]

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Authors: Cooper, L. T., Onuma, O. K., Sagar, S., Oberg, A. L., Mahoney, D. W., Asmann, Y. W., & Liu, P.
Affiliations: Mayo Clinic (US)
Massachusetts General Hospital (US)
University Health Network (CA)
Corresponding author: Cooper, Leslie T.
ORCID: Cooper, Leslie T.
Onuma, Oyere K.
Sagar, Sandeep
Oberg, Ann L.
Mahoney, Douglas W.
Asmann, Yan W.
Liu, Peter
Venue: Heart Failure Clinics
Publisher: Elsevier BV
Published: 2010-01
Volume: 6
Issue: 1
Pages: 75-85
ISSN: 1551-7136 (ISSN-L)
DOI: 10.1016/j.hfc.2009.08.012
OpenAlex: W1990230426
Cited by: 30
References: 89
Citations by year: 2026: 1 · 2023: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 5
FWCI: 0.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Heart Failure Clinics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: myocarditis, dilated cardiomyopathy, idiopathic dilated cardiomyopathy, viral persistence, cardiomyocytes, genomic screening, proteomic screening, biomarkers, therapeutic target, pathogenesis
MeSH terms: Animals, Cardiomyopathy, Dilated, Humans, Myocarditis, Prognosis, Biomarkers, Risk Assessment, Gene Expression Profiling, Proteomics

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Genomic and Proteomic Analysis of Myocarditis and Dilated Cardiomyopathy

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