Pathophysiology of Heart Failure with Preserved Ejection Fraction
Abstract
Heart failure with preserved ejection fraction (HFpEF) is a major public health problem that affects half of all patients with HF. It is rising in prevalence, is associated with high morbidity and mortality, and has very few effective treatments. HFpEF is currently understood as a heterogeneous syndrome originating from the interplay of cardiac and extracardiac abnormalities. The most important pathophysiology in patients with HFpEF is diastolic dysfunction, which presents with impairments in relaxation or increases in chamber stiffness that lead to an increase in left ventricular filling pressures at rest or during exercise that causes dyspnea.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The essence of HFpEF pathophysiology is the increase of LV filling pressure, meaning that the heart can adequately pump the blood at expense of an elevation of cardiac filling pressures that, if disproportionate during exercise or at rest, are responsible of dyspnea.
“Even if the diastolic dysfunction is the hemodynamic feature of HFpEF, the essence of its pathophysiology is the increase of LV filling pressure, meaning that the heart can adequately pump the blood at expense of an elevation of cardiac filling pressures that, if disproportionate during exercise or at rest, are responsible of dyspnea [102,103].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [103]
Cites
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429 · see citing works
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., Simonneau, G., Peacock, A., Vonk Noordegraaf, A., Beghetti, M., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv317 · Cited by 6,931 · see citing works
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F., Dokainish, H., Edvardsen, T., Flachskampf, F. A., Gillebert, T. C., Klein, A. L., Lancellotti, P., et al. (2016) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2016.01.011 · Cited by 6,790 · see citing works
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564 · see citing works
Nagueh, S. F., Middleton, K. J., Kopelen, H. A., Zoghbi, W. A., & Quiñones, M. A. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00344-6 · Cited by 3,024 · see citing works
Ommen, S. R., Nishimura, R. A., Appleton, C. P., Miller, F. A., Oh, J. K., Redfield, M. M., & Tajik, A. J. (2000) · Circulation · doi:10.1161/01.cir.102.15.1788 · Cited by 2,790 · see citing works
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap
Shah, S. J., Kitzman, D. W., Borlaug, B. A., van Heerebeek, L., Zile, M. R., Kass, D. A., & Paulus, W. J. (2016) · Circulation · doi:10.1161/circulationaha.116.021884 · Cited by 1,003 · see citing works
Heart Failure With Preserved Ejection Fraction In Perspective
Pfeffer, M. A., Shah, A. M., & Borlaug, B. A. (2019) · Circulation Research · doi:10.1161/circresaha.119.313572 · Cited by 843 · see citing works
Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Olson, T. P., Lam, C. S. P., Flood, K. S., Lerman, A., Johnson, B. D., & Redfield, M. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.077 · Cited by 733 · see citing works
The pathophysiology of heart failure with preserved ejection fraction
Borlaug, B. A. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.83 · Cited by 726 · see citing works
Borlaug, B. A., Melenovsky, V., Russell, S. D., Kessler, K., Pacak, K., Becker, L. C., & Kass, D. A. (2006) · Circulation · doi:10.1161/circulationaha.106.632745 · Cited by 699 · see citing works
Zile, M. R., Baicu, C. F., S. Ikonomidis, J., Stroud, R. E., Nietert, P. J., Bradshaw, A. D., Slater, R., Palmer, B. M., Van Buren, P., Meyer, M., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013215 · Cited by 681 · see citing works
Right heart dysfunction in heart failure with preserved ejection fraction
Melenovský, V., Hwang, S., Lin, G., Redfield, M. M., & Borlaug, B. A. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu193 · Cited by 671 · see citing works
Brubaker, P. H., & Kitzman, D. W. (2011) · Circulation · doi:10.1161/circulationaha.110.940577 · Cited by 643 · see citing works
Pulmonary hypertension due to left heart disease
Vachiéry, J., Tedford, R. J., Rosenkranz, S., Palazzini, M., Lang, I. M., Guazzi, M., Coghlan, G., Chazova, I. E., & Marco, T. D. (2018) · European Respiratory Journal · doi:10.1183/13993003.01897-2018 · Cited by 558 · see citing works
Right Ventricular Function in Heart Failure With Preserved Ejection Fraction
Mohammed, S. F., Hussain, I., AbouEzzeddine, O. F., Takahama, H., Kwon, S. H., Forfia, P. R., Roger, V. L., & Redfield, M. M. (2014) · Circulation · doi:10.1161/circulationaha.113.008461 · Cited by 455 · see citing works
Shah, S. J., Borlaug, B. A., Kitzman, D. W., McCulloch, A. D., Blaxall, B. C., Agarwal, R., Chirinos, J. A., Collins, S., Deo, R. C., Gladwin, M. T., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.041886 · Cited by 436 · see citing works
Estimating Left Ventricular Filling Pressure by Echocardiography
Andersen, Ø. S., Smiseth, O. A., Dokainish, H., Abudiab, M. M., Schutt, R. C., Kumar, A., Sato, K., Harb, S. C., Gude, E., Remme, E. W., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.058 · Cited by 427 · see citing works
Cellular and molecular pathobiology of heart failure with preserved ejection fraction
Mishra, S., & Kass, D. A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00480-6 · Cited by 423 · see citing works
Contractility and Ventricular Systolic Stiffening in Hypertensive Heart Disease
Borlaug, B. A., Lam, C. S. P., Roger, V. L., Rodeheffer, R. J., & Redfield, M. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.013 · Cited by 422 · see citing works
Krüger, M., Kötter, S., Grützner, A., Lang, P. M., Andresen, C., Redfield, M. M., Butt, E., dos Remedios, C. G., & Linke, W. A. (2008) · Circulation Research · doi:10.1161/circresaha.108.184408 · Cited by 408 · see citing works
Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J. K., Borlaug, B. A., Čelutkienė, J., Coats, A. J. S., Crespo‐Leiro, M. G., Guazzi, M., Harjola, V., Heymans, S. R. B., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.1029 · Cited by 396 · see citing works
Borlaug, B. A., Kane, G. C., Melenovský, V., & Olson, T. P. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw241 · Cited by 379 · see citing works
Haykowsky, M. J., Brubaker, P. H., Stewart, K. P., Morgan, T. M., Eggebeen, J., & Kitzman, D. W. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.055 · Cited by 358 · see citing works
Fayyaz, A. U., Edwards, W. D., Maleszewski, J. J., Konik, E. A., DuBrock, H. M., Borlaug, B. A., Frantz, R. P., Jenkins, S. M., & Redfield, M. M. (2017) · Circulation · doi:10.1161/circulationaha.117.031608 · Cited by 353 · see citing works
Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction
Kumar, A. A., Kelly, D. P., & Chirinos, J. A. (2019) · Circulation · doi:10.1161/circulationaha.118.036259 · Cited by 297 · see citing works
Gorter, T. M., Obokata, M., Reddy, Y. N. V., Melenovský, V., & Borlaug, B. A. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy331 · Cited by 217 · see citing works
Unger, E. D., Dubin, R. F., Deo, R., Daruwalla, V., Friedman, J. L., Medina, C., Beussink‐Nelson, L., Freed, B. H., & Shah, S. J. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.445 · Cited by 198 · see citing works
Pulmonary Hypertension in HFpEF and HFrEF
Guazzi, M., Ghio, S., & Adir, Y. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.06.069 · Cited by 149 · see citing works
Methawasin, M., Hutchinson, K. R., Lee, E., Smith, J. E., Saripalli, C., Hidalgo, C. G., Ottenheijm, C. A. C., & Granzier, H. L. M. (2014) · Circulation · doi:10.1161/circulationaha.113.005610 · Cited by 143 · see citing works
Packer, M., Lam, C. S. P., Lund, L. H., & Redfield, M. M. (2019) · Circulation · doi:10.1161/circulationaha.119.042996 · Cited by 133 · see citing works
Methawasin, M., Strom, J. G., Slater, R. E., Fernandez, V., Saripalli, C., & Granzier, H. L. M. (2016) · Circulation · doi:10.1161/circulationaha.116.023003 · Cited by 118 · see citing works
Update on heart failure management and future directions
Choi, H., Park, M., & Youn, J. (2018) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2018.428 · Cited by 115 · see citing works
Self-citationReddy, Y. N. V., El‐Sabbagh, A., & Nishimura, R. A. (2018) · JAMA Cardiology · doi:10.1001/jamacardio.2018.0318 · Cited by 109 · see citing works
Heart failure with preserved ejection fraction: controversies, challenges and future directions
Zakeri, R., & Cowie, M. (2018) · Heart · doi:10.1136/heartjnl-2016-310790 · Cited by 107 · see citing works
Heart failure with preserved ejection fraction: insights into diagnosis and pathophysiology
Nagueh, S. F. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa228 · Cited by 91 · see citing works
Mascherbauer, J., Zotter‐Tufaro, C., Duca, F., Binder, C., Koschutnik, M., Kammerlander, A. A., Aschauer, S., & Bonderman, D. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.08.005 · Cited by 88 · see citing works
Heart failure with preserved ejection fraction: present status and future directions
Yoon, S., & Eom, G. H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0323-2 · Cited by 84 · see citing works
CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia
Jang, W., Park, J., Kwon, A., Choi, H., Kim, J., Lee, D., Han, E., Jekarl, D. W., Chae, H., Han, K., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0195-x · Cited by 74 · see citing works
Kim, K.-J., Cho, H., Kim, M., Kang, J., Kim, K., Kim, D., Seo, S. M., Yang, J. H., Cha, M., Choi, J., et al. (2019) · International Journal of Heart Failure · doi:10.36628/ijhf.2019.0002 · Cited by 48 · see citing works
Youn, J., Jung, M. K., Yu, H. T., Kwon, J., Kwak, J.-E., Park, S., Kim, I., Park, M. S., Lee, S. K., Choi, S.-W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49332-5 · Cited by 46 · see citing works
Self-citationCardiac Rehabilitation in Heart Failure
Chun, K., & Kang, S. (2020) · International Journal of Heart Failure · doi:10.36628/ijhf.2020.0021 · Cited by 39 · see citing works
The Role of Arterial Stiffness and Central Hemodynamics in Heart Failure
Weber, T. (2020) · International Journal of Heart Failure · doi:10.36628/ijhf.2020.0029 · Cited by 36 · see citing works
Understanding Obesity-Related High Output Heart Failure and Its Implications
Shen, Q., Hiebert, J. B., Rahman, F. K., Krueger, K. J., Gupta, B. P., & Pierce, J. D. (2021) · International Journal of Heart Failure · doi:10.36628/ijhf.2020.0047 · Cited by 33 · see citing works
Common Co-Morbidities in Heart Failure – Diabetes, Functional Mitral Regurgitation and Sleep Apnoea
Coats, A. J. S. (2019) · International Journal of Heart Failure · doi:10.36628/ijhf.2019.0004 · Cited by 32 · see citing works
Paradigm Shifts of Heart Failure Therapy: Do We Need Another Paradigm?
Lee, H., & Oh, B. (2020) · International Journal of Heart Failure · doi:10.36628/ijhf.2020.0010 · Cited by 28 · see citing works
“Left ventricular filling pressure(s)” — Ambiguous and misleading terminology, best abandoned
Peverill, R. E. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.254 · Cited by 24 · see citing works
Heart Failure with Preserved Ejection Fraction: the Major Unmet Need in Cardiology
Shim, C. Y. (2020) · Korean Circulation Journal · doi:10.4070/kcj.2020.0338 · Cited by 24 · see citing works
KSHF Guidelines for the Management of Acute Heart Failure: Part II. Treatment of Acute Heart Failure
Lee, J., Kim, M., Yoo, B., Park, S., Park, J. J., Shin, M., Youn, J., Lee, S. E., Jang, S. Y., Choi, S., et al. (2018) · Korean Circulation Journal · doi:10.4070/kcj.2018.0349 · Cited by 22 · see citing works
Self-citationHeart failure with preserved ejection fraction: insights from recent clinical researches
Kim, M., & Park, S. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.104 · Cited by 17 · see citing works
Heart failure with preserved ejection fraction: insights from recent clinical researches
Kim, M., & Park, S. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.104.e1 · Cited by 14 · see citing works
Update on the Pharmacotherapy of Heart Failure with Reduced Ejection Fraction
Kim, E.-S., Youn, J., & Baek, S. H. (2020) · Cardiovascular Prevention and Pharmacotherapy · doi:10.36011/cpp.2020.2.e17 · Cited by 13 · see citing works
Self-citationKim, M., Park, S., Kim, H., Cho, D., Shim, J., Choi, J., Kim, Y., & Shim, W. J. (2020) · International Journal of Heart Failure · doi:10.36628/ijhf.2020.0003 · Cited by 11 · see citing works
Prognostic Value of Leg Muscle Strength in Acute Heart Failure Syndrome
Youn, J., Choi, S.-W., Lee, H. S., Han, S., Shin, E., Baek, S. H., & Kang, S. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002432 · Cited by 7 · see citing works
Self-citationDiastolic Function Assessment in Atrial Fibrillation Conundrum
Casaclang‐Verzosa, G. (2020) · International Journal of Heart Failure · doi:10.36628/ijhf.2020.0012 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Rinaldi, L., Coviello, F., Di Martino, A., Albanese, G., Colantuoni, S., Medicamento, G., et al. (2022) · Biomolecules · doi:10.3390/biom12020176 · Cited by 62 · see citing works
Korean Society of Heart Failure Guidelines for the Management of Heart Failure: Treatment
Youn, J., Kim, D., Cho, J. Y., Cho, D., Park, S. M., Jung, M., Hyun, J., Cho, H., Park, S., Choi, J., et al. (2023) · International Journal of Heart Failure · doi:10.36628/ijhf.2023.0011 · Cited by 52 · see citing works
Self-citationArterial Stiffness and Heart Failure With Preserved Ejection Fraction
Kim, H., & Jo, S. (2024) · Journal of Korean Medical Science · doi:10.3346/jkms.2024.39.e195 · Cited by 43 · see citing works
Amyloid-β and heart failure in Alzheimer’s disease: the new vistas
Al-Kuraishy, H. M., Sulaiman, G. M., Mohammed, H. A., Mohammed, S. G., Al-Gareeb, A. I., Albuhadily, A. K., Dawood, R. A., Ali, A. A., & Abu-Alghayth, M. H. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1494101 · Cited by 36 · see citing works
Biomarkers of HFpEF: Natriuretic Peptides, High-Sensitivity Troponins and Beyond
Morfino, P., Aimo, A., Castiglione, V., Vergaro, G., Emdin, M., & Clerico, A. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9080256 · Cited by 31 · see citing works
Lin, Y., Liao, K., Yu, T., Wu, J., & Lai, C. (2025) · Nature Communications · doi:10.1038/s41467-025-59616-2 · Cited by 31 · see citing works
Multimodal Imaging and Biomarkers in Cardiac Amyloidosis
Jung, M., Chang, S., Han, E. J., & Youn, J. (2022) · Diagnostics · doi:10.3390/diagnostics12030627 · Cited by 28 · see citing works
Self-citationKorean Society of Heart Failure Guidelines for the Management of Heart Failure: Treatment
Youn, J., Kim, D., Cho, J. Y., Cho, D., Park, S. M., Jung, M., Hyun, J., Cho, H., Park, S., Choi, J., et al. (2023) · Korean Circulation Journal · doi:10.4070/kcj.2023.0047 · Cited by 23 · see citing works
Self-citationMasarone, D., Kittleson, M., D'onofrio, A., Falco, L., Fumarolo, I., Massetti, M., Crea, F., Aspromonte, N., & Pacileo, G. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.09.021 · Cited by 17 · see citing works
Emerging roles of macrophages in heart failure and associated treatment approaches
Xie, L., Chen, J., Wang, Y., Jin, C., Xie, Y., Ma, H., & Xiang, M. (2023) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223231168755 · Cited by 16 · see citing works
Liu, B., Shalamu, A., Pei, Z., Liu, L., Wei, Z., Qu, Y., Song, S., Luo, W., Dong, Z., Weng, X., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83432 · Cited by 14 · see citing works
The association between pulse wave velocity and heart failure: a systematic review and meta-analysis
Esmaeili, Z., Bahiraie, P., Vaziri, Z., Azarboo, A., Behnoush, A. H., Khalaji, A., Bazrgar, A., Tayebi, P., & Ziaie, N. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1435677 · Cited by 15 · see citing works
Wu, M., Ni, D., Huang, L., & Qiu, S. (2023) · Clinical Cardiology · doi:10.1002/clc.24058 · Cited by 12 · see citing works
Ebong, I., Gill, A., Appiah, D., & Mauricio, R. (2025) · Heart Failure Reviews · doi:10.1007/s10741-025-10528-9 · Cited by 11 · see citing works
Hemodynamic Gain Index and Exercise Capacity in Heart Failure With Preserved Ejection Fraction
Morales-Oyarvide, V., Richards, D., HENDREN, N. S., Michelis, K. C., Chaikijurajai, T., MacNamara, J. P., Sarma, S., FARR, M. A., Drazner, M. H., Tang, W. H. W., et al. (2022) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2022.11.049 · Cited by 10 · see citing works
Fuentes-Abolafio, I. J., Trinidad‐Fernández, M., Ricci, M., Roldán‐Jiménez, C., Gómez‐Huelgas, R., Arjona-Caballero, J. M., Escriche-Escuder, A., Bernal-López, M. R., Perez-Belmonte, L. M., & Cuesta‐Vargas, A. (2023) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvad027 · Cited by 9 · see citing works
Suciu, B.-S., Turi, V., Crișan, S., Luca, C. T., Lazăr, D. C., Faur-Grigori, A. A., Petrescu, M., Dache, A., Cioca, F., Văcărescu, C., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14248781 · Cited by 6 · see citing works
Real-World Eligibility and Cost-Effectiveness Analysis of Empagliflozin for Heart Failure in Korea
Kim, E.-S., Park, S., Youn, J., Lee, H. S., Lee, H., Cho, H., Choi, J., Jeon, E., Lee, S. E., Kim, M., et al. (2023) · Journal of Korean Medical Science · doi:10.3346/jkms.2024.39.e8 · Cited by 6 · see citing works
Self-citationCognitive impairment and risk of dementia in heart failure: the exuberating role of digoxin
Al-Kuraishy, H. M., Fahad, E. H., Sulaiman, G. M., Mohammed, H. A., Jabir, M. S., Al-Gareeb, A. I., & Albuhadily, A. K. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04457-5 · Cited by 5 · see citing works
Kim, T., Sheen, M., Ryan, D., & Joseph, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020673 · Cited by 6 · see citing works
New Opportunities in Heart Failure with Preserved Ejection Fraction: From Bench to Bedside… and Back
Parra-Lucares, A., Romero-Hernández, E., Villa, E., Weitz-Muñoz, S., Vizcarra, G., Reyes, M., Vergara, D., Bustamante, S., Llancaqueo, M., V, & Toro, L. (2022) · Biomedicines · doi:10.3390/biomedicines11010070 · Cited by 5 · see citing works
Xie, Z. L., Xie, Q., Zheng, X.-Y., Wu, X., Liu, W., Li, R., Zhu, H., & Zhou, Q. G. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1525389 · Cited by 4 · see citing works
Levitskaya, E. S., Batyushin, М. М., Zakusilov, D. I., & Batiushina, A. M. (2024) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2024-4063 · Cited by 3 · see citing works
Lü, J., & Yin, L. (2023) · International Heart Journal · doi:10.1536/ihj.22-554 · Cited by 2 · see citing works
Leahy, M. G., & Sarma, S. (2025) · Heart Failure Reviews · doi:10.1007/s10741-025-10557-4 · Cited by 2 · see citing works
Mansoor, M., Depar, F. N., Talha, H. U., Rashid, H. U., Ashraf, A., Nouman, M., Abbas, M., Abbasi, M. T., & Sher, A. (2025) · World Journal of Cardiology · doi:10.4330/wjc.v17.i12.115254 · Cited by 2 · see citing works
Radu, R. I., Davison, B. A., Collins, S. P., Mebazaa, A., Savarese, G., Miró, Ò., Morishetty, P., Geavlete, O. D., Volterrani, M., Edwards, C., et al. (2026) · Cardiac failure review · doi:10.15420/cfr.2025.56 · Cited by 2 · see citing works
Cao, L., Guo, X., Liao, K., Qin, J., & Zheng, Y. (2024) · Clinical Cardiology · doi:10.1002/clc.70022 · Cited by 2 · see citing works
Ahmed, U., Hussain, H., Saeed, S., Manji, A. A.-K., Valencia, J. D., Yunus, R. A., Robitaille, M. J., Chen, G., Mahmood, F. U., & Matyal, R. (2025) · International Journal of Heart Failure · doi:10.36628/ijhf.2025.0029 · Cited by 2 · see citing works
Okubo, R., Yamamoto, N., Shao, X., Omori, T., Xiong, J., Changhui, L., Kato, R., Murata, M., Kitano, T., Ito, Y., et al. (2026) · Medical Sciences · doi:10.3390/medsci14020306 · Cited by 1 · see citing works
Larina, V. N., Константинович, С. И., Геннадьевич, Л. В., Михайлусова, М. П., & Skiba, A. S. (2022) · Cardiosomatics · doi:10.17816/cs110912 · Cited by 1 · see citing works
Liu, X., Wang, Y., Yiu, K.-H., Zhang, Y., & Wang, J. (2024) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2024.03.028 · Cited by 1 · see citing works
Global status and trends in heart failure with preserved ejection fraction over the period 2009-2020
Dong, Q., Zhang, J., Han, Q., Zhang, H., Wang, M., Huang, Q., & Zhao, J. (2022) · Medicine · doi:10.1097/md.0000000000029106 · Cited by 1 · see citing works
Prospective Changes in Diastolic Function in Patients with Rheumatoid ArthritisPreprint
Park, E., Ito, K., Iqbal, R., Amigues, I., Bokhari, S., Eyk, J. E. V., Depender, C., Giles, J. T., & Bathon, J. M. (2022) · Research Square · doi:10.21203/rs.3.rs-1506970/v1 · Cited by 1 · see citing works
Kapoor, A., Kapoor, A., & Mahajan, G. (2020) · Cardiology and Cardiovascular Research · doi:10.11648/j.ccr.20200404.14
Heart failure risk in younger adults needing more attention
Youn, J., & Baek, S. H. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.10.006
Self-citationTreatment of heart failure with a preserved ejection fraction
Ahn, Y., & Youn, J. (2022) · Journal of Korean Medical Association · doi:10.5124/jkma.2022.65.1.18
Self-citationTempe, D. K. (2025) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2025.02.031
Li, X., Yang, X., Zhou, Y., Wang, S., & Chen, X. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1672940
Strain-Volume Loop Dynamics: A Novel Perspective on Left Ventricular Dysfunction
Kim, H. M., Lee, H., Lim, Y., & Cho, G. (2026) · Korean Circulation Journal · doi:10.4070/kcj.2025.0331
Nashtar, M. A., Salemdawod, M., Sehovic, H., Garipoglu, G., Ödemis, B., Tzalavras, A., Steinmetz, M., Canbay, A., Özcürümez, M. K., Varnavas, V., et al. (2026) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2026.107034
Kalesi, A. E., Papanastasiou, C. A., Alexandrou, K., Khattab, E., Patsourakos, N. G., & Kadoglou, N. P. E. (2026) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2026.103386
Howie, J. O., Dziano, J. K., Ariyaratnam, J., Emami, M., Evans, S., Middeldorp, M. E., Puvrez, A., Kenny, G., Sanders, P., & Elliott, A. D. (2026) · Heart Rhythm O2 · doi:10.1016/j.hroo.2026.07.006
Adejumo, F. A., Obielodan, O. O., Adetoye, F., & Aderinto, N. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1948320
- Authors
- Youn, J.-C., Ahn, Y., & Jung, H. O.
- Affiliations
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Corresponding author
- Jung, Hae Ok
- Venue
- Heart Failure Clinics
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 17
- Issue
- 3
- Pages
- 327-335
- ISSN
- 1551-7136 (ISSN-L)
- OpenAlex
- W3164267406
- Cited by
- 45
- References
- 56
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 1 · 2020: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Heart Failure Clinics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Ministry of Science, ICT and Future Planning (NRF-2018R1C1B6005448)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- heart failure with preserved ejection fraction, pathophysiology, diastolic dysfunction, left ventricular filling pressure, left ventricular stiffness, dyspnea, extracardiac abnormalities, cardiac anomalies
- MeSH terms
- Heart Failure, Humans, Stroke Volume, Exercise, Treatment Outcome, Disease Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
