An unusual presentation of placental malaria: a single persisting nidus of sequestered parasites
Abstract
Placental malaria caused by Plasmodium falciparum is a public health concern in tropical countries. Peripheral blood smears to detect placental malaria are often negative, and recrudescences are common during pregnancy. We performed placental histology on a series of first-time mothers delivering in an area endemic for P falciparum. A single nidus of malaria-infected erythrocytes was identified by placental histology in a single intervillous space from a woman who had no other evidence of peripheral or placental blood parasitemia. This finding suggests ring stage-infected erythrocytes sequester in vivo, or P falciparum can persist as a dormant blood stage form.
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In the Mother-Offspring Malaria Studies Project experience, only one among 207 parturient women without detectable parasites in placental blood smear had parasites detected by histology, and in that unusual case parasites appeared as a single nidus in one intervillous space.
“In the Mother–Offspring Malaria Studies Project experience, only one among 207 parturient women without detectable parasites in placental BS had parasites detected by histology, and in that unusual case parasites appeared as a single nidus in one intervillous space [72].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [72]
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- Authors
- Muehlenbachs, A., Mutabingwa, T. K., Fried, M., & Duffy, P. E.
- Affiliations
- Center for Infectious Disease Research (US)
- Corresponding author
- Duffy, Patrick E.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 38
- Issue
- 3
- Pages
- 520-523
- ISSN
- 0046-8177 (ISSN-L)
- OpenAlex
- W2033942773
- Cited by
- 17
- References
- 11
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Pathology (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32-HL 07312, T32HL007312)
- National Institute of Allergy and Infectious Diseases (R01AI052059, R01AI52059)
- Fogarty International Center (TW05509, D43TW005509)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- placental malaria, Plasmodium falciparum, placental histology, intervillous space, pregnancy, recrudescence, primiparous women
- MeSH terms
- Adolescent, Adult, Erythrocytes, Female, Humans, Middle Aged, Placenta Diseases, Pregnancy, Pregnancy Complications, Parasitic, Malaria, Falciparum
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