Diagnosis of Placental Malaria

Mockenhaupt, Frank P.; Ulmen, Ulrike; von Gaertner, Christiane; Bedu-Addo, George; Bienzle, Ulrich

doi:10.1128/jcm.40.1.306-308.2002

Cited by 108Malaria Research and ControlBird parasitology and diseasesHemoglobinopathies and Related Disorders

Diagnosis of Placental Malaria

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Mockenhaupt, Frank P., Ulmen, Ulrike, von Gaertner, Christiane, Bedu-Addo, George, Bienzle, Ulrich·2002·Journal of Clinical Microbiology

DOI 10.1128/jcm.40.1.306-308.2002PMC PMC120131

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Abstract

In a group of 596 delivering Ghanaian women, the sensitivities of peripheral blood thick film microscopy, ICT Malaria P.f/P.v test, and PCR in detecting microscopically confirmed placental Plasmodium falciparum infection were 42, 80, and 97%, respectively. In addition to the gross underestimation of placental malaria by peripheral blood film microscopy, submicroscopic infections were found to be a risk factor for maternal anemia.

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When performed on peripheral blood for pregnancy malaria diagnosis, RDT-HRP2 sensitivity is more than 90% compared with peripheral blood smear and 80-95% compared with placental blood smear, with specificity between 61 and 94%.
“When performed on peripheral blood samples for PM diagnoses, RDT-HRP2 sensitivity was more than 90% when compared with peripheral BS, and 80–95% when compared with placental BS, with specificity between 61 and 94% [13–16].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [14]
Compared to PCR performed on placental or peripheral blood, the sensitivity of RDT tests was low in two of three pregnancy malaria diagnostics studies.
“Compared to PCR performed on placental or peripheral blood [14,15,17], the sensitivity of RDT tests was low in two of three PM diagnostics studies.”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [14]
Whether applied to peripheral blood or placental blood samples, PCR methods yield positivity rates 20% or more above those of blood smear microscopy.
“Whether applied to peripheral blood or placental blood samples, PCR methods yield positivity rates 20% or more above those of BS microscopy (Tables 3 & 4) [10,14–16,38–46].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [14]
Previous studies conducted at the time of birth have shown that RDT detecting P. falciparum HRP2 are more sensitive than blood smears, and appear to be reliable predictors of adverse outcomes of malaria in pregnancy.
“Previous studies conducted at the time of birth have shown that RDT detecting P. falciparum HRP2 are more sensitive than blood smears, and appear to be reliable predictors of adverse outcomes of malaria in pregnancy [30-32].”
From Reliability of rapid diagnostic test for diagnosing peripheral and placental malaria in an area of unstable malaria transmission in Eastern Sudan (2013) · cites this paper as [31]
Submicroscopic infections were linked with maternal anemia in some studies but not all.
“Submicroscopic infections were linked with maternal anemia in some 17,18,20,23 but not all 12,13,15,21 studies.”
From What is the burden of submicroscopic malaria in pregnancy in central India? (2015) · cites this paper as [18]

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Authors: Mockenhaupt, F. P., Ulmen, U., von Gaertner, C., Bedu-Addo, G., & Bienzle, U.
Affiliations: Humboldt-Universität zu Berlin (DE)
Presbyterian Mission Hospital, Agogo, Asante Akim
Komfo Anoyke Teaching Hospital, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana
ORCID: Mockenhaupt, Frank P.
Venue: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Published: 2002-01
Volume: 40
Issue: 1
Pages: 306-308
ISSN: 0095-1137 (ISSN-L)
1098-660X
DOI: 10.1128/jcm.40.1.306-308.2002
PMC: PMC120131
OpenAlex: W2144765379
Cited by: 108
References: 9
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 2 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 10
FWCI: 5.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Clinical Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords: placental malaria, Plasmodium falciparum, Plasmodium vivax, diagnostic sensitivity, PCR detection, anemia in pregnancy, pregnancy, Ghana
MeSH terms: Animals, Blood Specimen Collection, Female, Humans, Microscopy, Placenta, Placenta Diseases, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Polymerase Chain Reaction, Malaria, Falciparum

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