The DOI matches its Crossref record; 48 of the 51 references it cites were found in a registry or an index.
Expression of vitamin D receptor decreases during progression of pigmented skin lesions
Open accessAbstract
1,25-dihydroxyvitamin D3 affects proliferation, differentiation, and apoptosis and protects DNA against oxidative damage with a net tumorostatic and anticarcinogenic effect. It acts through a specific nuclear receptor that is widely distributed through the body. Although a beneficial role of vitamin D in melanoma patients has been suggested, there is lack of information on the changes in the expression pattern of vitamin D receptor during progression of pigmented lesions. Using immunohistochemistry, we analyzed the expression of vitamin D receptor in 140 samples obtained form 82 patients, including 25 benign nevi, 70 primary cutaneous melanomas, 35 metastases, 5 re-excisions, and 5 normal skin biopsies. The strongest expression was observed in normal skin that significantly decreased in melanocytic proliferations with the following order of expression: normal skin > melanocytic nevi > melanomas = metastases. The vitamin D receptor expression in skin surrounding nevi and melanoma was also significantly reduced as compared to normal skin. Tumor-infiltrating and lymph node lymphocytes retained high levels of vitamin D receptor. There was negative correlation between tumor progression and vitamin D receptor expression with a remarkable decrease of the immunoreactivity in nuclei of melanoma cells at vertical versus radial growth phases and with metastatic melanomas showing the lowest cytoplasmic receptor staining. Furthermore, lack of the receptor expression in primary melanomas and metastases was related to shorter overall patients' survival. In addition, the receptor expression decreased in melanized melanoma cells in comparison to amelanotic or poorly pigmented cells. Therefore, we propose that reduction or absence of vitamin D receptor is linked to progression of melanocytic lesions, that its lack affects survival of melanoma patients, and that melanogenesis can attenuate receptor expression. In conclusion, changes in vitamin D receptor expression pattern can serve as important variables for diagnosis, predicting clinical outcome of the disease, and/or as a guidance for novel therapy of melanomas based on use of vitamin D or its derivatives.
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“expression of the VDR and CYP27B1 decreased during melanoma progression, and melanization and melanogenesis negatively affected both overall- and stage III disease-survival”
From The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions (2014) · cites this paper as [81]
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- Slominski, 2000, Neuroendocrinology of the skin, Endocr Rev, 21, 457
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Items 101–120 of 120
Inhibition of the RIPK4 enhances suppression of human melanoma growth through vitamin D signaling
Olajossy, B., Slominski, A. T., & Wolnicka-Głubisz, A. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112603 · Cited by 5
Self-citationVitamin D axis and its role in skin carcinogenesis: a comprehensive review
Puerto, C. D., Navarrete‐Dechent, C., Molgó, M., Borzutzky, A., & González, S. (2016) · Applied cancer research/Applied Cancer Research · doi:10.1186/s41241-016-0006-4 · Cited by 5
Yang, W., Meng, X., Liu, T., Chen, N., Li, D., & Xu, Y. (2026) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s594944 · Cited by 4
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Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients
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Self-citationSkin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention, and Targeted Therapy
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Dermatoloji ve Kozmetolojide D Vitamini
Cenk, H., Rüstemoğlu, A., Akbulut, S., Uzdoğan, A., Yücel, Ç., Çifci, A., Yakut, H. İ., Oğuz, I. D., Türkmen, D., Demirbaş, A., et al. (2022) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.1313
An evidence-based study for assessment of the effects of Vitamin D in the treatment of vitiligo
Rozario, C. P. (2025) · International Journal of Pharmaceutical and Clinical Research · doi:10.33545/26647591.2025.v7.i1a.124
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Metadata
- Authors
- Brożyna, A. A., Jozwicki, W., Janjetovic, Z., & Slominski, A. T.
- Affiliations
- Nicolaus Copernicus University (PL)
- University of Tennessee Health Science Center (US)
- Corresponding author
- Slominski, Andrzej T.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 42
- Issue
- 5
- Pages
- 618-631
- ISSN
- 0046-8177 (ISSN-L)
- PMC
- PMC3078192
- OpenAlex
- W2153488515
- Cited by
- 120
- References
- 51
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 9
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Pathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- vitamin D receptor, melanoma, cutaneous melanoma, melanocytic nevi, metastatic melanoma, tumor progression, melanogenesis, patient survival, tumor-infiltrating lymphocytes, radial growth phase, vitamin D supplementation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cell Nucleus, Elastic Tissue, Female, Humans, Immunohistochemistry, Male, Melanins, Melanoma, Middle Aged, Mitosis, Nevus, Pigmented, Pigmentation Disorders, Skin, Skin Neoplasms, Tumor Cells, Cultured, Ultraviolet Rays, Survival Rate, Apoptosis, Receptors, Calcitriol, Disease Progression, Young Adult
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