The DOI matches its Crossref record; 48 of the 51 references it cites were found in a registry or an index.
Expression of vitamin D receptor decreases during progression of pigmented skin lesions
Open accessAbstract
1,25-dihydroxyvitamin D3 affects proliferation, differentiation, and apoptosis and protects DNA against oxidative damage with a net tumorostatic and anticarcinogenic effect. It acts through a specific nuclear receptor that is widely distributed through the body. Although a beneficial role of vitamin D in melanoma patients has been suggested, there is lack of information on the changes in the expression pattern of vitamin D receptor during progression of pigmented lesions. Using immunohistochemistry, we analyzed the expression of vitamin D receptor in 140 samples obtained form 82 patients, including 25 benign nevi, 70 primary cutaneous melanomas, 35 metastases, 5 re-excisions, and 5 normal skin biopsies. The strongest expression was observed in normal skin that significantly decreased in melanocytic proliferations with the following order of expression: normal skin > melanocytic nevi > melanomas = metastases. The vitamin D receptor expression in skin surrounding nevi and melanoma was also significantly reduced as compared to normal skin. Tumor-infiltrating and lymph node lymphocytes retained high levels of vitamin D receptor. There was negative correlation between tumor progression and vitamin D receptor expression with a remarkable decrease of the immunoreactivity in nuclei of melanoma cells at vertical versus radial growth phases and with metastatic melanomas showing the lowest cytoplasmic receptor staining. Furthermore, lack of the receptor expression in primary melanomas and metastases was related to shorter overall patients' survival. In addition, the receptor expression decreased in melanized melanoma cells in comparison to amelanotic or poorly pigmented cells. Therefore, we propose that reduction or absence of vitamin D receptor is linked to progression of melanocytic lesions, that its lack affects survival of melanoma patients, and that melanogenesis can attenuate receptor expression. In conclusion, changes in vitamin D receptor expression pattern can serve as important variables for diagnosis, predicting clinical outcome of the disease, and/or as a guidance for novel therapy of melanomas based on use of vitamin D or its derivatives.
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“expression of the VDR and CYP27B1 decreased during melanoma progression, and melanization and melanogenesis negatively affected both overall- and stage III disease-survival”
From The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions (2014) · cites this paper as [81]
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Overview of general physiologic features and functions of vitamin D
DeLuca, H. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1689s · Cited by 2,328
Melanin pigmentation in mammalian skin and its hormonal regulation
Slominski, A., Tobin, D. J., Shibahara, S., & Wortsman, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00044.2003 · Cited by 2,015
Self-citationVitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
Melanoma biology and new targeted therapy
Gray-Schopfer, V., Wellbrock, C., & Marais, R. (2007) · Nature · doi:10.1038/nature05661 · Cited by 1,371
Vitamin D: a millenium perspective
Holick, M. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10338 · Cited by 1,319
Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences
Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T. J., Anderson, R. R., Blank, I. H., Parrish, J. A., & Elias, P. M. (1980) · Science · doi:10.1126/science.6251551 · Cited by 778
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
Self-citationColston, K. W., Colston, M. J., & Feldman, D. (1981) · Endocrinology · doi:10.1210/endo-108-3-1083 · Cited by 564
Sun Exposure and Mortality From Melanoma
Berwick, M., Armstrong, B. K., Ben‐Porat, L., Fine, J., Kricker, A., Eberle, C. E., & Barnhill, R. L. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji019 · Cited by 429
Research works printed but not linked: 1
- Slominski, 2000, Neuroendocrinology of the skin, Endocr Rev, 21, 457
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Exploring vitamin D metabolism and function in cancer
Jeon, S., & Shin, E. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0038-9 · Cited by 581
L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions
Slominski, A. T., Zmijewski, M. A., & Pawelek, J. M. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00898.x · Cited by 449
Self-citationVitamin D and cancer: a review of molecular mechanisms
Fleet, J. C., DeSmet, M. L., Johnson, R., & Li, Y. (2011) · Biochemical Journal · doi:10.1042/bj20110744 · Cited by 416
Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship
Slominski, R. M., Sarna, T., Plonka, P. M., Raman, C., Brożyna, A. A., & Slominski, A. T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.842496 · Cited by 310
Self-citationReview of Natural Compounds for Potential Skin Cancer Treatment
Chinembiri, T. N., Plessis, D., Gerber, M., Hamman, J. H., & du Plessis, J. (2014) · Molecules · doi:10.3390/molecules190811679 · Cited by 276
Metadata
- Authors
- Brożyna, A. A., Jozwicki, W., Janjetovic, Z., & Slominski, A. T.
- Affiliations
- Nicolaus Copernicus University (PL)
- University of Tennessee Health Science Center (US)
- Corresponding author
- Slominski, Andrzej T.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 42
- Issue
- 5
- Pages
- 618-631
- ISSN
- 0046-8177 (ISSN-L)
- PMC
- PMC3078192
- OpenAlex
- W2153488515
- Cited by
- 120
- References
- 51
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 9
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Pathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- vitamin D receptor, melanoma, cutaneous melanoma, melanocytic nevi, metastatic melanoma, tumor progression, melanogenesis, patient survival, tumor-infiltrating lymphocytes, radial growth phase, vitamin D supplementation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cell Nucleus, Elastic Tissue, Female, Humans, Immunohistochemistry, Male, Melanins, Melanoma, Middle Aged, Mitosis, Nevus, Pigmented, Pigmentation Disorders, Skin, Skin Neoplasms, Tumor Cells, Cultured, Ultraviolet Rays, Survival Rate, Apoptosis, Receptors, Calcitriol, Disease Progression, Young Adult
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