Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma
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Because melanogenesis can affect immune responses to and chemotherapy and radiotherapy for melanoma, we analyzed overall survival and disease-free survival times in melanoma patients in relation to the degree of tumor pigmentation. Clinicopathologic data were obtained from the Oncology Centre, Prof Franciszek Łukaszczyk Memorial Hospital, Bydgoszcz, Poland. The overall survival and disease-free survival analyses were performed using the log-rank test, whereas differences between mean/median overall survival and disease-free survival (days) were analyzed using the Student t test. In patients with metastatic disease, those with melanotic melanomas exhibited significantly shorter disease-free survival and overall survival than those with amelanotic lesions. Similarly, melanin-producing lymph node metastases were linked to shorter overall survival and disease-free survival, which was confirmed by a significantly longer mean/median disease-free survival for amelanotic versus melanotic metastases. Melanogenesis shortens overall survival and disease-free survival in patients with metastatic melanoma. Inhibition of melanogenesis appears a rational adjuvant approach to the therapy of metastatic melanoma.
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VDR and CYP27B1 expression decrease during melanoma progression, and melanization and melanogenesis negatively affect overall and stage III disease survival.
“expression of the VDR and CYP27B1 decreased during melanoma progression, and melanization and melanogenesis negatively affected both overall- and stage III disease-survival”
From The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions (2014) · cites this paper as [79]
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- Authors
- Brożyna, A. A., Jóźwicki, W., Carlson, J. A., & Slominski, A. T.
- Affiliations
- Nicolaus Copernicus University (PL)
- Albany Medical College (US)
- University of Tennessee Health Science Center (US)
- Corresponding author
- Slominski, Andrzej T.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 44
- Issue
- 10
- Pages
- 2071-2074
- ISSN
- 0046-8177 (ISSN-L)
- PMC
- PMC3783651
- OpenAlex
- W2062933772
- Cited by
- 175
- References
- 13
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 13 · 2023: 8 · 2022: 21 · 2021: 11 · 2020: 9 · 2019: 17 · 2018: 14 · 2017: 16 · 2016: 14 · 2015: 17 · 2014: 14 · 2013: 1
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Pathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056666)
- Topics
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- melanogenesis, melanoma, tumor pigmentation, melanin, metastatic melanoma, lymph node metastasis, overall survival, disease-free survival, amelanotic melanoma, adjuvant therapy, melanogenesis inhibition
- MeSH terms
- Humans, Lymph Nodes, Lymphatic Metastasis, Melanoma, Melanosis, Neoplasm Staging, Poland, Skin Neoplasms, Comorbidity, Survival Rate, Disease-Free Survival
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